Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.085
Filtrar
1.
Radiology ; 299(2): E226-E229, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33591889

RESUMEN

Coronavirus disease 2019 (COVID-19) may affect various organs. This case series reports nine patients (one of nine [11%] women and eight of nine [89%] men; mean age ± standard deviation, 56 years ± 13) with globe MRI abnormalities obtained from a multicenter cohort of 129 patients presenting with severe COVID-19 from March 4, 2020, to May 1, 2020. Nine of 129 (7%) patients had one or several nodules of the posterior pole that were hyperintense at fluid-attenuated inversion-recovery imaging. All patients had nodules in the macular region, eight of nine (89%) had bilateral nodules, and two of nine (22%) had nodules outside the macular region. Screening of these patients might improve the management of potentially severe ophthalmologic manifestations of the virus. See also the editorial by Kirsch in this issue. © RSNA, 2021 Online supplemental material is available for this article.


Asunto(s)
/complicaciones , Oftalmopatías/complicaciones , Oftalmopatías/diagnóstico por imagen , Imagen por Resonancia Magnética/métodos , Estudios de Cohortes , Ojo/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
2.
Lancet Digit Health ; 3(2): e88-e97, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-33509389

RESUMEN

BACKGROUND: Ocular changes are traditionally associated with only a few hepatobiliary diseases. These changes are non-specific and have a low detection rate, limiting their potential use as clinically independent diagnostic features. Therefore, we aimed to engineer deep learning models to establish associations between ocular features and major hepatobiliary diseases and to advance automated screening and identification of hepatobiliary diseases from ocular images. METHODS: We did a multicentre, prospective study to develop models using slit-lamp or retinal fundus images from participants in three hepatobiliary departments and two medical examination centres. Included participants were older than 18 years and had complete clinical information; participants diagnosed with acute hepatobiliary diseases were excluded. We trained seven slit-lamp models and seven fundus models (with or without hepatobiliary disease [screening model] or one specific disease type within six categories [identifying model]) using a development dataset, and we tested the models with an external test dataset. Additionally, we did a visual explanation and occlusion test. Model performances were evaluated using the area under the receiver operating characteristic curve (AUROC), sensitivity, specificity, and F1* score. FINDINGS: Between Dec 16, 2018, and July 31, 2019, we collected data from 1252 participants (from the Department of Hepatobiliary Surgery of the Third Affiliated Hospital of Sun Yat-sen University, the Department of Infectious Diseases of the Affiliated Huadu Hospital of Southern Medical University, and the Nantian Medical Centre of Aikang Health Care [Guangzhou, China]) for the development dataset; between Aug 14, 2019, and Jan 31, 2020, we collected data from 537 participants (from the Department of Infectious Diseases of the Third Affiliated Hospital of Sun Yat-sen University and the Huanshidong Medical Centre of Aikang Health Care [Guangzhou, China]) for the test dataset. The AUROC for screening for hepatobiliary diseases of the slit-lamp model was 0·74 (95% CI 0·71-0·76), whereas that of the fundus model was 0·68 (0·65-0·71). For the identification of hepatobiliary diseases, the AUROCs were 0·93 (0·91-0·94; slit-lamp) and 0·84 (0·81-0·86; fundus) for liver cancer, 0·90 (0·88-0·91; slit-lamp) and 0·83 (0·81-0·86; fundus) for liver cirrhosis, and ranged 0·58-0·69 (0·55-0·71; slit-lamp) and 0·62-0·70 (0·58-0·73; fundus) for other hepatobiliary diseases, including chronic viral hepatitis, non-alcoholic fatty liver disease, cholelithiasis, and hepatic cyst. In addition to the conjunctiva and sclera, our deep learning model revealed that the structures of the iris and fundus also contributed to the classification. INTERPRETATION: Our study established qualitative associations between ocular features and major hepatobiliary diseases, providing a non-invasive, convenient, and complementary method for hepatobiliary disease screening and identification, which could be applied as an opportunistic screening tool. FUNDING: Science and Technology Planning Projects of Guangdong Province; National Key R&D Program of China; Guangzhou Key Laboratory Project; National Natural Science Foundation of China.


