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1.
BMC Infect Dis ; 20(1): 614, 2020 Aug 18.
Artículo en Inglés | MEDLINE | ID: mdl-32811466

RESUMEN

BACKGROUND: The most common aetiological agents of mucormycosis are Rhizopus, Mucor, Apophysomyces and Lichtheimia. Apophysomyces is comparatively rare, as it has been reported in less than 3% of mucormycosis cases. The genus Apophysomyces includes six species, and only A. elegans, A. mexicanus, A. variabilis and A. ossiformis have been reported to cause infections in both immunocompetent and immunocompromised patients. CASE PRESENTATION: We present a case of a 46-year-old male patient with bilateral blepharoedema, corneal opacity in the left eye and poorly controlled diabetes mellitus. The patient was subjected to total maxillectomy, exenteration of the left orbit and treatment with liposomal amphotericin B. Direct mycological analysis with KOH 10% revealed hyaline, coenocytic, long and wide hyphae. Apophysomyces ossiformis was identified from maxillary biopsy using 18S-ITS1-5.8S-ITS2-28S rRNA gene amplification and sequencing. The patient requested to be transferred to another hospital to continue treatment, where he died on the ninth day after admittance. CONCLUSION: To the best of our knowledge, this is the first case of rhino-orbital mucormycosis due to A. ossiformis with a fatal outcome. This case reveals the need to identify the fungus causing mucormycosis with molecular methods to identify adequate treatment therapies for patients with this infection.


Asunto(s)
Complicaciones de la Diabetes/microbiología , Mucorales/genética , Mucormicosis/complicaciones , Enfermedades Orbitales/complicaciones , Rinitis/complicaciones , Anfotericina B/uso terapéutico , Antifúngicos/uso terapéutico , Biopsia , Complicaciones de la Diabetes/tratamiento farmacológico , Complicaciones de la Diabetes/cirugía , Resultado Fatal , Humanos , Huésped Inmunocomprometido , Masculino , Maxilar/microbiología , Maxilar/patología , Maxilar/cirugía , Persona de Mediana Edad , Mucormicosis/tratamiento farmacológico , Mucormicosis/microbiología , Mucormicosis/cirugía , Enfermedades Orbitales/tratamiento farmacológico , Enfermedades Orbitales/microbiología , Enfermedades Orbitales/cirugía , ARN Ribosómico 28S/genética , Rinitis/tratamiento farmacológico , Rinitis/microbiología , Rinitis/cirugía
2.
J Pathol ; 251(3): 323-335, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-32418202

RESUMEN

The lymphatic system plays a crucial role in the maintenance of tissue fluid homeostasis and the immunological response to inflammation. The effects of lymphatic drainage dysfunction on periodontitis have not been well studied. Here we show that lymphatic vessel endothelial receptor 1 (LYVE1)+ /podoplanin (PDPN)+ lymphatic vessels (LVs) are increased in the periodontal tissues, with accumulation close to the alveolar bone surface, in two murine periodontitis models: rheumatoid arthritis (RA)-associated periodontitis and ligature-induced periodontitis. Further, PDPN+ /alpha-smooth muscle actin (αSMA)- lymphatic capillaries are increased, whereas PDPN+ /αSMA+ collecting LVs are decreased significantly in the inflamed periodontal tissues. Both mouse models of periodontitis have delayed lymph flow in periodontal tissues, increased TRAP-positive osteoclasts, and significant alveolar bone loss. Importantly, the local administration of adeno-associated virus for vascular endothelial growth factor C, the major growth factor that promotes lymphangiogenesis, increases the area and number of PDPN+ /αSMA+ collecting LVs, promotes local lymphatic drainage, and reduces alveolar bone loss in both models of periodontitis. Lastly, LYVE1+ /αSMA- lymphatic capillaries are increased, whereas LYVE1+ /αSMA+ collecting LVs are decreased significantly in gingival tissues of patients with chronic periodontitis compared with those of clinically healthy controls. Thus, our findings reveal an important role of local lymphatic drainage in periodontal inflammation-mediated alveolar bone loss. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.


