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1.
Zhongguo Zhong Yao Za Zhi ; 45(19): 4756-4765, 2020 Oct.
Artículo en Chino | MEDLINE | ID: mdl-33164443

RESUMEN

To systematically evaluate the efficacy and safety of Xinmailong Injection in the treatment of coronary heart disease complicated with heart failure. Seven databases,namely CNKI, VIP,WanFang,SinoMed,PubMed,EMbase,Cochrane Library, were retrieved by computer for collecting the randomized controlled trials about Xinmailong Injection in the treatment of coronary heart disease complicated with heart failure. The literatures were screened out, data was extracted, and the methodological quality evaluation was conducted by 2 researchers independently according to inclusion and exclusion criteria. RevMan 5.3 software was used for Meta-analysis and corresponding description analysis. A total of 19 studies involving 1 922 patients were included, including 967 cases in the trial group and 955 cases in the control group. All the clinical studies showed a low quality. Meta-analysis results showed that Xinmailong Injection combined with conventional treatment could better reduce the BNP level(SMD=-3.34, 95%CI[-4.06,-2.63]) in patients of coronary heart disease complicated with heart failure or NT-proBNP level, improve the cardiac function(RR=1.23,95%CI[1.18,1.29]) and LVEF(MD=6.85,95%CI[4.93,8.76]),increase 6 MWT(MD=24.34, 95%CI[16.05, 32.64]) and VEGF(MD=26.39,95%CI[24.30,28.49]),and decreased LVEDD(MD=-4.06, 95%CI[-6.33,-1.80]). And subgroup analysis suggested that the course of treatment may be related to the increase of LVEF. This study found that Xinmailong Injection for coronary heart disease complicated with heart failure can further alleviate clinical symptoms and relevant indicators, with no serious adverse reaction. However, it still needs the support of well-designed multicenter, double-blind and high-quality clinical trials.


Asunto(s)
Enfermedad Coronaria , Medicamentos Herbarios Chinos , Insuficiencia Cardíaca , Enfermedad Coronaria/complicaciones , Enfermedad Coronaria/tratamiento farmacológico , Medicamentos Herbarios Chinos/uso terapéutico , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/tratamiento farmacológico , Humanos , Inyecciones
2.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 6074-6077, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33019356

RESUMEN

The femoral nerve blockage is a procedure that aims to provide anesthesia to the hip, anterior thigh, and stifle. This procedure presents several challenges when performed in veterinary patients with diverse anatomy and physiology. Successful use of this technique will improve a dog's recovery time after surgery in comparison to the commonly used epidural block. A mixed reality application to guide practitioners in the femoral nerve block procedure was developed in Unity and Visual Studio. A 3D model for use within the application was created from pictures of a cadaver leg using photogrammetry software. The Microsoft HoloLens headset provides the mixed reality hardware platform. This paper presents the workflow used in developing the mixed reality application and custom 3D model, as well as initial results with respect to the utility of the application in guiding an anesthesiologist in the procedure of the femoral nerve block.


Asunto(s)
Anestesia Epidural , Bloqueo Nervioso , Animales , Realidad Aumentada , Perros , Nervio Femoral , Humanos , Inyecciones
3.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 5374-5377, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33019196

RESUMEN

Unfractionated heparin (UFH) is commonly used in the intensive care unit (ICU) to prevent blood clotting. Recently, many researchers focus on the development of data- driven methods to solve UFH related problems, which usually involves time series analysis. The performance of data-driven methods depends on whether the inter-correlation of attributes (or variables) in the dataset is closely examined and addressed. This study performs attribute selection, optimal time delay and inter-attributes relations on ICU time series data, in order to provide insights of time series data for UFH related problems. Medical records of 3211 patients with 22 attributes extracted from MIMIC (Medical Information Mart for Intensive Care) III database are used for the experiment. Experimental result shows that some of commonly selected attributes in the literature are less sensitive to the variations of UFH injection. Furthermore, some attributes are inter-dependent, which can increase the complexity of data-driven models, implying that the number of attributes could be reduced. There are 9 attributes found highly related and fast responding in 22 commonly used attributes. This study shows strong potential to provide clinicians with information about sensitive attributes that can help determine the UFH injection policy in ICU.