Asunto(s)
Algoritmos , Simulación por Computador , Aprendizaje Profundo , Enfermedades del Sistema Digestivo/diagnóstico , Ojo , Tamizaje Masivo/métodos , Modelos Biológicos , Adulto , Área Bajo la Curva , China , Conjuntiva/diagnóstico por imagen , Enfermedades del Sistema Digestivo/complicaciones , Ojo/diagnóstico por imagen , Fondo de Ojo , Humanos , Iris/diagnóstico por imagen , Hígado , Persona de Mediana Edad , Fotograbar/métodos , Estudios Prospectivos , Curva ROC , Esclerótica/diagnóstico por imagen , Microscopía con Lámpara de Hendidura/métodos
3.
Exp Eye Res ; 203: 108394, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-33310058

RESUMEN

Micro-CT visualization allows reconstruction of eye structures with the resolution of light microscopy and estimation of tissue densities. Moreover, this method excludes damaging procedures and allows further histological staining due to the similar steps in the beginning. We have shown the feasibility of the lab-based micro-CT machine usage for visualization of clinically important compartments of human eye such as trabecular outflow pathway, retina, iris and ciliary body after pre-treatment with iodine in ethanol. We also identified the challenges of applying this contrasting technique to lens, cornea, and retina and proposed alternative staining methods for these tissues. Thereby this work provides a starting point for other studies for imaging of human eyes in normal and pathological conditions using lab-based micro-CT systems.


Asunto(s)
Enucleación del Ojo , Ojo/anatomía & histología , Ojo/diagnóstico por imagen , Microtomografía por Rayos X , Cámara Anterior/anatomía & histología , Cámara Anterior/diagnóstico por imagen , Segmento Anterior del Ojo/anatomía & histología , Segmento Anterior del Ojo/diagnóstico por imagen , Estudios de Factibilidad , Humanos , Imagenología Tridimensional , Cristalino/anatomía & histología , Cristalino/diagnóstico por imagen , Retina/anatomía & histología , Retina/diagnóstico por imagen
4.
J Stroke Cerebrovasc Dis ; 30(3): 105500, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33360251

RESUMEN

BACKGROUND: Despite recent progress in the multidisciplinary management of large middle cerebral artery infarcts, the neurological prognosis remains worrying in a non-negligible number of cases. The objective of this study is to analyze the contribution of optic nerve and perioptic sheath measurement on MRI to the acute phase of large middle cerebral artery infarcts. METHODS: A retrospective case-control study between January 2008 and December 2019 in a single academic medical center was performed. Cases and controls were selected by interrogation of International Classification of Diseases (ICD), 10th edition, with ischemic stroke as criterion (code I64). Decompressive hemicraniectomy was a criterion for large middle cerebral artery infarcts (cases). Cases were matched with controls (1:3) based on age (± 5 years), sex, and year of hospitalization (± 2 years) The examinations were performed on 3T MRI (Siemens IRM 3T Magnetom).Optic nerve and perioptic sheath diameter was calculated using electronic calipers, 3 mm behind retina and in a perpendicular vector with reference to the orbit in axial 3D TOF sequence. RESULTS: Of 2612 patients, 22 patients met all the criteria of large middle cerebral artery infarcts and they were paired with 44 controls. Patients were mainly women, mean age of 53.6 years. There is a significant difference in the size of the optic nerve and perioptic sheath diameter measured on MRI at patient's admission (right: 5.13 ± 0.2 mm vs. 4.80 mm ± 0.18, p <0. 0001, left: 5.16 ± 0.17 vs 4.78 ± 0.20, p<0.0001). The AUC of optic nerve and perioptic sheath diameter was 0.93 (95%IC [0.85-1.00]), for a threshold at 5.03 mm, the sensitivity was 0.82 (95%IC [0.6-0.93]), specificity 0.94 (95%IC [0.85-0.98]). The Odds Ratio of large middle cerebral artery infarcts was 46.4 for optic nerve and perioptic sheath diameter the (95%IC [6.15-350.1] p=0.0002). CONCLUSION: Optic nerve and perioptic sheath diameter in the first MRI can predict the risk of developing large middle cerebral artery infarcts requiring a decompressive hemicraniectomy.


