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1.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3945-3948, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018863

RESUMEN

Continuous monitoring of cardiac parameters such as blood pressure (BP) and pulse transit time (PTT) from wearable devices can improve the diagnosis and management of the cardiovascular disease. Continuous monitoring of these parameters depends on monitoring arterial pulse wave based on the blood volume changes in the artery using non-invasive sensors such as bio-impedance (Bio-Z). PTT and BP monitoring require the measurement of multiple pulse signals along the artery through the placement of multiple sensors within a small distance. Conventionally, these Bio-Z sensors are excited by a single shared current source, which results in low directivity and distortion of pulse signal due to the interaction of the different sensors together. For a localized pulse sensing, each sensor should focus on a certain point on the artery to provide the most accurate arterial pulse wave, which improves PTT and BP readings. In this paper, we propose a multi-source multi-frequency method for multi-sensor Bio-Z measurement that relies on using separate current sources for each sensor with different frequencies to allow the separation of these signals in the frequency domain, which results in isolation in the spatial domain. The effectiveness of the new method was demonstrated by a reduction in the inter-beat-interval (IBI) root mean square error (RMSE) by 19% and an increase of average PTT by 15% compared to the conventional method.


Asunto(s)
Determinación de la Presión Sanguínea , Pulso Arterial , Presión Sanguínea , Impedancia Eléctrica , Análisis de la Onda del Pulso
2.
Compend Contin Educ Dent ; 41(9): 458-464; quiz 465, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-33001656

RESUMEN

More than 1 billion people worldwide have hypertension. Since the guidelines for classification and treatment of hypertension were updated in 2017 by American College of Cardiology/American Heart Association, it is now estimated that nearly half of the US adult population has hypertension. Hypertension may not show any sign or symptom apart from an elevated blood pressure reading until signs and symptoms of complications occur. Hence, dentists can play a unique role in identifying undiagnosed patients or those with uncontrolled blood pressure levels. This article is intended to provide dental clinicians essential information about hypertension and how the new guidelines affect the classification and treatment of the disease, and it discusses the management of patients with hypertension in the dental office.


Asunto(s)
Hipertensión/complicaciones , Hipertensión/diagnóstico , Hipertensión/terapia , Adulto , Presión Sanguínea , Humanos , Estados Unidos
3.
Khirurgiia (Mosk) ; (9): 38-42, 2020.
Artículo en Ruso | MEDLINE | ID: mdl-33030000

RESUMEN

OBJECTIVE: To report treatment outcomes in patients with congenital aortic arch disease. MATERIAL AND METHODS: There were 65 patients (45 boys and 20 girls) for the period from 2005 to 2019. Mean age of patients was 53±12 days (range 1-98), weight - 3,3±1,3 kg (range 2.2-4.6). All patients were divided into 2 groups depending on the method of surgical repair. The 1st group included 33 patients who underwent patch repair, the 2nd group (n=32) - anastomosis in end-to-side fashion. RESULTS: In group I, recurrent aortic arch coarctation was observed in 16.8% of cases, in group II - only in 4% of cases (p=0.02). Analysis of systolic pressure in both groups revealed that arterial hypertension was detected in 39% of cases in group I and only in 9,1% of cases in group II (p=0,0025). CONCLUSION: Surgical treatment of aortic arch disease using anastomosis in end-to-side fashion is associated with reduced risk of recurrent aortic arch coarctation and residual arterial hypertension in long-term postoperative period.


Asunto(s)
Aorta Torácica , Coartación Aórtica , Anastomosis Quirúrgica , Presión Sanguínea , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Resultado del Tratamiento
7.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2295-2298, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018466

