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1.
Gene ; 807: 145933, 2022 Jan 10.
Artículo en Inglés | MEDLINE | ID: mdl-34464678

RESUMEN

BACKGROUND: Cervical-cancer is among the most commonly diagnosed cancers in women, and infection with human papillomavirus (HPV) is associated with an increased risk of cervical cancer and altered serum concentrations of inflammatory cytokines. We have explored the association between a genetic variation in the Interleukin-10 (IL-10) gene (rs1800896) and cervical cancer risk and its relationship with tissue Interferon gamma (IFN-γ), Transforming growth factor beta (TGF-ß), Tumor necrosis factor alpha (TNF-α) concentrations in women with cervical cancer. METHODS: A total of 315 women with, or without cervical cancer, were recruited into the study. DNA was extracted from cervical cells, and genotyping was undertaken using Taq-man real-time PCR. The genotype frequency and allele distribution were analyzed together with their association with pathological data. The association of the rs1800896 gene variation with tissue levels of the inflammatory cytokines was also investigated. RESULTS: Our data showed a significant association between the A allele of the rs1800896 gene variant and the presence of cervical cancer. In particular, patients with AG/AA genotypes had an increased risk of cervical cancer with an odds ratio of 1.929 (95% confidence interval [CI]: 0.879-4.23, P < 0.001) in a recessive model, compared with the GG genotype. Also, the tissue concentrations of IFN-γ, TGF-ß, and TNF-α in cervical tissues were significantly higher in women with cervical cancer (P < 0.001) and were associated with the AA genotype. CONCLUSION: We have found an association between the polymorphism rs1800896 in the IL-10 gene and an increased risk of cervical cancer as well as a higher level of tissue inflammatory cytokines. Further investigations are necessary on the value of emerging biomarkers for the risk stratification for the management of cervical cancer patients.


Asunto(s)
Interleucina-10/genética , Neoplasias del Cuello Uterino/genética , Adulto , Alelos , Alphapapillomavirus/genética , Alphapapillomavirus/patogenicidad , Citocinas , Femenino , Frecuencia de los Genes/genética , Genotipo , Humanos , Inflamación , Interferón gamma , Interleucina-10/metabolismo , Persona de Mediana Edad , Oportunidad Relativa , Papillomaviridae/genética , Papillomaviridae/patogenicidad , Polimorfismo de Nucleótido Simple/genética , Reacción en Cadena en Tiempo Real de la Polimerasa , Factores de Riesgo , Factor de Crecimiento Transformador beta/metabolismo , Factor de Necrosis Tumoral alfa/metabolismo
2.
Infectio ; 25(4): 270-275, oct.-dic. 2021. tab, graf
Artículo en Español | LILACS, COLNAL | ID: biblio-1286721

RESUMEN

Resumen Objetivo: Comparar la expresión de mRNA y proteínas de SFRP1, PTPRN, CDO1, EDNRB, CDX2, EPB41L3 y HAND1 en pacientes con lesión intra-epitelial cervical de bajo y alto grado, con posterior progresión o regresión. Material y Método: Se realizó análisis de expresión de genes mediante RT-PCR y análisis de expresión de proteínas por inmunohistoquímica. El análisis estadís tico fue realizado con las pruebas: Wilcoxon, coeficiente de correlación de Spearman e índice de concordancia. Las muestras fueron pareadas en momento 1 y momento 2. Resultados: SFRP1 mostró tendencia de mayor expresión de mRNA en lesión intra-epitelial de bajo grado (momento 2) Vs. alto grado (momento 1). La expresión de proteínas por inmunohistoquímica de SFRP1 en casos de progresión (83,3 %) mostró disminución en su graduación (p = 0,0313*); los demás genes en estudio no tuvieron cambios estadísticamente significativos. Discusión: SFRP1 mostró comportamiento ajustado a resultados de estudios previos donde se encontró hipermetilado en lesiones intra-epiteliales de alto grado; su subexpresión por hipermetilación se reportó en otros canceres, proceso que colabora con su silenciamiento y transición epitelial-mesenquimatosa del cáncer de cuello uterino. Conclusiones. SFRP1 es potencial biomarcador en lesiones preneoplásicas del cuello uterino asociadas al virus de papiloma humano.


