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2.
Medicine (Baltimore) ; 99(22): e20329, 2020 May 29.
Artículo en Inglés | MEDLINE | ID: mdl-32481406

RESUMEN

Parental knowledge regarding the role of moisturizers in restoring the skin barrier, as well as regular and long-term use of moisturizers, is critical in the treatment of infantile eczema and the prevention of relapse.The parents of children with eczema were enrolled in this study. Their knowledge of the role, use, and effect of moisturizers on their children, as well as their concerns regarding moisturizers were surveyed.A total of 350 parents were enrolled in this study. Two hundred fifty-two parents (72%) knew that eczema requires moisturizers to restore the skin barrier. Among these 252 parents, 175 parents (50.0%) knew that moisturizers can restore the skin barrier. Only 27 parents (27/175, 15.4%) of them knew that moisturizers can improve eczema. Overall, 69.4% used moisturizers; of these, 75.3% used only moisturizers on the face, 87.2% on dry areas of face and other body parts, and only 6.6% on the entire body. Furthermore, 13.2% used topical moisturizers in the long-term; 62.6% used moisturizers 1 to 2 times per day, while 5.4% used moisturizers once every few days. A total of 80.7% discontinued moisturizers immediately after improvement in dryness, and 75.3% reported skin dryness despite moisturizer usage. Among parents of children who used moisturizers, 16.5% were worried about the side effects of moisturizers.Despite a fair level of knowledge about moisturizers, parents of children with eczema are using them inadequately. Pediatrician should be more patient to educate parents the information on the importance of moisturizers for the improvement of eczema and prevention of recurrence.


Asunto(s)
Dermatitis Atópica/terapia , Conocimientos, Actitudes y Práctica en Salud , Crema para la Piel/uso terapéutico , Dermatitis Atópica/patología , Femenino , Humanos , Lactante , Masculino , Padres , Índice de Severidad de la Enfermedad , Piel/patología , Crema para la Piel/administración & dosificación
4.
J Dermatol Sci ; 98(2): 75-81, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32381430

RESUMEN

BACKGROUND: Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized. OBJECTIVE: This review aims to provide an overview of various cutaneous manifestations in patients with COVID-19 through three case reports and a literature review. METHODS: A literature search was conducted using PubMed, OVID, and Google search engines for original and review articles. Studies written in the English language that mentioned cutaneous symptoms and COVID-19 were included. RESULTS: Eighteen articles and three additional cases reported in this paper were included in this review. Of these studies, 6 are case series and 12 are case report studies. The most common cutaneous manifestation of COVID-19 was found to be maculopapular exanthem (morbilliform), presenting in 36.1% (26/72) patients. The other cutaneous manifestations included: a papulovesicular rash (34.7%, 25/72), urticaria (9.7%, 7/72), painful acral red purple papules (15.3%, 11/72) of patients, livedo reticularis lesions (2.8%, 2/72) and petechiae (1.4%, 1/72). Majority of lesions were localized on the trunk (66.7%, 50/72), however, 19.4% (14/72) of patients experienced cutaneous manifestations in the hands and feet. Skin lesion development occurred before the onset of respiratory symptoms or COVID-19 diagnosis in 12.5% (9/72) of the patients, and lesions spontaneously healed in all patients within 10 days. Majority of the studies reported no correlation between COVID-19 severity and skin lesions. CONCLUSION: Infection with COVID-19 may result in dermatological manifestations with various clinical presentations, which may aid in the timely diagnosis of this infection.


Asunto(s)
Betacoronavirus/patogenicidad , Infecciones por Coronavirus/virología , Neumonía Viral/virología , Enfermedades Cutáneas Virales/virología , Piel/virología , Anciano , Antivirales/uso terapéutico , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/terapia , Progresión de la Enfermedad , Diagnóstico Precoz , Femenino , Humanos , Terapia por Inhalación de Oxígeno , Pandemias , Neumonía Viral/diagnóstico , Neumonía Viral/terapia , Valor Predictivo de las Pruebas , Piel/efectos de los fármacos , Piel/patología , Enfermedades Cutáneas Virales/diagnóstico , Enfermedades Cutáneas Virales/terapia , Factores de Tiempo , Resultado del Tratamiento
5.
Int J Nanomedicine ; 15: 2515-2527, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32368038