Asunto(s)
Ojo/diagnóstico por imagen , Infarto de la Arteria Cerebral Media/diagnóstico por imagen , Imagen por Resonancia Magnética , Nervio Óptico/diagnóstico por imagen , Craniectomía Descompresiva , Femenino , Humanos , Infarto de la Arteria Cerebral Media/cirugía , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Pronóstico , Estudios Retrospectivos
5.
Acta Vet Scand ; 62(1): 52, 2020 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-32912266

RESUMEN

BACKGROUND: Environmental changes contribute to the development of ophthalmic diseases in sea turtles, but information on their eye biometrics is scarce. The aim of this study was to describe ophthalmic ultrasonographic features of four different sea turtle species; Caretta caretta (Loggerhead turtle; n = 10), Chelonia mydas (Green turtle; n = 8), Eretmochelys imbricata (Hawksbill turtle; n = 8) and Lepidochelys olivacea (Olive ridley; n = 6) under human care. Corneal thickness, scleral ossicle width and thickness, anterior chamber depth, axial length of the lens, vitreous chamber depth and axial globe length were measured by B-mode sonography with a linear transducer. Carapace size and animal weight were recorded. A sonographic description of the eye structures was established. RESULTS: The four species presented an ovate eyeball, a relatively thin cornea, and a small-sized lens positioned rostrally in the eye bulb, near the cornea, resulting in a shallow anterior chamber. The scleral ossicles did not prevent the evaluation of intraocular structures, even with a rotated eye or closed eyelids; image formation beyond the ossicles and measurements of all proposed structures were possible. B-mode sonography was easily performed in all animals studied. The sonographic characteristics of the eye were similar among the four species. Since there was a correlation between the size of the eye structures and the size of the individual, especially its carapace size, the differences found between E. imbricata and Caretta caretta are believed to be due to their overall difference in size. CONCLUSIONS: Sonography is a valuable tool in ophthalmic evaluation of these species. Only minor differences were found between the species in this study, reinforcing their phylogenetic proximity and their similar functions and habitats.


Asunto(s)
Ojo/diagnóstico por imagen , Tortugas/anatomía & histología , Ultrasonografía/veterinaria , Animales , Animales de Zoológico/anatomía & histología , Brasil , Valores de Referencia , Especificidad de la Especie
6.
PLoS One ; 15(9): e0238983, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32956372

RESUMEN

The optic disc(OD) and the optic cup(OC) segmentation is an key step in fundus medical image analysis. Previously, FCN-based methods have been proposed for medical image segmentation tasks. However, the consecutive convolution and pooling operations usually hinder dense prediction tasks which require detailed spatial information, such as image segmentation. In this paper, we propose a network called Recurrent Fully Convolution Network(RFC-Net) for automatic joint segmentation of the OD and the OC, which can captures more high-level information and subtle edge information. The RFC-Net can minimize the loss of spatial information. It is mainly composed of multi-scale input layer, recurrent fully convolutional network, multiple output layer and polar transformation. In RFC-Net, the multi-scale input layer constructs an image pyramid. We propose four recurrent units, which are respectively applied to RFC-Net. Recurrent convolution layer effectively ensures feature representation for OD and OC segmentation tasks through feature accumulation. For each multiple output image, the multiple output cross entropy loss function is applied. To better balance the cup ratio of the segmented image, the polar transformation is used to transform the fundus image from the cartesian coordinate system to the polar coordinate system. We evaluate the effectiveness and generalization of the proposed method on the DRISHTI-GS1 dataset. Compared with the original FCN method and other state-of-the-art methods, the proposed method achieves better segmentation performance.


Asunto(s)
Procesamiento de Imagen Asistido por Computador/métodos , Disco Óptico/diagnóstico por imagen , Imagen Óptica/métodos , Algoritmos , Bases de Datos Genéticas , Ojo/diagnóstico por imagen , Ojo/embriología , Fondo de Ojo , Glaucoma , Humanos , Menisco , Redes Neurales de la Computación
7.
PLoS One ; 15(9): e0239131, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32915910

