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1.
Food Chem ; 334: 127498, 2021 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-32688179

RESUMEN

In this work, ultrasound-assisted enzymatic extraction (UAEE) conditions of umami compounds from Labeo rohita head (LRH) was optimised using the combination of fractional factorial design (FFD) and central composite design (CCD). Six factors that can potentially influence the degree of hydrolysis (DH), equivalent umami concentration (EUC), and extraction yield (EY) of umami extract were screened through FFD. The three most significant variables were further optimised using the CCD. The developed models were successfully fitted to the experimental data and used to determine optimal extraction conditions. The optimum DH (22.73%), EUC (6.61 g MSG/100 g protein), and EY (76.34%) of umami extract were achieved with a liquid-solid ratio of 3 (v/w), ultrasonication time of 19.20 min and hydrolysis time of 140.45 min. Besides, UAEE umami extract exhibited higher DH, EUC, EY, and umami taste compared to that of the conventional enzymatic extraction (CEE).


Asunto(s)
Productos Pesqueros/análisis , Sonicación , Aminoácidos/análisis , Animales , Cromatografía Líquida de Alta Presión , Cyprinidae , Proteínas de Peces/metabolismo , Hidrólisis , Proyectos de Investigación
2.
BMC Psychol ; 8(1): 113, 2020 Oct 31.
Artículo en Inglés | MEDLINE | ID: mdl-33129350

RESUMEN

BACKGROUND: The aim of this study was to investigate the relationship between executive function (EF), stuttering, and comorbidity by examining children who stutter (CWS) and children who do not stutter (CWNS) with and without comorbid conditions. Data from the National Health Interview Survey were used to examine behavioral manifestations of EF, such as inattention and self-regulation, in CWS and CWNS. METHODS: The sample included 2258 CWS (girls = 638, boys = 1620), and 117,725 CWNS (girls = 57,512; boys = 60,213). EF, and the presence of stuttering and comorbid conditions were based on parent report. Descriptive statistics were used to describe the distribution of stuttering and comorbidity across group and sex. Regression analyses were to determine the effects of stuttering and comorbidity on EF, and the relationship between EF and socioemotional competence. RESULTS: Results point to weaker EF in CWS compared to CWNS. Also, having comorbid conditions was also associated with weaker EF. CWS with comorbidity showed the weakest EF compared to CWNS with and without comorbidity, and CWS without comorbidity. Children with stronger EF showed higher socioemotional competence. A majority (60.32%) of CWS had at least one other comorbid condition in addition to stuttering. Boys who stutter were more likely to have comorbid conditions compared to girls who stutter. CONCLUSION: Present findings suggest that comorbidity is a common feature in CWS. Stuttering and comorbid conditions negatively impact EF.


Asunto(s)
Función Ejecutiva , Tartamudeo/epidemiología , Niño , Preescolar , Cognición , Comorbilidad , Femenino , Humanos , Masculino , Proyectos de Investigación , Habla
3.
Georgian Med News ; (306): 46-51, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33130645

RESUMEN

Generalized parodontal diseases (GPD) consistently occupy one of the leading places in the structure of dental diseases. Early diagnosis of the initial degree of generalized parodontitis (GP) is an effective way of secondary prevention. This is due to the complexity of understanding the etio-pathogenetic mechanisms of the development generalized parodontal diseases (GPD) and the high association of them with a number of diseases of the internal organs and systems with common points of contact between interdependence and mutual influence, in particular with anorexia nervosa (AN). The aim of this research was to develop a protocol for the treatment of GP in patients with AN. The object - 60 patients (mean age 26±3.8 years), with a diagnosis of GP, I-II degree, chronic, and AN, restrictive, which by simple randomization were divided into three groups (randomized by sex, age of patients, underlying and comorbidy diagnosis) to study the clinical effectiveness of our proposed method. Clinical, radiological, hygienic, immunological, biochemical, psychological and statistical methods were used. Conclusions. Thus, as a result of the proposed treatment protocol, the largest number of satisfactory treatment results was observed in group III patients (85.0±8.0%) with the inclusion of drugs that affect the pathogenetic mechanisms of the disease, including normalization of local immunity, markers of decline oxidative-antioxidant stress, radiological data of normalization of bone tissue of the alveolar process, a tendency to reduce microbial and tissue sensitization.


