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1.
BMC Health Serv Res ; 21(1): 22, 2021 Jan 06.
Artículo en Inglés | MEDLINE | ID: mdl-33407442

RESUMEN

BACKGROUND: In sub-Saharan Africa, there is dearth of trained laboratorians and strengthened laboratory systems to provide adequate and quality laboratory services for enhanced HIV control. In response to this challenge, in 2007, the African Centre for Integrated Laboratory Training (ACILT) was established in South Africa with a mission to train staffs from countries with high burdens of diseases in skills needed to strengthen sustainable laboratory systems. This study was undertaken to assess the transference of newly gained knowledge and skills to other laboratory staff, and to identify enabling and obstructive factors to their implementation. METHODS: We used Kirkpatrick model to determine training effectiveness by assessing the transference of newly gained knowledge and skills to participant's work environment, along with measuring enabling and obstructive factors. In addition to regular course evaluations at ACILT (pre and post training), in 2015 we sent e-questionnaires to 867 participants in 43 countries for course participation between 2008 and 2014. Diagnostics courses included Viral Load, and systems strengthening included strategic planning and Biosafety and Biosecurity. SAS v9.44 and Excel were used to analyze retrospective de-identified data collected at six months pre and post-training. RESULTS: Of the 867 participants, 203 (23.4%) responded and reported average improvements in accuracy and timeliness in Viral Load programs and to systems strengthening. For Viral Load testing, frequency of corrective action for unsatisfactory proficiency scores improved from 57 to 91%, testing error rates reduced from 12.9% to 4.9%; 88% responders contributed to the first national strategic plan development and 91% developed strategies to mitigate biosafety risks in their institutions. Key enabling factors were team and management support, and key obstructive factors included insufficient resources and staff's resistance to change. CONCLUSIONS: Training at ACILT had a documented positive impact on strengthening the laboratory capacity and laboratory workforce and substantial cost savings. ACILT's investment produced a multiplier effect whereby national laboratory systems, personnel and leadership reaped training benefits. This laboratory training centre with a global clientele contributed to improve existing laboratory services, systems and networks for the HIV epidemic and is now being leveraged for COVID-19 testing that has infected 41,332,899 people globally.


Asunto(s)
Epidemias/prevención & control , Infecciones por VIH/prevención & control , Laboratorios/organización & administración , Personal de Laboratorio/educación , África del Sur del Sahara/epidemiología , Servicios de Laboratorio Clínico , Infecciones por VIH/epidemiología , Investigación sobre Servicios de Salud , Humanos , Estudios Retrospectivos
2.
J Cell Biol ; 220(1)2021 01 04.
Artículo en Inglés | MEDLINE | ID: mdl-33332553

RESUMEN

The COVID-19 pandemic has created additional challenges for mid-career investigators seeking new academic opportunities. JCB asked scientists to share their experiences of uprooting their research careers and laboratories during the pandemic.


Asunto(s)
Investigación Biomédica/organización & administración , Pandemias , Investigadores/psicología , Transportes/métodos , Adulto , Selección de Profesión , Femenino , Humanos , Laboratorios/organización & administración , Masculino , Investigadores/organización & administración , /patogenicidad
3.
Zhonghua Nan Ke Xue ; 26(3): 219-222, 2020 Mar.
Artículo en Chino | MEDLINE | ID: mdl-33346960

RESUMEN

The novel coronavirus disease 2019 (COVID-19) broke out in December 2019 and has been rapidly escalating throughout the world. Clinical findings show that the patients with either symptomatic or asymptomatic COVID-19 can be a potential source of infection. Although respiratory droplets and close contact are considered to be the main routes of transmission, there is the possibility of aerosol transmission in a relatively closed environment. The nucleic acid of the novel coronavirus can be detected in nasopharyngeal swabs, sputum and other lower respiratory tract secretions, blood, feces, urine and so on, but whether it exists in the semen has not been confirmed. It is reported that the novel coronavirus may affect the testis that highly expresses angiotensin-converting enzyme 2 (ACE2) and theoretically the semen is a possible carrier of the virus considering the fact that it is discharged from the same channel as the urine. Andrology laboratorians are exposed to most of the specimens above, including semen, and some open operations in the laboratory increase the risk of aerosol generation. Therefore, corresponding protective procedures are necessitated in andrology laboratories to reduce the risk of infection during the outbreak of COVID-19. Based on the knowledge and experience available as regards the pandemic and the characteristics of the work in the andrology laboratory, we summarize some biosafety points for andrology laboratorians to attend to during the outbreak of COVID-19.