RESUMEN

This paper proposes a novel method to noninvasively measure the peak systolic pressure difference (PSPD) across coarctation of the aorta for diagnosing the severity of coarctation. Traditional non-invasive estimates of pressure drop from the ultrasound can underestimate the severity and invasive measurements by cardiac catheterization can carry risks for patients. To address the issues, we employ computational fluid dynamics (CFD) computation to accurately predict the PSPD across a coarctation based on cardiac magnetic resonance (CMR) imaging data and cuff pressure measurements from one arm. The boundary conditions of a patient-specific aorta model are specified at the inlet of the ascending aorta by using the time-dependent blood velocity, and the outlets of descending aorta and supra aortic branches by using a 3-element Windkessel model. To estimate the parameters of the Windkessel model, steady flow simulations were performed using the time-averaged flow rates in the ascending aorta, descending aorta, and two of the three supra aortic branches. The mean cuff pressure from one arm was specified at the outlet of one of the supra aortic branches. The CFD predicted PSPDs of 5 patients (n=5) were compared with the invasively measured pressure drops obtained by catheterization. The PSPDs were accurately predicted (mean µ=0.3mmHg, standard deviation σ =4.3mmHg) in coarctation of the aorta using completely non-invasive flow and cuff pressure data. The results of our study indicate that the proposed method could potentially replace invasive measurements for estimating the severity of coarctations.Clinical relevance-Peak systolic pressure drop is an indicator of the severity of coarctation of the aorta. It can be predicted without any additional risks to patients using non-invasive cuff pressure and flow data from CMR.


Asunto(s)
Coartación Aórtica , Aorta/diagnóstico por imagen , Coartación Aórtica/diagnóstico por imagen , Velocidad del Flujo Sanguíneo , Presión Sanguínea , Humanos , Hidrodinámica
8.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2561-2564, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018529

RESUMEN

OBJECTIVE: We investigate an optimized non-uniform sampling strategy for blood pressure time series from the operating room (OR). Our aim is to obtain an approximate bound on the achievable reconstruction fidelity given an average sampling rate constraint. METHODS: Our data set consists of 117 hours of recordings of continuous invasive blood pressure from 28 surgery patients. We evaluate the root mean squared error (RMSE) of the zero-order hold sampling reconstruction of the blood pressure time series. We quantitatively compare the errors achieved by uniform versus optimized non-uniform sample placements for several average sample rates, ranging from 2 to 24 measurements per hour. RESULTS: An optimized non-uniform measurement schedule can lead to approximately 50% reduction of reconstruction RMSE for systolic, mean, and diastolic blood pressure time series with respect to uniform sampling, while maintaining the same average sampling rate.


Asunto(s)
Determinación de la Presión Sanguínea , Quirófanos , Presión Sanguínea , Humanos , Manejo de Especímenes , Sístole
9.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2569-2572, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018531

RESUMEN

We assessed the effect of surgical aortic valve replacement (SAVR) on cardiovascular and cerebrovascular controls with particular attention to their complexity and presence of nonlinear behaviors via the analysis of spontaneous variability of heart period (HP), systolic and diastolic arterial pressure (SAP and DAP) and mean cerebral blood flow (MCBF). Variability series were acquired before (PRE) and after (POST) SAVR in 12 patients (age: 76±4.7 yrs, 7 males) at rest in supine position and during active standing. Complexity was assessed via a local nonlinear prediction approach exploiting the k-nearest neighbor strategy. The presence of nonlinear dynamics was checked by comparing the complexity marker computed over the original series with the distribution of values assessed over 100 surrogates preserving distribution and power spectral density of the original series but with random phases. We found that: i) HP variance was significantly reduced in POST; ii) the complexity of SAP and DAP variabilities increased in POST with a greater likelihood of observing nonlinear dynamics over SAP compared to PRE at supine rest; iii) the amplitude of MCBF fluctuations and its complexity in POST remained similar to PRE. SAVR induces important changes of the cardiac and vascular autonomic controls, while cerebrovascular regulation seems to be less affected.


Asunto(s)
Válvula Aórtica , Sistema Cardiovascular , Anciano , Anciano de 80 o más Años , Válvula Aórtica/cirugía , Sistema Nervioso Autónomo , Presión Sanguínea , Frecuencia Cardíaca , Humanos , Masculino
10.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2573-2576, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018532