Asunto(s)
Anorexia Nerviosa , Periodontitis , Adulto , Anorexia Nerviosa/complicaciones , Anorexia Nerviosa/terapia , Protocolos Clínicos , Humanos , Periodontitis/complicaciones , Proyectos de Investigación , Resultado del Tratamiento , Adulto Joven
4.
Medicine (Baltimore) ; 99(45): e22017, 2020 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-33157910

RESUMEN

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 viral infection resulting in corona virus disease 2019 (COVID-19) disease has recently been designated by the World Health Organization as a global pandemic. Some doctors are using convalescent plasma (CP) therapies to treat COVID-19 patients. However, whether CP therapy is effective for children with COVID-19 remains controversial. Therefore, this study further explores the effectiveness and safety of human coronavirus immune CP in the treatment of COVID-19 in children. METHODS: Comprehensively search the electronic databases such as the Cochrane Library, PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, and WanFang, and collect relevant documents. We will also look for other sources. All document sources will not be restricted by language and publication status. Two researchers will independently conduct research selection, data extraction and research quality assessment. RevMan 5.3 was used for statistical analysis. RESULTS: This study will provide high-quality comprehensive evidence for the effectiveness and safety of human coronavirus immuno CP in the treatment of COVID-19 in children CONCLUSIONS:: The results of this study will provide the basis for the effectiveness and safety of human coronavirus immuno CP treatment of COVID-19 in children. PROSPERO REGISTRATION NUMBER: CRD42020199410.


Asunto(s)
Infecciones por Coronavirus/terapia , Neumonía Viral/terapia , Betacoronavirus , Niño , Niño Hospitalizado , Humanos , Inmunización Pasiva , Metaanálisis como Asunto , Pandemias , Proyectos de Investigación , Revisiones Sistemáticas como Asunto
5.
Medicine (Baltimore) ; 99(45): e23015, 2020 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-33157948

RESUMEN

INTRODUCTION: The World Health Organization announce that novel coronavirus (COVID-19) is pandemic worldwide on March 11, 2020. In this pandemic, cancer patients are prone to become critically ill after being infected with COVID-19 due to special immune conditions, and cannot effectively benefit from the treatment plan designed for normal people. However, only a few literatures report the differences between cancer patients and normal people after being infected with COVID-19. There is no systematic review to evaluate the clinical, inflammatory, and immune differences between COVID-19 patients with and without cancer. The systematic review aims to summarize and analyze the clinical, inflammatory, and immune differences between them. METHODS AND ANALYSIS: We plan to conduct a systematic review according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) guidelines. Several databases (PubMed/MEDLINE, Embase, Web of Science, The Cochrane Library, CNKI, CBM, VIP, WanFang) were searched for relevant eligible observational studies on COVID-19 patients with cancer published from December 2019 to September 2020. Two researchers (Y.ZY and W.PP) will independently complete search strategy formulation, literature selecting, Information extraction, data collation, and quality assessment. The primary outcome will be the clinical characteristics differences between COVID-19 patients with and without cancer. Secondary outcomes will include immune function regulation characteristics such as T cell subset status, inflammation and other factors for COVID-19 patients with cancer. We intend to perform a meta-analysis of studies calculating odds ratio differences (Hedge g) for comparison in Forest plots and subgroup analysis after assessment of heterogeneity using I statistics based on compatibility on the basis of population and outcomes. ETHICS AND DISSEMINATION: We will use the information from published researches with no need for ethical assessment. Our findings will be published in a peer-reviewed journal according to the PRISMA guidelines. PROSPERO REGISTRATION NUMBER: CRD42020204417.


Asunto(s)
Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/inmunología , Neoplasias/complicaciones , Neumonía Viral/diagnóstico , Neumonía Viral/inmunología , Betacoronavirus , Humanos , Metaanálisis como Asunto , Estudios Observacionales como Asunto , Pandemias , Proyectos de Investigación , Revisiones Sistemáticas como Asunto
6.
Medicine (Baltimore) ; 99(45): e23044, 2020 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-33157957

