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1.
Endocrinol. diabetes nutr. (Ed. impr.) ; 66(10): 628-638, dic. 2019. tab
Artículo en Inglés | IBECS | ID: ibc-184790

RESUMEN

Background: Studies trying to find the association between vitamin D status and metabolic syndrome (MetS) have led to inconsistent results, and community-based data for individuals living in the Middle East are limited. Objectives: To find out if MetS and its components are associated with vitamin D status among female teachers residing in Yazd city during winter 2015. Materials and methods: A total of 276 female teachers (case group, n = 124 and control group, n = 152) aged 20-60 years were included. Weight, height, waist circumference, blood pressure, daily energy intake, physical activity, serum 25 hydroxy vitamin D (25(OH)D3), fasting blood glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C) levels were assessed. Logistic regression was used to examine the odds ratio of MetS according to vitamin D status. Results: Mean serum 25(OH)D3 was 32.79 ± 18.62 ng/ml and 33.73 ± 20.20, in females with and without MetS, respectively (P > 0.142). Compared to those with 25(OH)D3of < 20 ng/ml, the odds ratio for MetS was 1.01 (95% CI: 0.48-2.13) and 0.95 (95% CI: 0.56-1.60) for those with serum 25(OH)D3 levels of 20-29 ng/ml and ≥ 30 ng/ml, respectively (P trend = 0.84). The association remained insignificant after adjusting for potential confounders. Furthermore, vitamin D status was not associated with MetS components (P > 0.05). Conclusion: Although several studies have claimed the association between vitamin D status and MetS, we could not find a similar connection in a sample of Iranian female teachers. Prospective studies are needed to determine the possible effect of vitamin D in the development of MetS, particularly in the Yazd province


Antecedentes: Los estudios en busca de una asociación entre el estado de vitamina D y el síndrome metabólico (SM) han dado resultados no concluyentes, y los datos sobre comunidades de personas residentes en Oriente Próximo son limitados. Objetivos: Averiguar si existe asociación entre el SM y sus componentes y el estado de vitamina D en profesoras residentes en la ciudad de Yazd durante el invierno de 2015. Materiales y métodos: Se incluyó a un total de 276 profesoras (grupos de casos, n = 124 y grupo de control, n = 152) de 20-60 años de edad. Se determinaron el peso, la talla, el perímetro de la cintura, la presión arterial, la ingesta diaria de energía, la actividad física y los niveles de 25-hidroxivitamina D (25(OH)D3), glucosa en ayunas, triglicéridos y colesterol de las proteínas de alta densidad (C-HDL). Se utilizó regresión logística para determinar la razón de probabilidades de SM en función del estado de vitamina D. Resultados: La concentración sérica media de 25(OH)D3 era de 32,79 ± 18,62 ng/ml y 33,73 ± 20,20 en las mujeres con y sin SM, respectivamente (P > 0,142). En comparación con las que tenían < 20 ng/ml de 25(OH)D3, la razón de probabilidades de SM era 1,01 (IC al 95%, 0,48-2,13) y 0,95 (IC al 95%, 0,56-1,60) en las que tenían valores de 20-29 ng/ml y ≥ 30 ng/ml, respectivamente (tendencia de P = 0,84). La asociación seguía siendo no significativa después del ajuste por posibles factores de confusión. Además, el estado de vitamina D no se asociaba con los componentes del SM (P > 0,05). Conclusión: Aunque varios estudios han informado de una asociación entre el estado de la vitamina D y el SM, no pudimos hallar una relación similar en una muestra de profesoras iraníes. Se necesitan estudios prospectivos para determinar el posible efecto de la vitamina D en el desarrollo del SM, especialmente en la provincia de Yazd


Asunto(s)
Humanos , Femenino , Adulto , Persona de Mediana Edad , Vitamina D/administración & dosificación , Síndrome Metabólico/tratamiento farmacológico , Deficiencia de Vitamina D/dietoterapia , Irán , Modelos Logísticos , Peso por Estatura , Relación Cintura-Cadera , Presión Arterial , Presión Sanguínea , Ejercicio/fisiología
2.
Medicine (Baltimore) ; 98(44): e17736, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31689819

RESUMEN

To explore associated risk factors and their interactions with type 2 diabetes (T2DM) among the elderly with prediabetes in rural areas in China.A nested case-control study was conducted in a fixed cohort to identify the risk factors for T2DM among the elderly with prediabetes in rural areas of Yiyang City in China. A total of 37 elderly with T2DM were included in the cases group and 111 elderly subjects with prediabetes were matched in the control group. Data related to sociodemographic characteristics, lifestyle behavior, and anthropometric variables were collected by trained staff using standard tools. The risk factors for T2DM were determined using conditional logistic regression analysis, and their additive interactions were also explored.Multivariable conditional logistic regression analysis results showed that overweight/obesity (odds ratio [OR] = 4.80, 95% confidence interval [CI]: 1.20-12.28), family history of diabetes (OR = 3.63, 95% CI: 1.03-12.81), physically inactive (OR = 3.08, 95% CI: 1.14-8.30), high waist-to-hip ratio (WHR) (OR = 3.15, 95% CI: 1.27-7.80), and inadequate diabetes-specific health literacy (DSHL) (OR = 3.92, 95% CI: 1.14-13.48) increased the risk for T2DM. Additive interactions for T2DM were observed between a family history of diabetes and high WHR with a relative excess risk of interaction (RERI) of 10.02 (95% CI: 4.25, 15.78), and between high WHR and overweight or obesity, with an RERI of 3.90 (95% CI: 0.36, 7.44).The independent risk factors for T2DM are overweight or obesity, high WHR, family history of diabetes, physically inactive, and inadequate DSHL. High WHR as a risk factor for T2DM has additive interactions with family history of diabetes and overweight or obesity.