RESUMEN

This work proposes an empirical mode decomposition (EMD) method to assess the strength of the interactions between heart period (HP) and systolic arterial pressure (SAP) variability. EMD was exploited to decompose the original series (OR) into its first, and fastest, intrinsic mode function (IMF1) and the residual (RES) computed by subtracting the IMF1 from OR. EMD procedure was applied to both HP and SAP variability series. Then, the cross correlation function (CCF) was computed over OR, IMF1 and RES series derived from HP and SAP variability in 13 healthy subjects (age 27±8 yrs, 5 males) at rest in supine position (REST) and during head-up tilt (TILT). The first CCF maximum at negative time lags and the first CCF minimum at positive time lags were taken respectively as indexes of the coupling along the feedback baroreflex and feedforward mechanical arms of HP-SAP closed-loop control. Results showed that the coupling strength is increased during TILT on both arms and this result holds on REST. At REST the coupling along both arms was stronger when computed over IMF1 because interactions were mainly governed by respiration. This result was not observed during TILT possibly due to the reduced importance of respiration compared to other mechanisms acting at slower time scales. The proposed method allowed the investigation of the strength of HP-SAP variability interactions according to the time scales of the physiological mechanisms.The proposed EMD-based method allows the quantification of the strength of the HP-SAP closed-loop variability interactions according to the different time scales of respiration and slower baroreflex-mediated reflexes.


Asunto(s)
Presión Arterial , Barorreflejo , Presión Sanguínea , Corazón , Frecuencia Cardíaca , Masculino
11.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2581-2584, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018534

RESUMEN

The objective of this study was to determine potential effects of Respiratory-gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on cardiac autonomic activity in hypertensive patients.20 hypertensive subjects (57.3±6.2 years; 11 females, 9 males) were randomized to receive either active RAVANS at 25 Hz or sham stimulation for 5 consecutive days and were assessed 5 and 10 days later. Continuous electrocardiogram, pulse rate, and blood pressure signals were collected during 10-minute baseline, 30-minute stimulation, and 10-minute recovery periods for each session. LabChart was used to acquire and process heart rate variability and blood pressure indices. Percent changes of mean values during the recovery period were calculated comparing the final stimulation session and follow-up sessions to the first stimulation session. General linear models were applied to assess the effects of RAVANS on the variables evaluated, considering baseline values and sex as covariates in the models.We found that RAVANS increased high frequency (HF-HRV) power during recovery of the final stimulation session and both follow-up sessions in comparison to sham. RAVANS also lowered heart rate and increased average RR and root mean square of successive RR interval differences (RMSSD) during recovery on the final day of stimulation. No significant effects on blood pressure values were observed during these periods.These results suggest that RAVANS effectively stimulates cardiovagal activity in hypertension, with effects lasting up to 10 days. Future research incorporating larger sample sizes is needed to replicate the effects of RAVANS.Clinical Relevance- This research has implications for potential therapeutic effects of respiratory-gated tVNS on cardiovagal modulation in hypertensive patients.


Asunto(s)
Hipertensión , Estimulación del Nervio Vago , Presión Sanguínea , Femenino , Frecuencia Cardíaca , Humanos , Hipertensión/terapia , Masculino , Frecuencia Respiratoria
12.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2679-2682, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018558

RESUMEN

Pulse transit time (PTT) based continuous cuff-less blood pressure (BP) monitoring has attracted wide interests owing to its potential in improving the control and early prevention for cardiovascular diseases. However, it is still impractical in large-scale clinical application due to the concern of BP measurement accuracy. Since such approach strongly relies on the PTT-BP model under certain theoretical assumptions, the accuracy would be affected by the vessel properties alterations induced by cardiovascular disorders. Atrial fibrillation (AF) is one of the most common cardiac diseases which often coexist with hypertension. The present study sought to examine the Impact of AF on the PTT and BP, validate the capability of PTT based cuff-less methods on AF patients. By investigating the PTT and BP on 74 critically ill patients with AF, we found that parameters including PTT, R-R interval and diastolic BP (DBP) were significantly changed when AF occurs, while the systolic BP (SBP) value and photoplethysmography intensity ratio (PIR) changed little. Further, by performing two cuff-less BP estimation method, we found that the estimated accuracy is decreased on PTT based method when AF occurs, but there is little change on PIR based method. The findings demonstrated that the impact of AF on PTT is significant, which would also influence the PTT-BP relationship. But the PIR would still be a predictive factor for BP estimation for AF patients.


