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1.
BMC Oral Health ; 19(1): 262, 2019 11 27.
Artículo en Inglés | MEDLINE | ID: mdl-31775712

RESUMEN

BACKGROUND: There are conflicting opinions about the contribution of malocclusions to the development of dental caries and periodontal disease. This study's aim was to determine the association between specific malocclusion traits, caries, oral hygiene and periodontal health for children 6 to 12 years old. METHODS: The study was a household survey. The presence of malocclusion traits was assessed in 495 participants. The caries status and severity were assessed with the decayed, missing, and filled teeth (dmft/DMFT) index and the pulpal involvement, ulceration, fistula and abscess (pufa/PUFA) index. The Simplified Oral Hygiene Index (OHI-S) and Gingival Index (GI) were used to assess periodontal health. The association between malocclusion traits, the presence of caries, poor oral hygiene, and poor gingival health were determined with chi square and logistic regression analyses. Statistical significance was inferred at p < 0.05. RESULTS: Seventy-four (14.9%) study participants had caries, with mean (SD) dmft/DMFT scores of 0.27 (0.82) and 0.07 (0.39), respectively, and mean (SD) pufa/PUFA index scores of 0.09 (0.43) and 0.02 (0.20), respectively. The mean (SD) OHI-S score was 1.56 (0.74) and mean (SD) GI score was 0.90 (0.43). Dental Aesthetic Index scores ranged from 13 to 48 with a mean (SD) score of 20.7 (4.57). Significantly greater proportions of participants with crowding (p = 0.026) and buccal crossbite (p = 0.009) had caries. Significantly more children with increased overjet (p = 0.003) and anterior open bite (p = 0.008) had moderate to severe gingivitis. Poor oral hygiene (OR: 1.83; CI: 1.05-3.18 p = 0.033), crowding (OR: 1.97; CI: 1.01-3.49; p = 0.021) and buccal crossbite (OR: 6.57; CI: 1.51-28.51 p = 0.012) significantly increased the odds of having caries. Poor oral hygiene (p < 0.001), increased overjet (p = 0.003), and anterior open bite (p = 0.014) were the only significant traits associated with gingivitis. CONCLUSIONS: Crowding and buccal cross bite were associated with caries, whereas increased overjet and anterior open bite were associated with gingivitis. These findings justify the recommendation of orthodontic treatment to improve oral health.


Asunto(s)
Caries Dental , Maloclusión , Higiene Bucal , Niño , Estudios Transversales , Índice CPO , Caries Dental/complicaciones , Femenino , Humanos , Masculino , Maloclusión/complicaciones , Nigeria , Prevalencia
2.
Aust Vet J ; 97(11): 473-481, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31631313

RESUMEN

Malocclusions are a misalignment or incorrect positioning of the teeth when the upper and lower jaws close. These are poorly described in the koala and can result in irregular mastication which can have lifelong effects on body condition and oral health. A total of 370 koalas from two populations in Queensland (295) and one in South Australia (75) were examined for malocclusions. The prevalence of malocclusions in South Australian free-ranging koalas, captive Queensland koalas and Queensland free-ranging koalas was 39% (44), 30% (29) and 22% (29) respectively. Four types of malocclusion were identified based on severity of misalignment of the incisor/canine region, types 1, 2, 3 and 4. Maxillary overbite measurements of the molariform teeth were determined and these anisognathic values were then used to describe malocclusions within familial relationships in captive colonies. Captive koalas with a malocclusion had narrower mandibular width that ranged between 0.5 and 1% less than the normal measurements. The specific malocclusions reported in this study affected individuals by leading to tooth rotation, mobility and erosion with inefficient mastication of food and vegetation compaction. These changes increased the oral cavity pathology, by placing animals at risk of periodontal disease. There was evidence of familial links to malocclusion types in captive animals. Therefore captive breeding recommendations should consider known koala malocclusion traits to minimise their effect on future generations.


Asunto(s)
Maloclusión/veterinaria , Phascolarctidae , Desgaste de los Dientes/veterinaria , Animales , Animales Salvajes , Animales de Zoológico , Incisivo , Maloclusión/complicaciones , Maloclusión/epidemiología , Queensland/epidemiología , Australia del Sur/epidemiología , Desgaste de los Dientes/epidemiología , Desgaste de los Dientes/etiología
3.
Am J Orthod Dentofacial Orthop ; 156(3): 303-311, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31474260