Asunto(s)
Heparina , Trombosis , Coagulación Sanguínea , Heparina/efectos adversos , Humanos , Inyecciones , Proyectos de Investigación
4.
BMJ Case Rep ; 13(11)2020 Oct 13.
Artículo en Inglés | MEDLINE | ID: mdl-33051251

RESUMEN

Sudden onset sensorineural hearing loss (SSNHL) is frequently seen by otolaryngologists. The exact pathophysiology of the disease is still unknown, with the most likely causative factor being following a viral infection. Immediate steroids are the best treatment to improve prognosis. Despite a plethora of papers in the literature describing SSNHL, there are only a few reported cases of hearing loss following COVID-19, none of which have been reported in the UK. This paper presents the first UK case of SSNHL following COVID-19. Physical examination and imaging excluded any other cause of hearing loss. A literature review showed that four other cases have been previously described. Hearing loss can be a significant cause of morbidity and can easily be missed in the intensive care setting. Being aware and screening for SSNHL following COVID-19 enables an early course of steroids, which offers the best chance of recovering hearing.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus/complicaciones , Pérdida Auditiva Súbita/complicaciones , Pérdida Auditiva Súbita/tratamiento farmacológico , Hemisuccinato de Metilprednisolona/uso terapéutico , Neumonía Viral/complicaciones , Prednisolona/uso terapéutico , Administración Oral , Glucocorticoides/administración & dosificación , Glucocorticoides/uso terapéutico , Pérdida Auditiva Súbita/diagnóstico , Humanos , Inyecciones , Masculino , Hemisuccinato de Metilprednisolona/administración & dosificación , Persona de Mediana Edad , Pandemias , Prednisolona/administración & dosificación
5.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3517-3520, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018762

RESUMEN

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technology that modulates the excitability of the brain by delivering weak electric currents to the brain via scalp electrodes. Electrode configuration and injected current intensity are two important parameters in the tDCS design. This simulation study examined three commercially available electrode configurations, i.e. conventional low definition rectangular pad, high-definition Disc, and high-definition 4 x 1 with different electrode distances and different injected current intensity. Simulation results show that increasing the injected current intensity of HD-tDCS mainly increases the electrical field strength for all configurations. Both Disc and 4 x 1 high definition tDCS (HD-tDCS) have better focality than the conventional low-definition rectangular pad. Increasing the inter-electrode distance in HD-tDCS enlarges the electrical field strength and the depth of stimulation but reduces the focality. In motor rehabilitation, a trade-off needs to be made in the tDCS design to allow the electrical field reaching the white matter to facilitate the usage of the cortico-spinal tract without influencing other undesirable regions in the brain.


Asunto(s)
Estimulación Transcraneal de Corriente Directa , Sustancia Blanca , Encéfalo , Electrodos , Inyecciones
6.
Am J Vet Res ; 81(11): 843-848, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33107754

RESUMEN

OBJECTIVE: To investigate use of a candidate maxillary nerve block in rabbits. ANIMALS: 13 healthy New Zealand White rabbits (Oryctolagus cuniculus). PROCEDURES: In phase 1, the maxillary nerve block procedure was performed in 7 sedated rabbits with 2 volumes (0.25 and 0.5 mL) of a saline (0.9% NaCl)-tissue marker dye solution (1 injection/side by random assignment). Rabbits were euthanized and dissected; numeric scales were used to rate injection accuracy and extent of staining. In phase 2, the nerve block was performed with articaine hydrochloride-epinephrine solution (0.5 mL) on a randomly assigned side in 6 sedated rabbits, with the contralateral side used as a control. Sensory function of the relevant dermatome was tested in triplicate with an algesiometer 0, 30, and 90 minutes after recovery from sedation. Statistical methods were used to compare results between injection volumes (phase 1) and between treated and control sides (phase 2). RESULTS: In phase 1, dye was in contact with the targeted nerve after 13 of 14 injections. Accuracy and extent of staining did not differ significantly between volumes. In phase 2, algesiometer-applied force tolerance differed significantly between treated and control sides 30 minutes after recovery from sedation (56 to 145 minutes after the nerve block procedure). No adverse effects were detected in either study phase. CONCLUSIONS AND CLINICAL RELEVANCE: The described technique for a maxillary nerve block was accurate and effective for desensitization of the relevant dermatome as assessed by algesiometry in healthy rabbits. Additional studies are needed to assess use of this procedure in rabbits of other breeds and its efficacy for clinical use. (Am J Vet Res 2020;81:843-848).


