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1.
Braz. j. oral sci ; 20: e219638, jan.-dez. 2021. tab
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-1254752

RESUMEN

Diagnosis of oral and oropharyngeal cancer in advanced stages may be associated with social nature factors, access to health care, education, occupation, and behavioral/ cultural factors. Aim: To determine the factors related to high clinical-staging in patients diagnosed with squamous cell carcinoma in the oral and oropharyngeal region in a Cancer Center in Brazil between 2009 and 2015. Methods: It is an epidemiological, retrospective, and exploratory study. Patients diagnosed with squamous cell carcinoma had their medical records analyzed. The variables considered were sociodemographic, lifestyle, and disease characteristics. Descriptive and exploratory tests (Pearson's, chi-square test and, Student's t-test) were realized. Results: We analyzed 365 patient records, among which 289 (79.17%) were male, and 73 (20.0%) were female. Age ranged from 16 to 101 years, with a mean of 61.13. Regarding education, 157 (43.01%) studied < 8 years, 103 (28.21%) were illiterate and 102 (27.94%) studied > 8 years. 305 (83.56%) patients live in urban areas. There was an association between high clinical-staging and low educational level. For high clinical-staging, symptomatology, tobacco, and alcohol intake as well. Conclusion: Patients with low educational levels tend to report the disease later, and their diagnostics occurred in advanced stages. Thus, specific public health policies for this population, including access to dental care to recognize the clinical signs and early diagnosis, are necessary


Asunto(s)
Factores Socioeconómicos , Neoplasias de la Boca/diagnóstico , Neoplasias Orofaríngeas/diagnóstico , Registros Médicos
2.
Anticancer Res ; 41(10): 4771-4779, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34593426

RESUMEN

BACKGROUND/AIM: P53-binding protein 1 (53BP1) is one of the DNA damage response (DDR) molecules. This study aimed to assess 53BP1 expression by immunofluorescence (IF) as a biomarker to differentiate between oral squamous epithelial lesions (OSELs). MATERIALS AND METHODS: We analyzed 129 archival oral biopsy samples, including 18 benign squamous lesions (BSLs), 37 low-grade dysplasias (LGDs), 22 high-grade dysplasias (HGDs), and 52 oral squamous cell carcinomas (OSCCs). 53BP1 and Ki-67 expressions were examined by double IF to assess the type of 53BP1 expression. RESULTS: We found that OSCC exhibited several 53BP1 nuclear foci, particularly high-DNA damage response (HDDR) and large focus (LF)-type, suggesting the presence of endogenous DNA double-strand breaks in the cancer genome, which could disrupt DDR and induce genomic injury. We also found a difference in 53BP1 expression between LGD and HGD, but not between BSL and LGD. Among the Ki-67-positive cells, HDDR- and LF-type expressions were higher in OSELs of higher grades. CONCLUSION: 53BP1 expression can be a valuable biomarker for OSELs to help estimate the grade of oral epithelial dysplasia.


Asunto(s)
Roturas del ADN de Doble Cadena , Enfermedades de la Boca/metabolismo , Lesiones Intraepiteliales Escamosas/metabolismo , Proteína 1 de Unión al Supresor Tumoral P53/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/metabolismo , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/patología , Núcleo Celular/metabolismo , Progresión de la Enfermedad , Femenino , Inestabilidad Genómica , Humanos , Antígeno Ki-67/metabolismo , Masculino , Persona de Mediana Edad , Enfermedades de la Boca/patología , Neoplasias de la Boca/metabolismo , Neoplasias de la Boca/patología , Lesiones Intraepiteliales Escamosas/patología
3.
Prague Med Rep ; 122(3): 222-227, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34606435

RESUMEN

Melanoma is a malignant neoplasm of the epidermal melanocytes. Awareness and early recognition of pigmented lesion inside oral cavity helps in initial diagnosis and further investigation and treatment. Oral malignant melanoma is a rare aggressive neoplasm commonly seen among middle age. The diagnosis of melanoma initiates from the pre-existing pigmented lesions. The poor prognosis of oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied. A case of malignant melanoma of hard palate with its clinical, radiological and histopathological presentation along with brief review is presented. Prognosis of these lesion is poor with survival rate of 5 years.


