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1.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 55(11): 814-818, 2020 Nov 09.
Artículo en Chino | MEDLINE | ID: mdl-33171552

RESUMEN

Due to the highly predictable long-term clinical outcomes, modern implant dentistry has become one of the most preferred treatment modalities for restoring missing teeth. However, the complications of implant therapy compromise the long-term implant success and remain a great challenge to clinicians. Hardware complications include the mechanical complications which are related to the manufacturer-fabricated components of the prosthesis, such as abutment/screw loosening, fracture and implant fracture; and the technical complication which are related to laboratory-fabricated components of the prosthesis, such as veneer chipping. The biological complications mainly include peri-implant mucositis and peri-implantitis. It is crucial to figure out how to effectively avoid and manage the complications of implant therapy. This article reported the definitions, incidences, risk factors, prevention and treatment of both mechanical and biological complications of implant therapy.


Asunto(s)
Implantes Dentales , Periimplantitis , Estomatitis , Pérdida de Diente , Implantes Dentales/efectos adversos , Prótesis Dental de Soporte Implantado , Fracaso de la Restauración Dental , Humanos , Periimplantitis/etiología , Periimplantitis/prevención & control
2.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 38(5): 479-483, 2020 Oct 01.
Artículo en Chino | MEDLINE | ID: mdl-33085228

RESUMEN

Peri-implantitis is one of the most common complications in dental implant treatment. Peri-implantitis is a crucial implication of implant failure, which is characterized by high morbidity and intractability. Thus, how to understand peri-implantitis correctly and deeply, and how to prevent its occurrence, are important problems that every dental implant surgeon has to face.


Asunto(s)
Implantes Dentales , Periimplantitis , Humanos , Periimplantitis/prevención & control
3.
Artículo en Inglés | MEDLINE | ID: mdl-32121336

RESUMEN

Dental implants are one of the most commonly used ways to replace missing teeth. Nevertheless, the close contact with hard and soft oral tissues expose these devices to infectious peri-implant diseases. To prevent such infection, several surface treatments have been developed in the last few years to improve the antimicrobial properties of titanium dental implants. In this in-vitro pilot study, the antimicrobial activity of titanium surfaces coated with different types of graphene nanoplatelets are investigated. Six different colloidal suspensions of graphene nanoplatelets (GNPs) were produced from graphite intercalated compounds, setting the temperature and duration of the thermal shock and varying the number of the exfoliation cycles. Titanium disks with sand-blasted and acid-etched surfaces were sprayed with 2 mL of colloidal GNPs suspensions. The size of the GNPs and the percentage of titanium disk surfaces coated by GNPs were evaluated through a field emission-scanning electron microscope. The antibacterial activity of the specimens against Staphylococcus aureus was estimated using a crystal violet assay. The dimension of GNPs decreased progressively after each sonication cycle. The two best mean percentages of titanium disk surfaces coated by GNPs were GNPs1050°/2 and GNPs1150°/2. The reduction of biofilm development was 14.4% in GNPs1150°/2, 20.1% in GNPs1150°/3, 30.3% in GNPs1050°/3, and 39.2% in GNPs1050°/2. The results of the study suggested that the surface treatment of titanium disks with GNPs represents a promising solution to improve the antibacterial activity of titanium implants.


Asunto(s)
Antibacterianos , Grafito , Nanopartículas , Periimplantitis , Titanio , Antibacterianos/administración & dosificación , Humanos , Nanopartículas/administración & dosificación , Periimplantitis/microbiología , Periimplantitis/prevención & control , Proyectos Piloto , Infecciones Estafilocócicas/prevención & control , Staphylococcus aureus , Propiedades de Superficie
4.
J Oral Implantol ; 46(4): 381-388, 2020 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-32069361