Asunto(s)
Fibrilación Atrial , Fibrilación Atrial/diagnóstico , Presión Sanguínea , Determinación de la Presión Sanguínea , Humanos , Fotopletismografía , Análisis de la Onda del Pulso
13.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2707-2710, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018565

RESUMEN

Pulse wave velocity (PWV) is a function of the artery's material property, and its incremental nature in elastic modulus led to the concept of incremental PWV. Recent advancements in technology paved the way for reliable measurement of the variation in PWV within a cardiac cycle. This change in PWV has shown its potential as a biomarker for advanced cardiovascular diagnostics, screening, and has recently started using as a vascular screening tool and medical device development. In this work, we have demonstrated the concept of inter and intra-cycle variations of PWV with pressure using an excised bovine carotid artery. Results demonstrated that local PWV measured at the foot of the waveform followed the same trend as of the pressure. As the pressure level was increased to 68% across the cycles, resulting PWV increased up to 81%. An exponential PWV-Pressure relationship was obtained, in agreement with the widely used models. The incremental nature of PWV was recorded in a reflection-free region of the pressure pulse wave. This was further demonstrated in continuous pulse cycles with varying pressure ranges, by comparing the PWV values at two fiduciary points selected in the upstroke of the pressure wave. On average, a 48.11% increase in PWV was observed for 31.04% increase in pressure between the selected fiducial points within a pulse cycle. The article concludes, highlighting the clinical significance of incremental PWV.Clinical Relevance- This experimental study supplements the evidence for the incremental nature of PWV within a cardiac cycle, which has the potential for being a biomarker for advanced cardiovascular screening and diagnostics.


Asunto(s)
Arterias Carótidas , Análisis de la Onda del Pulso , Animales , Presión Sanguínea , Arteria Carótida Común , Bovinos , Frecuencia Cardíaca
14.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2711-2714, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018566

RESUMEN

Aortic stiffening is a process that is linked to cardiovascular risk factor increase. Then, aortic stiffness evaluation is considered as a good index of the evolution of pathophysiological situations, including myocardial infarction, heart failure, atherosclerosis or stroke. Today, pulse wave velocity (PWV) measurement is considered as the gold standard for evaluation of arterial stiffness. However, most of the current measurement techniques of PWV consider the time for the blood pressure pulse to propagate through a combined length of arteries and give access to arterial PWV. Therefore, none of the available techniques focuses only on the aorta. In the present context of smart clothes development, Inductive Plethsymography (IP) can be an interesting alternative for aortic PWV measure, since it has recently been shown that combination of thoracic and abdominal IP recordings can give cardiac information. We therefore investigate the potential of IP for aortic PWV measurement. In this preliminary study, a comparative analysis of PWV estimated from IP and PWV evaluated from the arm has been carried out on 11 healthy volunteers. Results show a significant linear correlation between both measures (r = 0.86, p<0.001), promising for future investigations on pathological populations.


Asunto(s)
Análisis de la Onda del Pulso , Rigidez Vascular , Aorta , Presión Sanguínea , Humanos , Pletismografía
15.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2719-2722, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018568

RESUMEN

The major challenges in deep learning approaches to cuffless blood pressure estimation is selecting the most appropriate representative of the blood pulse waveform and extraction of relevant features for data collection. This paper performs an analysis of a novel dataset consisting of 71 features from the carotid dual-diameter waveforms and 4 blood pressure parameters. In particular, the analysis uses gradient boosting and graph-theoretic algorithms to determine (1) features with high predictive power and (2) potential to be pruned. Identifying such features and understanding their physiological significance is important for building blood pressure estimation models using machine learning that is robust across diverse clinical environments and patient sets.