Asunto(s)
Diabetes Mellitus Tipo 2/etiología , Estado Prediabético/etiología , Población Rural/estadística & datos numéricos , Anciano , Antropometría , Estudios de Casos y Controles , China/epidemiología , Diabetes Mellitus Tipo 2/epidemiología , Diabetes Mellitus Tipo 2/fisiopatología , Ejercicio , Femenino , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Estado Prediabético/epidemiología , Estado Prediabético/fisiopatología , Riesgo , Factores de Riesgo , Conducta Sedentaria , Relación Cintura-Cadera
3.
BMC Public Health ; 19(1): 1439, 2019 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-31675936

RESUMEN

BACKGROUND: Studies indicate an effect of smoking toward abdominal obesity, but few assess hip and waist circumferences (HC and WC) independently. The present study aimed to assess the associations of smoking status and volume smoked with HC and WC and their ratio in a population with low prevalence of obesity together with high prevalence of smoking. METHODS: We used cross-sectional survey data from 11 of a total 19 Norwegian counties examined in 1997-99 including 65,875 men and women aged 39-44 years. Analysis of associations were adjusted for confounding by socioeconomic position, health indicators, and additionally for BMI. RESULTS: Compared with never-smokers, when adjusting for confounders and in addition for BMI, mean HC remained lower while mean WC and waist-hip-ratio (WHR) were higher in current smokers. The finding of a lower HC and higher WHR level among smokers was consistent by sex and in strata by levels of education and physical activity, while the finding of higher WC by smoking was less consistent. Among current smokers, BMI-adjusted mean HC decreased whereas WC and WHR increased by volume smoked. Compared with current smokers, former smokers had higher BMI-adjusted HC, lower WHR and among women WC was lower. CONCLUSIONS: The main finding in this study was the consistent negative associations of smoking with HC. In line with the hypothesis that lower percentage gluteofemoral fat is linked with higher cardiovascular risk, our results suggest that smoking impacts cardiovascular risk through mechanisms that reduce the capacity of fat storage in the lower body region.


Asunto(s)
Obesidad/epidemiología , Fumar Tabaco/epidemiología , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Noruega/epidemiología , Prevalencia , Circunferencia de la Cintura , Relación Cintura-Cadera/estadística & datos numéricos
4.
BMC Public Health ; 19(1): 1416, 2019 Oct 29.
Artículo en Inglés | MEDLINE | ID: mdl-31664979

RESUMEN

OBJECTIVES: This study aimed to evaluate and compare the abilities of waist circumference (WC), body mass index (BMI), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) to predict recently and previously diagnosed diabetes and hypertension and assess their appropriate cut-off values among Jordanian adults. METHODS: Data from the 2017 cardiovascular risk factors survey were analyzed to achieve the study objective. The survey collected extensive data from a national population-based sample of Jordanian residents. A structured questionnaire was used to collect sociodemographic variables and clinical data. Blood samples were taken for biochemical measurements. Anthropometric characteristics were measured by the same team of trained field researchers. RESULTS: This study included a total of 1193 men and 2863 women. Their age ranged from 18 to 90 year with a mean (SD) of 43.8 (14.2) year. WHtR performed better than other anthropometric measures and had a good ability (AUC > 0.80) among women and fair ability among men to predict newly diagnosed diabetes and previously diagnosed diabetes and hypertension. The appropriate cut-off points for anthropometric measures among women were 92 cm form WC, 104 cm for HC, 30 Kg/m2 for BMI, 0.85 for WHR, and 0.60 for WHtR. For men, the appropriate cut-off points were 100 cm for WC, 104 cm for HC, 27 Kg/m2 for BMI, 0.93 for WHR, and 0.57 for WHtR. CONCLUSION: WHtR performed better than other anthropometric measures in predicting diabetes and hypertension among adult population in Jordan. We recommend WHtR as a measure of choice with a cut-off value of 0.6 for women and 0.57 for men to predict diabetes and hypertension among Jordanians.


Asunto(s)
Antropometría/métodos , Diabetes Mellitus/epidemiología , Hipertensión/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Índice de Masa Corporal , Femenino , Cadera , Humanos , Jordania/epidemiología , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Circunferencia de la Cintura , Relación Cintura-Estatura , Relación Cintura-Cadera , Adulto Joven
5.
Medicine (Baltimore) ; 98(39): e16788, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31574794

RESUMEN

BACKGROUND: The aim of this study was to observe the effect and safety of Heyan Kuntai Capsule (HYKT) on glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS). METHODS: Hundred patients with PCOS were randomly divided into HYKT group (n = 50) and placebo groups (n = 50) in which the individuals were treated with HYKT and its placebo continuously for 6 months. Meanwhile, all participants received health education (such as exercise and diet). The primary outcomes were serum sex hormone levels, a series of blood lipid, fasting and postprandial 2 hours blood glucose. Body mass index (BMI), waist-hip ratio (WHR), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and insulin-sensitive index (ISI) were also observed. In addition, adverse events were recorded to evaluate the drug safety. RESULTS: After treatment, the BMI and WHR of all the patients were decreased. The fasting and postprandial 2 hours blood glucose levels were significantly declined when treated with HYKT, which were not observed in the placebo group. Similarly, serum sex hormones including luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH), and testosterone were lowered after treated with HYKT instead of the placebo. Besides, blood lipids outcomes such as total cholesterol, triglyceride, and low-density lipoprotein cholesterol, as well as insulin and HOMA-IR were decreased with significance in HYKT group when compared with those in the placebo group, whereas high-density lipoprotein cholesterol and ISI increased obviously. CONCLUSION: HYKT showed the effect on ameliorating the glucose and lipid metabolism disorder and improving insulin resistance and increase insulin sensitivity of PCOS patients, which is similar to insulin sensitizing agent.


Asunto(s)
Glucemia/metabolismo , Medicamentos Herbarios Chinos/efectos adversos , Medicamentos Herbarios Chinos/uso terapéutico , Lípidos/sangre , Síndrome del Ovario Poliquístico/sangre , Síndrome del Ovario Poliquístico/tratamiento farmacológico , Adolescente , Adulto , Índice de Masa Corporal , Método Doble Ciego , Estradiol/sangre , Femenino , Hormona Folículo Estimulante/sangre , Humanos , Insulina/sangre , Resistencia a la Insulina , Hormona Luteinizante/sangre , Prolactina/sangre , Testosterona/sangre , Relación Cintura-Cadera , Adulto Joven
6.
PLoS Genet ; 15(10): e1008405, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31647808

RESUMEN

Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains unclear whether there are similar causal effects of obesity traits on other non-communicable diseases. Also, it is largely unexplored whether there are any sex-specific differences in the causal effects of obesity traits on cardiometabolic diseases and other leading causes of death. We constructed sex-specific genetic risk scores (GRS) for three obesity traits; body mass index (BMI), waist-hip ratio (WHR), and WHR adjusted for BMI, including 565, 324, and 337 genetic variants, respectively. These GRSs were then used as instrumental variables to assess associations between the obesity traits and leading causes of mortality in the UK Biobank using Mendelian randomization. We also investigated associations with potential mediators, including smoking, glycemic and blood pressure traits. Sex-differences were subsequently assessed by Cochran's Q-test (Phet). A Mendelian randomization analysis of 228,466 women and 195,041 men showed that obesity causes coronary artery disease, stroke (particularly ischemic), chronic obstructive pulmonary disease, lung cancer, type 2 and 1 diabetes mellitus, non-alcoholic fatty liver disease, chronic liver disease, and acute and chronic renal failure. Higher BMI led to higher risk of type 2 diabetes in women than in men (Phet = 1.4×10-5). Waist-hip-ratio led to a higher risk of chronic obstructive pulmonary disease (Phet = 3.7×10-6) and higher risk of chronic renal failure (Phet = 1.0×10-4) in men than women. Obesity traits have an etiological role in the majority of the leading global causes of death. Sex differences exist in the effects of obesity traits on risk of type 2 diabetes, chronic obstructive pulmonary disease, and renal failure, which may have downstream implications for public health.