Asunto(s)
Melanoma , Neoplasias de la Boca , Neoplasias Cutáneas , Humanos , Melanoma/diagnóstico , Persona de Mediana Edad , Neoplasias de la Boca/diagnóstico , Pronóstico
4.
Anticancer Res ; 41(10): 5059-5063, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-34593455

RESUMEN

BACKGROUND/AIM: Follow-up after treatment for oral tongue cancer consists of routine follow-up visits for five years. It has been suggested that this program is inefficient for finding recurrences. The primary objective of this study was to investigate how recurrences are detected; at routine follow-up visits, at patient-initiated visits, or incidentally. The secondary objective was to investigate whether the two-year survival after diagnosis of recurrence depended on the manner of detection. PATIENTS AND METHODS: Patients with recurrences from oral tongue cancer between 1988 and 2016 were included. Survival was analysed by the Kaplan-Meier method and log-rank test. RESULTS: A total of 75 patients were included. In 67% of patients, recurrences were detected at routine follow-up visits, and in 27% at patient-initiated visits. No significant difference in survival between the groups was found (p=0.56). CONCLUSION: The majority of recurrences were detected at routine follow-up visits. Patient-initiated recurrence detection did not lead to increased survival.


Asunto(s)
Neoplasias de la Boca/terapia , Vigilancia de la Población , Neoplasias de la Lengua/terapia , Adulto , Anciano , Anciano de 80 o más Años , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/patología , Pronóstico , Estudios Retrospectivos , Tasa de Supervivencia , Suecia/epidemiología , Neoplasias de la Lengua/patología , Adulto Joven
5.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 56(10): 1005-1010, 2021 Oct 09.
Artículo en Chino | MEDLINE | ID: mdl-34619895

RESUMEN

Objective: To evaluate the effect of quantitative analysis of optical signal in the near infrared fluorescence molecular navigation surgery for oral squamous cell carcinoma (OSCC). Methods: SCC9, HSC3 and epithelial cell lines (Leuk-1) were co-cultured with indocyanine green (ICG) for 6 hours in vitro in order to verify whether the quantitative analysis of near infrared optical signal could distinguish tumor cells from normal cells. A total of 16 BALB/c male mice (5-6 weeks, 20-25 g) were selected and fed in clean grade equipment and were equally divided into two groups. SCC9 and HSC3 cells were inoculated into the back of each mouse at a concentration of 1×106 cells/ml to establish a subcutaneous graft tumor model. The 5 mg/kg ICG was injected into the caudal vein to each of the tumor bearing mouse and the difference between OSCC and normal tissues was then analyzed by near infrared optical signal quantitative analysis (Paired t test). Ten patients with OSCC were enrolled in the Department of Stomatology of the First Affiliated Hospital of Bengbu Medical College from November 2019 to July 2020, including 6 patients with tongue squamous cell carcinoma and 4 patients with buccal squamous cell carcinoma.The patients were 6 males and 4 females and the range of age was from 46 to 71 years with an average age of 58.6 years. These patients were injected ICG (0.75 mg/kg) via the cubital vein at 6-8 h before surgery. Intraoperatively, the fluorescence intensities (FI) of near infrared signal were measured at tumor, peritumor tissues (2.0 cm beyond the tumor boundary) and normal tongue or buccal mucosa respectively. The signal background ratios (SBR) from the three site groups were assessed using one-way ANOVA followed by the Tukey post hoc test for multiple comparisons. Results: In vitro, the levels of near infrared FI in HSC3 and SCC9 groups were higher than that in Leuk-1group (P<0.01). In vivo, the result showed that the SBR of OSCC and normal tissues was 8.67±0.35. Clinical studies showed that the intensity of tumor [(408.23±101.51) arbitrary units (AU)] was significantly higher than those of peritumoral [(253.12±64.89) AU] and normal tissues [(261.50±80.47) AU] respectively. The SBRs of near infrared FI of tumor and peritumoral tissues, tumor and normal tissues were 1.61±0.53 and 1.56±0.48 respectively, while that of peritumoral and normal tissues was 0.96±0.17. Conclusions: The quantitative analysis of near infrared optical signal could distinguish OSCC from normal cells and could locate the OSCC tissue intraoperatively. Optical signal quantification and ICG near infrared fluorescence molecular technology possessed the feasibility in primary OSCC resection.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Neoplasias de la Lengua , Animales , Femenino , Fluorescencia , Humanos , Masculino , Ratones , Ratones Endogámicos BALB C , Neoplasias de la Boca/cirugía , Carcinoma de Células Escamosas de Cabeza y Cuello
6.
J Med Microbiol ; 70(9)2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34553683