RESUMEN

The genotype of a single SNP, rs12913832, is the primary predictor of blue and brown eye colours. The genotypes rs12913832:AA and rs12913832:GA are most often observed in individuals with brown eye colours, whereas rs12913832:GG is most often observed in individuals with blue eye colours. However, approximately 3% of Europeans with the rs12913832:GG genotype have brown eye colours. The purpose of the study presented here was to identify variants that explain brown eye colour formation in individuals with the rs12913832:GG genotype. Genes and regulatory regions surrounding SLC24A4, TYRP1, SLC24A5, IRF4, TYR, and SLC45A2, as well as the upstream region of OCA2 within the HERC2 gene were sequenced in a study comprising 40 individuals with the rs12913832:GG genotype. Of these, 24 individuals were considered to have blue eye colours and 16 individuals were considered to have brown eye colours. We identified 211 variants within the SLC24A4, TYRP1, IRF4, and TYR target regions associated with eye colour. Based on in silico analyses of predicted variant effects we recognized four variants, TYRP1 rs35866166:C, TYRP1 rs62538956:C, SLC24A4 rs1289469:C, and TYR rs1126809:G, to be the most promising candidates for explanation of brown eye colour in individuals with the rs12913832:GG genotype. Of the 16 individuals with brown eye colours, 14 individuals had four alleles, whereas the alleles were rare in the blue eyed individuals. rs35866166, rs62538956, and rs1289469 were for the first time found to be associated with pigmentary traits, whilst rs1126809 was previously found to be associated with pigmentary variation. To improve prediction of eye colours we suggest that future eye colour prediction models should include rs35866166, rs62538956, rs1289469, and rs1126809.


Asunto(s)
Antiportadores/genética , Color del Ojo/genética , Glicoproteínas de Membrana/genética , Monofenol Monooxigenasa/genética , Oxidorreductasas/genética , Análisis Mutacional de ADN , Europa (Continente) , Grupo de Ascendencia Continental Europea/genética , Ojo/diagnóstico por imagen , Predicción/métodos , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Modelos Genéticos , Fotograbar , Polimorfismo de Nucleótido Simple
8.
Am J Trop Med Hyg ; 103(4): 1691-1693, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32783793

RESUMEN

Japanese encephalitis (JE) virus is a mosquito-borne flavivirus endemic throughout Asia. Incidence in non-endemic countries is rare, with an estimate of less than one case per one million travelers. Most human JE infections are asymptomatic or cause a mild, nonspecific febrile illness. Neurological involvement, if present, is usually severe and associated with high mortality or ongoing neurological sequelae in survivors. Ocular manifestations are rare with JE, but uveitis has been described to be associated with other flavivirus infections, including West Nile virus. We report the first probable case of JE chorioretinitis acquired by a 45-year-old Australian traveler to Bali. This case highlights the importance of a detailed ocular examination when there is clinical suspicion of JE.


Asunto(s)
Coriorretinitis/diagnóstico por imagen , Virus de la Encefalitis Japonesa (Especie)/inmunología , Encefalitis Japonesa/diagnóstico por imagen , Australia , Coriorretinitis/virología , Virus de la Encefalitis Japonesa (Especie)/aislamiento & purificación , Encefalitis Japonesa/patología , Encefalitis Japonesa/virología , Ojo/diagnóstico por imagen , Ojo/patología , Ojo/virología , Humanos , Indonesia , Masculino , Persona de Mediana Edad , Viaje
9.
J Vis Exp ; (161)2020 07 24.
Artículo en Inglés | MEDLINE | ID: mdl-32773758

RESUMEN

Spectral-domain optical coherence tomography (SD-OCT) is useful for visualizing retinal and ocular structures in vivo. In research, SD-OCT is a valuable tool to evaluate and characterize changes in a variety of retinal and ocular disease and injury models. In light induced retinal degeneration models, SD-OCT can be used to track thinning of the photoreceptor layer over time. In glaucoma models, SD-OCT can be used to monitor decreased retinal nerve fiber layer and total retinal thickness and to observe optic nerve cupping after inducing ocular hypertension. In diabetic rodents, SD-OCT has helped researchers observe decreased total retinal thickness as well as decreased thickness of specific retinal layers, particularly the retinal nerve fiber layer with disease progression. In mouse models of myopia, SD-OCT can be used to evaluate axial parameters, such as axial length changes. Advantages of SD-OCT include in vivo imaging of ocular structures, the ability to quantitatively track changes in ocular dimensions over time, and its rapid scanning speed and high resolution. Here, we detail the methods of SD-OCT and show examples of its use in our laboratory in models of retinal degeneration, glaucoma, diabetic retinopathy, and myopia. Methods include anesthesia, SD-OCT imaging, and processing of the images for thickness measurements.