RESUMEN

INTRODUCTION: One of the goals of malocclusion treatment is to improve the oral health-related quality of life (OHRQoL) of patients. The aim of this trial was to assess the OHRQoL of children before, during, and after anterior open bite (AOB) correction, compared with nontreated children, in a 2-arm parallel single-blind randomized controlled trial. METHODS: Eighty children with AOB aged 8-10 years were randomly assigned to 2 groups (n = 40 each): a group treated with the use of fixed palatal crib (FPC; TG) and a control group (nontreated; CG). Randomization was performed with the use of BioEstat software. The outcome (OHRQoL) was assessed with the use of the validated Brazilian Portuguese version of the Child Perceptions Questionnaire (CPQ8-10) applied before (baseline, phase 1), 3 months after FPC placement (phase 2), and 1 month after FPC removal (phase 3) in the TG. In the CG, CPQ8-10 was applied at baseline (phase 1), 3 months (phase 2), and 12 months (phase 3). Data were analyzed by means of a blinded statistic with the use of Friedman, Wilcoxon, and Mann-Whitney tests (α = 0.05). RESULTS: All participants finished the RCT, and demographic characteristics were similar between groups. In phase 1, the TG had lower scores for the "social well-being" domain (P = 0.02). In phase 2, the CG had higher scores than the TG for the "emotional well-being" and "social well-being" domains, but the opposite was observed for "oral symptoms" and "functional limitations" (P < 0.001). In phase 3, the TG showed a lower impact on OHRQoL than the CG in all domains and in the overall score (P < 0.001). In the 3 phases, the CG showed progressive increase (mean scores 70.37, 74.70, and 84.22, respectively; P < 0.001) and the TG a decrease (mean scores 70.20, 70.80, and 6.05, respectively; P < 0.001) in overall scores. The increase of scores in the CG was considered to represent a serious harm. CONCLUSIONS: Correction of AOB had a positive impact and failure to correct it had a negative impact on the OHRQoL of children. REGISTRATION: This trial was not registered. PROTOCOL: The protocol was not published before trial commencement.


Asunto(s)
Mordida Abierta/psicología , Mordida Abierta/terapia , Salud Bucal , Calidad de Vida , Brasil , Niño , Estética Dental , Femenino , Humanos , Masculino , Maloclusión/complicaciones , Ortodoncia Correctiva , Método Simple Ciego , Encuestas y Cuestionarios
4.
Oral Dis ; 25(7): 1759-1768, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31357246

RESUMEN

OBJECTIVES: To detect whether early growth response 1 (EGR1) in peripheral blood leucocytes (PBLs) indicates temporomandibular joint (TMJ) osteoarthritis (OA) lesions. MATERIALS AND METHODS: Egr1 mRNA expression levels in PBLs were detected in eight malocclusion patients without temporomandibular disorder (TMD) signs and 16 malocclusion patients with clinical TMD signs with (eight) or without (eight) imaging signs of TMJ OA. Twelve 6-week-old rats were randomized to a control group and a unilateral anterior crossbite (UAC) group and were sampled at 4 weeks. The Egr1 mRNA expression levels in PBLs and protein expression levels in different orofacial tissues were measured. RESULTS: Patients with TMD signs with/without TMJ OA diagnosis showed lower Egr1 mRNA expression levels in PBLs than patients without TMD signs. The lower Egr1 mRNA expression was also found in the PBLs of UAC rats, which were induced to exhibit early histo-morphological signs of TMJ OA lesions. In subchondral bone of UAC rats, EGR1 protein expression was decreased, co-localization of EGR1 with osterix or dentin matrix protein-1 was identified, and the number of EGR1 and osterix double-positive cells was reduced (all p < .05). CONCLUSION: Egr1 reduction in PBLs potentially indicates subchondral bone OA lesions at an early stage.


Asunto(s)
Cartílago Articular , Proteína 1 de la Respuesta de Crecimiento Precoz/metabolismo , Cóndilo Mandibular , Osteoartritis , Trastornos de la Articulación Temporomandibular/etiología , Animales , Cartílago Articular/metabolismo , Cartílago Articular/patología , Proteína 1 de la Respuesta de Crecimiento Precoz/genética , Maloclusión/complicaciones , ARN Mensajero , Distribución Aleatoria , Ratas , Articulación Temporomandibular , Trastornos de la Articulación Temporomandibular/metabolismo , Tomografía Computarizada por Rayos X , Factores de Transcripción/análisis
5.
Niger J Clin Pract ; 22(6): 817-823, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31187768