Abstract Objective. The aim of this work was to compare the expression of mRNA and proteins of SFRP1, PTPRN, CDO1, EDNRB, CDX2, EPB41L3 and HAND1 in patients with low and high grade cervical intraepithelial lesion, with subsequent progression or regression. Material and Methods: Gene expression analysis was conducted through RT-PCR and protein expression analysis was performed by immunohistochemistry. The statistics analysis were Wilcoxon test, Spearman's correlation coefficient and concordance index. The samples were paired during moment 1 (initial patient diag nosis) and moment 2 (follow-up histological diagnosis). Results: SFRP1 showed a trend of higher mRNA expression in low-grade intra-epithelial lesions (moment 2) Vs. high-grade (moment 1). The expression of proteins by immunohistochemistry of SFRP1 in progression cases (83.3%) showed a decrease in its graduation (p = 0.0313*); the other genes under study had no statistically significant. Discussion: SFRP1 showed a biological behavior adjusted to the results of previous studies where hypermethylation was found in high-grade intra-epithelial lesions; its subexpression by hypermethylation has been reported in other cancers, a process that collaborates with its silencing and epithelial-mesenchymal tran sition of cervical. Conclusions. SFRP1 is a potential biomarker in preneoplastic lesions of the cervix associated with human papillomavirus.


Asunto(s)
Humanos , Femenino , Adulto , Papiloma , Sondas de ADN de HPV , Virus , Proteínas , Neoplasias del Cuello Uterino , Progresión de la Enfermedad , Alphapapillomavirus
3.
Lakartidningen ; 1182021 11 01.
Artículo en Sueco | MEDLINE | ID: mdl-34730836

RESUMEN

In this review we summarize the current knowledge about the HPV vaccines developed in the beginning of the 21st century. The vaccines are very effective and safe, with no serious side effects. In Sweden we have a school-based prophylactic vaccination programme for both girls and boys. To this age group, we offer two doses of the nonavalent vaccine. The main purpose of the vaccination is to decrease the rate of genital cancer and its precursor lesions. This has mainly been studied for the cervix, which is the locus for the most important HPV-related cancer. Among other HPV 16-related malignancies that can be prevented by the vaccine is anal cancer. Genital warts are a challenging benign condition difficult to treat, often associated with psychosexual consequences. In Sweden we already have seen a decrease of HPV infection, genital warts, precancerous cervical lesions and cervical cancer.


Asunto(s)
Infecciones por Papillomavirus , Vacunas contra Papillomavirus , Neoplasias del Cuello Uterino , Femenino , Humanos , Programas de Inmunización , Masculino , Infecciones por Papillomavirus/prevención & control , Vacunas contra Papillomavirus/efectos adversos , Neoplasias del Cuello Uterino/prevención & control , Vacunación
4.
Reprod Health ; 18(1): 228, 2021 Nov 13.
Artículo en Inglés | MEDLINE | ID: mdl-34774076

RESUMEN

OBJECTIVE: To assess the effect of a blended educational program to promote performing the PST among Iranian women. DESIGN: In a randomized control trial four main variables; knowledge, attitude, self-efficacy, and practice about PST was evaluated using a man-made questionnaire for PST. SETTING: Women aged 18-49 living in Andimeshk (Khuzestan, Iran), covered by 16 health centers, participated in study from November 2019 till April 2019. METHOD: The educational intervention conducted to increasing women's performing the PST. The experimental group received an intervention, whereas the control group received usual care. Participants were tested at four-time points: pre-test (baseline), post-test 1 (immediately after the program's completion) post-test 2 (4 weeks after the program's completion) and post-test 3 (12 weeks after the program completion). RESULTS: A total of 84 women with average aged 32.27 (42 in the experimental group, 42 in the control group) were recruited from 16 health centers in Andimeshk, southern Iran. Significant group differences were found at different times in knowledge, attitude, self-efficacy, and practice about PST. CONCLUSION: A blended method was effective in sustaining the effects of the educational program in the experimental group. The development of appropriate teaching method on restricted situation such as COVID-19 pandemic to promote participation is suggested.