RESUMEN

Introduction. Squamous cell carcinoma is a highly aggressive type of oral cancer (OC). It is the most common cancer among men, and accounts for almost 90 % of all oral cancers in India. Consumption of tobacco is a leading factor contributing to maximum oral cancer incidences as per the WHO.Hypothesis/Gap statement. Researchers reported a direct association of microorganisms with dysbiosis in various oral lesions including oral cancer. However, there is a dearth of information related to compositional changes in the oral microbiome in long-term tobacco chewers and the Indian oral cancer population.Aim. The aim of this study was to identify and correlate the bacterial diversity in the oral cavity of tobacco chewers, patients with oral cancer and healthy subjects in the Indian population.Methods. Oral rinse samples were collected for ten subjects in each group followed by DNA extraction. The variable regions of the bacterial 16S rRNA gene (V6-V8) were amplified, sequenced, processed, and analysed using QIIME2 platform to assess alpha and beta diversity between the study groups.Results. This pilot study showed genus Streptococcus dominated the control group (18.54 %), and the abundance decreased in tobacco and OC group (9.63 and 5.45% respectively); whereas genus Prevotella dominated the tobacco and OC group (21.01 and 26.03% respectively). A shift in abundance of microbiome was observed from control population to oral cancer via the tobacco chewing population. Maximum alpha diversity of oral microbiome was found in Indian tobacco chewers. Beta diversity of tobacco chewers was similar to both the healthy population as well as oral cancer patients suggesting transitioning of the oral microbiome from healthy to oral cancer microbiome via the tobacco chewers microbiome.Conclusion. The data provides evidence of oral bacterial dysbiosis due to tobacco chewing habits that can further lead to progression towards cancer.


Asunto(s)
Disbiosis/microbiología , Microbiota , Neoplasias de la Boca/microbiología , Boca/microbiología , Uso de Tabaco/patología , Adulto , Anciano , Estudios de Casos y Controles , Femenino , Humanos , India/epidemiología , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/patología , Proyectos Piloto , Adulto Joven
7.
Medicina (Kaunas) ; 57(9)2021 Sep 14.
Artículo en Inglés | MEDLINE | ID: mdl-34577888

RESUMEN

Oral mucosal melanoma (OMM) represents an extremely rare entity that is associated with a poor prognosis due to late diagnosis and early metastasis. Here, extensive surgical therapy is the therapy of choice. In contrary, for OMM in situ, the respective therapeutical recommendations are lacking. In this case report, treatment modalities of an OMM in situ of the palate, including the maxillary alveolar process, are reported. The tumor relapsed twice despite adequate surgical therapy and reconstruction. Therefore, irradiation was performed as an adjuvant therapy. At a follow-up of two years, the patient was free from recurrences.


Asunto(s)
Melanoma , Neoplasias de la Boca , Neoplasias Cutáneas , Humanos , Melanoma/cirugía , Mucosa Bucal , Neoplasias de la Boca/cirugía , Recurrencia Local de Neoplasia
8.
J Int Med Res ; 49(9): 3000605211045555, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34586932

RESUMEN

Odontogenic carcinosarcoma is a very rare malignant odontogenic tumor, characterized by malignant epithelial and mesenchymal components. Studies have reported several cases of odontogenic carcinosarcoma, mainly in the upper and lower jaws, with malignant clinical manifestations. Herein, we present the case of a 58-year-old woman with odontogenic carcinosarcoma with dentinoid in the left maxilla. The invasion range was large, and the left maxillary molar was missing. Histology revealed odontogenic carcinosarcoma with bidirectional differentiation characteristics and comprising three components: malignant epithelium, malignant interstitium, and dentinoid. The patient subsequently underwent nasal endoscopic sinus tumor resection, and she recovered well after surgery. After a strict 4-year follow-up, to date, there are still no signs of disease or local recurrence. To our knowledge, this is the first reported case of odontogenic carcinosarcoma with dentinoid. Our study describes the clinical, morphological, and immunohistochemical characteristics of this case, and distinguishes it from related diseases.