RESUMEN

Biological implant failures are primarily related to biofilm, which can lead to peri-mucositis and, further on, peri-implantitis. The 810-nm diode laser has an affinity for pigmented chromophores, so its use in the peri-implant sulcus has a significant bactericidal effect on the black-pigmented anaerobes such as Porphyromonas gingivalis. Therefore, it can be used to eliminate or reduce the bacterial count in the peri-implant sulcular fluid (PISF), thus increasing the life of the implants and reducing the chances of failure. The purpose of this study was to evaluate the efficacy of the 810-nm diode laser for the maintenance of dental implants and its use as a regular in-office tool for limiting the microbiological count in the PISF. Twenty patients undergoing implant treatment at the Department of Periodontology and Oral Implantology were randomly selected for the study. PISF samples were collected before and after the sulcus was lased with an 810-nm diode laser and sent for quantitative microbiological analysis using universal bacterial count, and the quantity of P gingivalis was evaluated using real-time polymerase chain reaction (PCR). The analysis revealed that after diode application, the median percentage drop in the microbial count was 76.67% and the median percentage drop in P gingivalis count was 99.28%. The use of an 810-nm diode laser resulted in the following outcomes: (1) drastic reduction in the total bacterial count around the implant and (2) significant reduction in the P gingivalis count, as evaluated by real-time PCR.


Asunto(s)
Implantes Dentales , Periimplantitis , Líquido del Surco Gingival , Humanos , Láseres de Semiconductores/uso terapéutico , Periimplantitis/prevención & control , Porphyromonas gingivalis
5.
Molecules ; 25(3)2020 Jan 24.
Artículo en Inglés | MEDLINE | ID: mdl-31991678

RESUMEN

The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.


Asunto(s)
Candidiasis Bucal/prevención & control , Caries Dental/prevención & control , Sistemas de Liberación de Medicamentos , Periimplantitis/prevención & control , Periodontitis/prevención & control , Humanos
6.
Clin Implant Dent Relat Res ; 21(6): 1262-1270, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31729830

RESUMEN

BACKGROUND: Different procedures were proposed to augment soft tissue around dental implants. OBJECTIVE: Aims of this Systematic Review (SR) were to evaluate (a) clinical benefit of soft tissue augmentation at implant sites (b) which is the best surgical procedure to augment soft tissue. MATERIALS AND METHODS: Manual/electronic searches were performed to identify randomized controlled trials (RCTs). Change in keratinized tissue thickness (STT) and height (KT) were primary outcomes. Random effects meta-analyses were performed where suitable and expressed as weighted mean differences (MD) with their associated 95% confidence intervals (CI). RESULTS: Fourteen RCTs accounting for 475 patients and 538 implants were included. Only five studies were judged at low risk of bias. In the single studies, soft augmentation lead to higher STT and KT compared to no augmentation. Considering primary outcomes, connective tissue graft (CTG) was more effective than xenogeneic collagen matrix (XCM) to improve STT (MD: -0.30 mm; 95% CI -0.43; -0.17; P < .00001) in the meta-analysis for different techniques for augmentation. CONCLUSIONS: Even if further studies at low risk of bias are needed, soft tissue augmentation techniques improved quantity and quality of peri-implant soft tissue. Among the augmentation procedures, CTG was associated to higher STT change compared to XCM.


Asunto(s)
Implantes Dentales , Mucosa Bucal , Periimplantitis , Colágeno , Tejido Conectivo , Humanos , Periimplantitis/prevención & control , Ensayos Clínicos Controlados Aleatorios como Asunto
7.
J Dent Res ; 98(12): 1287-1293, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31633460

RESUMEN

The discovery of the phenomenon "osseointegration," or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on natural teeth when these are vital and intact. Furthermore, implants are suitable to improve subjective chewing function and to replace missing and strategically important abutments. The osseointegration process is characterized by a predictable sequence of healing events that encompass the formation of woven bone, parallel fibers, and lamellar bone and result in fully functional bone that will remodel throughout life. While the osseointegration facilitates the use of implants as prosthetic abutments, it has to be kept in mind that the peri-implant soft tissue may be subject to biological complications. This, in turn, may result in an infectious process that will jeopardize the osseointegration. Consequently, the monitoring of the peri-implant tissues is an important aspect, and early intervention in situations with peri-implant mucositis is mandatory for the prevention of peri-implantitis. Hence, it is evident that oral implants need lifelong maintenance care if their longevity is to be assured.