RESUMEN

Aim: The aim of this study was to assess the impact of the presence of early childhood caries (ECC), traumatic dental injury (TDI), and malocclusion, as well as severe conditions, on the oral health-related quality of life (OHRQoL) of preschool children and families. Materials and Methods: A cross-sectional survey was conducted in children aged 1 to 6 years old, who attended to the Department of Paediatric Dentistry, Gazi University. The questionnaires were adapted to Turkish, and OHRQoL was measured using the Turkish version of Early Childhood Oral Health Impact Scale (T-ECOHIS). Children were classified into four main groups, two subgroups in each group based on their severity conditions-Group 1: ECC group; Group 2: TDI group; Group 3: Malocclusion group; Group 4: Control group. Parents answered the questions about sociodemographic conditions and T-ECOHIS. The Kolmogorov-Smirnov test was used for non-normal distribution and Kruskal-Wallis and Mann-Whitney tests were used to compare T-ECOHIS score regarding ECC, TDI, and malocclusion. Results: Both simple and severe conditions of TDI showed a negative impact on the family and child based on T-ECOHIS scores (P < 0.05). The severe condition of ECC and malocclusion showed significantly negative impact on family (P > 0.05) but not on child (P > 0.0.5). Conclusion: The presence of ECC, TDI, and malocclusion has a negative effect on OHRQoL of Turkish preschool children and specially their families. So, public health programs should be carried out about oral health for raising parents' and children's awareness and increasing OHRQoL.


Asunto(s)
Caries Dental/complicaciones , Maloclusión/complicaciones , Calidad de Vida , Traumatismos de los Dientes/complicaciones , Adulto , Niño , Preescolar , Estudios Transversales , Caries Dental/psicología , Familia , Femenino , Humanos , Lactante , Masculino , Maloclusión/psicología , Salud Bucal , Padres , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios , Traumatismos de los Dientes/psicología , Índices de Gravedad del Trauma
6.
Orthod Fr ; 90(1): 65-74, 2019 Mar.
Artículo en Francés | MEDLINE | ID: mdl-30994450

RESUMEN

INTRODUCTION: Asymmetrical orthodontic cases frequently prove very difficult to correct. Anchorage mini-screws are often needed to treat these cases when the malocclusion is of maxillary origin. Nonetheless, a precise biomechanical assessment must be made to avoid undesirable sideeffects resulting from the mechanics used. Whether one uses a continuous or a segmented archwire, adverse events can occur and must be planned for in order to contain them. MATERIALS AND METHODS: The authors will first give an overview of the possible undesirable effects using the continuous arch technique and the principles underlying the segmented archwire technique. Various clinical cases will also be described to support their argument. CONCLUSION: The advantage of the segmented techniques lies in the precision and speed of the movements obtained in the three dimensions of space. However, they can also present major drawbacks. In practice, these techniques seem best-suited to complex atypical cases, and particularly cases involving asymmetry of the frontal and transverse planes.


Asunto(s)
Asimetría Facial/complicaciones , Asimetría Facial/terapia , Maloclusión/complicaciones , Maloclusión/terapia , Diseño de Aparato Ortodóncico , Alambres para Ortodoncia/clasificación , Artefactos , Fenómenos Biomecánicos , Tornillos Óseos , Femenino , Humanos , Mandíbula/cirugía , Maxilar/patología , Maxilar/cirugía , Métodos de Anclaje en Ortodoncia/efectos adversos , Métodos de Anclaje en Ortodoncia/instrumentación , Métodos de Anclaje en Ortodoncia/métodos , Diseño de Aparato Ortodóncico/efectos adversos , Diseño de Aparato Ortodóncico/clasificación , Diseño de Aparato Ortodóncico/métodos , Ortodoncia Correctiva/efectos adversos , Ortodoncia Correctiva/instrumentación , Ortodoncia Correctiva/métodos , Planificación de Atención al Paciente/normas
7.
J Clin Pediatr Dent ; 43(3): 211-217, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30964725

RESUMEN

Objective: The aim of this study was to investigate the relation between malocclusion in mixed dentition and its impact on the oral health-related quality of life OHRQoL of children and their families as well to determine if there were any reported differences in OHRQoL due to malocclusion severity. Study design: A total of 144 subjects, which included 70 children (aged 8-10 years) and their parents, were recruited on the basis of predetermined criteria and divided into the following groups: children with malocclusion (case group) and children without malocclusion (control group). The OHRQoL was assessed using the Child Perceptions Questionnaire (CPQ8-10) and the Family Impact Scale (FIS). The severity of malocclusion was assessed using the Dental Aesthetic Index. The specific types of malocclusions (anterior open bite, anterior/ posterior crossbite and overjet) and their severity were considered for the statistical analyses by applying the Mann-Whitney and Kruskal-Wallis tests, respectively, with a set at p<0.05. Results: The CPQ8-10 and FIS scores demonstrated higher impact on OHRQoL in the case group (p<0.01). There were no reported differences in OHRQoL according to the dental aesthetic index severity (p>0.05) and no differences between specific types of malocclusion (p>0.05) Conclusions: Mixed dentition malocclusion impacted the oral-health quality of life for children and their families independently of the severity.