Asunto(s)
Carcinosarcoma , Neoplasias de la Boca , Tumores Odontogénicos , Carcinosarcoma/diagnóstico por imagen , Carcinosarcoma/cirugía , Femenino , Humanos , Mandíbula , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Tumores Odontogénicos/diagnóstico por imagen , Tumores Odontogénicos/cirugía
9.
Evid Based Dent ; 22(3): 94-95, 2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-34561656

RESUMEN

Data sources The authors searched electronic databases of Medline, Embase, Web of Science, Scopus, CINAHL and Google Scholar until May 2019. They also searched within the reference lists of studies, citation indexes and related articles from these electronic databases. Ongoing studies were searched in Research Registry, and Electronic Theses Online Service was used for searching theses.Study selection The authors conducted a systematic review with meta-analyses of studies that looked at the oral cancer referral by general practitioners (GPs; also referred to as primary care doctors or physicians) and dentists. Specifically, their objectives were to find out the percentage or proportion of oral cancers referred by GPs and dentists, oral cancer stage, and the delay in referral. Twenty-two studies from ten countries fulfilled the inclusion criteria. These were predominantly case series, with some studies being questionnaires, patient interviews and a combination of these.Data extraction and synthesis The data from the studies were independently extracted by three authors, and when they had disagreement, they discussed it as a group to reach a consensus. They used MINORS index to assess the quality of included studies. They did due diligence to contact the authors of included studies to collect missing data. When missing data was not attainable, they assessed the available data. They used appropriate software for data analysis and generated forest plots and heterogeneity tests. They also conducted sub-group analyses of data from within the UK, which has the same medical care system.Results A total of 4,953 oral cancers were included in this systematic review of 22 studies originating from ten countries. For the first objective on percentage or proportion of oral cancers referred by GPs and dentists, the GPs referred 13-86% compared to dentists who referred between 15-80%. Meta-analysis of 22 studies showed that GPs referred more oral cancers than dentists (RR: 1.36; 95 CI: 0.99-1.86). In other words, for every ten patients referred by a dentist, GPs referred 14 patients. Doing the same analysis for the eight studies in the UK, the result was similar with GPs referring more than dentists (RR: 1.36; 95% CI 1.05-1.96). For the second objective on oral cancer stage on presentation, meta-analysis was feasible only on four studies, which showed that dentists tend to refer early-stage (stage 1 and 2) oral cancers more than GPs (RR: 1.37; 95% CI 1.17-1.60). In other words, for every ten early-stage oral cancer patients referred by GPs, dentists referred 14. For the third objective on the delay in referral, the authors were unable to conduct meta-analyses due to the inconsistency of measurement of delay in referral. The studies revealed no statistically significant difference between GPs and dentists.Conclusions Both GPs and dentists refer the majority of oral cancer patients. While GPs tend to refer more oral cancers than dentists, the dentists referred more early-stage oral cancers.


Asunto(s)
Neoplasias de la Boca , Médicos de Atención Primaria , Odontólogos , Humanos , Neoplasias de la Boca/diagnóstico , Atención Primaria de Salud , Derivación y Consulta
10.
J Pak Med Assoc ; 71(9): 2271-2274, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34580530

RESUMEN

Distant metastasis is the most important prognostic factor for head and neck cancer. This report presents the case of a 50-year-old man with distant metastasis of tongue carcinoma to the vastus lateralis muscle which presented to Nihon University Itabashi Hospital, Tokyo, Japan. Tumourectomy was performed with a diagnosis of tongue carcinoma (cT2N0M0, Stage II). Seven months later, radical neck dissection was performed for lymph node metastasis to a left supraclavicular lymph node. In addition, metastasis was then detected outside the neck dissection region. Tumourectomy and radiotherapy (50 Gy) were, therefore, added to the treatment regimen. However, left-sided vastus lateralis muscle metastasis was then observed. To the best of our knowledge, this is the first report of distant metastasis of oral squamous cell carcinoma to the vastus lateralis muscle.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Neoplasias de la Lengua , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/cirugía , Humanos , Ganglios Linfáticos/patología , Masculino , Persona de Mediana Edad , Disección del Cuello , Estadificación de Neoplasias , Músculo Cuádriceps , Lengua , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/cirugía
11.
Vet Clin Pathol ; 50(3): 404-409, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34472131