Asunto(s)
Nervio Maxilar , Bloqueo Nervioso , Animales , Inyecciones/veterinaria , Bloqueo Nervioso/veterinaria , Conejos
7.
Medicine (Baltimore) ; 99(43): e22757, 2020 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-33120780

RESUMEN

BACKGROUND: Pneumonia is a common respiratory disease. In severe cases, it can induce cardiovascular disease and even life-threatening. In particular, pneumonia caused by the new coronavirus (SARS-CoV-2) that broke out at the end of 2019 has seriously affected the health of people in all countries. In recent years, it has been treated with the combination of traditional Chinese medicine (TCM) (such as Reduning injection) and Western medicine, and its mortality has decreased significantly. But their efficacy has not been scientifically and systematically assessed. Accordingly, it is essential to provide a systematized review program to estimate the efficacy and safety of Reduning injection combined with Western medicine to treat pneumonia. METHODS: The following databases are retrieved from start to September 2020: Pubmed, Cochrane Library, EMBASE, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang database, the Chongqing VIP Chinese Science and Technology Periodical Database (VIP) databases, Chinese Biomedical Literature Database (CBM), and other databases, which are absorbed into clinical RCTs of pneumonia using western medicine alone or plus Reduning injections. The selection of studies, data extraction, and assessment of risk of bias will be performed independently by 2 reviewers. At the same time, Review Manager V.5.3.5 (Rev Man V.5.3.5) was used for bias risk assessment and data synthesis. RESULTS: The efficacy and safety of Reduning injection combined with western medicine in the treatment of pneumonia were evaluated in terms of overall effective rate, the patient's antipyretic time, antitussive time, rales disappearing time, X-ray recovery time, and the incidence of adverse reactions. CONCLUSIONS: This study provides reliable evidence-based support for the clinical application of Reduning injection combined with western medicine for pneumonia. ETHICS AND DISSEMINATION: Ethical approval is not required in this secondary research evidence, and we will publish the results of this study in a journal or relevant conferences. REGISTRATION NUMBER: DOI 10.17605/OSF.IO/VS75Y.


Asunto(s)
Antivirales/administración & dosificación , Medicamentos Herbarios Chinos/administración & dosificación , Medicina China Tradicional , Neumonía/tratamiento farmacológico , Antivirales/uso terapéutico , Betacoronavirus , Protocolos Clínicos , Infecciones por Coronavirus/tratamiento farmacológico , Quimioterapia Combinada , Medicamentos Herbarios Chinos/uso terapéutico , Humanos , Inyecciones , Pandemias , Neumonía Viral/tratamiento farmacológico
8.
Medicine (Baltimore) ; 99(43): e22872, 2020 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-33120828

RESUMEN

BACKGROUND: Shock is a major public health problem worldwide. At present, the morbidity and mortality of shock patients are relatively high. Vasomotor dysfunction is 1 of the key pathological aspects of shock. Shenfu injection has been widely used for the treatment of shock in China. Pharmacological studies have suggested that Shenfu injection can reduce peripheral circulation resistance and improve microcirculation. The purpose of this study is to evaluate the effect and safety of Shenfu injection on the microcirculation of patients with shock. METHODS: This review summarizes and meta-analyzes randomized controlled trials of Shenfu injection for the treatment of shock.Searched the following electronic databases: PubMed, Cochrane Library, Embase, CNKI, VIP and Wanfang Data. The Cochrane risk assessment tool was used to evaluate the methodological quality of randomized controlled trials. All tests are analyzed according to the standards of the Cochrane Handbook. Review Manager 5.3, R-3.5.1 software and Grading of Recommendations Assessment, Development, and Evaluation pro GDT web solution are used for data synthesis and analysis. RESULTS: This review focuses on the effects of Shenfu injection on the microcirculation of shock patients (blood lactic acid level, arteriovenous oxygen saturation, arteriovenous carbon dioxide partial pressure difference, sublingual microcirculation), 28-day mortality, 28-day ICU hospitalization and adverse reaction rate. CONCLUSION: This review provides a clear basis for evaluating the impact of Shenfu injection on the microcirculation of shock patients, as well as the effectiveness and safety of the treatment.