Asunto(s)
COVID-19 , Neoplasias del Cuello Uterino , Detección Precoz del Cáncer , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Irán , Pandemias , SARS-CoV-2 , Neoplasias del Cuello Uterino/epidemiología
5.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(10): 1855-1862, 2021 Oct 10.
Artículo en Chino | MEDLINE | ID: mdl-34814624

RESUMEN

Objective: To systematically summarize and assess risk prediction models for occurrence of cervical cancer and to provide evidence for selecting the most reliable model for practice, and guide cervical cancer screening. Methods: Two groups of keywords related to cervical cancer and risk prediction model were searched on Chinese databases (CNKI, and Wanfang) and English databases (PubMed, Embase, and Cochrane Library). Original articles that developed or validated risk prediction models and published before November 21, 2019, were selected. Information form was created based on the CHARMS checklist. The PROBAST was used to assess the risk of bias. Results: 12 eligible articles were identified, describing 15 prediction models, of which five were established in China. The predicted outcomes included multiple stages from cervical precancerous lesions to cancer occurrence, i.e., abnormal Pap smear (1), occurrence or recurrence of CIN (9), and occurrence of cervical cancer (5), etc. The most frequently used predictors were HPV infection (12), age (7), smoking (5), and education (5). There were two models using machine learning to develop models. In terms of model performance, the discrimination ranged from 0.53 to 0.87, while only two models assessed the calibration correctly. Only two models were externally validated in Taiwan of China, using people in different periods. All of the models were at high risk of bias, especially in the analysis domain. The problems were concentrated in the improper handling of missing data (13), preliminary evaluation of model performance (13), improper use of internal validation (12), and insufficient sample size (11). In addition, the problems of inconsistency measurements of predictors and outcomes (8) and the flawed report of the use of blindness for outcome measures (8) were also severe. Compared with the other models, the Rothberg (2018) model had relatively high quality. Conclusions: There are a certain number of cervical cancer risk prediction models, but the quality is poor. It is urgent to improve the measurement of predictors and outcomes, the statistical analysis details such as handling missing data and evaluation of model performance and externally validate existing models to better guide screening.


Asunto(s)
Neoplasias del Cuello Uterino , Sesgo , Detección Precoz del Cáncer , Femenino , Humanos , Pronóstico , Riesgo , Neoplasias del Cuello Uterino/diagnóstico , Neoplasias del Cuello Uterino/epidemiología
6.
Medicine (Baltimore) ; 100(41): e27457, 2021 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-34731120

RESUMEN

ABSTRACT: Human papillomavirus (HPV) vaccination in young women is low. Women aged 21 to 65 years in the United States (U.S.) have not reached the Healthy People 2020 objective of 93% for cervical cancer screening. The main aim of this study was to investigate the association between HPV vaccination status and cervical cancer screening among privately insured women aged 21 to 26 years in the U.S.This was a retrospective cohort study using the IBM MarketScan database (2006-2016). The study population included 190,982 HPV-vaccinated women and 763,928 matched unvaccinated women. Adjusted incidence rate ratio (IRR) and the 95% confidence intervals (CIs) were obtained using the generalized estimating equations models with a Poisson distribution.Among a total of 954,910 women included in the analysis, age (mean [SD]) was 23.3 [1.6] years. During 967,317 person-years of follow-up, a total of 475,702 incidents of cervical cancer screening were identified. The incidence density rates of cervical cancer screening were 461 per 1000 person-years (PY) for unvaccinated women and 787 per 1000 PY for those who received 3 doses of the HPV vaccine. After adjusting for other covariates, the IRR of cervical cancer screening was 34% higher among HPV-vaccinated women with at least one vaccine dose than unvaccinated women (adjusted IRR = 1.34, 95% CI: 1.33-1.35; P < .0001). The IRR of cervical cancer screening varied by the dose of HPV vaccination. There was evidence of a linear dose-response relationship between the number of HPV vaccine doses and cervical cancer screening (P-trend < .0001). Compared with unvaccinated women, the IRR of cervical cancer screening were 14%, 39%, and 60% higher among those who received 1, 2, and 3 doses of the HPV vaccine, respectively.In this large retrospective cohort study of privately insured women, HPV-vaccinated women were more likely to be screened for cervical cancer compared with unvaccinated women.


