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1.
Medicine (Baltimore) ; 100(21): e26100, 2021 May 28.
Artículo en Inglés | MEDLINE | ID: mdl-34032748

RESUMEN

BACKGROUND: Thyroid carcinoma comprises the fastest rising incidence of carcinomas over the past decade. Papillary thyroid carcinoma (PTC) is the most predominant type of thyroid carcinoma. This study aimed to assess the research trends in the field of PTC. METHODS: Publications from January 2010 to December 2019 were retrieved from the Web of Science Core Collection database using Thompson Reuters. Searching strategies were determined according to Medical Subject Heading terms. Different kinds of bibliometrics software, such as HistCite and VOSviewer, and online bibliometrics analysis platforms were utilized to evaluate and visualize the results. RESULTS: A total of 8102 publications across 93 countries were identified, with the annual number of publications showing an increasing trend. The United States, China, and South Korea showed their dominant position in PTC publication outputs, H-index, total citations, and international collaborations. Thyroid was the most productive journal. Akira Miyauchi published the most articles, and the most productive institution was Yonsei University. The hotspots keywords proliferation, invasion and metastasis, diagnoses and prognoses, therapeutic resistance, recurrence, and microcarcinomas appeared earlier and were sustained over the last 3 years. CONCLUSIONS: This bibliometric study provides a comprehensive analysis delineating the scientific productivity, collaboration, and research hotspots within the PTC field, which will be very helpful when focusing on the direction of research over the next few years.


Asunto(s)
Investigación Biomédica/tendencias , Oncología Médica/tendencias , Cáncer Papilar Tiroideo , Neoplasias de la Tiroides , Bibliometría , Investigación Biomédica/historia , Investigación Biomédica/estadística & datos numéricos , Historia del Siglo XXI , Humanos , Cooperación Internacional/historia , Oncología Médica/historia , Oncología Médica/estadística & datos numéricos
2.
Rev Esp Salud Publica ; 952021 May 27.
Artículo en Español | MEDLINE | ID: mdl-34042088

RESUMEN

The impact and the universality of the pandemic by SARS-CoV-2 has caused the need to have information quickly and accessible for the benefit of decision-making among healthcare professionals. In 10 months the scientific production on this new coronavirus has exceeded the number of 66 thousand articles, according to the LitCovid database, created by the National Library of Medicine, doubling and tripling every few weeks. This same urgency has characterized some of the main features of this voluminous production, in addition to its continuous and exponential growth, such as greater dissemination in open access and preprint repositories, a certain acceleration in the manuscript review process by editorials and an abundance of opinion articles, recommendations or comments compared to a smaller number of original articles with clinical data from large groups of patients.


Asunto(s)
Bibliometría , Investigación Biomédica/tendencias , COVID-19 , Edición/tendencias , Acceso a la Información , COVID-19/diagnóstico , COVID-19/epidemiología , COVID-19/terapia , Toma de Decisiones Clínicas , Bases de Datos Factuales , Medicina Basada en la Evidencia , Salud Global , Humanos , Pandemias
4.
Epilepsia Open ; 6(2): 255-265, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-34033250

RESUMEN

The COVID-19 pandemic has changed the face of many practices throughout the world. Through necessity to minimize spread and provide clinical care to those with severe disease, focus has been on limiting face-to-face contact. Research in many areas has been put on hold. We sought to determine the impact of the COVID-19 pandemic on epilepsy research from international basic science and clinical researchers. Responses to five questions were solicited through a convenience sample by direct email and through postings on the ILAE social media accounts and an ILAE online platform (utilizing Slack). Information was collected from 15 respondents in 11 countries by email or via Zoom interviews between May 19, 2020, and June 4, 2020. Several themes emerged including a move to virtual working, project delays with laboratory work halted and clinical work reduced, funding concerns, a worry about false data with regard to COVID research and concern about research time lost. However, a number of positive outcomes were highlighted, not least the efficiency of online working and other adaptations that could be sustained in the future.