Asunto(s)
Pérdida de Hueso Alveolar/prevención & control , Proceso Alveolar/metabolismo , Periodontitis Crónica/terapia , Terapia Genética , Linfa/metabolismo , Vasos Linfáticos/metabolismo , Maxilar/metabolismo , Factor C de Crecimiento Endotelial Vascular/biosíntesis , Factor C de Crecimiento Endotelial Vascular/genética , Pérdida de Hueso Alveolar/genética , Pérdida de Hueso Alveolar/metabolismo , Pérdida de Hueso Alveolar/patología , Proceso Alveolar/patología , Animales , Estudios de Casos y Controles , Periodontitis Crónica/genética , Periodontitis Crónica/metabolismo , Periodontitis Crónica/patología , Modelos Animales de Enfermedad , Humanos , Vasos Linfáticos/patología , Masculino , Maxilar/patología , Ratones Endogámicos C57BL , Ratones Transgénicos , Osteoclastos/metabolismo , Osteoclastos/patología , Factor de Necrosis Tumoral alfa/genética
3.
Tunis Med ; 98(3): 246-253, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32395819

RESUMEN

INTRODUCTION: By means of orthopedics, orthognathic surgery or orthodontics, the management of the maxillary transverse defisciency is a key element of the orthodontic treatment plan, and the guarantee of its stability. the following work aims to support, through a clinical case, the management and the progression of the treatment of the maxillary transverse deficiency associated to a class III skeletal anomaly. OBSERVATION: The authors report the case of a 15-year-old patient with a severe class III    malocclusion, with severe maxillary transverse deficiency. The objectives of the treatment were, first, to solve the transverse disharmony by surgically assisted rapid maxillary expansion (SARME), then, secondly, to remove the dentoalveolar compensations and a bimaxillary orthognathic surgery, was carried out to correct the sagittal and vertical disharmony. CONCLUSION: Surgically assisted rapid maxillary expansion (SARME) appears to be advantageous, both functionally and aesthetically to overcome transverse maxillary deficiency. The agreement between the orthodontist, the maxillofacial surgeon and / or the plastic surgeon, both in the schedule and in the choice of surgical interventions, remains decisive concerning ortho-surgical treatments.


Asunto(s)
Maloclusión de Angle Clase III/cirugía , Maxilar/cirugía , Procedimientos Quirúrgicos Ortognáticos/métodos , Técnica de Expansión Palatina , Adolescente , Humanos , Maloclusión de Angle Clase III/patología , Maxilar/patología , Índice de Severidad de la Enfermedad
5.
Artículo en Chino | MEDLINE | ID: mdl-32268686

RESUMEN

Objective: To investigate the application and clinical outcomes of using 3D computer-assisted printing technique combined with plastic titanium mesh in the reconstruction of maxillary defect. Methods: Clinical data of 14 patients in Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital from January 2016 to June 2018, who were treated for partial or total removal of the maxilla due to benign or malignant tumors and those acquired maxillary defects caused by severe compound trauma were analyzed retrospectively. Twelve males and 2 females were included, with the age ranging from 16 to 51 years old. The sinonasal malignant tumors included squamous carcinoma (n=2) while benign tumors included hemangioma (n=1), maxillary fibrous dysplasia (n=3), maxillary cyst (n=2) and giant cell tumor of the maxilla (n=1). Five cases of post-traumatic maxillary defect were also included. According to preoperative thin-layer CT scanning data, computer modeling data was transmitted to a 3D printer to print out the original model and the reconstructed model. Preoperative simulation of tumor removal and maxillary reconstruction was done on the patient's original model, and the titanium mesh was shaped on the reconstructed model in order to properly reconstruct the area needed to be repaired. The pre-made titanium mesh was implanted into the defect area, the soft tissue flaps were reset, layered stitching and the local pressured bandage were used after surgery. Through postoperative clinical and CT examination, the patient's maxillofacial shape, nasal function and complications were evaluated. The results were analyzed by descriptive statistical method. Results: Lesions could be completely removed within the predicted range on the preoperative 3D-printed models of all cases. After debridement, titanium mesh could be implanted easily without re-shaping and trimming during surgery as in trauma cases. Titanium mesh could completely cover the missing bone surface closely, with titanium nails fixed smoothly, and the implanted titanium mesh was solid and stable. After the follow-up of 6 to 20 months, all patients were satisfied with the facial symmetry and the function was recovered well. Conclusion: Using 3D computer-assisted printing technique combined with plastic titanium mesh in the reconstruction of maxillary defect can accurately restore the maxillary structure for soft tissue support, and restore the facial shape and function.