Asunto(s)
Tamizaje Masivo/estadística & datos numéricos , Neoplasias del Cuello Uterino/prevención & control , Cobertura de Vacunación/estadística & datos numéricos , Adulto , Detección Precoz del Cáncer/métodos , Femenino , Humanos , Seguro de Salud/estadística & datos numéricos , Vacunas contra Papillomavirus/administración & dosificación , Vacunas contra Papillomavirus/inmunología , Estudios Retrospectivos , Estados Unidos/epidemiología , Adulto Joven
7.
Ann Palliat Med ; 10(10): 11232-11238, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34763482

RESUMEN

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple organs and is caused by inactive mutations in the TSC1 or TSC2 genes. The main symptoms of TSC are neurocutaneous syndrome and benign hamartoma formation. Notably, malignancy is not an indication of TSC. In this article, we present the case of a 48-year-old female with cervical cancer (CC) combined with TSC, who was misdiagnosed with multiple metastases. Toe masses, pelvic nodules, and multiple osteogenic lesions were initially observed. Multi-site puncture biopsies and a toe amputation were performed; the pathology results did not indicate malignancy. Subsequently, hypomelanotic macules on the back, subependymal nodules (SENs), ungual fibromas, multiple renal cysts, and sclerotic-bone-lesions (SBLs) of the skull, and vertebrae were observed, leading to a diagnosis of TSC. Given that TSC is a benign disease and has not yet caused any organ disfunction, no special treatment was provided to this patient. After a follow-up period of almost 65 months, the patient's quality of life remained good without therapy. Oncologists should pay attention to benign diseases in the face of multiple lesions to reduce misdiagnosis and overtreatment. In addition, TSC may interact with CC through molecular mechanisms, such as the mammalian target of rapamycin (mTOR) pathway.


Asunto(s)
Esclerosis Tuberosa , Neoplasias del Cuello Uterino , Errores Diagnósticos , Femenino , Humanos , Persona de Mediana Edad , Calidad de Vida , Esclerosis Tuberosa/diagnóstico , Proteína 2 del Complejo de la Esclerosis Tuberosa , Neoplasias del Cuello Uterino/diagnóstico
8.
BMC Med Inform Decis Mak ; 21(Suppl 9): 309, 2021 11 16.
Artículo en Inglés | MEDLINE | ID: mdl-34789237

RESUMEN

BACKGROUND: We aimed to build a common terminology in the domain of cervical cancer, named Cervical Cancer Common Terminology (CCCT), that will facilitate clinical data exchange, ensure quality of data and support large scale data analysis. METHODS: The standard concepts and relations of CCCT were collected from ICD-10-CM Chinese Version, ICD-9-PC Chinese Version, officially issued commonly used Chinese clinical terms, Chinese guidelines for diagnosis and treatment of cervical cancer and Chinese medical book Lin Qiaozhi Gynecologic Oncology. 2062 cervical cancer electronic medical records (EMRs) from 16 hospitals, belong to different regions and hospital tiers, were collected for terminology enrichment and building common terms and relations. Concepts hierarchies, terms and relationships were built using Protégé. The performance of natural language processing results was evaluated by average precision, recall, and F1-score. The usability of CCCT were evaluated by terminology coverage. RESULTS: A total of 880 standard concepts, 1182 common terms, 16 relations and 6 attributes were defined in CCCT, which organized in 6 levels and 11 classes. Initial evaluation of the natural language processing results demonstrated average precision, recall, and F1-score percentages of 96%, 72.6%, and 88.5%. The average terminology coverage for three classes of terms, clinical manifestation, treatment, and pathology, were 87.22%, 92.63%, and 89.85%, respectively. Flexible Chinese expressions exist between regions, traditions, cultures, and language habits within the country, linguistic variations in different settings and diverse translation of introduced western language terms are the main reasons of uncovered terms. CONCLUSIONS: Our study demonstrated the initial results of CCCT construction. This study is an ongoing work, with the update of medical knowledge, more standard clinical concepts will be added in, and with more EMRs to be collected and analyzed, the term coverage will be continuing improved. In the future, CCCT will effectively support clinical data analysis in large scale.