Asunto(s)
Algoritmos , Determinación de la Presión Sanguínea , Presión Sanguínea , Frecuencia Cardíaca , Humanos , Aprendizaje Automático
16.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2723-2727, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018569

RESUMEN

Central aortic blood pressure (CABP) is a very-well recognized source of information to asses the cardiovascular system conditions. However, the clinical measurement protocol of this pulse wave is very intrusive and burdensome as it requires expert staff and complicated invasive settings. On the other hand, the measurement of peripheral blood pressure is much more straightforward and easy-to-get non-invasively. Several mathematical tools have been employed in the past few decades to reconstruct CABP waveforms from distorted peripheral pressure signals. More specifically, the cross-relation approach together with the widely used least-squares method, are shown to be effective as a way to estimate CABP waves. In this paper, we propose an improved cross-relation method that leverages the values of the diastolic and systolic pressures as box constraints. In addition, a mean-matching criterion is introduced to relax the need for the input and output mean values to be strictly equal. Using the proposed method, the root mean squared error is reduced by approximately 20% while the computational complexity is not significantly increased.


Asunto(s)
Aorta , Determinación de la Presión Sanguínea , Presión Sanguínea , Humanos , Análisis de los Mínimos Cuadrados , Reproducibilidad de los Resultados
17.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 2784-2787, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018584

RESUMEN

We present an approach to quantifying nocturnal blood pressure (BP) variations that are elicited by sleep disordered breathing (SDB). A sample-by-sample aggregation of the dynamic BP variations during normal breathing and BP oscillations prompted by apnea episodes is performed. This approach facilitates visualization and analysis of BP oscillations. Preliminary results from analysis of a full night study of 7 SDB subjects (5 Male 2 Female, 52±5.6 yrs., Body Mass Index 36.4±7.4 kg/m2, Apnea-Hypopnea Index 69.1±26.8) are presented. Aggregate trajectory and quantitative values for changes in systolic blood pressure (SBP) and diastolic blood pressure (DBP) concomitant with obstructive apnea episodes are presented. The results show 19.4 mmHg (15.3%) surge in SBP and 9.4 mmHg (13.6%) surge in DBP compared to their respective values during normal breathing (p<0.05). Further, the peak of the surge in SBP and DBP occurred about 9s and 7s, respectively, post the end of apnea events. The return of SBP and DBP to baseline values displays a decaying oscillatory pattern.


Asunto(s)
Hipertensión , Síndromes de la Apnea del Sueño , Presión Sanguínea , Determinación de la Presión Sanguínea , Femenino , Humanos , Hipertensión/diagnóstico , Masculino , Polisomnografía , Síndromes de la Apnea del Sueño/diagnóstico
18.
Medicine (Baltimore) ; 99(40): e22432, 2020 Oct 02.
Artículo en Inglés | MEDLINE | ID: mdl-33019423

RESUMEN

Nesfatin-1 was identified as a satiety factor involved in the regulation of metabolism. Altered levels of circulating nesfatin-1 had been observed in a variety of diseases characterized by energy imbalance. However, there was no published data about nesfatin-1 levels in acromegaly.We evaluated serum nesfatin-1 levels in 13 patients with acromegaly at baseline and postoperatively, and in 21 age- and body mass index (BMI)-matched healthy subjects.Compared with the healthy subjects, patients with acromegaly had significantly increased levels of serum insulin, high-density lipoprotein cholesterol, triglyceride, and growth hormone (GH). Moreover, the acromegaly group had nesfatin-1 levels higher than controls (1.96 ±â€Š0.56 ng/mL vs 0.61 ±â€Š0.10 ng/mL, P = .004). There was a positive correlation of serum nesfatin-1 levels with diastolic blood pressure (r = 0.579, P = .038) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.598, P = .031) in patients with acromegaly. While a successful surgery decreased serum GH levels, the serum nesfatin-1 levels did not change in acromegaly (P = .965). At last, we compared serum GH/nesfatin-1 levels with predictive markers for aggressive behaviors in pituitary adenomas. There was no relationship between serum nesfatin-1 levels and tumor's size, Ki-67 index, mutant p53, or MGMT proteins. However, increased serum GH levels were positively correlated with tumors' size (P = .023) and mutant p53 proteins expression (P = .028).Circulating nesfatin-1 was increased in acromegaly, which was involved in metabolism regulation.