Asunto(s)
Causas de Muerte , Enfermedad de la Arteria Coronaria/genética , Diabetes Mellitus Tipo 2/genética , Obesidad/genética , Enfermedad Pulmonar Obstructiva Crónica/genética , Adiposidad/genética , Anciano , Presión Sanguínea/genética , Índice de Masa Corporal , Enfermedad de la Arteria Coronaria/complicaciones , Enfermedad de la Arteria Coronaria/mortalidad , Enfermedad de la Arteria Coronaria/patología , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/mortalidad , Diabetes Mellitus Tipo 2/patología , Femenino , Estudio de Asociación del Genoma Completo , Humanos , Masculino , Análisis de la Aleatorización Mendeliana , Persona de Mediana Edad , Neoplasias , Obesidad/complicaciones , Obesidad/mortalidad , Obesidad/patología , Polimorfismo de Nucleótido Simple , Enfermedad Pulmonar Obstructiva Crónica/complicaciones , Enfermedad Pulmonar Obstructiva Crónica/mortalidad , Enfermedad Pulmonar Obstructiva Crónica/patología , Factores de Riesgo , Accidente Cerebrovascular , Relación Cintura-Cadera
7.
Nutr. hosp ; 36(5): 1049-1054, sept.-oct. 2019. tab, graf
Artículo en Inglés | IBECS | ID: ibc-184625

RESUMEN

Introduction: anthropometric indicators (AIs) such as waist circumference (WC), body mass index (BMI), waist/hip index (WHpI), waist/height index (WHtI) and body fat percentage (BFP) are useful tools for the diagnosis of nutritional status (NS) in adolescents. Each of these parameters has advantages and disadvantages. The purpose of the present study was to analyze the association of these AIs (WC, BMI, WHpI, WHtI, and BFP) to evaluate nutritional status and estimate the cardiometabolic risk (CMR) in Mexican adolescents. Material and method: in a cross-sectional descriptive study, the NS was analyzed through various AIs and CMR with the WHtI criteria. Nine hundred and seventeen adolescents between 15 and 17 years old participated in the study, of whom 488 (52.9%) were female and 429 (47.1%) male, all students of middle school in Tuxtla Gutiérrez, Chiapas, Mexico. Results and conclusion: women presented a higher prevalence of obesity according to most indicators. The WHtI was the parameter that detected the highest prevalence of obesity (31%), correlating with the BMI and the BFP. Moreover, there was evidence of a significant relation between NS (assessed by all the anthropometric indicators) and CMR. The WHtI could be considered as an adequate tool for the diagnosis of obesity associated with CMR in adolescents


Introducción: los indicadores antropométricos (IA) como la circunferencia de cintura (CC), el índice de masa corporal (IMC), el índice cintura/ cadera (ICC), el índice cintura/talla (ICT) y el porcentaje de grasa corporal (PGC) son herramientas útiles para el diagnóstico del estado nutricional (EN) en los adolescentes. Sin embargo, cada uno de estos IA presentan ventajas y desventajas. El propósito del presente estudio fue analizar la asociación de los IA (IMC, CC, ICC, ICT y PGC) para evaluar el EN y estimar el riesgo cardiometabólico (RCM) en adolescentes mexicanos. Material y método: el diseño del estudio fue descriptivo transversal. Se analizó el EN a través de diversos IA y el RCM bajo los criterios de ICT. Este estudio fue conducido en 917 adolescentes de entre 15 y 17 años, de los cuales 488 (52,9%) eran mujeres y 429 (47,1%) varones, todos estudiantes de nivel medio superior de Tuxtla Gutiérrez, Chiapas, México. Resultados y conclusión: las mujeres presentaron mayor prevalencia de obesidad con la mayoría de los IA utilizados. El ICT fue el IA que detectó mayor prevalencia de obesidad (31%), correlacionándose con el IMC y el PGC. Además, se evidenció una asociación significativa entre el EN valorado por todos los IA y el RCM. El ICT podría ser considerado como una herramienta adecuada para el diagnóstico de obesidad asociada a RCM en adolescentes


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Antropometría/métodos , Evaluación Nutricional , Estado Nutricional , Enfermedades Cardiovasculares/diagnóstico , Obesidad/epidemiología , Factores de Riesgo , Enfermedades Cardiovasculares/prevención & control , Relación Cintura-Cadera/métodos , Peso por Estatura , Estudios Transversales , México/epidemiología
8.
Nutr. hosp ; 36(5): 1061-1066, sept.-oct. 2019. tab
Artículo en Inglés | IBECS | ID: ibc-184627

RESUMEN

Introduction: children's food habits have an influence on physical and mental health and should be monitored. Objective: the purpose of this study was to determinate the association between children's food habits (i.e., Mediterranean diet adherence), anthropometric parameters and health-related quality of life (HRQoL) in Chilean schoolchildren. Material and methods: girls (n = 282, 11.86 ± 0.82 years) and boys (n = 352, 12.02 ± 0.87 years) enrolled in public schools were included in this study (n = 634). Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), body fat (BF), nutritional level and HRQoL were evaluated. Results: the schoolchildren with high nutritional levels reported higher HRQoL (p = 0.018) and presented lower BMI, WC and WtHR (p < 0.001). Likewise, according to the following questions: Have your parent(s) treated you fairly? and Have you felt full of energy? The schoolchildren with high nutritional levels reported the major proportion in very and extremely answers (p < 0.001). The BMI was negatively correlated with HRQoL (r = -0.33, p < 0.05). Beside, children's food habits had significant correlation with HRQoL (r = 0.48, p = 0.002). The BMI (B = -0.41, 95% CI = -0.55, 0.93, p = 0.001) and children's food habits (B = -0.78, 95% CI = -0.09, -0.02, p = 0.002) reported associations with HRQoL. Conclusion: in conclusion, the nutritional level (i.e., Mediterranean diet adherence) and BMI presented associations with HRQoL in Chilean schoolchildren; therefore, it is important to consider these results and develop different strategies in schoolchildren to improve their nutritional levels, as HRQoL represents a measure of happiness or satisfaction with life