Asunto(s)
Oftalmopatías/diagnóstico por imagen , Ojo/diagnóstico por imagen , Ojo/patología , Tomografía de Coherencia Óptica , Animales , Longitud Axial del Ojo , Modelos Animales de Enfermedad , Femenino , Procesamiento de Imagen Asistido por Computador , Masculino , Ratones Endogámicos BALB C , Miopía/diagnóstico por imagen , Miopía/patología , Células Fotorreceptoras de Vertebrados/patología , Ratas , Retina/diagnóstico por imagen , Retina/patología
10.
Zhongguo Yi Liao Qi Xie Za Zhi ; 44(4): 315-318, 2020 Apr 08.
Artículo en Chino | MEDLINE | ID: mdl-32762204

RESUMEN

Based on the analysis of the theoretical calculation model of axial resolution of optical coherence tomograph for the posterior segment of the human eye, a set of testing device for measuring its axial resolution is designed and developed. In view of a commercial ophthalmic optical coherence tomograph in clinical use, its axial resolution is calculated to be 5.07 µm theoretically, and the actual measurement value is 5.45 µm. The uncertainty of the detection device is evaluated and the result is (5.45±0.10) µm. The measurement error introduced by the testing device is very small. Meanwhile, the axial resolution measured by the testing device meets the requirements of the instrument(≤ 6 µm).


Asunto(s)
Algoritmos , Ojo/diagnóstico por imagen , Tomografía de Coherencia Óptica , Humanos , Incertidumbre
11.
J Vis Exp ; (160)2020 06 17.
Artículo en Inglés | MEDLINE | ID: mdl-32628177

RESUMEN

The innate immune system plays important roles in ocular pathophysiology including uveitis, diabetic retinopathy, and age-related macular degeneration. Innate immune cells, specifically mononuclear phagocytes, express overlapping cell surface markers, which makes identifying these populations a challenge. Multi-parameter flow cytometry allows for the simultaneous, quantitative analysis of multiple cell surface markers in order to differentiate monocytes, macrophages, microglia, and dendritic cells in mouse eyes. This protocol describes the enucleation of whole mouse eyes, ocular dissection, digestion into a single cell suspension, and staining of the single cell suspension for myeloid cell markers. Additionally, we explain the proper methods for determining voltages using single color controls and for delineating positive gates using fluorescence minus one controls. The major limitation of multi-parameter flow cytometry is the absence of tissue architecture. This limitation can be overcome by multi-parameter flow cytometry of individual ocular compartments or complimentary immunofluorescence staining. However, immunofluorescence is limited by its lack of quantitative analysis and reduced number of fluorophores on most microscopes. We describe the use of multi-parametric flow cytometry to provide highly quantitative analysis of mononuclear phagocytes in laser-induced choroidal neovascularization. Additionally, multi-parameter flow cytometry can be used for the identification of macrophage subsets, fate mapping, and cell sorting for transcriptomic or proteomic studies.


Asunto(s)
Ojo/citología , Ojo/diagnóstico por imagen , Citometría de Flujo , Fagocitos/citología , Animales , Anticuerpos/metabolismo , Células Dendríticas/citología , Femenino , Colorantes Fluorescentes/metabolismo , Rayos Láser , Macrófagos/citología , Masculino , Ratones Endogámicos C57BL , Microglía/citología , Monocitos/citología , Fagocitos/inmunología
13.
PLoS One ; 15(6): e0234664, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32544179

RESUMEN

PURPOSE: To compare quantitative changes in macular parameters in diabetic patients detected by two optical coherence tomography angiography (OCTA) instruments. METHODS: 80 phakic eyes were classified as no diabetes, diabetes without diabetic retinopathy (DR), mild non-proliferative diabetic retinopathy (NPDR), and severe NPDR or proliferative DR (PDR). OCTA was performed using devices from two manufacturers (Zeiss and Heidelberg). Superficial and deeper vascular skeleton density (SVSD, DVSD), superficial and deeper vessel area density (SVAD, DVAD), choriocapillaris flow voids (CCFV), and choroidal flow voids (CFV) were calculated. Inter-device comparisons were performed using the size comparison index (SCI) and the discrepancy index (DI). RESULTS: The two devices were inconsistent in SVSD, DVSD, DVAD, CCFV and CFV parameters (all P < 0.05). In addition, the SCI was positive for DVAD (all P < 0.001) and negative for SVSD, DVSD, CCFV and CFV in all groups (all P <0.001), except for DVSD in severe NPDR or PDR. The discrepancy index was not significantly different among groups for SVD, SPD, DVD, DPD and CFV (all P> 0.05). The mean DI of CCFV was statistically different between the four groups (P < 0.001). CONCLUSIONS: The two instruments were largely inconsistent in the measurement of macular parameters relevant to DR. The choice of imaging device can impact OCTA analytics and should be taken into account when drawing conclusions about DR-related changes.