Asunto(s)
Investigación Biomédica , COVID-19 , Epilepsia/terapia , Telemedicina , Investigación Biomédica/métodos , Investigación Biomédica/tendencias , COVID-19/epidemiología , COVID-19/prevención & control , Humanos , SARS-CoV-2
5.
Biomed Res Int ; 2021: 6634055, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33954187

RESUMEN

Background: We conducted a bibliometrics analysis to explore the recent trends in dental implant research which could help researchers have a clear grasp of the relevant research hotspots and prospects. Material and Methods. Altogether, 15,770 articles on dental implants, from January 1, 2010, to October 31, 2019, were selected from the Web of Science Core Collection. We used BICOMB software to extract the high-frequency MeSH terms and construct binary and coword matrices. gCLUTO software was used for biclustering and visual analysis, Ucinet 6 software for social network analysis, SCIMAT software for strategic diagram building, Citespace 5.5 software to form timeline visualization, and VOSviewer software, eventually, for bibliometrics cocitation network. Results: Altogether, 72 high-frequency keywords were extracted from the selected articles and 4 clusters and 7 subcategories were identified through biclustering analysis in the dental implant research field. The use of the strategic diagram also enabled us to find the research hotspot and development trends. Conclusions: The survival rate of dental implants and subsequent restoration have always been the core focus of research. Sinus floor elevation and guided bone regeneration are worthy of constant exploration owing to their reliability. With continuous improvement in technology, immediate loading could become a future research hot spot.


Asunto(s)
Bibliometría , Investigación Biomédica/tendencias , Implantes Dentales , Humanos , Red Social , Factores de Tiempo
6.
Biochem Pharmacol ; 188: 114543, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33812856

RESUMEN

INTRODUCTION: There is an urgent need for new animal models of SARS CoV-2 infection to improve research and drug development. This brief commentary examines the deficits of current models and proposes several improved alternates. The existing single transgene mouse models poorly mimic the clinical features of COVID-19; those strains get a milder disease than human COVID-19 disease. Many of the current transgenic models utilize random integration of several copies of single ACE2 transgenes, resulting in unnatural gene expression and exhibit rapid lethality. We suggest preparing precision knock-in of selected human mini genes at the mouse initiation codon and knock-out of the mouse homolog as a better option. Three genes critical for infection are suggested targets, ACE2 (the viral cellular receptor), its co-infection protease TMRPSS2, and the primary antibody clearance receptor FcγRT. To offer the best platform for COVID 19 research, preparation of single, double, and triple humanized combinations offers the researcher the opportunity to better understand the contributions of these receptors, coreceptors to therapeutic efficacy. In addition, we propose to create the humanized strains in the C57BL/6J and BALB/c backgrounds. These two backgrounds are Th1 responders and Th2 responders, respectively, and allow modeling of the variability seen in human pathology including lung pathology and late sequelae of COVID-19 disease (BALB/c). We suggest the need to do a thorough characterization of both the short-term and long-term effects of SAR-CoV-2 infection at the clinical, virologic, histopathologic, hematologic, and immunologic levels. We expect the multiply humanized strains will be superior to the single-gene and multiple-gene-copy transgenic models available to date. These mouse models will represent state-of-the-art tools for investigating mechanisms of COVID-19 pathogenesis and immunity and developing vaccines and drugs.


Asunto(s)
Investigación Biomédica/tendencias , COVID-19/tratamiento farmacológico , COVID-19/genética , Modelos Animales de Enfermedad , SARS-CoV-2/efectos de los fármacos , SARS-CoV-2/genética , Enzima Convertidora de Angiotensina 2/genética , Enzima Convertidora de Angiotensina 2/inmunología , Animales , Animales Modificados Genéticamente , Antivirales/farmacología , Antivirales/uso terapéutico , COVID-19/inmunología , Vacunas contra la COVID-19/farmacología , Vacunas contra la COVID-19/uso terapéutico , Desarrollo de Medicamentos/tendencias , Humanos , Ratones , SARS-CoV-2/inmunología
7.
Lancet Glob Health ; 9(5): e711-e720, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33865476

RESUMEN

COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts, there have been an overwhelmingly large number of clinical trials that have been registered that are of questionable methodological quality. As the final paper of this Series, we discuss how the medical research community has responded to COVID-19. We recognise the incredible pressure that this pandemic has put on researchers, regulators, and policy makers, all of whom were doing their best to move quickly but safely in a time of tremendous uncertainty. However, the research community's response to the COVID-19 pandemic has prominently highlighted many fundamental issues that exist in clinical trial research under the current system and its incentive structures. The COVID-19 pandemic has not only re-emphasised the importance of well designed randomised clinical trials but also highlighted the need for large-scale clinical trials structured according to a master protocol in a coordinated and collaborative manner. There is also a need for structures and incentives to enable faster data sharing of anonymised datasets, and a need to provide similar opportunities to those in high-income countries for clinical trial research in low-resource regions where clinical trial research receives considerably less research funding.