Asunto(s)
Dentición Mixta , Maloclusión , Calidad de Vida , Estudios de Casos y Controles , Niño , Humanos , Maloclusión/complicaciones , Maloclusión/psicología , Salud Bucal
8.
Int J Prosthodont ; 32(32): 214-216, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30856651

RESUMEN

Patients presenting both severe maxillary atrophy and dental malposition require a multidisciplinary treatment approach to achieve optimal esthetic and functional results. This case history report demonstrates how digital treatment planning and teeth set-up can serve as a reference for surgical, orthodontic, and prosthodontic procedures, leading to an all-ceramic full-arch implant-supported fixed prosthesis.


Asunto(s)
Periodontitis Crónica/complicaciones , Periodontitis Crónica/terapia , Prótesis Dental de Soporte Implantado/métodos , Planificación de Atención al Paciente , Grupo de Atención al Paciente , Impresión Tridimensional , Adulto , Estética Dental , Femenino , Humanos , Maloclusión/complicaciones , Atrofia Periodontal/etiología , Pérdida de Diente/etiología , Pérdida de Diente/terapia
9.
Minerva Stomatol ; 68(1): 11-16, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30667200

RESUMEN

BACKGROUND: The aim of this retrospective study was to evaluate the occlusion in adolescents with strabismus in comparison with healthy subjects without vision problems. METHODS: The test group included 50 subjects (23 males and 27 females) with a diagnosis of strabismus and the control group included 50 healthy patients (23 males and 27 females) without any past or present disturbance of vision. Dental cast analysis was performed to evaluate antero-posterior, transversal and vertical malocclusion and dental crowding. Furthermore, oral habits (mouth breathing, atypical swallowing, finger sucking) were recorded. Mann-Whitney test was performed in order to evaluate significant differences between the groups regarding overbite, overjet and dental crowding; Kruskal-Wallis non-parametric test was adopted to compare the samples. Chi square test and Fisher test were adopted for the analysis of cross-bite, Angle Class, and oral habits. RESULTS: No significant difference was found regarding the malocclusion and the unhealthy oral habits between the groups (P>0.05). The test group showed a slightly higher prevalence of cross-bite but the difference between the two groups was not significant (P>0.05). CONCLUSIONS: A possible relationship between the stomatognathic system and strabismus was not confirmed by the results of this study.


Asunto(s)
Maloclusión/complicaciones , Estrabismo/complicaciones , Adolescente , Técnica de Colado Dental , Femenino , Humanos , Masculino , Estudios Retrospectivos
10.
Cranio ; 37(4): 231-237, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29308993

RESUMEN

OBJECTIVE: To investigate the role of occlusion in temporomandibular disorders (TMDs) in the Northern Finland Birth Cohort 1966 (NFBC 1966). METHODS: Subjects (n = 1962) participated in clinical medical and dental examinations. The association between TMD signs and diagnoses with occlusal disturbances, i.e. malocclusions and occlusal interferences, was examined. Pearson's chi-square test, as expressed by odds ratios (OR) and 95% confidence intervals (CI) and logistic regression models, were used in the analysis. RESULTS: A statistically significant association was found between myalgia and lateral scissor bite and also between arthralgia and lateral deviation in the retruded contact position and intercuspal contact position (RCP-ICP) slide. Pain in the masticatory muscles was associated with negative overjet and the amount of RCP-ICP slide. DISCUSSION: Occlusal factors showed a statistically significant association with TMD. The TMD signs were associated with unstable occlusion, especially the amount and lateral deviation in RCP-ICP slide, as well as negative overjet.


Asunto(s)
Oclusión Dental , Trastornos de la Articulación Temporomandibular/epidemiología , Trastornos de la Articulación Temporomandibular/fisiopatología , Artralgia/epidemiología , Artralgia/etiología , Distribución de Chi-Cuadrado , Estudios de Cohortes , Femenino , Finlandia/epidemiología , Humanos , Modelos Logísticos , Masculino , Maloclusión/complicaciones , Maloclusión/epidemiología , Músculos Masticadores , Mialgia/epidemiología , Mialgia/etiología , Trastornos de la Articulación Temporomandibular/complicaciones , Factores de Tiempo
11.
Dent Traumatol ; 35(2): 95-100, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30501002