Asunto(s)
Semántica , Neoplasias del Cuello Uterino , China , Femenino , Humanos , Lenguaje , Procesamiento de Lenguaje Natural
9.
Curationis ; 44(1): e1-e7, 2021 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-34797107

RESUMEN

BACKGROUND: The primary purpose of screening is to detect individuals in danger of cervical cancer so as to prevent further progression of the disease. Cervical cancer remains a global concern, as it ranks as the fourth most commonly diagnosed female malignancy worldwide. It is the commonest female cancer in Zimbabwe. Women living with human immunodeficiency virus (HIV) have a disproportionate risk of invasive cervical cancer, as they are 2-12 times more likely to develop pre-cancerous lesions. As a result of the increased risk, routine screenings are suggested. Few women are screened for cervical cancer in Zimbabwe. OBJECTIVES: This study aimed at describing the experiences of screening for cervical cancer and motivation behind screening. METHOD: The study employed a qualitative research approach. In-depth one to one interviews and focus group discussions were conducted using interview and focus group guides. The study was conducted at an opportunistic infections clinic in Mpilo Central Hospital. Data analysis was performed by using Giorgi's descriptive method of data analysis. RESULTS: The themes that emerged from data analysis were facilitators to screening for cervical cancer, community awareness of cervical cancer screening, free cervical cancer treatment and more screening centres and integrating cervical cancer screening with HIV care. CONCLUSION: In-depth understanding of the factors that enable women to take part in cervical cancer screening is essential so that these factors can be strengthened to improve uptake of cervical cancer screening services.


Asunto(s)
Infecciones por VIH , Neoplasias del Cuello Uterino , Detección Precoz del Cáncer , Femenino , Infecciones por VIH/complicaciones , Infecciones por VIH/diagnóstico , Conocimientos, Actitudes y Práctica en Salud , Humanos , Tamizaje Masivo , Neoplasias del Cuello Uterino/diagnóstico , Zimbabwe
10.
AIDS ; 35(14): 2367-2374, 2021 11 15.
Artículo en Inglés | MEDLINE | ID: mdl-34723851

RESUMEN

OBJECTIVE: The aim of this study was to assess failure after treatment of high-grade cervical intraepithelial neoplasia (CIN2+) by HIV status and human papillomavirus (HPV) type. DESIGN: A population-based register study. METHODS: The Swedish National HIV Registry, the Swedish Population Registry and the Swedish National Cervical Screening Registry were linked to identify all women in Stockholm and Gothenburg counties (Sweden) living with HIV and diagnosed with CIN2+ sometime between 1983 and 2014 (n = 179). HIV-negative controls with CIN2+, were matched (2 : 1) for country of birth. CIN2+ biopsies were retrieved from biobanks and genotyped. Absolute risk and adjusted odds ratios (adjOR) of treatment failure by HIV status given HPV type (HPV16/18 vs. non-HPV16/18) were calculated. RESULTS: HPV16 (32%) and HPV35 (24%) dominated in women living with HIV (WLWH) with failure, HPV35 mainly in women born in sub-Saharan Africa (67%). The absolute risk of failure in women with HPV16/18 was 26% [95% confidence interval (95% CI) 14-44] in WLWH and 12% in HIV-negative (95% CI 7-19). The absolute risk of failure in women with non-HPV16/18 was 20% (95% CI 12-31) in WLWH and 5% in HIV-negative (95% CI 2-11). WLWH with non-HPV16/18 were six times more likely to fail than HIV-negative (adjOR 6.1, 95% CI 2.0-18.6). CONCLUSION: HPV35, not included in current HPV vaccines, was the second most common type in WLWH with failure. WLWH with non-HPV16/18 were six times more likely to fail than HIV-negative. This could have implications for surveillance and vaccination post CIN2+ treatment, particularly in WLWH from sub-Saharan Africa.


Asunto(s)
Alphapapillomavirus , Infecciones por VIH , Infecciones por Papillomavirus , Neoplasias del Cuello Uterino , Detección Precoz del Cáncer , Femenino , Genotipo , Infecciones por VIH/complicaciones , Papillomavirus Humano 16 , Papillomavirus Humano 18 , Humanos , Papillomaviridae/genética , Infecciones por Papillomavirus/complicaciones
11.
Prim Care ; 48(4): 583-595, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34752271

RESUMEN

Declining cervical cancer rates in the United States highlights the value of prevention and early detection of premalignant cervical disease afforded by the human papillomavirus vaccine and Pap smear. The availability of in-office loop electrosurgical excision procedure affords clinicians with a cost-effective and preferred tool for the excision of high-grade lesions of the cervix with minimal risk for severe adverse outcomes. The most recent American Society for Colposcopy and Cervical Pathology guidelines recommend a risk-based approach for the detection, treatment, and surveillance of cervical disease and specifically focus on the risk of developing cervical intraepithelial neoplasia 3 or worse histology.