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Microcirculación/efectos de los fármacos , Choque/tratamiento farmacológico , Estudios de Casos y Controles , China/epidemiología , Medicamentos Herbarios Chinos/administración & dosificación , Medicamentos Herbarios Chinos/efectos adversos , Femenino , Hospitalización/tendencias , Humanos , Inyecciones/métodos , Unidades de Cuidados Intensivos/estadística & datos numéricos , Masculino , Placebos/administración & dosificación , Ensayos Clínicos Controlados Aleatorios como Asunto , Seguridad , Choque/mortalidad , Resultado del Tratamiento
9.
Medicine (Baltimore) ; 99(43): e22716, 2020 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-33120767

RESUMEN

BACKGROUND: Diabetic nephropathy (DN) is the one that of the most common complications of diabetes mellitus (DM). Diabetic patients will experience a high mortality rate when DN progress to end-stage. So, it is extremely important to early treat DN. Although several interventions have been used to treat DN, a conclusive finding has not already been achieved. As one of the most common Chinese medicines, danhong injection (DHI) which has been shown to have various functions has also been prescribed to be as the alternative treatment option. However, no systematic review and meta-analysis has been conducted to objectively and comprehensively investigate its effectiveness and safety. Thus, we designed the current systematic review and meta-analysis to answer whether DHI can be preferably used to timely treat DN. METHODS: We will perform a systematic search to capture any potentially eligible studies in several electronic databases including PubMed, Cochrane library, Embase, China National Knowledgement Infrastructure (CNKI), Wanfang database, and Chinese sci-tech periodical full-text database (VIP) from their inception to August 31, 2020. We will assign 2 independent reviewers to select eligible studies, and assess the quality of included studies with Cochrane risk of bias assessment tool. We will perform all statistical analyses using RevMan 5.3 software. ETHICS AND DISSEMINATION: We will submit our findings to be taken into consideration for publication in a peer-reviewed academic journal. Meanwhile, we will also communicate our findings in important conferences. PROTOCOL REGISTRY: The protocol of this systematic review and meta-analysis has been registered at the International Plateform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) platform (https://inplasy.com/inplasy-2020-9-0005/, registry number: INPLASY202090005) and this protocol was funded through a protocol registry.


Asunto(s)
Nefropatías Diabéticas/tratamiento farmacológico , Medicamentos Herbarios Chinos/administración & dosificación , Metaanálisis como Asunto , Proyectos de Investigación , Revisiones Sistemáticas como Asunto , Intervención Médica Temprana , Humanos , Inyecciones
10.
Medicine (Baltimore) ; 99(43): e22739, 2020 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-33120774

RESUMEN

OBJECTIVES: It was recently proposed that a costoclavicular (CC) approach can be used in ultrasound (US)-guided infraclavicular brachial plexus block (BPB). In this study, we hypothesized that triple injections in each of the 3 cords in the CC space would result in a greater spread in the 4 major terminal nerves of the brachial plexus than a single injection in the CC space without increasing the local anesthetic (LA) volume. METHODS: Sixty-eight patients who underwent upper extremity surgery randomly received either a single injection (SI group, n = 34) or a triple injection (TI group, n = 34) using the CC approach. Ten milliliters of 2% lidocaine, 10 mL of 0.75% ropivacaine, and 5 mL of normal saline were used for BPB in each group (total 25 mL). Sensory-motor blockade of the ipsilateral median, radial, ulnar, and musculocutaneous nerves was assessed by a blinded observer at 5 minutes intervals for 30 minutes immediately after LA administration. RESULTS: Thirty minutes after the block, the blockage rate of all 4 nerves was significantly higher in the TI group than in the SI group (52.9% in the SI group vs 85.3% in the TI group, P = .004). But there was no significant difference in the anesthesia grade between the 2 groups (P = .262). The performance time was similar in the 2 groups (3.0 ±â€Š0.9 minutes in the SI group vs 3.2 ±â€Š1.2 minutes in the TI group, respectively; P = .54). DISCUSSION: The TI of CC approach increased the consistency of US-guided infraclavicular BPB in terms of the rate of blocking all 4 nerves without increasing the procedure time despite administering the same volume of the LA.


Asunto(s)
Anestésicos Locales/administración & dosificación , Bloqueo del Plexo Braquial/métodos , Antebrazo/cirugía , Mano/cirugía , Lidocaína/administración & dosificación , Ropivacaína/administración & dosificación , Adulto , Clavícula , Femenino , Humanos , Inyecciones/métodos , Inyecciones/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Método Simple Ciego , Resultado del Tratamiento
11.
Medicine (Baltimore) ; 99(43): e22762, 2020 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-33120783