RESUMEN

BACKGROUND/AIMS: Occlusal features may increase the risk of dental trauma. The aim of the present study was to evaluate the association between occlusal characteristics and the occurrence of dental trauma in preschool children. MATERIALS AND METHODS: A population-based case-control study was conducted with a representative sample of 200 children 3-5 years of age enrolled at private and public preschools in the city of Diamantina, Brazil. The case and control groups were matched for gender, age and type of preschool (public or private) at a ratio of 1:1 (100 cases and 100 controls). Independent variables of interest to the study (occlusal characteristics) and potential confounders (sociodemographic characteristics, sucking habits and lip coverage) were investigated. Intra-examiner and inter-examiner kappa values were higher than 0.80 for all oral conditions evaluated. The SPSS 22.0 program was used to analyse the data. Descriptive and univariate analyses as well as simple and multiple logistic regression analyses were performed. RESULTS: The occlusal feature most strongly associated with trauma was anterior open bite (OR = 3.80; 95% CI: 1.42-10.16). Maxillary anterior crowding (OR = 2.14, 95% CI: 1.00-4.63) and overjet (OR = 1.12, 95% CI: 0.58-2.17) were associated with the occurrence of trauma independently of the confounding variables (sociodemographic characteristics, sucking habits and lip coverage), but these variables lost their significance when adjusted for other types of malocclusion. Anterior open bite remained strongly associated with dental trauma, regardless of confounding variables and other types of malocclusion. CONCLUSION: Anterior open bite was the main variable associated with dental trauma in the preschool children analysed independently of the confounding variables and the presence of other malocclusions.


Asunto(s)
Maloclusión/complicaciones , Sobremordida , Traumatismos de los Dientes/complicaciones , Brasil , Estudios de Casos y Controles , Preescolar , Estudios Transversales , Femenino , Humanos , Masculino , Maloclusión/epidemiología , Prevalencia , Factores de Riesgo
12.
J Oral Rehabil ; 46(4): 321-329, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30472807

RESUMEN

BACKGROUND: Temporomandibular disorders (TMDs) are frequent and disabling, and hence, preventing them is an important health issue. Combining orthodontic and surgical treatments for malocclusions has been shown to affect temporomandibular joint (TMJ) health. However, publications regarding the risk factors that predict negative TMJ outcomes after orthognathic surgery are scarce. OBJECTIVE: Present prospective cohort study was conducted to identify an association between pre-operative dysfunctional/parafunctional oral habits and the presence of TMD symptoms after orthognathic surgery. METHOD: We included 237 patients undergoing orthodontics and surgical treatment for malocclusions associated with dentofacial deformities within the Department of Oral and Maxillofacial Surgery of the University of Lille. Their parafunctional and dysfunctional oral habits were recorded through clinical examination along with the presence of TMD symptoms before and after the surgery. According to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) classification, the TMD symptoms studied were myalgia, arthralgia, disc displacement with or without reduction. RESULTS: Multivariate analysis revealed significant associations among bruxism (odds ratio [OR] 3.17 [1.066; 9.432]), lingual interposition (OR 4.241 [1.351; 13.313]), as well as primary swallowing (OR 3.54 [1.225; 10.234]) and the presence of postoperative symptoms of myalgia. Moreover, a significant association was observed between the presence of any dysfunctional oral habit and postoperative disc displacement with reduction (OR 4.611 [1.249; 17.021]). CONCLUSION: Bruxism and dysfunctional oral habits were shown to be risk factors for the presence of TMD symptoms also after combined orthodontic and surgical treatment. Treating such habits before orthognathic surgery should help prevent TMD.


Asunto(s)
Bruxismo/cirugía , Maloclusión/cirugía , Cirugía Ortognática , Complicaciones Posoperatorias/fisiopatología , Trastornos de la Articulación Temporomandibular/fisiopatología , Adolescente , Adulto , Anciano , Bruxismo/complicaciones , Bruxismo/epidemiología , Bruxismo/fisiopatología , Femenino , Francia/epidemiología , Hábitos , Humanos , Masculino , Maloclusión/complicaciones , Maloclusión/epidemiología , Maloclusión/fisiopatología , Persona de Mediana Edad , Complicaciones Posoperatorias/epidemiología , Estudios Prospectivos , Factores de Riesgo , Trastornos de la Articulación Temporomandibular/epidemiología , Trastornos de la Articulación Temporomandibular/etiología , Adulto Joven
13.
J Craniofac Surg ; 30(2): 352-357, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30531274