Asunto(s)
Implantes Dentales , Restauración Dental Permanente/tendencias , Oseointegración , Humanos , Periimplantitis/prevención & control , Titanio , Anquilosis del Diente
8.
Braz Oral Res ; 33(suppl 1): e067, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31576951

RESUMEN

Peri-implantitis is currently a topic of major interest in implantology. Considered one of the main reasons of late implant failure, there is an emerged concern whether implant characteristics could trigger inflammatory lesion and loss of supporting bone. The purpose of this narrative review is to provide an evidence based overview on the influence of implant-based factors in the occurrence of peri-implantitis. A literature review was conducted addressing the following topics: implant surface topography; implant location; occlusal overload; time in function; prosthesis-associated factors (rehabilitation extension, excess of cement and implant-abutment connection); and metal particle release. Although existing data suggests that some implant-based factors may increase the risk of peri-implantitis, the evidence is still limited to consider them a true risk factor for peri-implantitis. In conclusion, further evidences are required to a better understanding of the influence of implant-based factors in the occurrence of peri-implantitis. Large population-based studies including concomitant analyses of implant- and patient-based factors are required to provide strong evidence of a possible association with peri-implantitis in a higher probability. The identification of these factors is essential for the establishment of strategies to prevent peri-implantitis.


Asunto(s)
Implantes Dentales/efectos adversos , Periimplantitis/etiología , Medición de Riesgo , Prótesis Anclada al Hueso/efectos adversos , Humanos , Periimplantitis/prevención & control , Factores de Riesgo , Propiedades de Superficie , Factores de Tiempo , Insuficiencia del Tratamiento
9.
Braz Oral Res ; 33(suppl 1): e074, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31576958

RESUMEN

Most of the literature evaluating dental implants focuses on implant survival, which is a limited proxy for the successful rehabilitation of patients with missing teeth. Success should include not only survival but also lack of mechanical, biological, and esthetics problems. A comprehensive review of local and systemic risk factors prior to implant placement will allow the tailoring of treatment planning and maintenance protocols to the patient's profile in order to achieve longitudinal success of the therapy. This review discusses the role of controlling different risk factors and prevention/treatment of peri-implant mucositis in order to avoid peri-implantitis. Although the literature addressing the topic is still scarce, the existing evidence shows that performing optimal plaque control and regular visits to the dentist seem to be adequate to prevent peri-implant lesions. Due to impossibility of defining a probing depth associate with peri-implant health, radiographic evaluations may be considered in the daily practice. So far, there is a strong evidence linking a past history of periodontal disease to peri-implant lesions, but this is not so evident for other factors including smoking and diabetes. The prevention of biological complications starts even before implant placement and include a broader analysis of the patient risk profile and tailoring the rehabilitation and maintenance protocols accordingly. It should be highlighted that the installation of implants does not modify the patient profile, since it does not modify genetics, microbiology or behavioral habits of any individual.


Asunto(s)
Interfase Hueso-Implante , Implantes Dentales/efectos adversos , Periimplantitis/prevención & control , Periodontitis/prevención & control , Estomatitis/prevención & control , Interfase Hueso-Implante/diagnóstico por imagen , Placa Dental/prevención & control , Humanos , Higiene Bucal , Periimplantitis/etiología , Índice Periodontal , Periodontitis/etiología , Radiografía Dental , Factores de Riesgo , Estomatitis/etiología
10.
J Biol Regul Homeost Agents ; 33(3 Suppl. 1): 129-134, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31538459

RESUMEN

Osseointegration can be affected by oral conditions; in particular, the micro gap at the implantabutment-connection (IAC) represents a site for dental plaque aggregation favoring bacterial leakage that can increase inflammatory cells at the level of the IAC, causing peri-implantitis. This micro gap, once early colonized, may constitute a bacterial reservoir that could subsequently contaminate fixture's surroundings and interfere with peri-implant tissues health. The aim of this review is to describe, according to the most recent literature, the different kind of implant-abutment connection and their ability to reduce bacterial leakage and thus preventing peri-implantitis. The following database were consulted: Pubmed (n=26), Scopus (n=90), Research gate (n=7) and 123 articles were found. Duplicates were excluded and after reading abstract and titles, those articles that were off topic were also excluded. The remaining ones (n=24) were assessed for full-text eligibility. We excluded 5 articles because they were case reports, 2 because there was no clear reference to the relationship between IAC and bacterial leakage and 2 because they were not pertinent to the argument. Fifteen articles were included in the review. From the review, it is clear that a relationship between the IAC and bacterial leakage exists. All the connections presented an amount of micro-gap and bacterial micro-leakage but conical and mixed connection systems seem to behave better. Moreover, both connections seem to have a better load distribution and the mixed one has anti-rotational properties, very useful during the positioning of the prosthesis.