RESUMEN

BACKGROUND: Adductor canal block (ACB) has emerged as an attractive alternative for femoral nerve blocks (FNB) as the peripheral nerve block of choice for total knee arthroplasty (TKA), preserving quadriceps motor function while providing analgesia comparable to FNB. However, its optimal application for TKA remains controversial. The objective of this meta-analysis was to compare continuous-injection ACB (CACB) vs single-injection ACB (SACB) for postoperative pain control in patients undergoing TKA. METHODS: This study attempts to identify the available and relevant randomized controlled trials (RCTs) regarding the analgesic effects of CACB compared to SACB in patients undergoing TKA according to electronic databases, including PubMed, Medline, Web of Science, EMbase, and the Cochrane Library, up to September 2019. Primary outcomes in this regard included the use of a visual analogue scale (VAS) pain score with rest or activity, while secondary outcomes were cumulative opioid consumption, length of hospital stay (LOS), complications of vomiting and nausea, and rescue analgesia. The corresponding data were analyzed using RevMan v5.3. ETHICAL REVIEW: Because all of the data used in this systematic review and meta-analysis has been published, the ethical approval was not necessary RESULTS:: This research included 9 studies comprised of 739 patients. The analyzed outcomes demonstrated that patients who received CACB had a better at rest-VAS scores at 4 hours (P = .007), 8 hors (P < .0001), 12 hours (P < .0001), 24 hours (P = .02), mobilization-VAS score at 48 hours (P < .0001), and rescue analgesia (P = .03) than those who underwent SACB. Nevertheless, no significant differences were present between the 2 strategies in terms of pain VAS scores 48 hours at rest (P = .23) and 24 hours at mobilization (P = .10), complications of vomiting and nausea (P = .42), and length of hospital stay (P = .09). CONCLUSION: This meta-analysis indicated that CACB is superior to SACB in regard to analgesic effect following TKA. However, due to the variation of the included studies, no firm conclusions can be drawn. Further investigations into RCT are required for verification.


Asunto(s)
Analgesia/métodos , Artroplastia de Reemplazo de Rodilla , Bloqueo Nervioso/métodos , Dolor Postoperatorio/prevención & control , Ensayos Clínicos Controlados Aleatorios como Asunto , Nervio Femoral , Humanos , Inyecciones , Resultado del Tratamiento
12.
Stroke Vasc Neurol ; 5(3): 311-314, 2020 09.
Artículo en Inglés | MEDLINE | ID: mdl-32994371

RESUMEN

BACKGROUNDS: Embolic stroke is one of the main mechanisms of ischaemic stroke. Even if treated with recommended antithrombotic agents, stroke recurrence remains high. The Shuxuetong injection, a purified extract of traditional Chinese medicine widely used for thrombus diseases in clinical practice in China, could be a promising agent to prevent stroke recurrence. AIMS: To describe the design of the Shuxuetong injection for prevention of recurrence in acute ischaemic stroke with embolism mechanisms. DESIGN: The Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism (SPACE) trial is a multicentre, randomised, double-blind, placebo-controlled, parallel-group, superiority trial to evaluate the efficacy and safety of Shuxuetong injection in reducing recurrence or silent new ischaemic lesions on patients with acute embolic stroke within 10 days. An estimated 2416 patients with embolic stroke within 72 hours of symptom onset from 80 hospitals will be randomly assigned to one of two groups receiving Shuxuetong injection or placebo injection for 10 days. The primary endpoint is symptomatic or asymptomatic new cerebral infarction within 10 days after randomisation. CONCLUSION: The SPACE Trial will provide valuable evidence for the efficacy and safety of Shuxuetong injection for the prevention of stroke recurrence in patients with imaging-defined embolic stroke. CLINICAL TRIAL REGISTRATION: NCT03090113.


Asunto(s)
Isquemia Encefálica/tratamiento farmacológico , Medicamentos Herbarios Chinos/administración & dosificación , Embolia Intracraneal/tratamiento farmacológico , Prevención Secundaria , Accidente Cerebrovascular/tratamiento farmacológico , Adolescente , Adulto , Anciano , Isquemia Encefálica/diagnóstico , China , Método Doble Ciego , Medicamentos Herbarios Chinos/efectos adversos , Estudios de Equivalencia como Asunto , Femenino , Humanos , Inyecciones , Embolia Intracraneal/diagnóstico , Masculino , Persona de Mediana Edad , Estudios Multicéntricos como Asunto , Recurrencia , Accidente Cerebrovascular/diagnóstico , Resultado del Tratamiento , Adulto Joven
13.
PLoS One ; 15(9): e0239544, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32966339