RESUMEN

INTRODUCTION: Orthognathic surgery plays an important role in restoring aesthetic facial contour, correcting dental malocclusion, and the surgical treatment of obstructive sleep apnea. However, the rate of complications following bimaxillary as compared with single-jaw orthognathic surgery remains unclear. The authors therefore sought to evaluate complication rates following bimaxillary as compared with single-jaw orthognathic surgery MATERIALS AND METHODS:: The American College of Surgeons National Surgical Quality Improvement Program database was used to identify comparison groups. Preoperative characteristics and postoperative outcomes were compared between groups. The listed procedures have different operating times and characteristics with longer time expected in the bimaxillary osteotomies group. Regression analyses were performed to control for potential confounders. RESULTS: The 3 groups of interest included patients who underwent mandibular osteotomies (n = 126), LeFort I osteotomy (n = 194), and bimaxillary osteotomies (n = 190). These procedures have different operating times, with a longer time expected with bimaxillary osteotomies. Patients undergoing bimaxillary osteotomies had significantly higher rates of early wound complications, overall complications, longer mean operative time, and mean hospital length of stay. Performing bimaxillary osteotomies in the outpatient setting was an independent risk factor for wound complications (OR = 12.58; 95% CI: 1.66-95.20; P = 0.01), while an ASA class of 3 or more was an independent risk factor for overall complications (OR = 3.61; 95% CI: 1.02-12.75; P = 0.04) and longer hospital length of stay (ß = 4.96; 95% CI: 2.64 - 7.29; P < 0.001). CONCLUSIONS: Surgery in the outpatient setting as well as patient American Society of Anesthesiology physical status class 3 or higher were independent factors for postoperative adverse events in patients undergoing bimaxillary surgery. Our findings highlight the importance of addressing modifiable risk factors preoperatively and the need for closer postoperative monitoring in this patient population for optimal outcomes.


Asunto(s)
Maloclusión/cirugía , Procedimientos Quirúrgicos Ortognáticos/efectos adversos , Complicaciones Posoperatorias/etiología , Adulto , Estética Dental , Femenino , Humanos , Masculino , Maloclusión/complicaciones , Osteotomía Mandibular/efectos adversos , Osteotomía Mandibular/métodos , Análisis Multivariante , Tempo Operativo , Procedimientos Quirúrgicos Ortognáticos/métodos , Osteotomía Le Fort/efectos adversos , Osteotomía Le Fort/métodos , Complicaciones Posoperatorias/epidemiología , Análisis de Regresión , Riesgo , Apnea Obstructiva del Sueño/etiología , Apnea Obstructiva del Sueño/cirugía
14.
Arch Oral Biol ; 98: 17-25, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30419485

RESUMEN

OBJECTIVE: To investigate the changes in insulin-like growth factor-1 (IGF-1) expression levels in the degenerative mandibular condylar cartilage. DESIGN: Thirty-six rats were divided into the unilateral anterior crossbite and control groups. The expression levels of IGF-1; IGF-1 receptor (IGF-1R); IGF-binding protein-3 and -5 (IGFBP-3 and -5); proliferating cell nuclear antigen (PCNA); aggrecan; type-I, -II, -VI, and -X collagen; tissue inhibitor of metalloproteinases-1 and -3 (TIMP-1 and -3); metalloproteinases of matrix metalloproteinases-3 and-13 (MMP-3 and -13); a disintegrin and metalloproteinase thrombospondin-4 and -5 (ADAMTS-4 and -5); alkaline phosphatase (ALP); ß-glucuronidase; and N-acetyl-ß-glucosaminidase in the mandibular condylar cartilage were assessed. RESULTS: The protein expression levels of IGF-1and IGF-1R were increased from week 4 in the unilateral anterior crossbite group. The mRNA expression level of IGFBP-3 and -5 was upregulated from week 4 and week 2, respectively; that of IGFBP-3 was downregulated at week 8; and that of PCNA, type-II collagen, type-X collagen, aggrecan, TIMP-1, and TIMP-3 was downregulated, whereas that of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, ß-glucuronidase, and N-acetyl-ß-glucosaminidase were upregulated from week 2. The positive area size of type-I collagen was increased and that of type VI collagen was decreased from week 2. The positive area size of type X collagen was increased at week 2 but decreased at week 8. The percentage of ALP-positive cells was increased from week 4. CONCLUSIONS: Unilateral anterior crossbite stimulated the multifarious expression of IGF-1 and IGFBP, which may be linked to chondrocyte proliferation and differentiation in the mandibular condylar cartilage that showed progressive degeneration.


Asunto(s)
Enfermedades de los Cartílagos/etiología , Cartílago Articular/patología , Factor I del Crecimiento Similar a la Insulina/metabolismo , Maloclusión/complicaciones , Cóndilo Mandibular/metabolismo , Cóndilo Mandibular/patología , Trastornos de la Articulación Temporomandibular/etiología , Proteína ADAMTS4/metabolismo , Proteína ADAMTS5/metabolismo , Agrecanos/metabolismo , Fosfatasa Alcalina/metabolismo , Animales , Condrocitos/patología , Colágeno/metabolismo , Modelos Animales de Enfermedad , Femenino , Perfilación de la Expresión Génica , Regulación Enzimológica de la Expresión Génica , Glucuronidasa/metabolismo , Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo , Proteína 5 de Unión a Factor de Crecimiento Similar a la Insulina/metabolismo , Metaloproteinasa 13 de la Matriz/metabolismo , Metaloproteinasa 3 de la Matriz/metabolismo , Antígeno Nuclear de Célula en Proliferación/metabolismo , Ratas , Ratas Sprague-Dawley , Receptor IGF Tipo 1/metabolismo , Inhibidor Tisular de Metaloproteinasa-1/metabolismo , Inhibidor Tisular de Metaloproteinasa-3/metabolismo , Regulación hacia Arriba
15.
J Oral Rehabil ; 46(4): 340-348, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30556174