Asunto(s)
Diseño Asistido por Computadora , Maxilar/cirugía , Impresión Tridimensional , Procedimientos Quirúrgicos Reconstructivos , Mallas Quirúrgicas , Adolescente , Adulto , China , Femenino , Humanos , Masculino , Maxilar/patología , Neoplasias Maxilares/cirugía , Persona de Mediana Edad , Plásticos , Estudios Retrospectivos , Titanio , Adulto Joven
6.
Artículo en Chino | MEDLINE | ID: mdl-32268687

RESUMEN

Objective: To evaluate the application of computer-assisted design and three-dimensional printing technique in reconstruction of maxillary defects with individual free fibular flap. Methods: A total of 13 patients, 7 males and 6 females with age from 12 to 55 years old, underwent the reconstruction of maxillary defects after subtotal or total maxillectomy for benign or malignant tumors between January 2016 and December 2018 were reviewed. Ther were 4 cases of subtotal maxillectomy and 9 cases of total maxillectomy. Before operation, osteotomy line was planned on three-dimensional images. A three-dimensional individual resin fibula model based on mirror images of the healthy side maxilla was obtained to fabricate an anatomically adapted osteomyocutaneous fibula free flap using computer-assisted design and forming. Oral, nasal, and eye functions and facial appearance were evaluated. Results: The 13 cases were followed up for 5-40 months, all flaps were alive except one due to flap failure and all cases were tumor free confirmed by CT or MRI. Ten patients could eat normal food without nasal food return, and 3 cases had palatal fistula. Eleven cases showed good speaking functional results. All cases had normal eye positions, no cases with diplopia and loss of vision. With evaluation by VAS, an average score of 8 was obtained, and most of patients were satisfied with their postoperative facial appearances. Conclusion: Reconstruction of maxillary defects by free fibular flap designed by three-dimensional printing and computer-assisted technique not only restored oral, nasal and eye functions, but also showed satisfactory facial appearance.


Asunto(s)
Diseño Asistido por Computadora , Colgajos Tisulares Libres , Maxilar/cirugía , Impresión Tridimensional , Procedimientos Quirúrgicos Reconstructivos , Cirugía Asistida por Computador , Adolescente , Adulto , Niño , Femenino , Peroné , Humanos , Masculino , Maxilar/patología , Neoplasias Maxilares/cirugía , Persona de Mediana Edad , Adulto Joven
7.
Cient. dent. (Ed. impr.) ; 17(1): 19-26, ene.-abr. 2020. ilus, graf
Artículo en Español | IBECS | ID: ibc-189745

RESUMEN

La pérdida ósea vertical en los sectores posteriores maxilares es un hecho frecuente tras la extracción dental. En muchas ocasiones para rehabilitar estas zonas podemos emplear técnicas de regeneración u optar por un abordaje más conservador con implantes cortos. En el presente caso clínico mostramos un caso rehabilitado bilateralmente con dos técnicas diferentes: elevación de seno y la inserción de implantes cortos, con un seguimiento de ocho años donde ambas técnicas han logrado resultados igualmente predecibles


Vertical bone loss in the posterior maxillary sectors is a frequent occurrence after tooth extraction. These areas can often be rehabilitated using regeneration techniques or by opting for a more conservative approach with short implants. The present clinical case shows bilateral rehabilitation with two different techniques: sinus lift and the insertion of short implants, with a follow-up of 8 years where both techniques have achieved equally predictable results


Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Atrofia , Maxilar/cirugía , Elevación del Piso del Seno Maxilar/métodos , Implantes Dentales , Maxilar/patología , Diente Molar/patología , Radiografía Panorámica
8.
PLoS One ; 15(2): e0229360, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32092128