Asunto(s)
Angiografía , Diabetes Mellitus/fisiopatología , Retinopatía Diabética/diagnóstico por imagen , Ojo/diagnóstico por imagen , Tomografía de Coherencia Óptica/instrumentación , Angiografía/instrumentación , Angiografía/métodos , Angiografía/normas , Estudios de Casos y Controles , Complicaciones de la Diabetes/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Estudios Retrospectivos , Tomografía de Coherencia Óptica/métodos , Tomografía de Coherencia Óptica/normas
14.
J Craniofac Surg ; 31(5): 1418-1420, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32487836

RESUMEN

Spiral computed tomography is a gold standard in diagnostics of intraorbital pathological changes. Modern software provides great opportunities at viewing and analyzing DICOM files. Earlier, the authors introduced a method of computed exophthalmometry for precise measurement of globes' position even in the cases of lateral orbital rim fracture. However, eye proptosis is known to be depending on the eye length (ocular component), retrobulbar volume (orbital component), as well as anatomy of neurocranium and brain (cerebral component). Nevertheless, conventional Hertel exophthalmometry and other proposed methods do not specify the component, involved in the pathogenesis of enophthalmos or exophthalmos, that is why additional examinations are required. In this article, the authors propose a novel approach, which can complement and/or substitute instrumental methods used for differential diagnostics of enophthalmos or exophthalmos.


Asunto(s)
Ojo/diagnóstico por imagen , Adulto , Enoftalmia/etiología , Exoftalmia/etiología , Femenino , Humanos , Masculino , Fracturas Orbitales/complicaciones , Tomografía Computarizada Espiral , Adulto Joven
15.
PLoS One ; 15(6): e0234151, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32520956

RESUMEN

OBJECTIVES: To examine interocular asymmetry of foveal avascular zone (FAZ) and parafoveal capillary density metrics in sickle cell retinopathy (SCR) using optical coherence tomography angiography (OCT-A). METHODS: This cross-sectional, retrospective study evaluated SCR patients and unaffected controls who underwent 3x3mm macular OCT-A imaging using a spectral domain-OCT system. FAZ (area, perimeter, and acircularity index) and parafoveal capillary density metrics were computed for both eyes of each participant. In unaffected controls, interocular difference in FAZ and parafoveal capillary density metrics were evaluated using Bland-Altman plots. SCR patients with interocular difference outside the upper 97.5% and lower 2.5% limits of agreement from controls were defined as having interocular asymmetry. Area under receiver operating characteristic curve (AROC) was also performed to determine the ability of the absolute interocular difference to differentiate between subjects with SCR-including non-proliferative SCR (NP-SCR) and proliferative SCR (P-SCR)-and unaffected controls. RESULTS: Thirty-one patients with SCR (21 NP-SCR and 10 P-SCR) and 14 race-matched and age-matched controls were included for analysis. Interocular asymmetry was seen for all FAZ and parafoveal capillary density metrics in NP-SCR and P-SCR subjects. SCR subjects showed greater disease severity in the left-eye for FAZ and parafoveal capillary density metrics. CONCLUSIONS: NP-SCR and P-SCR patients demonstrated quantifiable interocular asymmetry in FAZ and parafoveal capillary density metrics compared to unaffected subjects, with left-eye predominance in disease severity.