Asunto(s)
Pilares Dentales/microbiología , Implantes Dentales/microbiología , Filtración Dental/prevención & control , Oseointegración , Periimplantitis/prevención & control , Bacterias , Humanos
11.
J Biol Regul Homeost Agents ; 33(3 Suppl. 1): 161-167, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31538463

RESUMEN

Osseointegrated dental implants showed elevated success rates on the long-term treatment in the last ten years. However, the risk of peri-implantitis and implant failure is the main complication of implantology. The presence of a micro gap at the implant-abutment connection (IAC) allows microorganisms to penetrate and colonize the inner part of the implant leading to biofilm accumulation and consequently to peri-implantitis development. Some chemical devices (CD) has been studied to reduce bacterial penetration at IAC level but no one have been demonstrated to be effective for this purpose. Aim of the present study is to evaluate the effectiveness of a new chemical formulation STCX-1, placed in the internal part of dental implants for killing bacteria present in the IAC. To identify the antibacterial power of SXTC-1 at interface between implant-abutment connection, the passage of genetically modified Escherichia coli across IAC was evaluated. A total of eight implants were used (Edierre Implant System, Edierre SpA, Genova, Italy). The inner side of four out of the eight implants were firstly contaminated with few microliters of pure bacteria, subsequently were treated with SXTC-1 for few second and finally, the antibacterial was replaced with Lysogeny Broth (LB) and antibiotics without bacteria. The remaining four implants were not treated with SXTC-1 and just filled with LB with antibiotics. Bacteria viability was determined by measuring their Optical Density (OD) at 600nm. The analysis revealed that, in untreated implants, bacteria grew (internally and externally) for the first 48 hours, but subsequently they started to dye. In treated implants, instead, bacteria grew just in the space surrounding the device suggesting that, even if bacteria were able to get into, they immediately died thanks to the presence of SXTC-1. The STCX-1 liquid formulation have been demonstrated to be an adjuvant CD effective for prevention of of bacterial colonization at IAC level.


Asunto(s)
Pilares Dentales/microbiología , Diseño de Implante Dental-Pilar , Implantes Dentales/microbiología , Filtración Dental/prevención & control , Escherichia coli , Humanos , Técnicas In Vitro , Viabilidad Microbiana , Periimplantitis/prevención & control
12.
Stomatologiia (Mosk) ; 98(4): 20-24, 2019.
Artículo en Ruso | MEDLINE | ID: mdl-31513143

RESUMEN

The aim of this study was to evaluate the effectiveness of probiotics in the treatment and prevention of peri-implant complications. Clinical, immunological and microbiological studies were conducted before, 1 and 6 months after the periodontal treatment in 42 patients (120 implants) with peri-implant mucositis. The use of probiotics in the treatment of peri-implant mucositis led to a significant and more pronounced improvement in oral health state in terms of an increased functional activity of the salivary glands, local immunity factors and microbiocenosis.


Asunto(s)
Implantes Dentales , Mucositis , Periimplantitis , Probióticos , Estomatitis , Humanos , Mucositis/prevención & control , Periimplantitis/prevención & control , Índice Periodontal
13.
Int J Mol Sci ; 20(16)2019 Aug 09.
Artículo en Inglés | MEDLINE | ID: mdl-31405061