RESUMEN

Injection laryngoplasty (IL) has been used to treat various types of glottal insufficiency. The precise volume and location of the injected materials impact the outcomes. However, exactly how increasing volumes of material are distributed is unknown. In fact, the amount of IL material required to medialize a vocal cord tends to be determined empirically. Thus, the goal of this study was to investigate the pattern of IL material distribution by checking serial micro-computed tomography (MCT) and pressure changes during ILs. This experimental study used 10 excised canine larynges. Experimental devices included the IL syringe, pressure sensor, infusion pump, fixed frame, and monitoring system. We injected calcium hydroxyapatite in the thyroarytenoid muscle; whenever 0.1 mL of material was injected, we obtained an MCT scan while simultaneously measuring the pressure. After the experiments, we performed histologic analyses. MCT analyses showed that materials initially expanded centrifugally and then expanded in all directions within the muscle. The pressure initially increased rapidly but then remained relatively constant until the point at which the materials expanded in multiple directions. Histologic analyses showed that the IL material tended to expand within the epimysium of the thyroarytenoid muscle. However, in some cases, the MCT revealed that there were leakages to the surrounding space with a corresponding pressure drop. If the IL material passes through the epimysium, leakage can occur in the surrounding space, which can account for the reduction in resistance during ILs.


Asunto(s)
Laringoplastia/métodos , Animales , Materiales Biocompatibles/administración & dosificación , Perros , Durapatita/administración & dosificación , Técnicas In Vitro , Inyecciones/efectos adversos , Inyecciones/instrumentación , Inyecciones/métodos , Músculos Laríngeos/diagnóstico por imagen , Músculos Laríngeos/cirugía , Laringe/diagnóstico por imagen , Laringe/cirugía , Modelos Animales , Presión , Pliegues Vocales/diagnóstico por imagen , Pliegues Vocales/cirugía , Microtomografía por Rayos X
14.
Medicine (Baltimore) ; 99(35): e21929, 2020 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-32871932

RESUMEN

BACKGROUND: Cerebral infarction (CI) is a common disease with high morbidity and disability. Shuxuetong (SXT) injection is a Chinese Materia Medica standardized product used in the treatment of CI. Currently, there is a lack of high-quality evidence to support the effectiveness and safety of SXT on patients with CI. This systematic review protocol aims at describing a meta-analysis to evaluate the efficacy of SXT for the treatment of CI. METHODS: We will search the databases of PubMed, MEDLINE, Embase, Cochrane Library Central Register of Controlled Trials, China national knowledge infrastructure database (CNKI), Wan fang database, Chongqing VIP information, and SinoMed from their inception to Jun 2020. Two reviewers will independently screen Randomized controlled trials of SXT for the treatment of CI. The meta-analysis will be conducted using RevMan V.5.3 software. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: The conclusion of our systematic review will provide evidence to judge whether SXT is an effective intervention for patients with CI. TRIAL REGISTRATION NUMBER: 10.17605/OSF.IO/3F6ZH.


Asunto(s)
Infarto Cerebral/tratamiento farmacológico , Medicamentos Herbarios Chinos/uso terapéutico , Metaanálisis como Asunto , Revisiones Sistemáticas como Asunto , Adulto , Medicamentos Herbarios Chinos/efectos adversos , Humanos , Inyecciones , Ensayos Clínicos Controlados Aleatorios como Asunto , Resultado del Tratamiento
15.
Medicine (Baltimore) ; 99(35): e21932, 2020 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-32871934

RESUMEN

BACKGROUND: Xiaoaiping injection, extracted from the Chinese herb Marsdenia tenacissima (Roxb.) Wight et Arn., is a broad-spectrum anti-tumor drug and has been widely used for the treatment of breast cancer in China. The aim of this study is to systematically investigate the efficacy and safety of Xiaoaiping injection for the treatment of breast cancer. METHODS: We will perform the comprehensive literature search in the following databases from their inceptions to August 2020 for data extraction: PubMed, the Cochrane Library, Embase, the China National Knowledge Infrastructure, Wanfang Database, Chinese Science and Technology Periodical Database, and Chinese Biomedical Literature Database. Cochrane Risk of Bias tool will be used to assess the risk of bias of included studies. The RevMan 5.4 and Stata 16.0 software will be applied for statistical analyses. Statistical heterogeneity will be computed by I2 tests. Sensitivity analysis will be conducted to evaluate the stability of the results. The publication bias will be evaluated by funnel plots and Egger's test. The quality of evidence will be assessed by the GRADE system. RESULTS: The results of our research will be published in a peer-reviewed journal. CONCLUSION: The conclusion of this study will provide evidence to show whether Xiaoaiping injection is an effective intervention for patient with breast cancer. OSF REGISTRATION NUMBER: 10.17605/OSF.IO/4ZUXC.