Asunto(s)
Anemia de Células Falciformes/patología , Capilares/fisiología , Fóvea Central/fisiología , Enfermedades de la Retina/patología , Adulto , Anemia de Células Falciformes/complicaciones , Área Bajo la Curva , Estudios de Casos y Controles , Estudios Transversales , Ojo/diagnóstico por imagen , Femenino , Fóvea Central/irrigación sanguínea , Humanos , Masculino , Persona de Mediana Edad , Curva ROC , Enfermedades de la Retina/etiología , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Tomografía de Coherencia Óptica , Adulto Joven
16.
PLoS One ; 15(6): e0234016, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32480401

RESUMEN

PURPOSE: We propose a new method to calculate proptosis by using the simple Heron's formula and analyze its feasibility. METHOD: It was a none-inferiority trial. The registration number was ChiCTR1900026490. The absolute value of proptosis in 120 eyes, 60 patients without eye injury or diseases, was measured by computed tomography (CT) and simple Heron's formula. We did regression analysis and analyzed the differences between the two methods with Medcalc software version 19.0.4. The result was showed by Passing-Bablok regression analysis diagram and Bland and Altman plot. RESULTS: The Passing-Bablok showed that the result of proptosis measured by CT and simple Heron's formula showed good positive correlation. A 95% limit of agreement in proptosis between CT and Heron's formula method was -0.46 to 0.54 mm in right eye and -0.45 to 0.46 mm in left eye. 1.66% (1/60) point was outside 95% LoA in both eyes. Moreover, a 95% limit of agreement between CT and Heron's formula method was -0.42 to 0.56 mm in difference of both eyes. 3.33% (2/60) points were outside 95% LoA. The points in all Bland and Altman plots were lower than 5%. It means that the results of comparison between the two methods had a good consistency in the measurement of proptosis. CONCLUSIONS: Heron's formula could be applied to calculate proptosis and has a good consistency compared with computed tomography (CT). This method is practical in proptosis assessment because of its accuracy, reliability and simplicity.


Asunto(s)
Antropometría/métodos , Exoftalmia/diagnóstico , Adulto , Antropometría/instrumentación , Ojo/diagnóstico por imagen , Estudios de Factibilidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Tomografía Computarizada por Rayos X , Adulto Joven
18.
Int J Comput Assist Radiol Surg ; 15(5): 781-789, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32242299

RESUMEN

PURPOSE: Intraoperative optical coherence tomography (iOCT) was recently introduced as a new modality for ophthalmic surgeries. It provides real-time cross-sectional information at a very high resolution. However, properly positioning the scan location during surgery is cumbersome and time-consuming, as a surgeon needs both his hands for surgery. The goal of the present study is to present a method to automatically position an iOCT scan on an anatomy of interest in the context of anterior segment surgeries. METHODS: First, a voice recognition algorithm using a context-free grammar is used to obtain the desired pose from the surgeon. Then, the limbus circle is detected in the microscope image and the iOCT scan is placed accordingly in the X-Y plane. Next, an iOCT sweep in Z direction is conducted and the scan is placed to centre the topmost structure. Finally, the position is fine-tuned using semantic segmentation and a rule-based system. RESULTS: The logic to position the scan location on various anatomies was evaluated on ex vivo porcine eyes (10 eyes for corneal apex and 7 eyes for cornea, sclera and iris). The mean euclidean distances (± standard deviation) was 76.7 (± 59.2) pixels and 0.298 (± 0.229) mm. The mean execution time (± standard deviation) in seconds for the four anatomies was 15 (± 1.2). The scans have a size of 1024 by 1024 pixels. The method was implemented on a Carl Zeiss OPMI LUMERA 700 with RESCAN 700. CONCLUSION: The present study introduces a method to fully automatically position an iOCT scanner. Providing the possibility of changing the OCT scan location via voice commands removes the burden of manual device manipulation from surgeons. This in turn allows them to keep their focus on the surgical task at hand and therefore increase the acceptance of iOCT in the operating room.


