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1.
J Vis Exp ; (168)2021 02 13.
Artículo en Inglés | MEDLINE | ID: mdl-33645555

RESUMEN

The retina transforms light signals from the environment into electrical signals that are propagated to the brain. Diseases of the retina are prevalent and cause visual impairment and blindness. Understanding how such diseases progress is critical to formulating new treatments. In vivo microscopy in animal models of disease is a powerful tool for understanding neurodegeneration and has led to important progress towards treatments of conditions ranging from Alzheimer's disease to stroke. Given that the retina is the only central nervous system structure inherently accessible by optical approaches, it naturally lends itself towards in vivo imaging. However, the native optics of the lens and cornea present some challenges for effective imaging access. This protocol outlines methods for in vivo two-photon imaging of cellular cohorts and structures in the mouse retina at cellular resolution, applicable for both acute- and chronic-duration imaging experiments. It presents examples of retinal ganglion cell (RGC), amacrine cell, microglial, and vascular imaging using a suite of labeling techniques including adeno-associated virus (AAV) vectors, transgenic mice, and inorganic dyes. Importantly, these techniques extend to all cell types of the retina, and suggested methods for accessing other cellular populations of interest are described. Also detailed are example strategies for manual image postprocessing for display and quantification. These techniques are directly applicable to studies of retinal function in health and disease.


Asunto(s)
Fotones , Pupila/fisiología , Retina/diagnóstico por imagen , Animales , Calcio/metabolismo , Dependovirus/metabolismo , Procesamiento de Imagen Asistido por Computador , Inyecciones Intravítreas , Ratones , Ratones Transgénicos , Microglía/citología , Células Ganglionares de la Retina/citología , Programas Informáticos
2.
Medicine (Baltimore) ; 100(10): e24670, 2021 Mar 12.
Artículo en Inglés | MEDLINE | ID: mdl-33725826

RESUMEN

ABSTRACT: To report the rationale, design, and baseline demographic characteristics of TuYou-County Pediatric Eye study, which mainly aimed to determine the retinal microvascular changes with optical coherence tomography angiography (OCTA) and its association with eye abnormalities in school aged children and adolescents at suburban location in Northern China.TuYou-County Pediatric Eye study was a school-based survey conducted in TuYou-County. Multi-ethnic (Mongol, Han, and Hui) participants will be followed up for 5 years. Standardized ophthalmological examinations include visual acuity, ocular biometry, retinal photography, and OCTA. A questionnaire survey was conducted to collect variables regarding to eye disease such as parental history of eye diseases, near work, outdoor activities, living and eating habits, etc.After sampling, 687 participants were eligible for investigation, and 20 students did not attend the investigation, living 667 (response rate, 97.1%) students completed questionnaires and all ocular examinations. The average age of all participants was 14.9 ±â€Š5.11.TYPE study is the first large-scale school-based multi-ethnic survey in suburban site of Northern China. Continuous identification of retinal microvascular changes with eye diseases will provide new insights into the control related diseases in school-age children and adolescents.


Asunto(s)
Microvasos/diagnóstico por imagen , Proyectos de Investigación , Retina/diagnóstico por imagen , Vasos Retinianos/diagnóstico por imagen , Trastornos de la Visión/diagnóstico , Adolescente , Angiografía , Niño , China/epidemiología , Femenino , Humanos , Incidencia , Masculino , Prevalencia , Instituciones Académicas/estadística & datos numéricos , Población Suburbana/estadística & datos numéricos , Tomografía de Coherencia Óptica , Trastornos de la Visión/epidemiología , Agudeza Visual
3.
Vestn Oftalmol ; 137(1): 46-52, 2021.
Artículo en Ruso | MEDLINE | ID: mdl-33610149

RESUMEN

PURPOSE: To evaluate the first outcomes of non-contact navigated laser retinopexy for peripheral tears and rhegmatogenous degenerations of the retina. MATERIAL AND METHODS: This prospective single-center interventional pilot study included 58 patients (68 eyes), among which 19 males and 39 females aged 47.5±16.9 years with peripheral retinal degenerations and symptomatic retinal tears who received non-contact laser retinopexy with the Navilas 577s navigated laser system and non-contact PRP widefield objective. All patients (68 eyes) underwent laser treatment for the following disorders: horseshoe tear in 13 eyes, retinal hole in 11 eyes, operculated retinal hole in 3 eyes, lattice degeneration in 19 eyes, snail track degeneration in 1 eye, vitreoretinal tufts in 16 eyes, and progressing bullous retinoschisis in 5 eyes. Pain intensity was assessed using a four-point verbal rating scale. RESULTS: All patients were followed up for 5 to 21 months (9.0±3.3 months on average). Stable condition of the retina was observed in 65 cases (95.5%). In 3 eyes (4.4%), newly formed retinal tears prompted additional laser treatment: horseshoe tear in 2 eyes and retinal hole in 1 eye. The mean pain score during non-contact navigated laser retinopexy was 0.9±0.5. No complications associated with laser treatment were observed. CONCLUSION: Non-contact navigated laser retinopexy performed with the Navilas 577s navigated laser system is a safe and well-tolerated procedure with effectiveness comparable to conventional laser retinopexy.