Introducción: los hábitos alimentarios de los niños influyen en su salud física y mental, por lo tanto, deben controlarse. Objetivo: el propósito de este estudio fue determinar la asociación entre los hábitos alimentarios de los niños (adherencia a la dieta mediterránea), los parámetros antropométricos y la calidad de vida relacionada con la salud (CVRS) en escolares chilenos. Material y métodos: se incluyeron en este estudio (n = 634) niñas (n = 282, 11,86 ± 0,82 años) y niños (n = 352, 12,02 ± 0,87 años) inscritos en escuelas públicas. Se evaluaron el índice de masa corporal (IMC), la circunferencia de la cintura (CC), la relación cintura-altura (RCE), la grasa corporal (GC), el nivel nutricional y la CVRS. Resultados: los escolares con niveles nutricionales altos tuvieron una CVRS más alta (p = 0,018) y presentaron un IMC, CC y RCE más bajos (p < 0,001). Del mismo modo, de acuerdo a las preguntas "¿te han tratado tus padres de manera justa?" y "¿te has sentido lleno de energía?", los escolares con altos niveles nutricionales obtuvieron la mayor proporción en respuestas muy y muy altas (p < 0,001). El IMC se correlacionó negativamente con la CVRS (r = -0,33, p < 0,05). Además, los hábitos alimenticios de los niños tuvieron una correlación significativa con la CVRS (r = 0,48, p = 0,002). El IMC (B = -0,41; IC 95% = -0,55, 0,93, p = 0,001) y los hábitos alimentarios de los niños (B = -0.78, IC 95% = -0.09, -0.02, p = 0,002) reportaron asociaciones con la CVRS. Conclusión: en conclusión, el nivel nutricional (es decir, la adherencia a la dieta mediterránea) y el IMC presentaron asociaciones con la CVRS en escolares chilenos; por lo tanto, es importante tener en cuenta estos resultados y desarrollar diferentes estrategias en los escolares para mejorar sus niveles nutricionales, ya que la CVRS representa una medida de felicidad o satisfacción con la vida


Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Conducta Alimentaria/fisiología , Antropometría/métodos , Calidad de Vida , Salud Mental , Dieta Mediterránea , Relación Cintura-Cadera , Estudios Transversales , Chile
9.
Zhongguo Dang Dai Er Ke Za Zhi ; 21(9): 910-914, 2019 Sep.
Artículo en Chino | MEDLINE | ID: mdl-31506152

RESUMEN

OBJECTIVE: To study the relationship between serum microRNA-122 (miR-122) and insulin resistance in obese children. METHODS: Forty-seven children with severely obesity aged 7-14 years and 45 age- and gender matched healthy children with normal weight (control group) were enrolled. The levels of height, weight, waistline, hip circumference, fasting blood glucose (FBG), fasting insulin (FINS), triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), interleukin-6 (IL-6) and miR-122 in the two groups were measured. Body mass index (BMI), waist-hip ratio (WHR) and insulin resistance index (HOMA-IR) were calculated. RESULTS: Compared with the control group, the height, weight, BMI, WHR, FINS, HOMA-IR, TG, FFA, IL-6, and miR-122 levels in the obese group were significantly increased (P<0.05). MiR-122 levels in the obese group were positively correlated with FINS, HOMA-IR and IL-6 levels (r=0.408, 0.442, and 0.464 respectively, P<0.05). The changes of miR-122 have a linear regression relationship with IL-6 (b'=0.318, P<0.05). CONCLUSIONS: The elevated serum miR-122 levels may be correlated with insulin resistance in obese children. The mechanism needs to be further studied.


Asunto(s)
Resistencia a la Insulina , MicroARNs/genética , Adolescente , Glucemia , Índice de Masa Corporal , Niño , Humanos , Insulina , Obesidad , Relación Cintura-Cadera
10.
Endocrinol. diabetes nutr. (Ed. impr.) ; 66(7): 402-409, ago.-sept. 2019. graf, tab
Artículo en Inglés | IBECS | ID: ibc-182859

RESUMEN

Background: This study was designed to detect the potential association of a nonfunctional adrenal incidentaloma (NFAI) with insulin resistance and associated metabolic disturbances, with a subsequent increase in cardiovascular risk factors. Methods: Eighty-three NFAI patients and 56 volunteers (controls) without any adrenal abnormalities on computed tomography (CT) were included. Fasting blood glucose (FBG), fasting insulin, lipid profiles, uric acid, homocysteine, fibrinogen, high sensitivity C-reactive protein (hs-CRP), and adiponectin levels were measured in both groups. Blood pressure (BP), waist circumference, body mass index (BMI), and carotid intima media thickness (CIMT) were evaluated in both the patients and volunteers. Results: There were no significant difference between the NFAI and control groups with respect to age, sex, BMI, waist circumference, systolic and diastolic BP, smoking, concomitant disease, and medications. Fasting insulin and glucose levels and homeostasis model of assessment-insulin resistance (HOMA-IR) scores were significantly higher in the NFAI group as compared with those in the control group (p<0.01). The frequency of metabolic syndrome in the NFAI group was higher than that in the control group (p<0.01). All the lipid fractions, except triglyceride (TG), (p<0.05), homocysteine (p=0.01), and fibrinogen levels (p<0.001), were significantly higher in the NFAI group as compared with the levels in the control group. There were no significant differences between the NFAI and control groups in terms of uric acid, hs-CRP, and adiponectin levels. The CIMT values in the NFAI group were significantly higher than those in the control group (0.74±0.14 vs. 0.53±0.09, p<0.001). The mean CIMT value showed a statistically positive correlation with age (r=0.245, p=0.004); the HOMA-IR score (r=0.490, p<0.001); and FBG (r=0.521, p<0.001), fasting insulin (r=0.432, p<0.001), total cholesterol (TC) (r=0.267, p=0.002), and fibrinogen (r=0.398, p<0.001) levels in the NFAI group. Conclusions: The results indicated that the NFAI patients had an elevated risk of insulin resistance, with metabolic syndrome and increased CIMT values. Long-term follow-up studies should be designed to evaluate postsurgical alterations in metabolic parameters and cardiovascular risk factors in NFAI patients