RESUMEN

Although oral cytology using Papanicolaou stain is useful for the early detection of oral premalignant lesions and squamous cell carcinoma (SCC) in people, little work has been conducted on this topic in veterinary medicine. This paper describes the features of oral cytology using Papanicolaou stain and immunocytochemistry on liquid-based cytology slides in a case of oral SCC in an Indo-Pacific bottlenose dolphin (Tursiops aduncus). In this case, dysplastic cells with koilocyte-like changes and SCC cells were identified using the Papanicolaou stain. These cells were positive for p53 using an immunocytochemistry analysis. A cytologic diagnosis of SCC was made. We believe that the early detection of premalignant oral lesions and SCC in dolphins can be significantly improved with cytology using liquid-based cytology, Papanicolaou staining, and immunocytochemistry.


Asunto(s)
Delfín Mular , Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Animales , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/veterinaria , Colorantes , Neoplasias de Cabeza y Cuello/veterinaria , Inmunohistoquímica , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/veterinaria , Carcinoma de Células Escamosas de Cabeza y Cuello/veterinaria
12.
Orv Hetil ; 162(37): 1471-1479, 2021 09 12.
Artículo en Húngaro | MEDLINE | ID: mdl-34516393

RESUMEN

Összefoglaló. A szájüregi daganatok kuratív kezelésében az elsodlegesen választandó mutét mellett a sugárterápiának is jelentos szerepe van. A lokális tumormentesség biztosításához azonban dóziseszkaláció szükséges. Ennek külso besugárzással való megvalósítása a környezo normálszövetek fölösleges dózisterhelésével és az ebbol következo mellékhatások elofordulásának emelkedésével jár. A brachytherapia (BT) - amelynek során radioaktív sugárforrást/sugárforrásokat juttatunk a tumorba vagy annak közelébe - lehetové teszi a helyileg magasabb dózis leadását a környezo ép szövetek kímélésével. A BT a korai, T1-2N0 stádiumú szájüregi tumoroknál - kedvezo prognosztikai faktorok mellett - akár kizárólagosan vagy mint posztoperatíve egyedül alkalmazott terápiás modalitás jön szóba. Kedvezotlenebb prognózis esetén vagy elorehaladottabb stádiumban (T3-4 vagy N+) a mutétet és/vagy a percutan irradiációt kiegészíto eljárásként alkalmazható kedvezo sugárfizikai tulajdonságai miatt. A kis dózisteljesítményu (low-dose-rate, LDR) BT-t már évtizedek óta alkalmazzák a terápiában, de ezt kezdi kiszorítani a nagy dózisteljesítményu (high-dose-rate, HDR), illetve a pulzáló dózisteljesítményu (pulse-dose-rate, PDR) BT. A jelen áttekinto tanulmány célja irodalmi adatok alapján a BT szerepének és indikációjának ismertetése a szájüregi daganatok kuratív kezelésében, alrégiókra lebontva. Orv Hetil. 2021; 162(37): 1471-1479. Summary. Radiation therapy plays a significant role in the curative treatment of oral cavity tumors, in addition to the primary choice of surgery. However, dose escalation is required to ensure local tumor control. Its implementation with external irradiation is accompanied by an unnecessary dose exposure to the surrounding normal tissues and an increase in the incidence of consequent side effects. Brachytherapy (BT), in which a radiation source/sources is/are placed inside or close to the tumor, allows a higher dose to be delivered locally, sparing the surrounding intact tissues. In addition to favorable prognostic factors in early T1-2N0 stage oral cavity tumors, BT is considered either exclusively or as a sole postoperative therapeutic modality. At less favorable prognosis or at a more advanced stage (T3-4 or N+), BT can be used as a complementary procedure after surgery and/or percutaneous irradiation based on its favorable radio-physical properties. Low-dose-rate (LDR) BT has been used in the therapy for decades, but recently it has been replaced by high-dose-rate (HDR) and pulse-dose-rate (PDR) BT. The purpose of this review is to describe the role and indications of BT in the treatment of oral cavity tumors categorized into subregions, based on the literature data. Orv Hetil. 2021; 162(37): 1471-1479.