RESUMEN

BACKGROUND: A new type of coronavirus (COVID-19), is spreading all over the world. Under the background of the comprehensive medical treatment and strict prevention and control in China, the number of discharged patients increased substantially. By the end of July, more than 80,000 patients had been cured and discharged from hospital in China. In order to effectively promote the full recovery of the patient's physical and mental functions and quality of life, gradually shift the emphasis of clinical work to convalescence therapy is very important, thus Chinese experts draw up Expert Consensus on Rehabilitation of Chinese Medicine for COVID-19. This systematic review and meta-analysis will assess studies of the effects of traditional Chinese exercise (TCE) for COVID-19 patients. METHODS AND ANALYSIS: We will search 6 English and 4 Chinese databases by 01, December 2020. After a series of screening, Randomized Clinic Trials (RCTs) will be included related to TCE for COVID-19. Two assessors will use the Cochrane bias risk assessment tool to assess the RCTs. Finally, the evidence grade of the results will be evaluated. RESULTS: This study will provide a reliable evidence for the selection of TCE therapies for COVID-19. CONCLUSION: The results of this study will provide references for the selection of TCE treatment for COVID-19, and provide decision making references for clinical research. PROSPERO REGISTRATION NUMBER: CRD42020179095.


Asunto(s)
Infecciones por Coronavirus/rehabilitación , Terapia por Ejercicio , Neumonía Viral/rehabilitación , Betacoronavirus , Humanos , Metaanálisis como Asunto , Pandemias , Qigong , Ensayos Clínicos Controlados Aleatorios como Asunto , Proyectos de Investigación , Revisiones Sistemáticas como Asunto , Tai Ji
7.
Syst Rev ; 9(1): 256, 2020 11 04.
Artículo en Inglés | MEDLINE | ID: mdl-33148320

RESUMEN

BACKGROUND: The COVID-19 pandemic has created a sense of urgency in the research community in their bid to contribute to the evidence required for healthcare policy decisions. With such urgency, researchers experience methodological challenges to maintain the rigour and transparency of their work. With this in mind, we offer reflections on our recent experience of undertaking a rapid Cochrane qualitative evidence synthesis (QES). METHODS: This process paper, using a reflexive approach, describes a rapid QES prepared during, and in response to, the COVID-19 pandemic. FINDINGS: This paper reports the methodological decisions we made and the process we undertook. We place our decisions in the context of guidance offered in relation to rapid reviews and previously conducted QESs. We highlight some of the challenges we encountered in finding the balance between the time needed for thoughtfulness and comprehensiveness whilst providing a rapid response to an urgent request for evidence. CONCLUSION: The need for more guidance on rapid QES remains, but such guidance needs to be based on actual worked examples and case studies. This paper and the reflections offered may provide a useful framework for others to use and further develop.


Asunto(s)
Infecciones por Coronavirus , Toma de Decisiones , Medicina Basada en la Evidencia , Pandemias , Neumonía Viral , Edición , Proyectos de Investigación , Literatura de Revisión como Asunto , Betacoronavirus , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/virología , Exactitud de los Datos , Humanos , Neumonía Viral/epidemiología , Neumonía Viral/virología , Investigación Cualitativa
8.
Medicine (Baltimore) ; 99(45): e23054, 2020 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-33157960

RESUMEN

BACKGROUND: A growing number of studies have suggested that the Long intergenic noncoding RNA 00511 (LINC00511) is aberrantly expressed in multiple malignancies and is related to patient survival. Herein, we conducted a systematic review and meta-analysis to comprehensively evaluate the prognostic significance of LINC00511 in human malignancies. METHODS: Eligible studies published by March 11, 2020 were identified in 4 electronic databases including PubMed, EMBASE, Web of Science, and the Chinese National Knowledge Infrastructure. Hazard ratios and 95% confidence intervals (CIs) were used to evaluate the prognostic significance of LINC00511 expression in malignant tumors. The association between LINC00511 expression and cancer clinicopathologic features were assessed using Odds ratios (ORs) and CIs. RESULTS: A total of 13 studies, comprising 1,053 patients, were included in the meta-analysis. The calculated hazard ratio was 2.00 (95% CI: 1.59-2.52, P < .000), suggesting that higher LINC00511 expression could predict poorer overall survival in patients with malignancies. Additionally, our statistical analysis indicated that elevated LINC00511 expression closely associated with bigger tumors (OR = 2.92, 95% CI 1.65-5.18, P < .000), higher incidence of lymph node metastasis (OR = 3.46, 95% CI 2.11-5.66, P < .000) and distant metastasis (OR = 2.40, 95% CI 1.14-5.05, P = .02), poorer differentiation (OR = 1.55, 95% CI 1.11-2.16, P = .01), as well as more advanced TNM stage (OR = 3.90, 95% CI 2.70-5.63, P < .000). CONCLUSIONS: High LINC00511 expression may predict unfavorable prognosis in patients with malignancies. It should be further explored as a potential prognostic and therapeutic biomarker for human cancer.