Asunto(s)
Andrología/organización & administración , Contención de Riesgos Biológicos , Laboratorios/organización & administración , Humanos , Masculino
6.
Emerg Infect Dis ; 26(11): 2549-2554, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32956612

RESUMEN

In many settings, the ongoing coronavirus disease (COVID-19) pandemic coincides with other major public health threats, in particular tuberculosis. Using tuberculosis (TB) molecular diagnostic infrastructure, which has substantially expanded worldwide in recent years, for COVID-19 case-finding might be warranted. We analyze the potential of using TB diagnostic and research infrastructures for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We focused on quality control by adapting the 12 Quality System Essentials framework to the COVID-19 and TB context. We conclude that diagnostic infrastructures for TB can in principle be leveraged to scale-up SARS-CoV-2 testing, in particular in resource-poor settings. TB research infrastructures also can support sequencing of SARS-CoV-2 to study virus evolution and diversity globally. However, fundamental principles of quality management must be followed for both TB and SARS-CoV-2 testing to ensure valid results and to minimize biosafety hazards, and the continuity of TB diagnostic services must be guaranteed at all times.


Asunto(s)
Betacoronavirus , Técnicas de Laboratorio Clínico/normas , Infecciones por Coronavirus/diagnóstico , Laboratorios/organización & administración , Neumonía Viral/diagnóstico , Tuberculosis/diagnóstico , Creación de Capacidad , Infecciones por Coronavirus/epidemiología , Humanos , Pandemias , Neumonía Viral/epidemiología , Control de Calidad , Tuberculosis/epidemiología
7.
Sheng Wu Gong Cheng Xue Bao ; 36(7): 1459-1464, 2020 Jul 25.
Artículo en Chino | MEDLINE | ID: mdl-32748604

RESUMEN

The teaching laboratory is the central place to teach lab courses to undergraduate students. It is thus critical to evaluate how lab skills of students will be affected by the management of this lab. This study attempts to introduce the 6S concept, referring to "Seiri", "Seiton", "Seiso", "Seiketsu", "Shisuke", and "Safety", to the management of teaching laboratory, in particular, to the management of environments, safety, item deposition, reagents and consumables in the laboratory. We find that applying the "6S" management maintains a tidy lab environment, facilitates teaching the lab skills, and improves the quality of teaching, which together achieves the goal of education with the atmosphere. This study can provide a guideline for establishing and managing teaching laboratories in universities.


Asunto(s)
Educación , Laboratorios , Universidades , Educación/organización & administración , Educación/normas , Planificación Ambiental , Humanos , Laboratorios/organización & administración , Laboratorios/normas , Estudiantes , Universidades/organización & administración , Universidades/normas
8.
Artículo en Ruso | MEDLINE | ID: mdl-32827381

RESUMEN

The analysis of various needs in medical laboratory services among physicians of the Samara oblast is targeted to further improvement of laboratory service at oblast level. It is established that effectiveness of laboratory service depends on the needs of customer of service sector which are both physicians and patients. Ignoring their needs results in an increasing both of number of unsatisfied customers and level of mistrust individual operators and laboratory service itself. On the contrary, client-centric approach facilitates dialog of all participants of process of providing laboratory services.