Asunto(s)
Neoplasias de la Mama/tratamiento farmacológico , Medicamentos Herbarios Chinos/efectos adversos , Medicamentos Herbarios Chinos/uso terapéutico , Metaanálisis como Asunto , Revisiones Sistemáticas como Asunto , Femenino , Humanos , Inyecciones , Ensayos Clínicos Controlados Aleatorios como Asunto
16.
Medicine (Baltimore) ; 99(35): e21808, 2020 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-32871901

RESUMEN

BACKGROUND: Viral pneumonia is a common respiratory disease that leads to high mortality around the world. Tanreqing (TRQ) injection has been widely used to treat viral pneumonia in China. However, the efficiency and safety of TRQ injection for viral pneumonia have not been scientifically and methodically evaluated up to now. Thus, this protocol describes a plan of performing a systematic review and meta-analysis to evaluate the efficacy and safety of TRQ injection on patients with viral pneumonia. METHODS: Only randomized controlled trials will be enrolled in our study, and we will search eligible studies in the following electronic databases: PubMed, Embase, Cochrane Central Register of Controlled Trials, Clinical Trials, China National Knowledge Infrastructure, the Wanfang database, the Chinese Scientific Journal Database, and the Sinomed. The total effective rate of clinical efficacy will be used as primary outcome. Time to relieve symptoms, incidence of adverse reactions, and the laboratory parameters will be used as secondary outcomes. Any side effects and adverse events will be recorded and assessed as safety outcomes. Study inclusion, data extraction, and quality assessment will be performed independently by 2 reviewers, and any disagreement will be resolved by a third reviewer. After that, data synthesis and subgroup analysis will be conducted with the Review Manager V.5.3.3 software. RESULTS: This review will provide a high-quality synthesis to assess the effectiveness and safety of TRQ injection for viral pneumonia patients. CONCLUSION: Our study will provide comprehensive evidence to decide whether TRQ injection is effective and safe for viral pneumonia patients. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42020164164.


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Metaanálisis como Asunto , Neumonía Viral/tratamiento farmacológico , Revisiones Sistemáticas como Asunto , Humanos , Inyecciones , Medicina China Tradicional , Proyectos de Investigación
17.
Medicine (Baltimore) ; 99(35): e21993, 2020 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-32871951

RESUMEN

BACKGROUND: Xiaoaiping injection, extracted from the Chinese herb Marsdenia tenacissima (Roxb.) Wight et Arn., is a broad-spectrum anti-tumor drug and has been widely used for the treatment of liver cancer in China. The aim of this study is to systematically investigate the efficacy and safety of Xiaoaiping injection for the treatment of liver cancer. METHODS AND ANALYSIS: Seven electronic databases including the Cochrane Library, PubMed, Excerpt Medica Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Scientific Journal Database, and Wanfang Database will be systematically retrieved for data extraction from their inceptions to August 2020. Cochrane Risk of Bias tool will be used to assess the risk of bias of included studies. The RevMan 5.4 and Stata 16.0 software will be applied for statistical analyses. Statistical heterogeneity will be computed by I tests. Sensitivity analysis will be conducted to evaluate the stability of the results. The publication bias will be evaluated by funnel plots and Eggers test. The quality of evidence will be assessed by the GRADE system. RESULTS: The results of our research will be published in a peer-reviewed journal. CONCLUSION: The conclusion of this study will provide helpful evidence of the effect and safety of Xiaoaiping injection for the treatment of liver cancer in clinical practice. OSF REGISTRATION NUMBER: 10.17605/OSF.IO/9BD6A.


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Neoplasias Hepáticas/tratamiento farmacológico , Humanos , Inyecciones , Marsdenia , Metaanálisis como Asunto , Fitoterapia , Revisiones Sistemáticas como Asunto
18.
Medicine (Baltimore) ; 99(35): e22010, 2020 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-32871955