RESUMEN

Purpose: Reactive oxygen species (ROS)-induced oxidative stress plays a key role in the pathogenesis and progression of psoriasis by causing inflammation. Antioxidative strategies eradicating ROS may serve as effective and easy treatment options for psoriasis, while nanozymes with intrinsic antioxidant enzyme-like activity have not been explored for psoriasis treatment. The aim of this study is to fabricate ß-cyclodextrins (ß-CDs)-modified ceria nanoparticles (ß-CDs/CeO2 NPs) with drug-loaded and multimimic-enzyme activities for combinational psoriasis therapy. Methods: The ß-CDs/CeO2 NPs were synthesized by a hydrothermal method using unmodified ß-CDs as a protecting agent. The structure, size and morphology were analyzed by dynamic light scattering, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FTIR) spectroscopy. Considering the superoxide dismutase (SOD)- and catalase-mimetic activities, the in vitro antioxidant activity of the ß-CDs/CeO2 NPs was investigated. After dithranol (DIT) was loaded, the drug-loading capacity and release profile were determined by UV-visible light spectrophotometer and high-performance liquid chromatography. The anti-psoriatic efficacy was studied in the imiquimod (IMQ)-induced mouse model on the basis of morphological evaluation, psoriasis area and severity index calculation (PASI), and inflammatory cytokine expression. Results: The average particle size of the blank ß-CDs/CeO2 NPs was 60.89±0.32 nm with a polydispersity index (PDI) of 0.12, whereas that of the DIT-loaded NPs was 79.38±1.06 nm with a PDI of 0.27. TEM results showed the as-prepared NPs formed a uniform quasi-spherical shape with low polydispersity. XPS indicates synthesized NPs have a mixed Ce3+/Ce4+ valence state. FTIR spectroscopy confirmed the presence of ß-CDs and DIT in the NPs. Inhibition of superoxide anion rate by NPs could be reached to 79.4% in the presence of 200 µg/mL, and elimination of H2O2 efficiency reached about 50% in the presence of 40 µg/mL, demonstrating excellent superoxide dismutase- and catalase-mimicking activities, thereby providing remarkable cryoprotection against ROS-mediated damage. Furthermore, ß-CDs on the surface endowed the NPs with drug-loading function via host-guest interactions. The entrapment efficiency and drug loading of DIT are 94.7% and 3.48%, respectively. The in vitro drug release curves revealed a suitable release capability of DIT@ß-CDs/CeO2 NPs under physiological conditions. In IMQ-induced psoriatic model, the DIT@ß-CDs/CeO2 NPs exhibited excellent therapeutic effect. Conclusion: This study may pave the way for the application of nanozyme ß-CDs/CeO2 NPs as a powerful tool for psoriasis therapy.


Asunto(s)
Cerio/química , Nanopartículas/química , Psoriasis/terapia , beta-Ciclodextrinas/química , Animales , Catalasa/metabolismo , Línea Celular , Supervivencia Celular , Terapia Combinada , Depuradores de Radicales Libres/química , Hidrodinámica , Imiquimod/farmacología , Imiquimod/uso terapéutico , Masculino , Ratones Endogámicos BALB C , Nanopartículas/ultraestructura , Tamaño de la Partícula , Espectroscopía de Fotoelectrones , Psoriasis/tratamiento farmacológico , Especies Reactivas de Oxígeno/metabolismo , Piel/efectos de los fármacos , Piel/patología , Espectroscopía Infrarroja por Transformada de Fourier , Superóxido Dismutasa/metabolismo , Factor de Necrosis Tumoral alfa/metabolismo , beta-Ciclodextrinas/síntesis química
9.
BMC Infect Dis ; 20(1): 286, 2020 Apr 17.
Artículo en Inglés | MEDLINE | ID: mdl-32303196

RESUMEN

BACKGROUND: Henoch-Schönlein purpura (HSP) may be caused by several allergens. However, to date, HSP caused by Orientia tsutsugamushi has not been reported. Here, we report an unusual rash with features of HSP caused by Orientia tsutsugamushi. CASE PRESENTATION: A man visited a tertiary hospital with bilateral symmetrical purpura and fever. He presented with an eschar in the left popliteal fossa and proteinuria. He was diagnosed with tsutsugamushi disease by indirect fluorescent antibody and positive polymerase chain reaction tests. Purpura biopsy demonstrated a feature of leukocytoclastic vasculitis and IgA deposition in dermal vessels, indicative of HSP. CONCLUSIONS: When examining patients with unique rashes, such as in this case, we suggest investigating out-door activities and evidence of mite bites. Furthermore, differential diagnosis of tsutsugamushi disease should be considered when necessary.