RESUMEN

This study evaluated the von Mises stress (MPa) and equivalent strain occurring around monolithic yttria-zirconia (Zir) implant using three clinically simulated finite element analysis (FEA) models for a missing maxillary central incisor. Two unidentified patients' cone-beam computed tomography (CBCT) datasets with and without right maxillary central incisor were used to create the FEA models. Three different FEA models were made with bone structures that represent a healed socket (HS), reduced bone width edentulous site (RB), and immediate extraction socket with graft (EG). A one-piece abutment-implant fixture mimicking Straumann Standard Plus tissue level RN 4.1 X 11.8mm, for titanium alloy (Ti) and Zir were modeled. 178 N oblique load and 200 N vertical load were used to simulate occlusal loading. Von Mises stress and equivalent strain values for around each implant model were measured. Within the HS and RB models the labial-cervical region in the cortical bone exhibited highest stress, with Zir having statistically significant lower stress-strain means than Ti in both labial and palatal aspects. For the EG model the labial-cervical area had no statistically significant difference between Ti and Zir; however, Zir performed better than Ti against the graft. FEA models suggest that Ti, a more elastic material than Zir, contributes to the transduction of more overall forces to the socket compared to Zir. Thus, compared to Ti implants, Zir implants may be less prone to peri-implant bone overloading and subsequent bone loss in high stress areas especially in the labial-cervical region of the cortical bone. Zir implants respond to occlusal loading differently than Ti implants. Zir implants may be more favorable in non-grafted edentulous or immediate extraction with grafting.


Asunto(s)
Implantes Dentales de Diente Único , Análisis del Estrés Dental/métodos , Análisis de Elementos Finitos , Circonio/química , Fenómenos Biomecánicos , Simulación por Computador , Humanos , Incisivo/química , Ensayo de Materiales , Maxilar/patología , Estrés Mecánico , Itrio/química
9.
J Biol Regul Homeost Agents ; 34(1 Suppl. 1): 115-117, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32064844

RESUMEN

Oral rehabilitation of edentulous maxilla is particularly difficult because of the lack of bone in correspondence of maxillary sinuses, therefore, the surgeon is forced to place implants in sites where bone is more prevalent. In addition, patients require more frequent oral immediate rehabilitation in order to reduce the discomfort related to wearing a total denture. A viable solution to provide stability and retention of the prosthesis in a short time is represented by the technique of intraoral welding supporting total denture or fixed prosthesis. This goal may be achieved thanks to the technique of welding titanium bars onto implant abutments. In fact, the procedure can be performed directly in the mouth, eliminating the possibility of errors or distortions due to prosthetic procedures. This paper describes a case report and the most recent data regarding long-term success and high predictability of intraorally-welded titanium bar in immediate loading implants.


Asunto(s)
Implantes Dentales , Prótesis Dental de Soporte Implantado , Soldadura Dental , Arcada Edéntula , Maxilar/patología , Humanos
10.
BMC Oral Health ; 20(1): 55, 2020 02 17.
Artículo en Inglés | MEDLINE | ID: mdl-32066451

RESUMEN

BACKGROUND: The aim of this study was to assess the difference of palatal morphology in different vertical patterns between skeletal Class I subjects and skeletal Class II subjects with retrusive mandible. METHODS: Seventy-six skeletal Class II subjects with retrusive mandible (38 females, 38 males) and 85 skeletal Class I subjects (45 females, 40 males) were collected retrospectively and divided into hyperdivergent, normodivergent and hypodivergent groups. CBCT images of these subjects were reoriented by Dolphin 3D Imaging software. Three-dimensional (3D) maxilla was segmented by ProPlan software before using Geomagic Studio software to reconstruct 3D palatal morphology. Deviation patterns on 3D colored map analysis was performed to compare the difference of 3D palatal morphology between different groups. RESULTS: 3D colored map analysis showed that male's palate was higher and wider than that of female in the posterior part, regardless of different sagittal and vertical patterns. In skeletal Class II subjects with retrusive mandible, males with hyperdivergent and normodivergent showed higher and narrower in the posterior part of palate, while females with hyperdivergent and normodivergent had a higher but no obviously narrow palate compared with the hypodivergent subjects. Skeletal Class II subjects with retrusive mandible showed flatter and narrower in the posterior part of palate than that of skeletal Class I subjects. CONCLUSIONS: Sagittal and vertical patterns have great influence on the palatal morphology and as the vertical dimension increased, the palate tended to be higher and narrower.