Asunto(s)
Neoplasia Intraepitelial Cervical , Neoplasias del Cuello Uterino , Neoplasia Intraepitelial Cervical/diagnóstico , Neoplasia Intraepitelial Cervical/cirugía , Colposcopía , Electrocirugia , Femenino , Humanos , Embarazo , Neoplasias del Cuello Uterino/diagnóstico , Neoplasias del Cuello Uterino/cirugía , Frotis Vaginal
12.
Cien Saude Colet ; 26(10): 4497-4509, 2021 Oct.
Artículo en Portugués, Inglés | MEDLINE | ID: mdl-34730638

RESUMEN

This article analyzes cervical cancer control policies and actions in Brazil and Chile, focusing on prevention and screening. We adopted a comparative approach to identify similarities and differences in guidelines and cervical cancer prevention and screening strategies between the two countries. We used the following data collection techniques: analysis of official documents and secondary data, consultations with experts, government officials and program coordinators, and literature review. The findings show that Chile has a well-structured program with centralized decision-making and a system that permits monitoring of actions. Brazil on the other hand faces ongoing issues with lack of coordination and shortcomings in the follow-up of women with abnormal test results. The following challenges to consolidating cervical cancer screening stand out in Brazil: lack of active tracking of the target population; absence of a test quality assurance system; and inadequate follow-up of women with abnormal test results. Both countries need to increase coverage and implement organized screening.


Asunto(s)
Neoplasias del Cuello Uterino , Brasil , Chile , Detección Precoz del Cáncer , Femenino , Humanos , Tamizaje Masivo , Neoplasias del Cuello Uterino/diagnóstico , Neoplasias del Cuello Uterino/prevención & control
13.
Rev Saude Publica ; 55: 67, 2021.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-34730748

RESUMEN

OBJECTIVES: To analyze the magnitude of changes in the incidence and mortality from cervical cancer (CC) and breast cancer (BC) in Campinas, São Paulo State, between the five-year periods of 1991-1995 and 2010-2014. METHODS: data on cancer were obtained from the Campinas Population-Based Cancer Registry and data on deaths from the Mortality Information System of the Computing Department of the Unified Health System. Age-standardized incidence and mortality rates were calculated by the direct method, with the respective 95% confidence intervals. The magnitude of the changes was measured by the rate ratio (rate ratio; 95%CI). RESULTS: among the periods studied, there was a threefold increase in the detection rate of in situ CC (3.03; 95%CI: 2.64-3.47) and fivefold increase for in situ BC (5.23; 95%CI: 4.98-5.50). The proportion of cases of in situ BC in relation to the total number of cases of BC increased from 3.31% to 11.05%. The incidence rate of invasive CC decreased by 57% (0.43; 95%CI: 0.40-0.47), and the incidence rate of invasive BC increased by 40% (1.40; 95%CI: 1.33-1.47). The mortality rate of the CC decreased by 58% (0.42; 95%CI: 0.32-0.56), and that of BC by 15% (0.85; 95%CI: 0.82-0.89). CONCLUSION: the incidence of in situ carcinomas of CC and BC increased in almost two decades. The rate of invasive carcinoma of CC decreased, and that of BC increased. Mortality from both cancers decreased. Observing these changes is useful for assessing the impact of the actions carried out in the period and for planning future actions.


Asunto(s)
Neoplasias de la Mama , Neoplasia Intraepitelial Cervical , Neoplasias del Cuello Uterino , Brasil/epidemiología , Neoplasias de la Mama/epidemiología , Femenino , Humanos , Incidencia , Mortalidad , Sistema de Registros , Neoplasias del Cuello Uterino/epidemiología
14.
Obstet Gynecol Clin North Am ; 48(4): 705-722, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34756291

RESUMEN

Gynecologic cancers contribute to a significant portion of cancer morbidity and mortality among women in the United States and across the globe. This article provides a comprehensive review of current screening guidelines and novel techniques that have promise in the prevention and early detection of gynecologic cancers in the future. The authors anticipate a move toward less invasive testing modalities, use of cancer biomarkers, and the prevention and treatment of high-risk factors such as human papilloma virus infection and obesity.