RESUMEN

The bacterial biofilm formation in the oral cavity and the microbial activity around the implant tissue represent a potential factor on the interface between bone and implant fixture that could induce an inflammatory phenomenon and generate an increased risk for mucositis and peri-implantitis. The aim of the present clinical trial was to investigate the bacterial quality of a new antibacterial coating of the internal chamber of the implant in vivo at six months. The PIXIT implant (Edierre srl, Genova Italy) is prepared by coating the implant with an alcoholic solution containing polysiloxane oligomers and chlorhexidine gluconate at 1%. A total of 15 healthy patients (60 implants) with non-contributory past medical history (nine women and six men, all non-smokers, mean age of 53 years, ranging from 45-61 years) were scheduled to receive bilateral fixed prostheses or crown restorations supported by an implant fixture. No adverse effects and no implant failure were reported at four months. All experimental sites showed a good soft tissue healing at the experimental point times and no local evidence of inflammation was observed. Real-Time Polymerase Chain Reaction (PCR) analysis on coated and uncoated implants showed a decrease of the bacterial count in the internal part of the implant chamber. The mean of total bacteria loading (TBL) detected in each PCR reaction was lower in treated implants (81038 units/reaction) compared to untreated implants (90057 units/reaction) (p < 0.01). The polymeric chlorhexydine coating of the internal chamber of the implant showed the ability to control the bacterial loading at the level of the peri-implant tissue. Moreover, the investigation demonstrated that the coating is able to influence also the quality of the microbiota, in particular on the species involved in the pathogenesis of peri-implantitis that are involved with a higher risk of long-term failure of the dental implant restoration.


Asunto(s)
Antibacterianos/administración & dosificación , Clorhexidina/análogos & derivados , Materiales Biocompatibles Revestidos/química , Implantes Dentales/microbiología , Periimplantitis/prevención & control , Antibacterianos/uso terapéutico , Antiinfecciosos Locales/administración & dosificación , Antiinfecciosos Locales/uso terapéutico , Carga Bacteriana/efectos de los fármacos , Clorhexidina/administración & dosificación , Clorhexidina/uso terapéutico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Siloxanos/química
14.
Photobiomodul Photomed Laser Surg ; 37(6): 356-361, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-31188089

RESUMEN

Background: Diode lasers have been used for implant decontamination. However, the use of initiated or noninitiated tips remains unevaluated to verify potential photothermal risks. Objective: To assess the photothermal effects of defocused-initiated versus noninitiated irradiation. Materials and methods: A dental implant (3.5 × 11 mm) was placed into an artificial bone, an infrabony defect was created to simulate a four-wall peri-implant defect. Irradiation was performed using pulsed diode lasers of 940, 975, and 980 nm. The laser tips were positioned parallel to the implant (maximum 2W pulsed mode). The implant was irradiated for 30 sec using noninitiated, cork-, and blue paper-initiated tips. Temperature differences were observed at the apical and coronal regions of the implant. The data were statistically evaluated and compared using one-way analysis of variance and Tukey tests. Results: The average temperature increase and the amount of time that it took to yield the critical temperature were comparable at the coronal level for the 940 and 975 nm diode lasers (p > 0.05). For the 980 nm laser, blue-initiated tip had the highest temperature increase (22.4°C), followed by cork (18.8°C) and noninitiated tip (17.3°C). The critical threshold at the coronal portion for the 980 nm laser was reached in 11.5, 8.79, and 6.46 sec for the blue paper-, cork-, and noninitiated tips, respectively. The 975 and 980 nm lasers had average temperature increases, comparable among the blue paper-, cork-, and noninitiated tips at the apical level (p > 0.05). Apically, for the 940 nm, the noninitiated tip had the highest temperature increase (5.57°C), followed by the cork- (4.96°C) and blue paper-initiated tip (4.54°C). Conclusions: The initiator does not affect the temperatures produced during implant decontamination although noninitiated diode lasers may overheat (within 30 sec) than initiated tips. There is minimal risk of overheating at the apical portion. It seems that the 940 nm diode is the safest of the evaluated laser systems.