Antecedentes: Este estudio se diseñó para detectar la posible asociación del incidentaloma suprarrenal no funcionante (ISNF) con resistencia a la insulina y trastornos metabólicos asociados, con un incremento subsecuente en los factores de riesgo cardiovascular. Métodos: Se incluyó a 83 pacientes con ISNF y a 56 voluntarios (controles) sin anomalías suprarrenales en la tomografía computarizada (TC). Se determinaron en ambos grupos los valores de glucemia en ayunas (GA), insulina en ayunas, perfiles lipídicos, ácido úrico, homocisteína, fibrinógeno, proteína C reactiva de alta sensibilidad (PCRas) y adiponectina. Se evaluaron la presión arterial (PA), el perímetro de la cintura, el índice de masa corporal (IMC) y el grosor íntima-media carotídea (GIMC) tanto en los pacientes como en los voluntarios. Resultados: No había una diferencia significativa entre los grupos con ISNF y de control en cuanto a edad, sexo, IMC, perímetro de la cintura, PA sistólica y diastólica, tabaquismo, enfermedades concomitantes y medicamentos. Las concentraciones de insulina y glucosa en ayunas y las puntuaciones del modelo homeostático de evaluación de la resistencia a la insulina (HOMA-IR) fueron significativamente mayores en el grupo con ISNF que en el de control (p<0,01). La frecuencia de síndrome metabólico fue mayor en el grupo con ISNF que en el de control (p<0,01). Los valores de todas las fracciones lipídicas, excepto los de triglicéridos (TG) (p<0,05), homocisteína (p=0,01) y fibrinógeno (p<0,001), fueron significativamente mayores en el grupo con ISNF que en el de control. No hubo diferencias significativas entre los grupos con ISNF y de control en las concentraciones de ácido úrico, PCRas y adiponectina. Los valores del GIMC en el grupo con ISNF fueron significativamente mayores que los del grupo de control (0,74±0,14 frente a 0,53±0,09; p<0,001). El valor medio del GIMC mostró una correlación estadísticamente positiva con la edad (r=0,245; p=0,004); la puntuación del HOMA-IR (r=0,490; p<0,001), y la GA (r=0,521; p<0,001), la insulina en ayunas (r=0,432; p<0,001), el colesterol total (CT) (r=0,267; p=0,002) y el fibrinógeno (r=0,398; p<0,001) en el grupo con ISNF. Conclusión: Los resultados indicaban que los pacientes con ISNF tenían un riesgo elevado de resistencia a la insulina, con síndrome metabólico y aumento de los valores del GIMC. Deben diseñarse estudios de seguimiento a largo plazo para evaluar los cambios posquirúrgicos de los parámetros metabólicos y los factores de riesgo cardiovascular en pacientes con ISFN


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Hallazgos Incidentales , Factores de Riesgo , Neoplasias de las Glándulas Suprarrenales/complicaciones , Enfermedades Cardiovasculares/metabolismo , Grosor Intima-Media Carotídeo , Síndrome Metabólico/complicaciones , Resistencia a la Insulina , Glándulas Suprarrenales/patología , Síndrome Metabólico/diagnóstico , Neoplasias de las Glándulas Suprarrenales/diagnóstico , Enfermedades Cardiovasculares/complicaciones , Síndrome Metabólico/fisiopatología , Voluntarios Sanos , Presión Arterial , Índice de Masa Corporal , Relación Cintura-Cadera
11.
Crit Rev Oncol Hematol ; 142: 94-118, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31394434

RESUMEN

BACKGROUND: An increase in survival rates of childhood cancer is associated with long-term health issues in survivors. METHODS: We conducted a systematic review and meta-analysis comparing health status-related endpoints in childhood cancer survivors (CCS) versus controls. RESULTS: Eighty-six studies (n = 98,480 participants, 62% CCS) were included in the review. Of these, 73 studies (n = 96,550, 63% CCS) could be meta-analyzed. CCS showed a lower left ventricular ejection and fractional shortening (SMD=-0.59 and -0.55, respectively, both p < 0.01 [n=1,824 and 1,880]), a lower HDL-cholesterol concentration (SMD=-0.48, p<0.001, n=1,378) and a higher waist-to-hip ratio (SMD=0.61, p < 0.01, n=229) than their healthy peers. No significant differences were found for the remaining endpoints. CONCLUSIONS: CCS is associated with a lower left ventricular function and HDL-cholesterol level, and a higher waist-to-hip ratio than healthy controls. These findings support the need to closely monitor the cardiometabolic health status of CCS and to implement preventive lifestyle interventions for this population.


Asunto(s)
Supervivientes de Cáncer , Estado de Salud , Adolescente , Adulto , Niño , Preescolar , HDL-Colesterol/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Disfunción Ventricular Izquierda , Relación Cintura-Cadera , Adulto Joven
12.
Diabetes Metab Syndr ; 13(4): 2335-2338, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31405639

RESUMEN

BACKGROUND: Hypertension and obesity have become a global issue and an important public health concern due to an unhealthy lifestyle. The present study aims to determine the prevalence of hypertension and its association with various adiposity indicators among Sunni Muslim population of Lucknow, Uttar Pradesh. MATERIALS AND METHODS: A cross-sectional study was conducted among 214 individuals using purposive sampling method. Somatometric measurements were taken using the ISAK protocol. Correlation analysis and odds ratio were calculated to determine the best predictor of hypertension. RESULTS: 41% of males and 42.1% of females were found to be in Stage-II hypertension. BMI and WC were found to have the highest correlation with SBP among males and females, respectively. WHR followed by WC and BMI, was found to be the strongest predictor of hypertension in males. In the case of females, WHtR Followed by, BMI and WHR were found to be the strongest predictors of hypertension. CONCLUSION: Among the presently studied Muslim population of Lucknow, a high prevalence of hypertension was found among both males and females. Also, WHR among males and WC among females were found to be better predictors of hypertension. Thus, for better prediction of risk of hypertension, sex and ethnicity-specific adiposity indicator should be used in clinical practice.