Asunto(s)
Braquiterapia , Neoplasias de la Boca , Humanos , Incidencia , Neoplasias de la Boca/radioterapia
13.
JNMA J Nepal Med Assoc ; 59(234): 124-127, 2021 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-34506468

RESUMEN

INTRODUCTION: Head and neck cancer is the sixth most common cancer in the world. The disease burden is increasing at an alarming rate in developing Southeast Asian countries. This study aims to report the histopathological spectrum of oral cavity lesions at a tertiary cancer center in central Nepal. METHODS: This study included all those cases of oral cavity lesions, of which diagnostic biopsy was done from January 2018 to December 2019. The data were retrieved from the Department of Pathology of BP Koirala Memorial Cancer Hospital. The study proposal was approved by the Institutional Review Committee at BPKMCH (Ref: 247/2020) on 28th June 2020. Convenience sampling was done. Data was analyzed using Statistical Package for the Social Sciences version 20 using descriptive statistics. RESULTS: A total of 851 cases of oral cavity lesions were included in this study. The mean age of the study population was 55.9 years, with male to female ratio of 3:1. Malignant lesions composed of 472 (55.5%) cases followed by premalignant lesion of 104 (12%). More than 453 (95%) malignant cases were squamous cell carcinoma, of which 342 (75%) were a well-differentiated type. The buccal cavity is the most common site of malignant lesion 212 (45%), followed by tongue 96 (20%) and lower gingivobuccal region 86 (18%). CONCLUSIONS: Malignant lesions are the most common histopathological findings in the oral cavity lesion with squamous cell carcinoma type. Oral cancer is common cancer that can be prevented and cured if detected early.


Asunto(s)
Neoplasias de la Boca , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/diagnóstico , Neoplasias de la Boca/epidemiología , Nepal/epidemiología , Centros de Atención Terciaria
14.
BMJ Case Rep ; 14(9)2021 Sep 20.
Artículo en Inglés | MEDLINE | ID: mdl-34544715

RESUMEN

A 55-year-old man initially presented with an undifferentiated, HPV-p16-negative squamous cell carcinoma (SCC) in the left tonsillar region (cT4a N0 M0), which was treated with a combination of radiotherapy and chemotherapy. Several months later, the patient developed osteoradionecrosis on the left side of the mandible as well as a second primary lesion at the left base of the tongue. Surgical resection and mandibular reconstruction with a free vascularised fibula flap was performed. Regional clinical and radiologic follow-up showed no signs of tumour recurrence. However, routine positron emission tomography (PET)-CT showed a hypermetabolic mass intracardially. MRI confirmed the presence of a mass intramurally in the left ventricle, highly indicative of metastasis. Cardiac metastasis following oral cancer is rare and usually asymptomatic. Therefore, it can be missed easily and is mostly described as a finding postmortem. Reporting these cases is important for contributing to the insight into the uncommon development of metastasis.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Humanos , Masculino , Mandíbula , Persona de Mediana Edad , Carcinoma de Células Escamosas de Cabeza y Cuello
15.
Medicine (Baltimore) ; 100(36): e27127, 2021 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-34516504

RESUMEN

ABSTRACT: In Malaysia, oral cancer is very common and the reported 5-year survival of such patients is nearly 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries. This study aimed to investigate the socio-demographic and clinicopathological parameters that influence the mortality rate of the patients suffering from oral squamous cell carcinoma (OSCC) in the Kelantanse population.In this retrospective study, data regarding socio-demographic, clinicopathological factors, and treatment outcome associated with OSCC were gathered from the archives of the medical records office of Hospital Universiti Sains Malaysia. For statistical analysis, simple and multiple logistic regression were performed. The significance level was set to P < .25.A total of 211 OSCC cases were registered in Hospital Universiti Sains Malaysia from January 1, 2000 to December 31, 2018. Majority of them were male (57.82%), non-smoker (54.97%), non-alcohol consumer (91.94%), and non-betel quid chewer (93.83%) Malay (60.66%) patients. The tongue was the most commonly involved part of the oral cavity (41.52%). Histologically, the majority of the cases had moderately-differentiated OSCC (52.82%). Most of the patients were diagnosed at stage IV at the time of diagnosis (61.61%). When this study was performed, the survival status of the majority of the patients was alive (68.24%).Within the analyzed socio-demographic and clinicopathological parameters, gender, alcohol consumption, T-classification, histological grading, and treatment status have been demonstrated as an independent risk factors for mortality rate in multivariate analysis. Hence, these parameters need to be taken into account for the individualized therapy management of OSCC patients.