Asunto(s)
Metástasis Linfática/genética , Neoplasias/genética , ARN Largo no Codificante/genética , China/epidemiología , Bases de Datos Factuales , Femenino , Humanos , Masculino , Estadificación de Neoplasias/métodos , Neoplasias/mortalidad , Pronóstico , Proyectos de Investigación , Tasa de Supervivencia
9.
Rev Esp Salud Publica ; 942020 Nov 03.
Artículo en Español | MEDLINE | ID: mdl-33140740

RESUMEN

OBJECTIVE: The health crisis caused by COVID-19 required the prompt launch of research in order to generate scientific evidence pertaining to the new disease oriented to control its devastating effects and continuous spread. Therefore, it was essential to adapt the work flow of Research Ethics Committees, to prioritize and to accelerate the evaluation of projects related to this disease. METHODS: This work analyses the evaluation conducted by our Regional Ethics Committees during the initial period of the health emergency (between 13th March and 28th May 2020). RESULTS: 81 research projects were evaluated, 73 of them of regional scope (62 single-centre), 4 national and 4 international. 57 projects obtained a favourable opinion, 4 were withdrawn by the sponsors, 6 did not require ethics approval and 14 did not respond to the clarifications requested up to the date of the study's closure. CONCLUSIONS: The most important research procedures to be analysed in this context are those related to the methodology and informed consent process. It is also essential to address aspects related to the privacy of personal data, and to take into account the workload of the researchers. As an improvement proposal, we think that greater collaboration between the different research teams should be encourage to obtain more robust results.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Comités de Ética en Investigación , Neumonía Viral/epidemiología , Proyectos de Investigación/normas , Flujo de Trabajo , Betacoronavirus , Humanos , Consentimiento Informado , Pandemias , España
10.
Zhongguo Zhong Yao Za Zhi ; 45(18): 4500-4509, 2020 Sep.
Artículo en Chino | MEDLINE | ID: mdl-33164381

RESUMEN

Network Meta-analysis has been widely applied in the field of traditional Chinese medicine(TCM) due to its unique advantages. This study aimed to conduct a visual analysis on the state of the application network Meta-analysis in the field of traditional Chinese medicine. Databases of CNKI and Web of Science were retrieved to identify the qualified literatures and then screen out their titles and abstracts. Institutions, authors, cited references, and keywords were analyzed using the information visualization analysis software CiteSpace. Finally, 79 English and 186 Chinese articles were included. The results indicated that the literatures were mainly published in Chinese, and the number of articles was increased rapidly since 2015. Cooperation between institutions and authors were mainly concentrated inside the institutions. The most important four institutions were four universities who attached more importance to evidence-based medical education and academic exploration. The keywords beside the method of network Meta-analysis could be summarized into three types: the main interventions in traditional Chinese medicine(Chinese herbal injection, herb medicine, acupuncture, etc.), disease types(cancer, circulatory system disease, bone joint disease, urinary system disease, etc.) and the outcome of interests(efficacy, safety, symptom, survive, mortality, etc.), which reflected the current research hotspots to certain extent. In addition, the most cited articles were methodology articles, including the introduction of methodology and the guides of application software, suggesting that the exploration of methodological articles will be extremely concerned.


Asunto(s)
Terapia por Acupuntura , Medicamentos Herbarios Chinos , Medicina China Tradicional , Metaanálisis en Red , Publicaciones , Proyectos de Investigación
11.
Zhongguo Zhong Yao Za Zhi ; 45(17): 4081-4088, 2020 Sep.
Artículo en Chino | MEDLINE | ID: mdl-33164392

RESUMEN

Jiuniucao in Qizhou, known as "Qiai", was precious and expensive in the Ming and Qing Dynasties. But the authentic plant of Jiuniucao is not mentioned in the Ben Cao Tu Jing and other medical books in the Song, Ming and Qing Dynasties. In history, mugwort leaf originates from many species of plants, Jiuniucao may be one of it. So this paper is to identify the original plant of Jiuniucao and clarify the historical origin of Jiuniucao and mugwort leaf. The textual research and geographical origin analysis of Jiuniucao in ancient literature was conducted. Then field investigation and sampling of Jiuniucao in Qizhou was proceeded, combing with feature comparison of Jiuniucao and Artemisia specimen in the Herbarium of Institute of Botany, Chinese Academy of Sciences. The study concluded that A. stolonifera is the authentic Jiuniucao for medical use. Jiuniucao was also an important original plant of mugwort leaf and it is worth further development and utilization.