Asunto(s)
Adiposidad , Índice de Masa Corporal , Hipertensión/epidemiología , Islamismo , Obesidad/fisiopatología , Circunferencia de la Cintura , Relación Cintura-Cadera , Adulto , Biomarcadores/análisis , Estudios Transversales , Femenino , Estudios de Seguimiento , Humanos , India/epidemiología , Masculino , Prevalencia , Pronóstico , Factores de Riesgo
13.
Diabetes Metab Syndr ; 13(4): 2739-2745, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31405702

RESUMEN

INTRODUCTION: The association of individuals' anthropometric indices with their development of metabolic syndrome (MetS) has been investigated in several studies. Taking into account the ethnic differences, this study aimed to determine the most appropriate cut-off points of anthropometric indices in predicting the incidence of MetS and its components in Ahvaz. METHODS: This study is part of a cohort study conducted at the Diabetes Research Center of Ahvaz Jundishapur University of Medical Sciences on a population of over 20 in Ahvaz during 2009-2014. Of the 592 patients, 505 patients who were not diagnosed with MetS in 2009, were entered into this study. The data analyzed involved demographic information including age and sex, anthropometric information including height, weight, waist circumference (WC), hip circumference (HC) and the ratios between them, laboratory data including blood levels of Triglyceride (TG), Fasting plasma glucose (FPG) and High-density lipoprotein cholesterol (HDL-C), and clinical data including systolic(S) and diastolic(D)blood pressure(BP). After 5 years, the subjects were re-evaluated for MetS based on the National Cholesterol Education Program - Adult Treatment Panel III (NCEP-ATP III) criteria and the most appropriate cut-off points of anthropometric indices for the prediction of the incidence of MetS using the Receiver Operative Characteristic (ROC) curves were obtained. RESULTS: Waist-to-Height Ratio (WHtR) index with a cut-off point of 0.53 followed by WC with a cut-off point of 87.5 cm had the highest power to predict the incidence of MetS. The cut-off points of WC and Body mass index (BMI) were respectively 89.5 cm and 26 kg/m2 for men, and 83.5 cm and 27.5 kg/m2 for women. All anthropometric indices were able to predict the components of this syndrome (with the exception of low HDL-C). The cut-off point of WC in predicting High FBS, High TG and High BP was 84.5, 84.8, and 86.5 cm, respectively. CONCLUSION: Overall, it seems that given its ease of measurement, the WC index is preferred to other indices for predicting the incidence of MetS and its components in clinical screening.


Asunto(s)
Biomarcadores/análisis , Índice de Masa Corporal , Síndrome Metabólico/epidemiología , Obesidad/fisiopatología , Circunferencia de la Cintura , Relación Cintura-Estatura , Relación Cintura-Cadera , Adulto , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Masculino , Pronóstico , Estudios Prospectivos , Factores de Riesgo , Adulto Joven
14.
PLoS Genet ; 15(8): e1008277, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31369549

RESUMEN

Obesity is a worldwide health problem that is closely linked to many metabolic disorders. Regular physical exercise has been found to attenuate the genetic predisposition to obesity. However, it remains unknown what kinds of exercise can modify the genetic risk of obesity. This study included 18,424 unrelated Han Chinese adults aged 30-70 years who participated in the Taiwan Biobank (TWB). A total of 5 obesity measures were investigated here, including body mass index (BMI), body fat percentage (BFP), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR). Because there have been no large genome-wide association studies on obesity for Han Chinese, we used the TWB internal weights to construct genetic risk scores (GRSs) for each obesity measure, and then test the significance of GRS-by-exercise interactions. The significance level throughout this work was set at 0.05/550 = 9.1x10-5 because a total of 550 tests were performed. Performing regular exercise was found to attenuate the genetic effects on 4 obesity measures, including BMI, BFP, WC, and HC. Among the 18 kinds of self-reported regular exercise, 6 mitigated the genetic effects on at least one obesity measure. Regular jogging blunted the genetic effects on BMI, BFP, and HC. Mountain climbing, walking, exercise walking, international standard dancing, and a longer practice of yoga also attenuated the genetic effects on BMI. Exercises such as cycling, stretching exercise, swimming, dance dance revolution, and qigong were not found to modify the genetic effects on any obesity measure. Across all 5 obesity measures, regular jogging consistently presented the most significant interactions with GRSs. Our findings show that the genetic effects on obesity measures can be decreased to various extents by performing different kinds of exercise. The benefits of regular physical exercise are more impactful in subjects who are more predisposed to obesity.


Asunto(s)
Ejercicio , Predisposición Genética a la Enfermedad , Estudio de Asociación del Genoma Completo , Obesidad/prevención & control , Adulto , Bancos de Muestras Biológicas/estadística & datos numéricos , Índice de Masa Corporal , Femenino , Humanos , Masculino , Persona de Mediana Edad , Obesidad/diagnóstico , Obesidad/genética , Polimorfismo de Nucleótido Simple , Factores de Riesgo , Autoinforme/estadística & datos numéricos , Taiwán , Circunferencia de la Cintura/genética , Relación Cintura-Cadera
15.
Adv Exp Med Biol ; 1193: 135-154, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31368102

RESUMEN

Obesity is multifactorial and complex. Remarkable progress has been made recently in search for polygenic obesity through genome-wide association study (GWAS), but biology of polygenic effects on obesity is largely poor. This review summarizes the available evidence and provides an overview of the links between ALDH2 variants and adiposity, which were firstly and mainly derived from studies of polygenic obesity and also indirectly investigated by using cell lines and mice. The genetic association studies have observed consistent associations of ALDH2 variants with obesity-related traits including BMI, waist circumference (WC), waist-to-hip ratio (WHR), and visceral fat accumulation. In consideration of ALDH2 variants with enzyme activity and alcohol consumption behavior in physiological mechanism studies, we proposed a model by which the physiological and behavioral consequences of alcohol consumption serve as an intermediary process between polymorphisms in ALDH2 and obesity.