Asunto(s)
Láseres de Semiconductores , Terapia por Luz de Baja Intensidad/instrumentación , Periimplantitis/prevención & control , Descontaminación , Temperatura
15.
Artículo en Inglés | MEDLINE | ID: mdl-31116831

RESUMEN

PURPOSE: The purpose of this review was to explore the available literature and compile studies that discuss the relevance of the biofilm, onset and progression of disease, critical peri-implant pocket depth, frequency of supportive implant therapy, excess cement, and keratinized peri-implant tissues as related to peri-implant disease. MATERIALS AND METHODS: PubMed, Cochrane Oral Health Group Specialized Trial Register, and hand searches of related journals were performed in relationship to the focused question. Reports describing techniques, preclinical studies, and case reports were excluded. RESULTS: Due to the absence of controlled studies, a meta-analysis could not be performed. Summaries of relevant publications were completed for each topic area. Clinical recommendations were developed to provide guidance to the practitioner. CONCLUSION: The importance of proper diagnosis, planning, and clinical treatment cannot be overstated. Patient factors including systemic disease, periodontal status, and oral hygiene significantly impact peri-implant health. Clinician factors such as implant position, excess cement, and restorative design can contribute to development of peri-implant disease. Surveillance of implant status is essential and can be assisted by the assessment of risk factors, establishment of a proper recall program, and monitoring changes in bone and peri-implant pocket depths.


Asunto(s)
Cementos Dentales/efectos adversos , Implantes Dentales/efectos adversos , Membrana Mucosa/patología , Periimplantitis/etiología , Biopelículas , Humanos , Higiene Bucal , Periimplantitis/prevención & control , Factores de Riesgo
16.
Artículo en Inglés | MEDLINE | ID: mdl-30794253

RESUMEN

Peri-implant mucositis has been defined as a reversible inflammatory reaction in the soft tissues around a functioning implant with no bone loss. This paper reviews the prevalence, etiology, risk indicators, prevention, and treatment of mucositis. Relying on the literature concerning mucositis, the bacterial etiology is discussed as well as the varying ranges of prevalence, reported to be from 20% to 80% of subjects (13% to 62% of implants) after a minimum of 5 years of implant function. A discussion of the definition of mucositis questions the assumption of it being completely reversible following treatment and challenges the concept of mucositis "transfer" (conversion) to peri-implantitis.


Asunto(s)
Implantes Dentales/efectos adversos , Periimplantitis/etiología , Estomatitis/etiología , Humanos , Periimplantitis/prevención & control , Periimplantitis/terapia , Estomatitis/prevención & control , Estomatitis/terapia
17.
J Biomed Mater Res A ; 107(7): 1466-1475, 2019 07.
Artículo en Inglés | MEDLINE | ID: mdl-30786152

RESUMEN

The idea of permanent tooth replacement goes back to the year 2000 BC at least, when carved bamboo pegs were used to replace missing teeth in ancient China. The phenomenon of osseointegration, however, was not verified until the mid-1960s, when Branemark discovered that titanium could integrate to bone. Since then, the osseointegration capacity of implants has been profoundly investigated and implants as such have evolved enormously in all possible aspects, from material selection and processing to specific surface engineering, among many others. This review article, in particular, focuses on dental implants and aims to introduce the main concerns involved in modern dentistry, concentrating especially on the importance of finding an effective way to prevent peri-implantitis. In this sense, strategies such as shifting from metal to ceramic implant components and applying novel antimicrobial antibiotic-free coatings seem to be taking the lead. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.


Asunto(s)
Implantes Dentales/tendencias , Odontología/tendencias , Estética , Fenómenos Mecánicos , Periimplantitis/prevención & control , Antiinfecciosos/farmacología , Humanos , Periimplantitis/diagnóstico por imagen
18.
Photodiagnosis Photodyn Ther ; 25: 382-388, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-30684671