RESUMEN

BACKGROUND: The temporomandibular joint (TMJ) disc plays a role in joint movement and in load absorbance and distribution. An experimental unilateral anterior crossbite (UAC) prosthesis induces mandibular condylar cartilage degeneration in rats. However, the changes in the articular disc are still unknown. OBJECTIVE: To describe changes in the TMJ discs of UAC rats. METHODS: The discs of fifty-four Sprague-Dawley rats, equally distributed into a UAC group and an age-matched sham-operated control group at 4, 12 and 20 weeks (n = 9), were evaluated by gross and histomorphological observation and by detection at the mRNA or protein expression levels of the markers related to the matrix elements. RESULTS: No macro- or micro-morphological differences were observed between groups. However, there were catabolic degradative changes at the molecular level in the UAC group, showing a significant reduction in the mRNA and/or protein expression levels of many molecules. The reduction became worse with time (P < 0.05). The reduced molecules included: (a) those related to the extracellular matrix, such as type I collagen, decorin and fibromodulin; (b) those related to chondrogenesis, such as type II collagen and aggrecan; and (c) those related to osteogenesis, such as alkaline phosphatase and runt-related transcription factor 2. The mRNA expression of vascular endothelial growth factor did not change. In contrast, fibronectin, which can promote wound healing, and its N-terminal fragment, which can induce cartilage degradation, were accumulated (P < 0.05). CONCLUSION: TMJ discs were stimulated to catabolic changes by the aberrant dental occlusion and seemed to go to inanimate with time.


Asunto(s)
Maloclusión/metabolismo , Maloclusión/patología , Cóndilo Mandibular/metabolismo , Cóndilo Mandibular/patología , Disco de la Articulación Temporomandibular/metabolismo , Disco de la Articulación Temporomandibular/patología , Animales , Cartílago Articular/patología , Condrocitos/patología , Oclusión Dental , Modelos Animales de Enfermedad , Femenino , Maloclusión/complicaciones , Fenómenos Mecánicos , Ratas , Ratas Sprague-Dawley
16.
Stomatologija ; 20(3): 90-95, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30531163

RESUMEN

THE AIM OF THE STUDY: Was to evaluate the relationship of mandibular condylar and ramal symmetry with unilateral posterior crossbite during late adolescence. MATERIAL AND METHOD: 120 pre-orthodontic patients of the Lithuanian University of Health Sciences Department of Orthodontics were included in the study. The main inclusion criteria of the study group were the following: permanent dentition, age 15 to 18 years, unilateral crossbite. Panoramic radiographs database were analyzed, the following parameters were evaluated: mandibular condylar and ramal height, and asymmetry index according to Habets' technique. Statistical data analysis was performed using SPSS 22.0 statistical software. RESULTS: In the study group the mandibular condylar height, ramal height, and ramal plus condylar height on the crossbite side were statistically significantly lower than those on the noncrossbite side. Comparing the asymmetry indices between the study and the control groups, it was found all indices were statistically significantly higher in the group with unilateral posterior crossbite than those in the control group, p<0.001. CONCLUSION: Relationship between unilateral posterior crossbite and mandibular asymmetry during late adolescent was found, in subjects with unilateral posterior crossbite statistically significantly reduced mandibular condylar height and mandibular ramal height on the crossbite side was detected, they demonstrated a higher mandibular condylar and mandibular ramal asymmetry index, compared to the control group subjects, p<0.001.


Asunto(s)
Asimetría Facial/complicaciones , Maloclusión/complicaciones , Mandíbula/anatomía & histología , Adolescente , Asimetría Facial/diagnóstico por imagen , Humanos , Maloclusión/diagnóstico por imagen , Mandíbula/diagnóstico por imagen , Cóndilo Mandibular/anatomía & histología , Radiografía Panorámica
18.
Geriatr Gerontol Int ; 18(10): 1439-1446, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30295988