Asunto(s)
Cefalometría/métodos , Imagenología Tridimensional/métodos , Maloclusión de Angle Clase II/patología , Mandíbula/anatomía & histología , Maxilar/anatomía & histología , Paladar (Hueso)/patología , Dimensión Vertical , Adolescente , Adulto , Femenino , Humanos , Masculino , Maloclusión de Angle Clase II/diagnóstico por imagen , Maxilar/diagnóstico por imagen , Maxilar/patología , Radiografía Dental Digital/métodos , Estudios Retrospectivos , Adulto Joven
11.
Oral Dis ; 26(3): 609-620, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31903673

RESUMEN

OBJECTIVES: This study aimed to investigate the therapeutic effect of different doses of teriparatide (TPTD) on bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: To establish the BRONJ model, 20 mice were randomly divided into two groups: a group that received tail vein administration of zoledronic acid with dexamethasone (ZA-125 µg/kg, DEX 5 mg/kg) and a group that received saline weekly. The mice subsequently underwent bilateral maxillary first molar extraction. After 8 weeks of modelling administration, the maxilla samples were examined by micro-computed tomography and histological staining (haematoxylin and eosin, Masson's trichrome and tartrate-resistant acid phosphatase) and the cytokine level was measured (enzyme-linked immunosorbent assay and Western blot). To determine the role of TPTD in BRONJ, the same protocol as previously described was applied in 100 mice (80 received ZA + DEX, and 20 received saline). After 8 weeks of modelling administration, 80 ZA + DEX mice were randomly divided into four groups: three groups with subcutaneous administration of TPTD (i.e. T1-3, T2-10 and T3-30 µg kg-1  day-1 ) and one group with saline daily for the next 8 weeks. The other 20 saline mice continued to receive saline daily. RESULTS: In Part 1, the level of receptor activator of nuclear factor-kappa Β ligand and the numbers of osteoclasts differed between the model and control groups. In Part 2, we found that TPTD had a positive effect on BRONJ in a mouse model based on clinical and histomorphological observations. Among the three treatment groups, the T1 and T2 groups significantly differed from the model group, whereas the T3 group showed no statistical differences. CONCLUSION: Subcutaneous administration of TPTD has a beneficial effect on BRONJ in mice. Nevertheless, further studies are needed to determine whether the therapeutic effect on BRONJ is dose-dependent.


Asunto(s)
Osteonecrosis de los Maxilares Asociada a Difosfonatos/tratamiento farmacológico , Conservadores de la Densidad Ósea/efectos adversos , Difosfonatos/efectos adversos , Maxilar/patología , Teriparatido/administración & dosificación , Animales , Maxilar/efectos de los fármacos , Ratones , Distribución Aleatoria , Microtomografía por Rayos X
12.
Homo ; 71(1): 51-61, 2020 Feb 13.
Artículo en Inglés | MEDLINE | ID: mdl-31939991

RESUMEN

Syphilis, together with its variant congenital syphilis, is a disease caused by Treponema pallidum subsp. pallidum. This paper documents possible new skeletal evidence for congenital syphilis from the Medieval Era (twelfth and thirteenth centuries CE) burial site of Medinaceli in the Province of Soria in North-Central Spain. What is involved is dental alteration due to congenital syphilis, mercury treatment, or a combination of both. This study focuses on the hypoplastic dental changes observed in a child approximately eight years of age. Only a fragmented skull with left maxilla and the left side of the mandible were preserved. Macroscopic analysis, X-rays, computerized tomography (CT) and mercury detection analysis by inductively coupled plasma mass spectrometry (ICP-MS) techniques were used to observe dental abnormalities. In addition to extensive caries in the upper second deciduous molar, pulpo-alveolar lesions and facial alterations were observed. The absence of the rest of the skeleton tends to make a diagnosis of congenital syphilis difficult. However, the dental stigmata observed do permit a reasonable diagnosis.