Asunto(s)
Carcinoma de Células Escamosas/mortalidad , Neoplasias de la Boca/mortalidad , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/etiología , Estudios Transversales , Femenino , Humanos , Malasia , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/etiología , Estudios Retrospectivos , Factores de Riesgo , Análisis de Supervivencia , Adulto Joven
16.
Anal Chem ; 93(39): 13152-13160, 2021 10 05.
Artículo en Inglés | MEDLINE | ID: mdl-34551257

RESUMEN

Single-cell EV (extracellular vesicle) secretion analysis is emerging for a better understanding of non-genetic cellular heterogeneity regulating human health and diseases through intercellular mediators. However, the requirements of expensive and bulky instrumentations hinder its widespread use. Herein, by combining gold nanoparticle-enhanced silver staining and the Poisson distribution, we reported the use of a home-use scanner to realize high-throughput single-cell EV secretion analysis without cell counting. We applied the platform to analyze the secretions of different EV phenotypes with the human oral squamous cell carcinoma cell line and primary cells from patients, which generated single-cell results comparable with those of the immunofluorescence approach. Notably, we also realized the quantification of the number of EVs secreted from every single cell using their respective titration curves obtained from population samples, making it possible to directly compare different EV phonotypes in regard to their secretion number, secretion rate, and so forth. The technology introduced here is simple, easy to operate, and of low cost, which make it a potential, easily accessible, and affordable tool for widespread use in both basic and clinical research.


Asunto(s)
Carcinoma de Células Escamosas , Vesículas Extracelulares , Nanopartículas del Metal , Neoplasias de la Boca , Oro , Humanos
17.
World J Surg Oncol ; 19(1): 279, 2021 Sep 17.
Artículo en Inglés | MEDLINE | ID: mdl-34535149

RESUMEN

BACKGROUND: The administration of postoperative radiotherapy remains controversial in pN1 oral cavity cancer patients without extranodal extension. The aim is to determine whether postoperative radiotherapy reduces the neck recurrence rate and improves the survival outcomes of pN1 patients. METHODS: This study consecutively enrolled 1056 patients with newly diagnosed oral squamous cell carcinoma who underwent tumor wide excision and neck dissection from September 2002 to November 2019. One hundred two pN1 patients without extranodal extension were eligible for analysis. Then, a subgroup analysis of 40 patients was performed after patients with other adverse risk factors (positive margins, close margins, lymphovascular invasion, perineural invasion, tumor depth ≥ 10 mm, and poor histological differentiation) were excluded. RESULTS: Of the 102 eligible pN1 patients, 26 patients received surgery alone, and 76 received postoperative radiotherapy. No significant differences were observed in the neck recurrence rate (7.7% vs. 15.8%, p = 0.30). Similarly, in patients without other adverse risk factors, no significant differences were observed in the neck recurrence rate (5% vs. 20%, p = 0.15) between surgery alone group and postoperative radiotherapy group. Moreover, no significant difference was found in the neck recurrence-free survival rate, overall survival, and disease-specific survival (77.1% vs. 52.5%, p = 0.42, 83.5% vs. 64.5%, p = 0.81, and 88.2% vs. 67.9%, p = 0.34, respectively). CONCLUSION: Postoperative radiotherapy did not significantly decrease the probability of neck recurrence and survival outcomes in pN1 patients without extranodal extension. Radical surgery alone may be considered sufficient treatment for pN1 patients without other adverse risk factors.


Asunto(s)
Carcinoma de Células Escamosas , Neoplasias de Cabeza y Cuello , Neoplasias de la Boca , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células Escamosas/cirugía , Extensión Extranodal , Humanos , Neoplasias de la Boca/patología , Neoplasias de la Boca/radioterapia , Neoplasias de la Boca/cirugía , Recurrencia Local de Neoplasia/patología , Recurrencia Local de Neoplasia/radioterapia , Estadificación de Neoplasias , Pronóstico , Estudios Retrospectivos
18.
Head Face Med ; 17(1): 38, 2021 Sep 03.
Artículo en Inglés | MEDLINE | ID: mdl-34479595