Asunto(s)
Neoplasias de los Genitales Femeninos , Neoplasias Ováricas , Infecciones por Papillomavirus , Neoplasias del Cuello Uterino , Detección Precoz del Cáncer , Femenino , Neoplasias de los Genitales Femeninos/diagnóstico , Humanos , Infecciones por Papillomavirus/diagnóstico , Estados Unidos/epidemiología , Neoplasias del Cuello Uterino/diagnóstico
15.
Artículo en Inglés | MEDLINE | ID: mdl-34770117

RESUMEN

OBJECTIVE: This study aimed (1) to study the effects of health education on preventive behaviors and cancer literacy among women with cervical intraepithelial neoplasia (CIN); (2) to compare the effects of mobile application program (App)-assisted health education with traditional book-form health education. PARTICIPANTS: A total of 132 women ages 20 to 69 years women. METHODS: This prospective longitudinal study enrolled 132 CIN women who were evaluated three times. Propensity score matching was used by controlling subjects' age strata, body mass index, education level, occupation, and type of surgery. RESULTS: The influences of various educational tools were investigated. Four domains were assessed, including health behavior, attitude towards behavior change, self-efficacy of behavior, and cervical cancer (CCa) literacy. Significant improvements in behavior change and CCa literacy due to a health education program were observed (p ≤ 0.002). The App combined with a traditional booklet had the highest score for behavior change and was significantly greater than the booklet-only learning (p = 0.002). The App-assisted form, either App alone or combined with booklet, had a significantly better impact on health promotion when compared to the booklet alone (p = 0.045 and 0.005, respectively). App-only learning had the highest score of CCa literacy (p = 0.004). CONCLUSION: Health education interventions can have positive effects in terms of change of behavior and CCa literacy. App-assisted learning could be used as a supportive technology, and App learning alone or combined with a traditional booklet may be an innovative model of clinical health promotion for women with CIN.


Asunto(s)
Neoplasia Intraepitelial Cervical , Alfabetización en Salud , Aplicaciones Móviles , Neoplasias del Cuello Uterino , Adulto , Anciano , Femenino , Educación en Salud , Promoción de la Salud , Humanos , Alfabetización , Estudios Longitudinales , Persona de Mediana Edad , Estudios Prospectivos , Neoplasias del Cuello Uterino/prevención & control , Adulto Joven
16.
BMC Infect Dis ; 21(1): 1158, 2021 Nov 15.
Artículo en Inglés | MEDLINE | ID: mdl-34781884

RESUMEN

BACKGROUND: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Characteristics of HPV infections, including the HPV genotype and duration of infection, determine a patient's risk of high-grade lesions. Risk quantification of cervical lesions caused by different HPV genotypes is an important component of evaluation of cervical lesion. Data and evidence are necessary to gain a deeper understanding of the pathogenicity of different HPV genotypes. The present study investigated the clinical characteristics of patients infected with single human papillomavirus (HPV) 53. METHODS: This retrospective study analyzed the clinical data of patients who underwent cervical colposcopy guided biopsy between October 2015 and January 2021. The clinical outcomes and the follow-up results of the patients with single HPV53 infection were described. RESULTS: 82.3% of the initial histological results of all 419 patients with single HPV53 infection showed negative (Neg). The number of patients with cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, vaginal intraepithelial neoplasia (VaIN)1, CIN1 + VaIN1, CIN1 + VaIN2, and CIN2 + VaIN2 was 45, 10, 2, 9, 6, 1, and 1, respectively. Cancer was not detected in any patient. When the cytology was negative for intraepithelial lesion or malignancy (NILM), atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesion (LSIL), we observed a significant difference in the distribution of histological results (P < 0.05). 95 patients underwent follow-up with cytology according to the exclusion criteria. No progression of high-grade lesions was observed during the follow-up period of 3-34 months. CONCLUSIONS: The lesion caused by HPV53 infection progressed slowly. The pathogenicity of a single HPV53 infection was low.