Asunto(s)
Hipoplasia del Esmalte Dental , Mercurio , Sífilis Congénita , Niño , Hipoplasia del Esmalte Dental/inducido químicamente , Hipoplasia del Esmalte Dental/complicaciones , Historia Medieval , Humanos , Mandíbula/patología , Maxilar/patología , Mercurio/efectos adversos , Mercurio/uso terapéutico , Paleopatología , España , Sífilis Congénita/complicaciones , Sífilis Congénita/tratamiento farmacológico , Sífilis Congénita/historia , Diente/patología
14.
J Craniofac Surg ; 31(1): e75-e78, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31634309

RESUMEN

OBJECTIVE: This article describes the case report of a prostate adenocarcinoma in the mandible. BACKGROUND: Prostate adenocarcinoma is a malignant tumor common in men from the fourth decade of life. The occurrence of oral metastatic lesions is rare. CASE REPORT: A 78-year-old male patient was referred to the oral and maxillofacial surgery service of the Pontifical Catholic University of Rio Grande do Sul for complaints of painless volume increase in the mandible. The diagnosis through the association of clinical, radiographic, and histopathological examination with the patient's health history determined that the lesion was prostatic adenocarcinoma metastasis. CONCLUSION: Despite the rare occurrence of metastases in the oral region, the dental surgeon should be aware of the possibility for correct diagnostic conduction and, subsequently, the institution of treatment in the early stages of disease.


Asunto(s)
Adenocarcinoma/secundario , Maxilar/patología , Neoplasias de la Próstata/patología , Anciano , Humanos , Masculino , Mandíbula/patología
15.
J Forensic Sci ; 65(1): 304-313, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31145812

RESUMEN

In 1949, the American Graves Registration Service Pacific Zone proposed the identification of 27 sets of remains (skulls/crania/mandibles) based on comparisons with written dental records. All were denied, and the remains were buried as unknowns. In 2003 and 2015, the remains were exhumed by the DPAA. Currently, 26 individuals previously recommended for identification have been positively identified. The DPAA Science Director's opinion corresponded with 24 of their recommendations, while DNA excluded three. Caution should be taken by the forensic scientist when building assemblages through skeletal and dental articulation. The forensic odontologist must always consider variations in restorative care/extraction patterns and the possibility of documentation errors when reviewing/interpreting historical and current day dental records used for AM/PM comparisons. The odontologist should base their opinion on the strength of the antemortem/postmortem comparison, number and type of concordances, and distinct dental care and extraction patterns.


Asunto(s)
Restos Mortales , Registros Odontológicos , Odontología Forense/métodos , Amalgama Dental , Prótesis Dental , Exhumación , Historia del Siglo XX , Humanos , Mandíbula/patología , Maxilar/patología , Personal Militar/historia , Fotograbar , Radiografía Dental , Diente/patología , Estados Unidos , Segunda Guerra Mundial
16.
J Synchrotron Radiat ; 27(Pt 1): 199-206, 2020 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-31868752

RESUMEN

This study explores the application of synchrotron radiation and conventional microcomputed tomography (SR-µCT and C-µCT, respectively) in evaluating bone-biopsy specimens. Bone-biopsy specimens were obtained using a trephine bur during bone-graft removal for implant placement six months after performing a maxillary sinus bone-graft procedure. Image data of specimens were obtained using SR-µCT and C-µCT. SR-µCT was performed using the 6C biomedical imaging beamline at the Pohang Accelerator Laboratory with a monochromatic X-ray beam of 23 keV, and C-µCT was performed using a table-top CT scanner (Skyscan 1272). Reconstruction images obtained using the two methods were qualitatively compared with 2D images evaluated under 3D visualization. The SR-µCT images, especially of the new-bone-graft-woven-bone formation, were less noisy and sharper than the C-µCT images. To evaluate the new-bone-graft-woven-bone formation, only the SR-µCT images showed areas of new bone (NB) formation with bone substitute (BS; Bio-Oss) and woven bone (WB) contact, and correctly visualized true 3D structures of bone formation. Hence, µCT techniques are non-destructive and can provide detailed images of bone biopsy. In particular, SR-µCT can be used to obtain improved image quality with contrast of NB, BS and WB, demonstrating a level of detail comparable with bone formation. SR-µCT could be an unbiased 3D alternative for imaging WB formation and for high-throughput analysis.