Asunto(s)
Desprendimiento de Retina , Perforaciones de la Retina , Adulto , Femenino , Humanos , Coagulación con Láser , Rayos Láser , Masculino , Persona de Mediana Edad , Proyectos Piloto , Estudios Prospectivos , Retina/diagnóstico por imagen , Retina/cirugía , Desprendimiento de Retina/diagnóstico , Desprendimiento de Retina/etiología , Desprendimiento de Retina/cirugía , Perforaciones de la Retina/diagnóstico , Perforaciones de la Retina/etiología , Perforaciones de la Retina/cirugía
4.
Vestn Oftalmol ; 137(1): 107-114, 2021.
Artículo en Ruso | MEDLINE | ID: mdl-33610158

RESUMEN

Chronic kidney disease (CKD) is a significant public health problem with a high risk of developing age-dependent eye diseases. Renal glomeruli and the choroid have similar structures and vascular networks; the internal hematoretinal barrier and the glomerular filtration barrier have similar developmental path; the renin-angiotensin-aldosterone hormonal system is found in both the eye and the kidneys. All this determines the similarity of physiological and pathogenetic features of the development of diseases associated with these organs. The article discusses general risk factors and pathophysiological mechanisms of development of retinal and renal lesions in CKD, the influence of various factors of pathogenesis on their development and progression. The anatomical similarity of vascularization, accompanied by microvascular changes in the retina and kidneys, leads to similar complications in both organs. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A) are accurate, well reproducible and non-invasive methods for diagnosing and assessing changes in the retinal microvascular bed, which make it possible to assess microvasculature changes in the kidneys. In CKD, the retina shows signs of impaired capillary perfusion, a decrease in their density, expansion of intercapillary spaces, a rarefaction of the density of the parafoveolar capillary network, which may indicate a decrease in peritubular capillary blood flow, blood circulation of the kidneys in general and their ischemia. Significant thinning of the retina and choroid, along with a decrease in macular volume, even in the initial stages of CKD, is accompanied by impaired renal function (changes in the estimated glomerular filtration rate and urinary albumin excretion), which is a sign of systemic microvascular lesion and pathological process in the kidneys. Therefore, monitoring of retinal vessels using OCT and OCT-A can become a reliable indicator of the progression of renal microvascular changes at any stage of the disease.


Asunto(s)
Insuficiencia Renal Crónica , Vasos Retinianos , Coroides , Angiografía con Fluoresceína , Humanos , Insuficiencia Renal Crónica/complicaciones , Insuficiencia Renal Crónica/diagnóstico , Retina/diagnóstico por imagen , Vasos Retinianos/diagnóstico por imagen , Tomografía de Coherencia Óptica
5.
Ideggyogy Sz ; 74(1-2): 57-63, 2021 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-33497054

RESUMEN

Background and purpose: The study aims to investigate the relationship between the progression of idiopathic Parkinson's disease (IPD) and retinal morphology. Methods: The study was carried out with 23 patients diagnosed with early-stage IPD (phases 1 and 2 of the Hoehn and Yahr scale) and 30 age-matched healthy controls. All patients were followed up at least two years, with 6-month intervals (initial, 6th month, 12th month, 18th month, and 24th month), and detailed neurological and ophthalmic examinations were performed at each follow-up. Unified Parkinson's Disease Rating Scale part III (UPDRS Part III) scores, Hoehn and Yahr (H&Y) scores, best-corrected visual acuity (BCVA), intraocular pressure (IOP) measurement, central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness were analyzed at each visit. Results: The average age of the IPD and control groups was 43.96 ± 4.88 years, 44.53 ± 0.83 years, respectively. The mean duration of the disease in the IPD group was 7.48 ± 5.10 months at the start of the study (range 0-16). There was no statistically significant difference in BCVA and IOP values between the two groups during the two-year follow-up period (p> 0.05, p> 0.05, respectively). Average and superior quadrant RNFL thicknesses were statistically different between the two groups at 24 months and there was no significant difference between other visits (p=0.025, p=0.034, p> 0.05, respectively). There was no statistically significant difference in CMT between the two groups during the follow-up period (p> 0.05). Conclusion: Average and superior quadrant RNFL thicknesses were significantly thinning with the progression of IPD.