Asunto(s)
Investigación Biomédica/tendencias , COVID-19/epidemiología , Salud Global , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto
9.
Indian J Med Res ; 153(1 & 2): 26-63, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33818466

RESUMEN

Since the beginning of the year, the deadly coronavirus pandemic, better known as coronavirus disease 2019 (COVID-19), brought the entire world to an unprecedented halt. In tandem with the global scenario, researchers in India are actively engaged in the conduct of clinical research to counter the pandemic. This review attempts to provide a comprehensive overview of the COVID-19 research in India including design aspects, through the clinical trials registered in the Clinical Trials Registry - India (CTRI) till June 5, 2020. One hundred and twenty two registered trials on COVID-19 were extracted from the CTRI database. These trials were categorized into modern medicine (n=42), traditional medicine (n=67) and miscellaneous (n=13). Of the 42 modern medicine trials, 28 were on repurposed drugs, used singly (n=24) or in combination (n=4). Of these 28 trials, 23 were to evaluate their therapeutic efficacy in different severities of the disease. There were nine registered trials on cell- and plasma-based therapies, two phytopharmaceutical trials and three vaccine trials. The traditional medicine trials category majorly comprised Ayurveda (n=45), followed by homeopathy (n=14) and others (n=8) from Yoga, Siddha and Unani. Among the traditional medicine category, 31 trials were prophylactic and 36 were therapeutic, mostly conducted on asymptomatic or mild-to-moderate COVID-19 patients. This review would showcase the research being conducted on COVID-19 in the country and highlight the research gaps to steer further studies.


Asunto(s)
Investigación Biomédica/tendencias , COVID-19 , Sistema de Registros , Ensayos Clínicos como Asunto , Humanos , India/epidemiología
10.
BMC Med Res Methodol ; 21(1): 68, 2021 04 12.
Artículo en Inglés | MEDLINE | ID: mdl-33845785

RESUMEN

RATIONALE: The spread of severe acute respiratory syndrome coronavirus-2 has suspended many non-COVID-19 related research activities. Where restarting research activities is permitted, investigators need to evaluate the risks and benefits of resuming data collection and adapt procedures to minimize risk. OBJECTIVES: In the context of the multicountry Household Air Pollution Intervention (HAPIN) trial conducted in rural, low-resource settings, we developed a framework to assess the risk of each trial activity and to guide protective measures. Our goal is to maximize the integrity of reseach aims while minimizing infection risk based on the latest scientific understanding of the virus. METHODS: We drew on a combination of expert consultations, risk assessment frameworks, institutional guidance and literature to develop our framework. We then systematically graded clinical, behavioral, laboratory and field environmental health research activities in four countries for both adult and child subjects using this framework. National and local government recommendations provided the minimum safety guidelines for our work. RESULTS: Our framework assesses risk based on staff proximity to the participant, exposure time between staff and participants, and potential viral aerosolization while performing the activity. For each activity, one of four risk levels, from minimal to unacceptable, is assigned and guidance on protective measures is provided. Those activities that can potentially aerosolize the virus are deemed the highest risk. CONCLUSIONS: By applying a systematic, procedure-specific approach to risk assessment for each trial activity, we were able to protect our participants and research team and to uphold our ability to deliver on the research commitments we have made to our staff, participants, local communities, and funders. This framework can be tailored to other research studies conducted in similar settings during the current pandemic, as well as potential future outbreaks with similar transmission dynamics. The trial is registered with clinicaltrials.gov NCT02944682 on October 26. 2016 .


Asunto(s)
Investigación Biomédica/tendencias , COVID-19/prevención & control , Pandemias , Medición de Riesgo/métodos , Control de Enfermedades Transmisibles/métodos , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Proyectos de Investigación
11.
PLoS Biol ; 19(4): e3000959, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33798194