Asunto(s)
Aldehído Deshidrogenasa Mitocondrial/genética , Obesidad/genética , Adiposidad/genética , Animales , Índice de Masa Corporal , Estudio de Asociación del Genoma Completo , Humanos , Ratones , Polimorfismo de Nucleótido Simple , Circunferencia de la Cintura , Relación Cintura-Cadera
16.
Nutr. hosp ; 36(4): 854-861, jul.-ago. 2019. tab, graf
Artículo en Inglés | IBECS | ID: ibc-184711

RESUMEN

Background: postpartum weight retention (PWR) strongly predicts obesity, the major nutritional concern of this century; however, there is a gap in nutritional care for postpartum women in Brazil. Objective: to evaluate the effect of nutritional counselling provided at primary health care on the reduction of PWR. Method: pilot study carried out in a low-income community in southeastern Brazil, involving postpartum women with PWR, who were provided with individual monthly appointments with a nutritionist over three months of follow-up. Nutritional counselling was based on the Dietary Approach to Stop Hypertension (DASH diet) aiming at healthy and gradual weight loss. Anthropometric evaluation included measurement of weight, height, waist circumference and percentage of body fat. Dietary intake was assessed using a food frequency questionnaire and adherence to diet was evaluated using a DASH score. Results: women who participated in the study (n = 26) showed a reduction in PWR (median -1.80 kg, p = 0.004), body mass index (-0.57 kg/m², p = 0.004), and waist circumference (-2.50 cm, p = 0.024), as well as 91.67% of them presented good adherence to diet. Conclusion: nutritional counselling provided to low-income postpartum women at primary health care contributed to the reduction of PWR, body mass index and waist circumference, as the study participants presented good adherence to a healthy dietary pattern


Introducción: la retención de peso después del parto (RPDP) predice firmemente la obesidad, que es la principal preocupación nutricional de este siglo; sin embargo, existe una brecha en la atención nutricional para las mujeres después del parto en Brasil. Objetivo: evaluar el efecto del asesoramiento nutricional brindado en Atención Primaria sanitaria sobre la reducción de RPDP. Método: estudio piloto realizado en una comunidad de bajos ingresos en el sureste de Brasil, en el que participaron mujeres postparto con RPDP, que recibieron citas mensuales individuales con un nutricionista durante tres meses de seguimiento. El asesoramiento nutricional se basó en la dieta Dietary Approach to Stop Hypertension (DASH) y apuntó a una pérdida de peso saludable y gradual. La evaluación antropométrica incluyó la medición del peso, la altura, la circunferencia de la cintura y el porcentaje de grasa corporal. La ingesta dietética se evaluó mediante un cuestionario de frecuencia alimentaria y la adherencia a la dieta se evaluó mediante un score DASH. Resultados: las mujeres que participaron en el estudio (n = 26) mostraron una reducción en la RPDP (mediana de -1,80 kg, p = 0,004), índice de masa corporal (-0,57 kg/m², p = 0,004) y circunferencia de la cintura (-2,50 cm, p = 0,024); el 91.67% de ellas presentaron buena adherencia a la dieta. Conclusión: el asesoramiento nutricional brindado a las mujeres de bajos ingresos después del parto en Atención Primaria sanitaria contribuyó a la reducción de la RPDP, el índice de masa corporal y la circunferencia de la cintura, ya que los participantes del estudio presentaron una buena adherencia a un patrón de dieta saludable


Asunto(s)
Humanos , Femenino , Ganancia de Peso Gestacional/fisiología , Atención Primaria de Salud , Antropometría , Evaluación Nutricional , Proyectos Piloto , Peso Corporal/fisiología , Relación Cintura-Cadera , Índice de Masa Corporal , Brasil
17.
Anatol J Cardiol ; 22(1): 33-43, 2019 06.
Artículo en Inglés | MEDLINE | ID: mdl-31264654

RESUMEN

OBJECTIVE: The aim of the present study was to assess different obesity indices, as well as their best cut-off point, to predict the occurrence of hypertension (HTN) in an Iranian population. METHODS: In a population-based study, subjects aged 35 years and older were followed for 7 years. Blood pressure was measured at baseline and after the follow-up. Anthropometry indices included body mass index (BMI), body adiposity index (BAI), the waist-to-height ratio (WHtR), the waist-to-hip ratio (WHpR), and waist and hip circumferences (WC and HC). Logistic regression was employed to calculate the odds ratio (OR) and 95% confidence intervals (CI) per standard deviation (SD) increment. The operating characteristic analysis was used to derive the best cut-off value for each index. RESULTS: Among original 6504 participants, 2450 subjects who had no cardiovascular diseases (CVD) and HTN at baseline were revisited, and 542 (22.1%) new cases of HTN were detected. There were minimal differences between most indices in the adjusted models; however, the best HTN predictors were BMI (OR per SD 1.32; 95% CI 1.12-1.56) and almost equally WC (1.35; 1.13-1.60) in men and WC (1.20; 1.04-1.39) in women. As a binary predictor, BMI with a cut-off point of 24.9 kg/m2 in men (1.91; 1.40-2.62) and WC with a cut-off point of 98 cm in women (1.57; 1.17-2.10) were the best in adjusted models. WC, WHpR, and WHtR were significantly associated with an increased risk of HTN only in participants whose weight was normal (BMI, 18.5-24.9 kg/m2). CONCLUSION: Therefore, BMI in men and WC in women were the best predictors of HTN, both as continuous and binary factors at their appropriate cut-off points.


Asunto(s)
Hipertensión/epidemiología , Obesidad/complicaciones , Adiposidad , Adulto , Antropometría , Determinación de la Presión Sanguínea , Índice de Masa Corporal , Estudios de Cohortes , Femenino , Estudios de Seguimiento , Humanos , Hipertensión/etiología , Incidencia , Entrevistas como Asunto , Irán/epidemiología , Funciones de Verosimilitud , Masculino , Persona de Mediana Edad , Obesidad/epidemiología , Examen Físico , Curva ROC , Encuestas y Cuestionarios , Circunferencia de la Cintura , Relación Cintura-Estatura , Relación Cintura-Cadera
18.
Nutrients ; 11(7)2019 Jul 12.
Artículo en Inglés | MEDLINE | ID: mdl-31336862

RESUMEN

Socioeconomically disadvantaged people are disproportionally more likely to develop obesity and obesity-related diseases. However, it remains unclear to what extent diet quality contributes to socioeconomic inequalities in obesity. We aimed to assess the role of diet quality in the association between socioeconomic status (SES) and obesity. Data originated from the national nutrition survey, a cross-sectional sample of the adult Swiss population (N = 1860). We used education and income as proxies for SES; calculated the Alternate Healthy Eating Index (AHEI) as a measure of diet quality; and used body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) as obesity markers. We applied counterfactual mediation modelling to generate odds ratios, 95% confidence intervals, and the proportion mediated by diet quality. Individuals with less than a tertiary education were two to three times more likely to be obese, regardless of the marker (OR (95% CI): 3.36 (2.01, 5.66) using BMI; 2.44 (1.58, 3.75) using WC; 2.48 (1.63, 3.78) using WHR; and 2.04 (1.43, 2.96) using WHtR). The proportion of the association between educational level and obesity that was mediated by diet quality was 22.1% using BMI, 26.6% using WC, 31.4% using WHtR, and 35.8% using WHR. Similar findings were observed for income. Our findings suggest that diet quality substantially contributes to socioeconomic inequalities in obesity while it does not fully explain them. Focusing efforts on improving the diet quality of disadvantaged groups could help reduce social inequalities in obesity.