Asunto(s)
Artemisia , Medicamentos Herbarios Chinos , Libros , China , Humanos , Medicina China Tradicional , Proyectos de Investigación
12.
Hist Philos Life Sci ; 42(4): 53, 2020 Nov 03.
Artículo en Inglés | MEDLINE | ID: mdl-33141370

RESUMEN

The SARS-CoV-2 pandemic constituted a crisis situation in which science was very far from Kitcher's ideal of well-ordered science. I suggest that this could and should have been different. Kitcher's ideal should play a role in assessing the allocation of research resources in future crisis situations, as it provides a way to balance highly divergent interests and incorporate the common good into decision-making processes on research.


Asunto(s)
Infecciones por Coronavirus/prevención & control , Pandemias/prevención & control , Neumonía Viral/prevención & control , Proyectos de Investigación , Investigación/organización & administración , Betacoronavirus/fisiología , Infecciones por Coronavirus/epidemiología , Humanos , Neumonía Viral/epidemiología
13.
F1000Res ; 9: 1109, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33149899

RESUMEN

Global health pandemics, such as coronavirus disease 2019 (COVID-19), require efficient and well-conducted trials to determine effective interventions, such as treatments and vaccinations. Early work focused on rapid sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequent in-vitro and in-silico work, along with greater understanding of the different clinical phases of the infection, have helped identify a catalogue of potential therapeutic agents requiring assessment. In a pandemic, there is a need to quickly identify efficacious treatments, and reject those that are non-beneficial or even harmful, using randomised clinical trials. Whilst each potential treatment could be investigated across multiple, separate, competing two-arm trials, this is a very inefficient process. Despite the very large numbers of interventional trials for COVID-19, the vast majority have not used efficient trial designs. Well conducted, adaptive platform trials utilising a multi-arm multi-stage (MAMS) approach provide a solution to overcome limitations of traditional designs. The multi-arm element allows multiple different treatments to be investigated simultaneously against a shared, standard-of-care control arm. The multi-stage element uses interim analyses to assess accumulating data from the trial and ensure that only treatments showing promise continue to recruitment during the next stage of the trial. The ability to test many treatments at once and drop insufficiently active interventions significantly speeds up the rate at which answers can be achieved. This article provides an overview of the benefits of MAMS designs and successes of trials, which have used this approach to COVID-19. We also discuss international collaboration between trial teams, including prospective agreement to synthesise trial results, and identify the most effective interventions. We believe that international collaboration will help provide faster answers for patients, clinicians, and health care systems around the world, including for future waves of COVID-19, and enable preparedness for future global health pandemics.


Asunto(s)
Ensayos Clínicos Adaptativos como Asunto , Infecciones por Coronavirus , Pandemias , Neumonía Viral , Proyectos de Investigación , Betacoronavirus , Humanos
14.
PLoS One ; 15(11): e0242131, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33147603

RESUMEN

Social distancing resulting from the new coronavirus (SARS-CoV2) has disrupted the airplane boarding process. Social distancing norms reduce airplane capacity by keeping the middle seats unoccupied, while an imposed aisle social distance between boarding passengers slows the boarding. Recent literature suggests the Reverse Pyramid boarding method is a promising way to reduce health risk and keep boarding times low when 10 apron buses (essentially 10 boarding groups) are used to transport passengers from the airport terminal to a two-door airplane. We adapt the Reverse Pyramid method for social distancing when an airplane is boarded using a jet bridge that connects the terminal the airplane's front door. We vary the number of boarding groups from two to six and use stochastic simulation and agent-based modelling to show the resulting impact on four performance evaluation metrics. Increasing the number of boarding groups from two to six reduces boarding time only up to four groups but continues to reduce infection risk up to six groups. If the passengers carry fewer luggage aboard the airplane, health risks (as well as boarding times) decrease. One adaptation of the Reverse Pyramid (RP) method (RP-Spread) provides slightly faster boarding times than the other (RP-Steep), when luggage volumes are high, while RP-Steep results in less risk to window seat passengers from later-boarding passengers walking by their row. Increasing the minimum aisle social distance from 1 m to 2 m increases boarding times but results in lower health risks to passengers walking down the aisle and to the previously seated passengers they pass.