RESUMEN

The world continues to face a life-threatening viral pandemic. The virus underlying the Coronavirus Disease 2019 (COVID-19), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has caused over 98 million confirmed cases and 2.2 million deaths since January 2020. Although the most recent respiratory viral pandemic swept the globe only a decade ago, the way science operates and responds to current events has experienced a cultural shift in the interim. The scientific community has responded rapidly to the COVID-19 pandemic, releasing over 125,000 COVID-19-related scientific articles within 10 months of the first confirmed case, of which more than 30,000 were hosted by preprint servers. We focused our analysis on bioRxiv and medRxiv, 2 growing preprint servers for biomedical research, investigating the attributes of COVID-19 preprints, their access and usage rates, as well as characteristics of their propagation on online platforms. Our data provide evidence for increased scientific and public engagement with preprints related to COVID-19 (COVID-19 preprints are accessed more, cited more, and shared more on various online platforms than non-COVID-19 preprints), as well as changes in the use of preprints by journalists and policymakers. We also find evidence for changes in preprinting and publishing behaviour: COVID-19 preprints are shorter and reviewed faster. Our results highlight the unprecedented role of preprints and preprint servers in the dissemination of COVID-19 science and the impact of the pandemic on the scientific communication landscape.


Asunto(s)
COVID-19 , Difusión de la Información/métodos , Edición/tendencias , SARS-CoV-2 , Investigación Biomédica/tendencias , COVID-19/epidemiología , Comunicación , Humanos , Publicación de Acceso Abierto/tendencias , Pandemias , Revisión de la Investigación por Pares/tendencias , Preimpresos como Asunto , SARS-CoV-2/patogenicidad
13.
Mol Biol Cell ; 32(10): 1007-1008, 2021 05 01.
Artículo en Inglés | MEDLINE | ID: mdl-33914594

RESUMEN

For biologic scientists, as for the society in general, the year 2020 was one that few will soon forget. However, in the realm of science, it is possible that it won't be remembered purely, or even mainly, for the advent of the COVID-19 pandemic and the many discoveries related to its causative agent. Even as non-SARS-related research was brought to a near standstill for much of the year, we may in time come to recognize that revolutionary work in other areas of biology was emerging unnoticed under the shadow of the virus.


Asunto(s)
Investigación Biomédica/métodos , Vacunas contra la COVID-19/inmunología , COVID-19/prevención & control , SARS-CoV-2/inmunología , Investigación Biomédica/tendencias , COVID-19/epidemiología , COVID-19/virología , Humanos , Pandemias , SARS-CoV-2/aislamiento & purificación , SARS-CoV-2/fisiología
14.
Health Qual Life Outcomes ; 19(1): 130, 2021 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-33892744

RESUMEN

BACKGROUND: The number of research articles on health-related quality of life (HRQoL) has been strikingly increasing. This study aimed to explore the general trends and hotspots of HRQoL. METHODS: Based on the Web of Science database, research on HRQoL published between 2000 and 2019 were identified. A bibliometric analysis was performed based on the number of articles, citations, published journals, authors' addresses, and keywords. Descriptive analysis, visualization of geographic distribution and keyword clustering analysis were applied to the collected data. RESULTS: The annual number of articles showed growth over the past twenty years, but the annual total citations and annual citations per article were both in decreasing trends. Articles about HRQoL were more likely to be published in journals of multi-subject categories. The HRQoL research was mainly distributed across North America and Europe throughout the twenty years and ushered in a vigorous development worldwide after 2015. Cooperation strength between domestic institutions was much greater than that of international institutions. HRQoL research had six concentrated clusters: HRQoL, Depression, Obesity, Disability, Oncology, Fatigue. CONCLUSION: This study provided an overall perspective of global research trends and hotspots in HRQoL, and a potential insight for future research. HRQoL research had experienced significant increasing development during 2000-2019, especially the HRQoL measurement instruments, however, there were significant regional disparities in scientific output in HRQoL.


Asunto(s)
Bibliometría , Investigación Biomédica/estadística & datos numéricos , Investigación Biomédica/tendencias , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Publicaciones Periódicas como Asunto/tendencias , Calidad de Vida/psicología , Informe de Investigación/tendencias , Europa (Continente) , Predicción , Humanos , América del Norte
15.
Med Sci (Paris) ; 37(4): 315-316, 2021 04.
Artículo en Francés | MEDLINE | ID: mdl-33908844
16.
Am J Hum Genet ; 108(3): 371-372, 2021 03 04.
Artículo en Inglés | MEDLINE | ID: mdl-33667387

RESUMEN

In 2021, the genetics and genomics community needs to communicate to policymakers how the field of human genetics and genomics is transforming biomedical research and medicine, including its essential role in combatting COVID-19. This is important for ensuring that policies enable a thriving scientific enterprise and provide resources for research advances.


Asunto(s)
Investigación Biomédica/tendencias , Genética Médica/tendencias , Genómica/tendencias , COVID-19 , Humanos , Pandemias
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