Asunto(s)
Alphapapillomavirus , Neoplasia Intraepitelial Cervical , Infecciones por Papillomavirus , Neoplasias del Cuello Uterino , Neoplasia Intraepitelial Cervical/epidemiología , Colposcopía , Femenino , Humanos , Papillomaviridae/genética , Infecciones por Papillomavirus/epidemiología , Embarazo , Estudios Retrospectivos , Neoplasias del Cuello Uterino/epidemiología , Frotis Vaginal
17.
J Community Health Nurs ; 38(4): 201-208, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34787044

RESUMEN

PURPOSE: To assess and improve school nurse knowledge of HPV-associated cancers. DESIGN: An experimental quality improvement study. METHODS: At a continuing education regional conference, an interactive HPV education session was provided. Pre- and post-education surveys were completed by attendees. FINDINGS: After the educational intervention, 89.9% of nurses indicated a change in knowledge and 83.2% indicated a planned change in practice. CONCLUSIONS: An education intervention aimed at school nurses can be impactful in broadening the understanding of HPV oncogenesis. CLINICAL EVIDENCE: Educational interventions can be a strategy to increase school nurse knowledge and subsequently patient knowledge about HPV associated cancers.


Asunto(s)
Alphapapillomavirus , Neoplasias , Enfermeras y Enfermeros , Infecciones por Papillomavirus , Vacunas contra Papillomavirus , Neoplasias del Cuello Uterino , Competencia Clínica , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Papillomaviridae , Infecciones por Papillomavirus/prevención & control , Instituciones Académicas , Encuestas y Cuestionarios , Neoplasias del Cuello Uterino/prevención & control , Vacunación
18.
Anticancer Res ; 41(11): 5477-5480, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34732417

RESUMEN

BACKGROUND/AIM: Itraconazole shows anticancer activity in various types of cancer but its underlying mechanism is unclear. We investigated the effect of itraconazole on membrane-associated lipids. MATERIALS AND METHODS: To investigate the influences of itraconazole on cholesterol trafficking, cervical cancer CaSki cells were cultured with itraconazole and analyzed by Filipin staining followed by confocal microscopy. Effect on the glycerophospholipid profiles was analyzed by liquid chromatography/mass spectrometry (LC/MS). RESULTS: After itraconazole treatment, Filipin staining revealed cholesterol accumulation in the intracellular compartments, which was similar to the distribution after treatment of U18666A (cholesterol transport inhibitor). LC/MS analysis showed a significant decrease in phosphatidylserine levels and an increase in lysophosphatidylcholine levels in CaSki cells. CONCLUSION: Itraconazole inhibited cholesterol trafficking and altered the phospholipid composition. Alterations in the cell membrane can potentiate the anticancer activity of itraconazole.


Asunto(s)
Antineoplásicos/farmacología , Colesterol/metabolismo , Itraconazol/farmacología , Fosfatidilserinas/metabolismo , Neoplasias del Cuello Uterino/tratamiento farmacológico , Transporte Biológico , Línea Celular Tumoral , Femenino , Humanos , Lisofosfatidilcolinas/metabolismo , Neoplasias del Cuello Uterino/metabolismo , Neoplasias del Cuello Uterino/patología
19.
Salud Colect ; 17: e3572, 2021 Aug 23.
Artículo en Español | MEDLINE | ID: mdl-34752024

RESUMEN

With the purpose of analyzing women's perceptions and classifying their modes of understanding a positive human papillomavirus (HPV+) test, we conducted 38 in-depth interviews with women who had received an HPV diagnosis (normal and abnormal Pap smear), screened in Jujuy's public health system in 2016. A typology based on women's understandings of the result was developed: 1) understanding; 2) lack of understanding; a) underestimation; b) overestimation; c) confusion. The interviewees who experienced confusion over the results reported contradictory perceptions in relation to a positive HPV test and its severity; those who underestimated it tended to mention the absence of symptoms and expressed little concern over the result; while those who overestimated it considered themselves sick and described concern, narrating a biographical disruption and physical pain. These findings confirm the need to improve the delivery of results and the provision of information in order to decrease psychosocial impact and increase follow-up adherence in HPV-positive women.


Asunto(s)
Alphapapillomavirus , Infecciones por Papillomavirus , Neoplasias del Cuello Uterino , Argentina , Femenino , Conocimientos, Actitudes y Práctica en Salud , Humanos , Papillomaviridae , Infecciones por Papillomavirus/diagnóstico , Percepción , Neoplasias del Cuello Uterino/diagnóstico , Frotis Vaginal
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