Asunto(s)
Aeronaves , Infecciones por Coronavirus/prevención & control , Pandemias/prevención & control , Neumonía Viral/prevención & control , Distancia Social , Viaje en Avión , Simulación por Computador , Aglomeración , Humanos , Proyectos de Investigación , Factores de Tiempo , Caminata
15.
Recurso Educacional Abierto en Portugués | CVSP - Regional | ID: oer-3906

RESUMEN

Esta aula faz parte da sessão tira duvidas realizada no 5 Encontro da Rede de Referencistas - RefNet


Asunto(s)
Proyectos de Investigación , Bibliotecas Digitales
16.
Artículo en Inglés | MEDLINE | ID: mdl-33050203

RESUMEN

This study reports on a systematic review of the published literature used to reveal the current research investigating the hospitality industry in the face of the COVID-19 pandemic. The presented review identified relevant papers using Google Scholar, Web of Science, and Science Direct databases. Of the 175 articles found, 50 papers met the predefined inclusion criteria. The included papers were classified concerning the following dimensions: the source of publication, hospitality industry domain, and methodology. The reviewed articles focused on different aspects of the hospitality industry, including hospitality workers' issues, loss of jobs, revenue impact, the COVID-19 spreading patterns in the industry, market demand, prospects for recovery of the hospitality industry, safety and health, travel behavior, and preference of customers. The results revealed a variety of research approaches that have been used to investigate the hospitality industry at the time of the pandemic. The reported approaches include simulation and scenario modeling for discovering the COVID-19 spreading patterns, field surveys, secondary data analysis, discussing the resumption of activities during and after the pandemic, comparing the COVID-19 pandemic with previous public health crises, and measuring the impact of the pandemic in terms of economics.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Industrias , Pandemias , Neumonía Viral/epidemiología , Restaurantes , Humanos , Proyectos de Investigación
17.
Folia Biol (Praha) ; 66(3): 86-90, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33069187

RESUMEN

Covid-19 or SARS-CoV-2, a new RNA virus with high infectivity, and seemingly low mutability, which appeared in 2019 in the Wuhan province of China, has created a pandemic with dire consequences. At the end of May 2020, it became the first cause of mortality. As no treatment or vaccine may become available before many months, and because occurrence of similar pandemics is only a matter of time, arguments are presented here for testing the effect of transfer factor (TF), an immunomodulator devoid of toxicity, which has been extensively studied in the past for the treatment and prevention of viral infections.


Asunto(s)
Infecciones por Coronavirus/inmunología , Infecciones por Coronavirus/terapia , Neumonía Viral/inmunología , Neumonía Viral/terapia , Factor de Transferencia/uso terapéutico , Adyuvantes Inmunológicos/uso terapéutico , Animales , Betacoronavirus , Humanos , Pandemias , Proyectos de Investigación
18.
Medicine (Baltimore) ; 99(42): e22734, 2020 Oct 16.
Artículo en Inglés | MEDLINE | ID: mdl-33080732

RESUMEN

BACKGROUND: Postmenopausal osteoporosis (PMOP) is the focus and difficult problem in the world at present, and we found that Chinese patent medicine(CPM) shown a more miraculous effect. Many kinds of Chinese patent medicine have been proved to be effective in the treatment of this disease, but it is still unclear which kind of Chinese patent medicine has the best effect. Therefore, we propose a network meta-analysis (NMA) protocol to observe the efficacy of various CPM for this disease and provide guidance for clinical practice. METHODS: We will use the NMA method to complete this study. First, all the randomized controlled trials of CPM or CPM combined with western medicine in the treatment of PMOP were collected by searching all online Chinese and English databases. The information time limit is from the establishment of the database to August 30, 2020. Then 2 staff members will sift through all the literature and analyze the data using Stata and Winbugs. RESULTS: Through this analysis, we will observe and rank the clinical effects of different CPM for PMOP. The main evaluation indexes include: New fracture, Quality of life, Severe side effects, Death from all causes. Secondary outcome indicators include Bone Mineral density, clinical efficiency, and some laboratory indicators, such as estradiol, serum calcium, serum, etc. CONCLUSION:: This study will rank the therapeutic effects of various proprietary Chinese medicines in the treatment of PMOP, which will be helpful in improving the PMOP treatment regimen.INPLASY registration number: INPLASY202090047.