RESUMEN

BACKGROUND: S. aureus biofilm plays a predominant role in the establishment and development of peri-implantitis. It is suggested to combine different modalities as peri-implantitis treatment. The aim of this study was to evaluate the disinfection efficacy of combined application of antiseptics with PDT on Staphylococcus aureus (S. aureus) biofilm formed on titanium(Ti) disks with different surface roughness. METHODS: S. aureus biofilm was incubated on polished and sandblasted large-grit acid-etched (SLA) Ti surfaces for 48 h. 72 contaminated Ti disks (36 polished, 36 SLA) were randomly divided into 6 different groups as follows: (a) PBS, (b) 0.2% chlorhexidine digluconate (CHX), (c) 3% hydrogen peroxide (H2O2), (d) PDT, (e) 0.2% CHX + PDT, and (f) 3% H2O2+PDT. Colony forming unit (CFU) was measured to determine antimicrobial effects. Biofilm structure was assessed using scanning electron microscopy (SEM) and confocal laser scanning microscope (CLSM). RESULTS: All disinfection methods significantly reduced bacteria amounts compared to control group on both polished and SLA Ti surfaces (P < 0.001). PDT demonstrated stronger decontamination ability in eliminating S. aureus from Ti surfaces than CHX and H2O2 did (P < 0.05). The combined CHX or H2O2 with PDT treatment were more effective in bacterial disinfection than a single administration of these treatments (P < 0.001). CONCLUSION: The combination of CHX or H2O2 administration with PDT was more effective in eradicating S. aureus on both polished and SLA Ti disks in comparison with either treatment alone, suggesting that combined usage of antiseptics with PDT could be a more efficient method for the treatment of peri-implantitis.


Asunto(s)
Antiinfecciosos Locales/farmacología , Biopelículas/efectos de los fármacos , Fotoquimioterapia/métodos , Fármacos Fotosensibilizantes/farmacología , Staphylococcus aureus/efectos de los fármacos , Titanio/química , Clorhexidina/análogos & derivados , Clorhexidina/farmacología , Desinfección/métodos , Peróxido de Hidrógeno/farmacología , Microscopía Electrónica de Rastreo , Periimplantitis/microbiología , Periimplantitis/prevención & control , Células Madre , Cloruro de Tolonio/farmacología
19.
Clin Oral Implants Res ; 30(2): 150-155, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30636066

RESUMEN

This perspective article on peri-implantitis and its prevention was produced as a supplement to a 3-D, computer-animated film aiming at presenting key characteristics of peri-implant health, the build-up of a biofilm and the ensuing host-response resulting in peri-implant mucositis and, subsequently, peri-implantitis. Treatment concepts for peri-implantitis were briefly reviewed, and prevention of the condition was brought to attention as a priority in implant dentistry. The overview also highlighted the 2017 World Workshop on Classification of Periodontal and Peri-implant diseases and Conditions, in which new disease definitions and case definitions were presented for peri-implant health, peri-implant mucositis, and peri-implantitis.


Asunto(s)
Periimplantitis , Biopelículas/crecimiento & desarrollo , Humanos , Periimplantitis/prevención & control , Estomatitis
20.
Clin Implant Dent Relat Res ; 21(1): 154-159, 2019 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-30444054

RESUMEN

BACKGROUND: Oral rehabilitation with dental implants has become increasingly common; however, the increase of peri-implantitis is a great concern. Doxycycline (DOX) is a widely used antibiotic that inhibits bacteria growth, inflammation, and bone resorption. OBJECTIVES: To evaluate the progression of peri-implantitis of hydroxyapatite (HA)-coated implants with (5 mg/mL, DOX group) or without (HA group) DOX treatment on the surface. MATERIALS AND METHODS: The maxillary first molars of 20 male mice were extracted. Eight weeks later, small titanium screw implants coated with thin HA and treated with or without DOX were placed at the extracted sites. Four weeks after implant placement, half of the animals in both groups were sacrificed, and ligatures were placed around the implant necks in the other half. These mice were sacrificed 4 weeks later. The bone around the implants was examined radiologically and histologically. RESULTS: Four weeks after the ligature placement, the radiographic measurements revealed that peri-implant bone levels of palatal and mesial sites, and histological measurements showed that bone levels of mesial and distal sites in the DOX group were significantly higher than those in the HA group. CONCLUSIONS: The present results indicating that the DOX-treated HA implant surface attenuates the progression of peri-implantitis.


Asunto(s)
Antibacterianos/uso terapéutico , Doxiciclina/uso terapéutico , Durapatita/uso terapéutico , Periimplantitis/tratamiento farmacológico , Animales , Antibacterianos/administración & dosificación , Implantación Dental Endoósea/efectos adversos , Doxiciclina/administración & dosificación , Durapatita/administración & dosificación , Masculino , Ratones , Ratones Endogámicos C57BL , Periimplantitis/diagnóstico por imagen , Periimplantitis/patología , Periimplantitis/prevención & control
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