Asunto(s)
Monitoreo Intraoperatorio/métodos , Procedimientos Quirúrgicos Oftalmológicos/métodos , Tomografía de Coherencia Óptica/métodos , Algoritmos , Animales , Estudios Transversales , Ojo/diagnóstico por imagen , Microscopía/instrumentación , Procedimientos Quirúrgicos Oftalmológicos/instrumentación , Porcinos
19.
BMC Geriatr ; 20(1): 155, 2020 04 28.
Artículo en Inglés | MEDLINE | ID: mdl-32345233

RESUMEN

BACKGROUND: Ocular imaging receives much attention as a source of potential biomarkers for dementia. In the present study, we analyze these ocular biomarkers in cognitively impaired and healthy participants in a population aged over 90 years (= nonagenarian), and elucidate the effects of age on these biomarkers. METHODS: For this prospective cross-sectional study, we included individuals from the EMIF-AD 90+ study, consisting of a cognitively healthy (N = 67) and cognitively impaired group (N = 33), and the EMIF-AD PreclinAD study, consisting of cognitively healthy controls aged ≥60 (N = 198). Participants underwent Optical Coherence Tomography (OCT) and fundus photography of both eyes. OCT was used to asses total and individual inner retinal layer thickness in the macular region (Early Treatment Diabetic Retinopathy Study circles) as well as peripapillary retinal nerve fiber layer thickness, fundus images were analyzed with Singapore I Vessel Assessment to obtain 7 retinal vascular parameters. Values for both eyes were averaged. Differences in ocular biomarkers between the 2 nonagenarian groups were analyzed using linear regression, differences between the individual nonagenarian groups and controls were analyzed using generalized estimating equations. RESULTS: Ocular biomarkers did not differ between the healthy and cognitively impaired nonagenarian groups. 19 out of 22 ocular biomarkers assessed in this study differed between either nonagenarian group and the younger controls. CONCLUSION: The ocular biomarkers assessed in this study were not associated with cognitive impairment in nonagenarians, making their use as a screening tool for dementing disorders in this group limited. However, ocular biomarkers were significantly associated with chronological age, which were very similar to those ascribed to occur in Alzheimer's Disease.


Asunto(s)
Disfunción Cognitiva/complicaciones , Ojo/diagnóstico por imagen , Enfermedades de la Retina/diagnóstico por imagen , Tomografía de Coherencia Óptica/métodos , Anciano , Anciano de 80 o más Años , Biomarcadores , Disfunción Cognitiva/diagnóstico por imagen , Estudios Transversales , Femenino , Fondo de Ojo , Humanos , Masculino , Estudios Prospectivos , Retina/diagnóstico por imagen , Singapur
20.
PLoS One ; 15(4): e0231351, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32267887

RESUMEN

PURPOSE: To investigate the association between different stages of posterior vitreous detachment (PVD) and macular microvasculature in the elderly. METHODS: Swept-source optical coherence tomography (OCT), OCT angiography, and color fundus images of 490 eyes without retinal pathologies of 322 participants aged ≥65 years were evaluated. PVD was classified using enhanced vitreous visualization mode as no apparent PVD (stage 0/1), vitreous adhesions at the fovea and optic disc (stage 2), adhesion at the optic disc (stage 3), or complete PVD (stage 4). Microvascular parameters, including foveal avascular zone (FAZ) and vessel density (VD), were analyzed for their associations with complete PVD. Additionally, the association between PVD and central retinal thickness (CRT) was also addressed. RESULTS: Overall, 80, 31, 31, and 349 eyes were categorized into stages 0/1, 2, 3, and 4, respectively. Using multivariate mixed-effects model, the mean superficial FAZ area was smaller in stage 4 compared with stages 0-3 (0.29 vs. 0.32 mm2; P = 0.014), and the mean superficial VD was lower in stage 4 compared with stages 0-3 (34.96% vs. 35.24%; P = 0.0089). However, PVD was not significantly associated with deep macular microvascular parameters or CRT. CONCLUSIONS: Complete PVD was associated with smaller FAZ area and lower VD in superficial macular microvasculature, while it was not associated with central retinal thickness.


Asunto(s)
Microvasos/fisiología , Desprendimiento del Vítreo/diagnóstico , Anciano , Estudios Transversales , Ojo/diagnóstico por imagen , Femenino , Angiografía con Fluoresceína , Humanos , Mácula Lútea/irrigación sanguínea , Mácula Lútea/diagnóstico por imagen , Mácula Lútea/fisiología , Degeneración Macular/diagnóstico , Degeneración Macular/patología , Masculino , Microvasos/diagnóstico por imagen , Persona de Mediana Edad , Retina/fisiología , Índice de Severidad de la Enfermedad , Tomografía de Coherencia Óptica , Desprendimiento del Vítreo/patología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...