Asunto(s)
Medicina China Tradicional , Metaanálisis como Asunto , Medicamentos sin Prescripción/uso terapéutico , Osteoporosis Posmenopáusica/tratamiento farmacológico , Revisiones Sistemáticas como Asunto , Femenino , Humanos , Metaanálisis en Red , Proyectos de Investigación
19.
Medicine (Baltimore) ; 99(42): e22737, 2020 Oct 16.
Artículo en Inglés | MEDLINE | ID: mdl-33080733

RESUMEN

BACKGROUND: Allergic rhinitis (AR), characterized by nasal itching, sneezing, and congestion, is a common disorder of nose. In the United States, AR affects 10% to 20% of adults. The negative impact of the high prevalence of AR has caused a great economic burdens worldwide. Modern Western Medicine mainly treats AR with antihistamine drugs, glucocorticoids, allergic immunotherapy (AIT), but it seriously affects patients compliance because of its long course of treatment, high medical costs and side effect. And now, as an important mean of treating AR, acupoint injection has been widely used in clinics, and has achieved significant efficacy. METHODS AND ANALYSIS: The following databases will be searched for relevant information before July 2020: PubMed, Embase, Cochrane Library, Web of Science, and CNKI. MAJOR RESULTS: scores of Rhinitis Quality of Life (RQLQ), Rhinitis Total Symptom Scores (RTSS). Secondary results: levels of antigen-specific serum immunoglobulin E (IgE), total effective rate, adverse event. Data will be collected independently by 2 researchers, and the risk of bias in meta-analysis will be evaluated according to "Cochrane Handbook for Systematic Reviews of Interventions". All data analysis will be conducted using Review Manager V.5.3. and Stata V.12.0. RESULTS: The curative effect and safety of acupoint injection treatment for AR patients will be evaluated systematically. CONCLUSION: The systematic review of this study will summarize the currently published evidence of acupoint injection treatment for AR to further guide its promotion and application. ETHICS AND DISSEMINATION: The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required. The results may be published in a peer-reviewed journal or disseminated in relevant conferences.Open Science Framework (OSF) registration number: https://osf.io/fa9dq.


Asunto(s)
Terapia por Acupuntura , Metaanálisis como Asunto , Rinitis Alérgica/terapia , Revisiones Sistemáticas como Asunto , Humanos , Proyectos de Investigación
20.
Medicine (Baltimore) ; 99(42): e22754, 2020 Oct 16.
Artículo en Inglés | MEDLINE | ID: mdl-33080741

RESUMEN

BACKGROUND: Heart failure (HF) is the terminal stage of various common cardiovascular diseases with quite a frequent readmission and a high mortality rate, and brings heavy financial burdens to families and society. Oral Chinese patent medicine (CPM) has been widely applied in the treatment of HF in China because of its simplicity, cheapness, convenience, and high efficiency. However, due to the large number and broad clinical selectivity of oral CPMs, there is a lack of uniformity and clinical application standardization. To choose more effective and safe medicine among so many oral CPMs is particularly essential for further improving the therapeutic effect. In this study, the efficacy and safety of different oral CPMs will be compared by a network meta-analysis (NMA), and the best CPM will be selected for the treatment of HF. METHODS: According to the search strategy, 4 English and 4 Chinese databases will be searched from the construction of the library to July 31, 2020. The NMA will include clinical randomized controlled trials (RCTs) of different oral CPMs in HF treatment. The methodological quality is assessed according to the bias risk assessment tool of Cochrane. The Bayesian NMA is performed by Aggregate Data Drug Information System (ADDIS), and the results are visualized using Stata 15.0 software. The GRADE approach is used to assess the quality of evidence and recommendation intensity. RESULTS: The NMA will identify the best oral CPM in the complementary treatment of HF. A peer-reviewed journal will publish the results of the study. CONCLUSION: This study can provide reliable evidence for the efficacy and safety of oral CPMs in the treatment of HF, and help decision-makers and patients to select more effective and safer oral CPM. PROTOCOL REGISTRATION NUMBER: INPLASY202090053.


Asunto(s)
Insuficiencia Cardíaca/tratamiento farmacológico , Medicina China Tradicional , Metaanálisis como Asunto , Medicamentos sin Prescripción/uso terapéutico , Revisiones Sistemáticas como Asunto , Administración Oral , Humanos , Metaanálisis en Red , Proyectos de Investigación
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