RESUMEN

BACKGROUND: Hyperspectral imaging (HSI) is a promising non-contact approach to tissue diagnostics, generating large amounts of raw data for whose processing computer vision (i.e. deep learning) is particularly suitable. Aim of this proof of principle study was the classification of hyperspectral (HS)-reflectance values into the human-oral tissue types fat, muscle and mucosa using deep learning methods. Furthermore, the tissue-specific hyperspectral signatures collected will serve as a representative reference for the future assessment of oral pathological changes in the sense of a HS-library. METHODS: A total of about 316 samples of healthy human-oral fat, muscle and oral mucosa was collected from 174 different patients and imaged using a HS-camera, covering the wavelength range from 500 nm to 1000 nm. HS-raw data were further labelled and processed for tissue classification using a light-weight 6-layer deep neural network (DNN). RESULTS: The reflectance values differed significantly (p < .001) for fat, muscle and oral mucosa at almost all wavelengths, with the signature of muscle differing the most. The deep neural network distinguished tissue types with an accuracy of > 80% each. CONCLUSION: Oral fat, muscle and mucosa can be classified sufficiently and automatically by their specific HS-signature using a deep learning approach. Early detection of premalignant-mucosal-lesions using hyperspectral imaging and deep learning is so far represented rarely in in medical and computer vision research domain but has a high potential and is part of subsequent studies.


Asunto(s)
Aprendizaje Profundo , Neoplasias de la Boca , Inteligencia Artificial , Humanos , Imágenes Hiperespectrales , Neoplasias de la Boca/diagnóstico por imagen , Membrana Mucosa , Músculos , Redes Neurales de la Computación
19.
Anticancer Res ; 41(9): 4515-4522, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34475077

RESUMEN

BACKGROUND/AIM: The role of tumour-infiltrating CD45Ro+ T-cells in oral squamous cell carcinoma (OSCC) is unclear. This study aimed to evaluate prognostic biomarkers for OSCC. PATIENTS AND METHODS: We determined the density of tumour-infiltrating CD45Ro+ T cells in the parenchyma and stroma at the tumour centre (TCe) and invasive front (IF) and examined the association between the density of these cells and histopathological status in 142 patients. RESULTS: Five-year overall survival (OS) and recurrence-free survival were favourable in patients with high CD45Ro+ T-cell density in the TCe stroma. OS was favourable in patients with high CD45Ro+ T-cell density in the IF stroma. Stepwise Cox regression model analysis indicated that CD45Ro+ T-cells in the stroma of the IF and TCe were an independent prognostic factor for OS. CONCLUSION: CD45Ro+ T-cells in the stroma of the IF and TCe play a role in cancer immune surveillance and may be a useful prognostic factor.


Asunto(s)
Carcinoma de Células Escamosas/mortalidad , Antígenos Comunes de Leucocito/metabolismo , Linfocitos Infiltrantes de Tumor/inmunología , Neoplasias de la Boca/mortalidad , Linfocitos T/inmunología , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/metabolismo , Carcinoma de Células Escamosas/inmunología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/inmunología , Pronóstico , Análisis de Regresión , Estudios Retrospectivos , Análisis de Supervivencia
20.
Anticancer Res ; 41(9): 4563-4570, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34475084

RESUMEN

BACKGROUND/AIM: Maspin has tumor-suppressor functions; however, its prognostic value in patients with oral squamous cell carcinoma (OSCC) remains unknown. We aimed to assess the prognostic importance of the subcellular localization of maspin in patients with OSCC. PATIENTS AND METHODS: Eighty resected specimens were analyzed by immunohistochemistry. Cytoplasmic-only expression observed in >10% of the tumor was defined as maspin-positive. RESULTS: The maspin-positive status (25%) was significantly associated with a higher recurrence rate and shorter disease-free survival (DFS). Cox's multivariate analysis showed that maspin-positive status was an independent factor for shorter DFS. All OSCC cell lines (HSC2, HSC3, HSC4, Ca9-22 and SAS) showed maspin protein localization to both the cytoplasm and nucleus using western blot analysis. In HSC4 cells, cell invasion was significantly increased in response to maspin knockdown. CONCLUSION: Cytoplasmic-only expression of maspin could be an independent poor prognostic factor for patients with OSCC.


Asunto(s)
Carcinoma de Células Escamosas/cirugía , Citoplasma/metabolismo , Neoplasias de la Boca/cirugía , Serpinas/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/metabolismo , Carcinoma de Células Escamosas/metabolismo , Línea Celular Tumoral , Núcleo Celular/metabolismo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/metabolismo , Análisis Multivariante , Pronóstico , Análisis de Supervivencia
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