RESUMEN

AIM: Previous studies have reported significant associations between tooth loss or periodontal status and cognitive function; however, animal experimental studies have shown that occlusion might be a more important factor in cognitive decline. The purpose of the present study was to investigate the influence of a lack of posterior occlusal support by residual teeth on the decline of cognitive function over a 3-year period among 80-year-old Japanese people. METHODS: Participants were community-dwelling older adults (n = 515, age 79-81 years). Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment. At baseline, participants were divided into two groups: those with and without posterior occlusal support. Participants whose Japanese version of the Montreal Cognitive Assessment score decreased by ≥3 points over the 3-year period were defined as the declined group. Logistic regression was carried out for the decline in Japanese version of the Montreal Cognitive Assessment scores, including dental status and possible risk factors as independent variables. RESULTS: More participants without posterior occlusal support tended to be in the cognitive decline group (49.4%) than in the maintained group (38.5%; χ2 -test, P = 0.02). Logistic regression analysis showed that a lack of posterior occlusal support was a significant variable (odds ratio 1.55, P = 0.03) for cognitive decline, even after adjusting for other risk factors. However, the number of teeth or mean periodontal pocket depth was not significantly correlated with cognitive decline. CONCLUSIONS: The present findings suggest that a lack of posterior occlusal support predicted the incidence of cognitive decline, even after adjusting for possible risk factors in community-dwelling old-old people. Geriatr Gerontol Int 2018; 18: 1439-1446.


Asunto(s)
Disfunción Cognitiva/epidemiología , Disfunción Cognitiva/fisiopatología , Maloclusión/complicaciones , Pérdida de Diente/complicaciones , Anciano de 80 o más Años , Disfunción Cognitiva/etiología , Estudios de Cohortes , Progresión de la Enfermedad , Femenino , Evaluación Geriátrica , Humanos , Vida Independiente , Japón , Modelos Logísticos , Masculino , Análisis Multivariante , Pronóstico , Estudios Prospectivos , Índice de Severidad de la Enfermedad , Factores de Tiempo
19.
Eur J Oral Sci ; 126(6): 466-475, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-30341927

RESUMEN

Unilateral anterior crossbite (UAC) has been demonstrated to cause masseter hyperactivity via the periodontal trigeminal mesencephalic nucleus (Vme)-trigeminal motor nucleus circuit. Here, we studied activation of motor neurons of the facial nucleus (VII), hypoglossal nucleus (XII), nucleus ambiguus (Amb), and spinal nucleus of the accessory nerve (SNA) in rats with UAC via their similar connections with Vme. An anterograde tracer, biotinylated dextran amine (BDA), was injected into the Vme to identify the central axon terminals around the motor neurons of VII, XII, Amb, and SNA. The expression of vesicular glutamate transporter 1 (VGLUT1) in neurons of VII, XII, Amb, and SNA, and the expression of acetylcholinesterase (AChE) were measured in the stapedius, lingualis, palatopharyngeal, and sternocleidomastoid muscles. In BDA-treated rats, many BDA-labeled cell bodies in the Vme and terminals in VII, XII, Amb, and SNA were identified. Compared with control rats, rats with UAC showed higher expression of VGLUT1 in these nuclei, and statistically significantly higher expression of AChE in the stapedius, lingualis, and sternocleidomastoid muscles, but not in the palatopharyngeal muscle. These findings suggest that UAC activates orofacial, head, and cervical multimotor behaviors via connections between the Vme and the corresponding motor nuclei.


Asunto(s)
Estimulantes del Sistema Nervioso Central , Maloclusión/complicaciones , Trastornos de la Articulación Temporomandibular/etiología , Trastornos de la Articulación Temporomandibular/metabolismo , Proteína 1 de Transporte Vesicular de Glutamato/metabolismo , Acetilcolinesterasa/metabolismo , Animales , Colina O-Acetiltransferasa/metabolismo , Modelos Animales de Enfermedad , Núcleo Motor del Nervio Facial/metabolismo , Femenino , Proteínas Ligadas a GPI/metabolismo , Expresión Génica , Bulbo Raquídeo , Neuronas Motoras/metabolismo , Ratas , Ratas Sprague-Dawley , Trastornos de la Articulación Temporomandibular/patología
20.
Wiad Lek ; 71(5): 1071-1075, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30176643

RESUMEN

Results of review of native and foreign publications based on the problem of dental and orthodontic aid to patients with hearing difficulty are presented in this article. Hearing loss affects the ability of a person to communicate with other people. Depriving of opportunities for communication can have a significant impact on everyday life, causing feelings of loneliness, isolation and despair. Spread of dentofacial abnormalities in people with hearing difficulties is very high. Problem of dental aid to patients with hearing difficulties especially with orthodontic one is very topical.


Asunto(s)
Atención Odontológica/métodos , Pérdida Auditiva/complicaciones , Maloclusión/terapia , Ortodoncia/métodos , Adolescente , Niño , Humanos , Maloclusión/complicaciones
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