Asunto(s)
Orientia tsutsugamushi/aislamiento & purificación , Púrpura de Schoenlein-Henoch/diagnóstico , Tifus por Ácaros/diagnóstico , Antibacterianos/uso terapéutico , Biopsia , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Orientia tsutsugamushi/genética , Orientia tsutsugamushi/inmunología , Púrpura de Schoenlein-Henoch/tratamiento farmacológico , Púrpura de Schoenlein-Henoch/microbiología , Púrpura de Schoenlein-Henoch/patología , Tifus por Ácaros/tratamiento farmacológico , Tifus por Ácaros/microbiología , Tifus por Ácaros/patología , Piel/patología , Resultado del Tratamiento
10.
PLoS Negl Trop Dis ; 14(4): e0007732, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-32310955

RESUMEN

BACKGROUND: Buruli ulcer is a necrotising infection of skin and soft tissue caused by Mycobacterium ulcerans (M. ulcerans). Buruli ulcer most often occurs on limbs, and it is hypothesized this is explained by direct exposure to the environment. However, even on exposed areas Buruli ulcer is not randomly distributed. M. ulcerans prefers an in vitro temperature of 30-33°C and growth is inhibited at higher temperatures. This study investigated whether variations in skin surface temperature distribution in healthy volunteers could partly account for Buruli ulcer lesion distribution. METHODOLOGY/PRINCIPAL FINDINGS: In this observational study, a thermal camera (FLIR E8) was used to measure skin surface temperature at the sternal notch and at 44 predetermined locations on the limbs of 18 human participants. Body locations of high, middle and low Buruli ulcer incidence were identified from existing density maps of lesion distribution. Skin temperature of the three incidence location groups were compared, and differences in age and sex groups were also analysed. We found an inverse relationship between skin temperature and lesion distribution, where high incidence locations were significantly cooler and low incidence locations significantly warmer (Kruskal-Wallis test p<0.0001). Linear mixed effects regression analysis estimated that skin surface temperature accounts for 22.0% of the variance in Buruli ulcer lesion distribution (marginal R-squared = 0.219) in the anterior location group, and 0.6% in the posterior group (marginal R-squared 0.006). Men had warmer upper and lower limbs than females (Mann-Whitney U test p = 0.0003 and p<0.0001 respectively). CONCLUSIONS/SIGNIFICANCE: We have found an inverse relationship between skin temperature and Buruli ulcer lesion distribution, however this association is weak. Additional unknown factors are likely to be involved that explain the majority of the variation in Buruli lesion distribution.


Asunto(s)
Úlcera de Buruli/patología , Mycobacterium ulcerans/crecimiento & desarrollo , Piel/patología , Temperatura , Adolescente , Adulto , Anciano , Niño , Femenino , Voluntarios Sanos , Humanos , Masculino , Persona de Mediana Edad , Piel/microbiología , Adulto Joven
12.
Zhonghua Shao Shang Za Zhi ; 36(3): 244-246, 2020 Mar 20.
Artículo en Chino | MEDLINE | ID: mdl-32241051

RESUMEN

The early accurate diagnosis of burn depth is of great significance in determining the corresponding clinical intervention methods and judging the prognosis quality of burn patients. However, the current diagnostic method of burn depth still relies mainly on the empirical subjective judgment of clinicians, with low diagnostic accuracy. Especially for deep partial-thickness burn wounds, the error of early diagnosis is pretty big. In recent years, with the rapid development of artificial intelligence technology, deep learning algorithm combined with image analysis technology can better identify and analyze the information of medical images. This article reviews the research progress of artificial intelligence technology in the diagnosis of burn depth.