RESUMEN

BACKGROUND: Tanreqing injection, as a kind of traditional Chinese medicine injection widely used in clinic, has the effects of clearing heat, reducing phlegm and detoxifying, and avoids the problems of slow effect and complicated decocting of traditional Chinese medicine. Severe pneumonia is a critical disease of the respiratory system, with symptoms such as dyspnea, shortness of breath, high fever, and coma. Clinical studies have found that Tanreqing injection combined with Western medicine has a good effect in the treatment of severe pneumonia. In order to explore the efficacy and safety of Tanreqing injection combined with antibiotics in the treatment of severe pneumonia, we plan to conduct a systematic evaluation and meta-analysis. METHODS: Randomized controlled trials (RCTs) on the treatment of severe pneumonia with Tanreqing injection combined with western medicine were collected by searching PubMed, The Cochrane Library, Embase, Web of Science, CNKI, Wanfang Database, Weipu Database, and China Biomedical Literature Service System (CBM) by computer with the retrieval time from establishment of database to July 2020. Two researchers independently screened and extracted the literature, and finally evaluated the bias risk of the included study, and meta-analysis was conducted using RevMan5.3 software. RESULTS: The study evaluated the efficacy and safety of Tanreqing injection combined with Western medicine in the treatment of severe pneumonia in terms of total response rate, CURB-65 score, white blood cell count (WBC), antipyretic time (AT), adverse reaction incidence, etc. CONCLUSIONS:: This study will provide a reliable evidence-based basis for the clinical application of Tanreqing injection in the treatment of severe pneumonia. ETHICS AND DISSEMINATION: The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/SQDMG.


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Neumonía/tratamiento farmacológico , Humanos , Inyecciones , Metaanálisis como Asunto , Revisiones Sistemáticas como Asunto
19.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 32(8): 1018-1019, 2020 Aug.
Artículo en Chino | MEDLINE | ID: mdl-32912422

RESUMEN

Ampoule bottle is a small glass container for liquid medicine, with a capacity of 1-20 mL. It is often used to contain all kinds of liquid medicine for injection, vaccines, etc. Medical ampoules are related to all aspects of clinical work. In the process of operation, the opened ampoule bottle is often placed directly on the operating table. There are many shortcomings and deficiencies, for example, ampoules are easily to be overturned, causing environmental pollution, residual drug pollution, medical personnel exposure damage from their sharp ends, etc. For this reason, the medical staff from Northern Jiangsu People's Hospital designed a return box for ampoule bottle placement and obained a national utility model patent. The utility model has the advantages of being simple structured, convenient, safe and clean in the use process. The box can separate the opened ampoule bottles, reduce the waste of liquid medicine and drug pollution, effectively protect the ampoule bottle and avoid the injury of the medical staff. This new device is worth popularizing in clinical work.


Asunto(s)
Embalaje de Medicamentos , Vidrio , Humanos , Inyecciones
20.
Zhongguo Zhong Yao Za Zhi ; 45(15): 3518-3524, 2020 Aug.
Artículo en Chino | MEDLINE | ID: mdl-32893539

RESUMEN

To analyze the clinincal application characteristics of Xiyanping Injection in real world. The data of the patients came from the hospital information systerm(HIS) of 29 tertiary hospitals in China from 2006 to 2016. It included three parts about basic information, Western medicine diagnosis information, and doctor advice information. The exploration was conducted for the characteristics of the patients and disease distribution as well as the therapeutic regimen. Apriori algorithm was adopted to establish the models, and Clementing 12.0 was used for a correlation analysis of the comprehensive therapeutic regimen of Xiyanping Injection. There were 194 873 cases in the study. The male to female ratio was 1.44∶1. The median age was 4 years old. The median daily dosage was 200 mg. 46.68% of the patients were administered with 250-500 mg, and 33.07% were 50-100 mg one day. 47.08% of the patients were administered for 4-7 d, and 32.65% of the patients were 1-3 d. In the doctor advice information, the most frequently types of Western medicine, traditional Chinese medicine were mucilagin, heat-clearing agent. Second generation cephalosporins, third generation cephalosporins, compound penicillin were the most common types of antibiotic. Interferon, nucleoside and nucleotide, human immunoglobulin were the most common types of antiviral drug. The mining association rules results were analyzed, finding the application of Xiyanping Injection in severe infectious diseases. To improve respiratory symptoms, Xiyanping Injection treaments were Budesonide + Ipratropium Bromide + Ambroxol. To severe pulmonary infection, the treaments were Dopamine + Ambroxine. To severe hand, foot and mouth disease, the treatments were Namefen + Mannitol. To pulmonary heart failure, the treatments were Dobutamine + Heparin. Based on the results of the real world HIS, we could provide clinical application the idea, and a reference for further excavation of the applicable diseases of Xiyanping Injection.


Asunto(s)
Medicamentos Herbarios Chinos/uso terapéutico , Infecciones del Sistema Respiratorio/tratamiento farmacológico , Preescolar , China , Femenino , Humanos , Inyecciones , Masculino , Medicina China Tradicional
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