Asunto(s)
Acromegalia/sangre , Nucleobindinas/sangre , Adenoma/sangre , Adenoma/patología , Adenoma/cirugía , Adulto , Presión Sanguínea , Estudios de Casos y Controles , Femenino , Hormona de Crecimiento Humana/sangre , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Hipofisarias/sangre , Neoplasias Hipofisarias/patología , Neoplasias Hipofisarias/cirugía , Curva ROC
19.
Medicine (Baltimore) ; 99(40): e22436, 2020 Oct 02.
Artículo en Inglés | MEDLINE | ID: mdl-33019425

RESUMEN

In addition to governing key functions in bone metabolism and the immune system, the RANK/RANKL/OPG system plays a role in the vascular system, particularly in vascular calcification and atherosclerosis.Given that these 2 phenotypes are considered a major cause of high blood pressure (BP), in this study we analyzed the association of SNPs in RANK and OPG genes with blood pressure. An observational study was conducted of 2 SNPs in the RANK gene (rs884205 and rs78326403) and 1 in the OPG gene (rs4876869) with systolic (SBP) and diastolic blood pressure (DBP) in a cohort of 695 women.Data analysis revealed a statistically significant association between the SNP rs884205 and BP pressure (SBP and DBP). Analyzing this relationship by the dominant inheritance model for this SNP (allele risk: A), women of the AA/AC genotype showed higher BP than women of the CC genotype, both for SBP (P = .001) and for DBP (P = .003), and these associations both surpassed the Bonferroni threshold for multiple comparisons. Multivariate regression analysis including known predictors of BP as independent variables was performed to evaluate the strength of this association, which in the case of the SNP rs884205 of the RANK gene remained statistically significant after adjustment for both SBP (P = .0006) and DBP (P = .005), demonstrating the key role of this SNP in BP.We report a robust association between the SNP rs884205 in RANK gene and BP in women, and this SNP is validated as a candidate in cardiovascular risk studies.


Asunto(s)
Presión Sanguínea/genética , Receptor Activador del Factor Nuclear kappa-B/sangre , Femenino , Estudio de Asociación del Genoma Completo , Humanos , Persona de Mediana Edad , Osteoprotegerina/sangre , Polimorfismo de Nucleótido Simple , España
20.
Vestn Oftalmol ; 136(5): 103-108, 2020.
Artículo en Ruso | MEDLINE | ID: mdl-33056970

RESUMEN

Primary open-angle glaucoma is a major cause of irreversible blindness in all countries of the world. The pathogenesis of primary open-angle glaucoma has not been resolved. In addition to increased intraocular pressure, pathogenetic factors of this disease such as reduced systemic blood pressure, deterioration of ocular blood flow, as well as vascular dysregulation, reperfusion damage and oxidative stress of ocular tissues are now generally recognized. The role of α1-adrenoreceptors in regulation of, for example, ocular blood flow, blood flow in the retina, permeability of the vascular wall etc has already been described. PURPOSE: To identify the effects of different subtypes of α1-adrenoreceptors on the level of systemic blood pressure in laboratory mice. MATERIAL AND METHODS: Features of blood pressure of 36 laboratory mice older than 18 months having a genetic defect (lines ADRA-1A, ADRA-1D and ADRA-1D) of one of the subtypes of α1-adrenoreceptors (α1a, α1b, α1d) were studied. The control group included ten healthy laboratory mice of the same age. The blood pressure of mice was measured with modern high-precision and noninvasive method using the CodaTM Standard system (Kent Scientific Corporation, U.S.A.). RESULTS: The mice of the ADRA-1A line were revealed to have reduced systolic and diastolic blood pressure and maximum level of pulse pressure, as well as the greatest fluctuations of pulse pressure; for the ADRA-1B line - the highest levels of systolic and diastolic blood pressure; for the ADRA-1D line - the smallest systolic and diastolic blood pressure and the minimum values of pulse pressure. CONCLUSION: The obtained results show the specific contribution of α1a, α1b and α1d subtypes of the adrenoreceptors in the maintenance of normal hemodynamic of an organism, which should be considered when studying pathogenesis of primary open-angle glaucoma.


Asunto(s)
Glaucoma de Ángulo Abierto , Glaucoma , Animales , Presión Sanguínea , Ojo , Glaucoma de Ángulo Abierto/genética , Ratones , Receptores Adrenérgicos alfa 1/genética
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