Asunto(s)
Inteligencia Artificial , Quemaduras , Quemaduras/diagnóstico , Quemaduras/patología , Diagnóstico Precoz , Humanos , Pronóstico , Piel/patología , Tecnología
14.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239887

RESUMEN

Follicular occlusion triad is a symptom complex of three conditions with a similar pathophysiology including hidradenitis suppurativa (HS), dissecting cellulitis of the scalp, and acne conglobata. Although the exact pathogenesis of the triad is unknown, it appears to be related to follicular occlusion in areas with apocrine glands. Wolf isotopic response refers to the occurrence of a new dermatosis at the site of another, unrelated, previously healed dermatosis. We present a 26-year-old man with a history of pemphigus foliaceus (PF) who developed large draining nodules with scarring and sinus tracts, compatible with follicular occlusion triad, preferentially at areas previously affected by PF thirteen months after treatment with rituximab. To the authors' knowledge there are no reported cases of follicular occlusion triad or HS manifesting as an isotopic response. However, one member of the triad, HS, has been reported to occur infrequently following the use of biologic agents such as adalimumab, infliximab, tocilizumab, and rituximab for chronic immune-mediated inflammatory diseases (psoriasis, Crohn disease, rheumatoid arthritis, and ankylosing spondylitis).


Asunto(s)
Acne Conglobata/inducido químicamente , Celulitis (Flemón)/inducido químicamente , Hidradenitis Supurativa/inducido químicamente , Factores Inmunológicos/efectos adversos , Rituximab/efectos adversos , Acne Conglobata/patología , Acné Vulgar/tratamiento farmacológico , Adulto , Antibacterianos/efectos adversos , Celulitis (Flemón)/patología , Doxiciclina/efectos adversos , Hidradenitis Supurativa/patología , Humanos , Masculino , Pénfigo , Piel/patología
15.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239889

RESUMEN

Transient acantholytic dermatosis (TAD) is a relatively common entity that has been also noted to occur in patients with cancer. Herein, we describe a case of transient acantholytic dermatosis occurring in a patient with a history of prostate cancer status post radiation, now being treated with combination therapy with pembrolizumab and carboplatin-pemetrexed for advanced lung adenocarcinoma. Our case emphasizes the importance of being cognizant of TAD and its associations, particularly in cancer patients.


Asunto(s)
Acantólisis/etiología , Adenocarcinoma/complicaciones , Anticuerpos Monoclonales Humanizados/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Ictiosis/etiología , Neoplasias Pulmonares/complicaciones , Acantólisis/patología , Adenocarcinoma/tratamiento farmacológico , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Carboplatino/administración & dosificación , Diagnóstico Diferencial , Humanos , Ictiosis/patología , Neoplasias Pulmonares/tratamiento farmacológico , Masculino , Pemetrexed/administración & dosificación , Neoplasias de la Próstata/complicaciones , Neoplasias de la Próstata/radioterapia , Piel/patología
16.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239891

RESUMEN

Dermatomyositis is an auto-immune inflammatory myopathy that primarily affects the skin and muscle and can be triggered by exposure to various environmental factors. We present a patient with active syphilis infection who developed dermatomyositis and discuss the significance of anti-NXP2 autoantibody positivity.


Asunto(s)
Adenosina Trifosfatasas/inmunología , Enfermedades Autoinmunes/etiología , Proteínas de Unión al ADN/inmunología , Dermatomiositis/etiología , Piel/patología , Sífilis/complicaciones , Adulto , Autoanticuerpos/sangre , Enfermedades Autoinmunes/patología , Dermatomiositis/inmunología , Dermatomiositis/patología , Humanos , Masculino
17.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239892

RESUMEN

Grover disease (GD) is an acquired, nonfamilial, nonimmune mediated, transient or persistent acantholytic dermatosis. Herein, we present a 72-year-old man who had clinical and histopathologic findings of GD following two weeks of treatment with vemurafenib without MEK inhibitor. The patient was successfully treated with topical emollients and a high-potency corticosteroid. Meanwhile, vemurafenib was temporarily discontinued. Drug-induced GD has increasingly been reported in patients on BRAF inhibitor monotherapy as an immune-related adverse event. The cutaneous side effects seem to arise secondary to a paradoxical activation of the mitogen-activated protein kinase signaling of BRAF inhibitor treatment, leading to keratinocyte proliferation. Although the pathogenesis of GD has not been delineated, there is suggestion of activation of T lymphocytes, particularly helper cells under the action of pro-inflammatory cytokines, resulting in proliferation of keratinocytes. Combination therapy with a MEK inhibitor appears to prevent BRAF-induced GD. Given that there is a higher prevalence of GD in patients with hematologic malignancy, a direct causal relationship between the initiation of vemurafenib therapy and development of GD in this case may be difficult to establish.