Asunto(s)
Laboratorios/organización & administración , Laboratorios/normas , Médicos , Humanos , Federación de Rusia
10.
Health Secur ; 18(3): 232-236, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32522074

RESUMEN

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen that causes coronavirus disease 2019 (COVID-19), which was first detected in Wuhan, China. Recent studies have updated the epidemiologic and clinical characteristics of COVID-19 continuously. In China, diagnostic tests and laboratory tests of specimens from persons under investigation are usually performed in a biosafety level 2 environment. Laboratory staff may be at greater risk of exposure due to a higher concentration and invasiveness of emerging pathogens. Current infection prevention strategies are based on lessons learned from severe acute respiratory syndrome, expert judgments, and related regulations. This article summarizes biosafety prevention and control measures performed in severe acute respiratory syndrome coronavirus 2 testing activities and provides practical suggestions for laboratory staff to avoid laboratory-acquired infections in dealing with public health emergencies.


Asunto(s)
Técnicas de Laboratorio Clínico/métodos , Contención de Riesgos Biológicos/métodos , Infecciones por Coronavirus/sangre , Infección de Laboratorio/prevención & control , Equipo de Protección Personal/estadística & datos numéricos , Neumonía Viral/sangre , Betacoronavirus , China , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/epidemiología , Desinfección/organización & administración , Femenino , Humanos , Laboratorios/organización & administración , Masculino , Salud Laboral , Pandemias , Neumonía Viral/epidemiología , Manejo de Especímenes/métodos
14.
Cytometry A ; 97(9): 882-886, 2020 09.
Artículo en Inglés | MEDLINE | ID: mdl-32583531

RESUMEN

Operating shared resource laboratories (SRLs) in times of pandemic is a challenge for research institutions. In a multiuser, high-turnover working space, the transmission of infectious agents is difficult to control. To address this challenge, imaging core facility managers being members of German BioImaging discussed how shared microscopes could be operated with minimal risk of spreading SARS-CoV-2 between users and staff. Here, we describe the resulting guidelines and explain their rationale, with a focus on separating users in space and time, protective face masks, and keeping surfaces virus-free. These recommendations may prove useful for other types of SRLs. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals LLC. on behalf of International Society for Advancement of Cytometry.


Asunto(s)
Betacoronavirus/patogenicidad , Investigación Biomédica/organización & administración , Infecciones por Coronavirus/prevención & control , Control de Infecciones , Laboratorios/organización & administración , Microscopía , Salud Laboral , Pandemias/prevención & control , Neumonía Viral/prevención & control , Conducta Cooperativa , Infecciones por Coronavirus/transmisión , Infecciones por Coronavirus/virología , Descontaminación , Contaminación de Equipos/prevención & control , Alemania , Humanos , Exposición Profesional/prevención & control , Equipo de Protección Personal , Neumonía Viral/transmisión , Neumonía Viral/virología , Factores Protectores , Investigadores/organización & administración , Medición de Riesgo , Factores de Riesgo , Flujo de Trabajo
16.
Emerg Infect Dis ; 26(8): 1944-1946, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-32433015
18.
Indian J Med Res ; 151(2 & 3): 172-176, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32242878

RESUMEN

Novel coronavirus infection [coronavirus disease 2019 (COVID-19)] has spread to more than 203 countries of various regions including Africa, America, Europe, South East Asia and Western Pacific. The WHO had declared COVID-19 as the global public health emergency and subsequently as pandemic because of its worldwide spread. It is now one of the top-priority pathogens to be dealt with, because of high transmissibility, severe illness and associated mortality, wide geographical spread, lack of control measures with knowledge gaps in veterinary and human epidemiology, immunity and pathogenesis. The quick detection of cases and isolating them has become critical to contain it. To meet the increasing demand of the diagnostic services, it is necessary to enhance and expand laboratory capabilities since existing laboratories cannot meet the emerging demand. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a BSL-2 (Biosafety Level 2) agent and needs to be handled in biosafety cabinet using standard precautions. This review highlights minimum requirements for the diagnostic laboratories opting testing of material for the diagnosis of COVID-19 and associated biorisk to the individuals and to the community.


Asunto(s)
Contención de Riesgos Biológicos/métodos , Infecciones por Coronavirus/diagnóstico , Laboratorios/organización & administración , Neumonía Viral/diagnóstico , Betacoronavirus , Técnicas de Laboratorio Clínico , Humanos , Pandemias , Medición de Riesgo
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