Asunto(s)
Dieta/normas , Encuestas Nutricionales , Obesidad/epidemiología , Obesidad/etiología , Clase Social , Adulto , Índice de Masa Corporal , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Suiza/epidemiología , Circunferencia de la Cintura , Relación Cintura-Estatura , Relación Cintura-Cadera
19.
Georgian Med News ; (290): 89-96, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-31322522

RESUMEN

The aim of the research was standard and alternative measurement of anthropometric indices in Georgian healthy elderly population for determining the reliability/validity of the widely used and recognized assessment tools. Our research is the first study of the anthropometry as the part of of nutritional status assessment in Georgian elderly. For anthropometric assessment we first time used 1. Standard measurements (weight, height, WC, HC, MAC /MUAC, TSF, BMI, WHR, AMA using standard methods and tools for measurable values and standard formulas for calculating values), and 2. Alternative measurements (demispan, demispan equivalent height and BMI (DEH, DE BMI), Mindex for women, Demiquet for men. using Bassey's equations). Our study group formed for the nutritional status assessment in Georgian healthy elderly (Study group ≥ 60 y (n=75): men (n=14); women (n=61). Subgroup <75 y (n=64): men (n=9); women (n=55); Subgroup 75+ y (n=11); men (n=5); women (n=6)). Based on BMI range, the data from 78.7% of participants' were above the norm, 21.3% - normal and 0 - below the norm. The findings of our study have shown that BMI is not height-dependent variable, moreover, BMI as mindex and demiquet is a mass/weight-dependent anthropometric characteristic. BMI, demiquet and mindex had nearly same correlation with other anthropometric parameters (especially for women). High correlation between direct measured/calculated BMI and DE BMI were confirmed by Pearson coefficient 0.979 (p<0.01). The Cohen's Unweighted Kappa index was 0.8518 (0.81 - 1.00 almost perfect or perfect agreement). According to the Paired Samples Test results, there were no difference between BMI and DE BMI. Statistically significant difference between the BMI and DE BMI was determined only for men (0.003 - difference is significant at p<0.05). However, there were only 14 men in our research group and the use of this method recommended in a larger group. Graphical Bland and Altman agreement analysis demonstrated the absence of the trends in differences between BMI and DE BMI. The findings of our research confirm that Demi-span is a reliable measure of stature in Georgian healthy elderly. Demiquet and Mindex are useful indices for our population and suitable for use in clinical practice and in the study of the Georgian elderly when the use of standard weight to height indices may be questionable. Considering to results of statistical analysis, strength of correlation and agreement between direct measured BMI and alternative BMI confirms that the Bassey's equation is valid for Georgian healthy elderly, Demispan equivalent height and BMI is reliable and, accordingly, useful in case of lack of standard calculations or to avoid errors of direct measurements. However, further studies with higher subject numbers are needed to confirm our findings. Additional studies covering other communities in Georgia with different socioeconomic and ethnic composition, also, with different diseases would be necessary to obtain a better anthropometric characterization of the Georgian elderly.


Asunto(s)
Antropometría , Brazo/anatomía & histología , Estatura , Índice de Masa Corporal , Evaluación Geriátrica/métodos , Anciano , Anciano de 80 o más Años , Antropometría/métodos , Estudios Transversales , Femenino , Georgia , Voluntarios Sanos , Humanos , Masculino , Estado Nutricional , Valores de Referencia , Reproducibilidad de los Resultados , Grosor de los Pliegues Cutáneos , Circunferencia de la Cintura , Relación Cintura-Cadera
20.
BMC Public Health ; 19(1): 700, 2019 Jun 06.
Artículo en Inglés | MEDLINE | ID: mdl-31170949

RESUMEN

BACKGROUND: Little is known about the long-term shifts in distributions of three abdominal-obesity-related indicators, waist circumference (WC), waist-to-hip ratio (WHpR) and waist-to-height ratio (WHtR) among Chinese adults. Traditional mean regression models used in the previous analyses were limited in their ability to capture cross-distribution among effects. The current study aims to describe the shift in distribution of WC, WHpR, and WHtR over a period of 18 years (1993-2011) in China, and to reveal quantile-specific associations of the three indicators with key covariates. METHODS: Longitudinal data from seven waves of the China Health and Nutrition Surveys (CHNS) in 1993, 1997, 2000, 2004, 2006, 2009 and 2011 were analyzed. The LMS method was used to illustrate the gender-specific quantile curves of WC, WHtR and WHpR over age. Separate gender-stratified longitudinal quantile regressions were employed to investigate the effect of important factors on the trends of the three indicators. RESULTS: A total of 11,923 participants aged 18-65 years with 49,507 observations were included in the analysis. The density curves of WC, WHtR and WHpR shifted to right and became wider. The three outcomes all increased with age and increased more at upper percentiles. From the multivariate quantile regression, physical activity was negatively associated in both genders; smoking only had a negative effect on male indicators. Education and drinking behavior both had opposite effects on the three indicators between men and women. Marital status and income were positively associated with the shifts in WC, WHtR and WHpR in male and female WC, while urbanicity index had a positive effect on three outcomes in men but inconsistent effect among female outcomes. CONCLUSIONS: The abdominal-obesity related indicators of the Chinese adults experienced rapid growth according to our population-based, age- and gender-specific analyses. Over the 18-year study period, major increases in WC, WHtR and WHpR were observed among Chinese adults. Specifically, these increases were greater at upper percentiles and in men. Age, physical activity, energy intake, drinking, smoking, education, income and urbanicity index were associated with elevated abdominal obesity indicators, and the effects differed among percentiles and between genders.


Asunto(s)
Grupo de Ascendencia Continental Asiática/estadística & datos numéricos , Obesidad/epidemiología , Circunferencia de la Cintura , Relación Cintura-Estatura , Relación Cintura-Cadera , Adolescente , Adulto , Anciano , Índice de Masa Corporal , China/epidemiología , Ingestión de Energía , Ejercicio , Femenino , Humanos , Renta , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Encuestas Nutricionales , Obesidad Abdominal/epidemiología , Análisis de Regresión , Adulto Joven
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