Asunto(s)
Acantólisis/inducido químicamente , Ictiosis/inducido químicamente , Leucemia de Células Pilosas/complicaciones , Inhibidores de Proteínas Quinasas/efectos adversos , Vemurafenib/efectos adversos , Acantólisis/patología , Anciano , Biopsia/métodos , Humanos , Ictiosis/patología , Leucemia de Células Pilosas/tratamiento farmacológico , Masculino , Inhibidores de Proteínas Quinasas/uso terapéutico , Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores , Inducción de Remisión , Piel/patología , Vemurafenib/uso terapéutico
18.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239894

RESUMEN

Disseminated herpes simplex virus (HSV) is mainly seen in immunocompromised individuals. Atypical lesions can be present in both primary infection and reactivation disease. Compared with the general population, inmunocompromised hosts are at greater risk of increased persistency and severity of clinical manifestations, including severe systemic involvement such as esophagitis, meningitis, and hepatitis. Herein, we report the case of a liver transplant recipient with atypical disseminated herpes simplex virus-1 complicated by HSV-related hepatitis. Dermatological consultation and histological assessment were crucial for a correct diagnosis and treatment.


Asunto(s)
Hepatitis Viral Humana/virología , Herpes Simple/patología , Herpesvirus Humano 1/aislamiento & purificación , Huésped Inmunocomprometido , Piel/patología , Anticuerpos Antivirales/sangre , Hepatitis Viral Humana/inmunología , Herpesvirus Humano 1/inmunología , Humanos , Trasplante de Hígado , Masculino , Persona de Mediana Edad
19.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239897

RESUMEN

Erythema nodosum (EN) is a form of septal panniculitis, which is believed to represent a delayed hypersensitivity reaction activated by infectious agents, drugs, granulomatous and autoimmune diseases, pregnancy, and malignancies. There are only four reported cases of EN during oral isotretinoin therapy to our knowledge, all of them occurring in patients with severe acne. Since acne itself can trigger EN, the question as to whether there is indeed a causative relationship between isotretinoin and EN in the reported cases remains to be elucidated. We present herein a 20-year-old woman with multiple vulvar condylomata acuminata who developed EN two weeks after onset of oral isotretinoin therapy. To the best of our knowledge, this is the first report of EN occurring during isotretinoin treatment in a patient without acne and strongly indicates that the pathogenesis of EN can be directly related to the biological actions of isotretinoin. Erythema nodosum should be regarded as a rare side effect of oral isotretinoin therapy, regardless of the underlying disease. Physicians should be aware of this rare side effect.


Asunto(s)
Condiloma Acuminado/tratamiento farmacológico , Fármacos Dermatológicos/efectos adversos , Eritema Nudoso/inducido químicamente , Isotretinoína/efectos adversos , Piel/patología , Administración Oral , Biopsia , Fármacos Dermatológicos/uso terapéutico , Eritema Nudoso/patología , Femenino , Seronegatividad para VIH , Humanos , Isotretinoína/uso terapéutico , Adulto Joven
20.
Dermatol Online J ; 26(2)2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-32239899

RESUMEN

Prurigo pigmentosa is a rare inflammatory dermatosis that primarily affects Japanese patients. Various triggers have been identified, including the ketogenic diet. Given the current popularity of the ketogenic diet, the incidence of prurigo pigmentosa may be on the rise. Herein, to the best of our knowledge, we present the first case of prurigo pigmentosa reported in a Hispanic patient in the United States.


Asunto(s)
Dieta Cetogénica/efectos adversos , Hiperpigmentación/etiología , Prurigo/etiología , Piel/patología , Femenino , Humanos , Hiperpigmentación/patología , Prurigo/patología , Adulto Joven
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