Asunto(s)
Regeneración Ósea , Huesos/ultraestructura , Sincrotrones , Microtomografía por Rayos X/métodos , Absorción de Radiación , Biopsia , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Maxilar/patología , Maxilar/cirugía , Refractometría
17.
BMC Oral Health ; 19(1): 243, 2019 11 11.
Artículo en Inglés | MEDLINE | ID: mdl-31711493

RESUMEN

BACKGROUND: Follicular lymphoid hyperplasia (FLH) is characterized by an increased number and size of lymphoid follicles. In some cases, the etiology of FLH is unclear. FLH in the oral and maxillofacial region is an uncommon benign entity which may resemble malignant lymphoma clinically and histologically. CASE PRESENTATION: We report the case of a 51-year-old woman who presented with an asymptomatic firm mass in the left posterior maxillary site. Computed tomography scan of her head and neck showed a clear circumscribed solid mass measuring 28 × 23 mm in size. There was no evidence of bone involvement. Incisional biopsy demonstrated benign lymphoid tissue. The patient underwent complete surgical resection. Histologically, the resected specimen showed scattered lymphoid follicles with germinal centers and predominant small lymphocytes in the interfollicular areas. Immunohistochemically, the lymphoid follicles were positive for CD20, CD79a, CD10, CD21, and Bcl6. The germinal centers were negative for Bcl2. Based on these findings, a diagnosis of benign FLH was made. There was no recurrence at 1 year postoperatively. CONCLUSIONS: We diagnosed an extremely rare case of FLH arising from an unusual site and whose onset of entity is unknown. Careful clinical and histopathological evaluations are essential in making a differential diagnosis from a neoplastic lymphoid proliferation with a nodular growth pattern.


Asunto(s)
Tejido Linfoide/patología , Maxilar/patología , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Hiperplasia , Persona de Mediana Edad
18.
Acta Odontol Latinoam ; 32(2): 88-96, 2019 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-31664299

RESUMEN

The aim of this study was to determine the differences in arch length, inter-canine distance, inter-premolar distance, intermolar distance and arch shape between dental discrepancies (crowding and spacing) in a sample of dental casts from the Afro-Colombian population of San Basilio de Palenque. An analytical, cross-sectional study was conducted on a convenience sample of 63 subjects aged 11 to 57years, of Afro-Colombian origin, with full dentition from first molar to first molar, without extensive caries or restorations, and excluding casts with defects due to loss. The differences between arch (upper and lower) variables were analyzed according to dental discrepancies. Plaster models digitalized with a TR1OS3 Mono scanner with exactitude (6.9 ± 0.9 pm) and precision (4.5 ± 0.9 pm) were analyzed with Orthonalyzer software. Statistical analyses were done on SPSS software (Version 20 for Windows) and Real Statistics. Spacing discrepancy of68.25% was found for upper arch and 66.66% for lower arch; crowding discrepancy of 19.04% for upper arch and 20.63% for lower arch, and an adequate ratio of 12.69% for both arches. No statistically significant difference (p>0.05) was found between arch parameters except for inter-premolar distance on the lower arch. The most frequent arch shape in the population was oval for both upper arch, with 76.19%, and lower arch, with 71.42%. Tooth size was larger in males than females but the difference was not statistically significant.


Asunto(s)
Arco Dental/patología , Maloclusión/etiología , Corona del Diente/patología , Adolescente , Adulto , Cefalometría/estadística & datos numéricos , Niño , Colombia/epidemiología , Estudios Transversales , Coronas , Modelos Dentales , Diastema/etiología , Femenino , Humanos , Masculino , Maloclusión/epidemiología , Maloclusión/patología , Maxilar/patología , Persona de Mediana Edad , Odontometría/estadística & datos numéricos , Tamaño de los Órganos , Adulto Joven
19.
Medicina (Kaunas) ; 55(9)2019 Sep 03.
Artículo en Inglés | MEDLINE | ID: mdl-31484416

RESUMEN

Background and objectives: This study investigated the morphology of the labial and palatal bony wall of the maxillary central and lateral incisors using cone-beam computed tomography (CBCT). The difference between males and females and the measurement between right and left sides were measured. Materials and Methods: Twenty participants, consisting of 11 females and 9 males having normal occlusion, were used for the analysis. The mean age was 21.9 ± 3.0 years. The thickness of the labial bony wall and palatal bony wall, perpendicular to the long axis of the root, were evaluated at 3 and 5 mm apical from the cemento-enamel junction (CEJ) and at the root apex. The available bony wall below the apex of the central and lateral incisors, and the angulation between the long axis of the tested tooth and outer surface of the labial bone were measured. Results: The mean labial bony wall thickness at the 3 and 5 mm apical from the CEJ were 1.1 ± 0.3 mm and 1.0 ± 0.4 mm for central incisors, respectively, as well as 1.2 ± 0.4 mm and 1.0 ± 0.4 mm for lateral incisors, respectively. The mean palatal bony wall thickness at 5 mm from the CEJ was above 2 mm in the central and lateral incisors. The percentage of labial bony wall thickness 2 mm or greater at the root apex in central incisors was higher than in lateral incisors (62.5% vs. 55.0%). The percentage of palatal bony wall thickness ≥2 mm at 3 mm apical from the CEJ in the central incisors was higher than in the lateral incisors (37.5% vs. 15.0%). The results on the left and right sides did not show statistically significant differences, except in the labial and palatal bony wall thickness at 3 mm from the CEJ in the lateral incisor. Generally, no significant differences were seen between males and females, but males had a significantly higher labial bony wall thickness at 3 and 5 mm from the CEJ in the central and lateral incisors when compared with females. Conclusions: This study showed that a majority of the cases of Korean participants had less than 2 mm of labial bony wall thickness at 3 and 5 mm apical from the CEJ at central and lateral incisors, and this should be kept in mind while performing dental practices, including tooth extraction or immediate implantation in anterior regions. Preoperative analysis using CBCT may be beneficial for establishing the treatment plan.


Asunto(s)
Pérdida de Hueso Alveolar/clasificación , Oclusión Dental , Incisivo/patología , Adolescente , Tomografía Computarizada de Haz Cónico/métodos , Femenino , Humanos , Masculino , Maxilar/patología , Adulto Joven
20.
Braz Oral Res ; 33: e086, 2019 Aug 29.
Artículo en Inglés | MEDLINE | ID: mdl-31483052

RESUMEN

Treatment of patients with bisphosphonate usage is a significant concern for oral surgeons because it interferes with jaw bone turnover and regeneration. In case of adverse effects manifesting related to bisphosphonate use, oral surgeons are usually treating and keep the patient's symptoms under control. In this study, we aimed to investigate a new treatment protocol for medication-related osteonecrosis of the jaw (MRONJ). This treatment protocol consisted of administering human parathyroid hormone (hPTH) loaded chitosan microspheres which were prepared by ionotropic gelation method or/and the prepared microspheres were suspended in a poloxamer gel. After in-vitro optimization studies, the efficacy of the chosen formulations was evaluated in-vivo studies. Zoledronic acid was administered daily to forty-eight adult female Sprague-Dawley rats, divided into four experimental groups, at a daily concentration of 0.11 mg/kg over three weeks to induce the MRONJ model. At the end of this period, maxillary left molar teeth were extracted. In the first group, the subjects received no treatment. In the negative control group, poloxamer hydrogel containing empty microspheres were immediately applied to the soft tissues surrounding the extraction socket. The treatment group-1 was treated with local injections of poloxamer hydrogel containing hPTH. The treatment group-2 was treated with a single local injection of poloxamer hydrogel containing hPTH-loaded chitosan microspheres. Both treatment groups received a total of 7 µg of hPTH at the end of the treatment protocol. Our study demonstrates successful attenuation of MRONJ through a local drug delivery system combined with hPTH, as opposed to previously attempted treatment strategies.


Asunto(s)
Conservadores de la Densidad Ósea/farmacología , Quitosano/farmacología , Maxilar/efectos de los fármacos , Hormona Paratiroidea/farmacología , Animales , Osteonecrosis de los Maxilares Asociada a Difosfonatos/tratamiento farmacológico , Osteonecrosis de los Maxilares Asociada a Difosfonatos/etiología , Conservadores de la Densidad Ósea/efectos adversos , Conservadores de la Densidad Ósea/uso terapéutico , Quitosano/uso terapéutico , Preparaciones de Acción Retardada , Femenino , Humanos , Maxilar/patología , Microesferas , Modelos Animales , Hormona Paratiroidea/uso terapéutico , Poloxámero/administración & dosificación , Poloxámero/química , Ratas Sprague-Dawley , Ácido Zoledrónico/efectos adversos
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