Asunto(s)
Enfermedad de Parkinson , Adulto , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Fibras Nerviosas , Retina/diagnóstico por imagen , Tomografía de Coherencia Óptica
6.
J Med Case Rep ; 15(1): 15, 2021 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-33451352

RESUMEN

BACKGROUND: Hyperreflective lesions at the level of ganglion cell (GCL) and inner plexiform retinal layers (IPL) by optical coherence tomography (OCT) and cotton wool spots in the examination of the eye fundus have recently been described as findings in patients with COVID-19 infection. CASE REPORT: We report the case of a 42-year-old healthy Caucasian male anesthetist who had treated COVID-19 patients during the previous 5 weeks and suddenly presented with a temporal relative scotoma in his left eye. Best-corrected visual acuity was 20/20 for the left eye, and no discromatopsy or afferent pupillary defect was present. Visual field test was performed, with no significant findings associated with the focal loss of sensitivity described by the patient. The anterior segment was unremarkable on slit lamp examination in both eyes. Fundus examination of the left eye showed no significant findings. A placoid, hyperreflective band at the level of the GCL and IPL was visible in OCT which spared the outer retina, at the time of diagnosis and 1 month later. An oropharyngeal swab test was performed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA), immunoglobulin G (IgG) and immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) determination. Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) was negative. ELISA testing and a third rapid antibody detection test performed 7 days after the onset of symptoms were positive. CONCLUSIONS: Ocular signs and symptoms in COVID-19 cases are rarely reported, but may be underestimated, especially those that affect the retina and occur in asymptomatic or paucisymptomatic cases. We present a case of COVID-19 diagnosis based on retinal ophthalmic examination.


Asunto(s)
Fondo de Ojo , Retina/diagnóstico por imagen , Escotoma , Tomografía de Coherencia Óptica/métodos , Adulto , Infecciones Asintomáticas , /diagnóstico , /métodos , Errores Diagnósticos/prevención & control , Técnicas de Diagnóstico Oftalmológico , Humanos , Masculino , Escotoma/diagnóstico , Escotoma/etiología , Agudeza Visual
7.
BMJ Case Rep ; 14(1)2021 Jan 06.
Artículo en Inglés | MEDLINE | ID: mdl-33408110

RESUMEN

A 10-year-old boy underwent stem cell transplant for Hodgkin's lymphoma and developed vomiting and seizure in the postoperative period. An ophthalmic referral was made from intensive care unit, to rule out papilledema. On examination, there was no papilledema in both eyes, instead there were areas of retinal necrosis with no haemorrhages or vitritis in right eye. Cerebrospinal fluid serology was negative for herpes but MRI showed hyperintensity in temporal lobe. A clinical diagnosis of progressive outer retinal necrosis (PORN) was made and fundus picture was documented with help of a smartphone and 20D lens. High-dose intravenous injection acyclovir was started and PORN lesion improved on treatment.


Asunto(s)
Antivirales/administración & dosificación , Trasplante de Médula Ósea/efectos adversos , Infecciones por Herpesviridae/diagnóstico , Enfermedad de Hodgkin/terapia , Retina/patología , Retinitis/diagnóstico , Aciclovir/administración & dosificación , Niño , Diagnóstico Diferencial , Relación Dosis-Respuesta a Droga , Infecciones por Herpesviridae/tratamiento farmacológico , Infecciones por Herpesviridae/inmunología , Enfermedad de Hodgkin/inmunología , Humanos , Inmunosupresores/efectos adversos , Hallazgos Incidentales , Imagen por Resonancia Magnética , Masculino , Necrosis/diagnóstico , Necrosis/tratamiento farmacológico , Necrosis/inmunología , Retina/diagnóstico por imagen , Retina/virología , Síndrome de Necrosis Retiniana Aguda/diagnóstico , Retinitis/tratamiento farmacológico , Retinitis/inmunología , Resultado del Tratamiento , Activación Viral/inmunología
8.
Psychiatr Danub ; 32(3-4): 351-358, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33370732

RESUMEN

BACKGROUND: Retina is considered as a window to the brain due to the similarities in terms of development and pathologies. Optical coherence tomography (OCT) can perform quantitative examinations in the retina. In this study, we aimed to investigate the effects of drugs used in schizophrenia and bipolar disorder (BD) on retinal nerve fiber layer (RNFL) and macular thickness. SUBJECTS AND METHODS: The study included schizophrenia (n=35) and euthymic BD (n=46) patients on various medications, and age, gender matched healthy control group (n=31). For retinal evaluation, measurements of RNFL and macula were performed with Optovue RTVue Premier OCT. RESULTS: In the schizophrenia group, chlorpromazine equivalent dose of antipsychotics was a statistically significant negative predictor of left RNFL nasal superior region thickness. In the BD group, serum valproate level was a significant positive predictor of thickness in the right macular inferior outer, left macular nasal outer region, right RNFL inferotemporal, left temporal and inferotemporal regions. CONCLUSION: Since the retina consists of neurons, morphological or functional examination of retina may be beneficial for the evaluation of the effects of psychopharmalogical treatments in schizophrenia and BD. The outcome of this study implies that valproate has neuroprotective effects on the optic nerve and macula, and this finding is consistent with the literature implying neurotrophic effects of valproate.


Asunto(s)
Trastorno Bipolar/diagnóstico por imagen , Trastorno Bipolar/tratamiento farmacológico , Retina/efectos de los fármacos , Retina/diagnóstico por imagen , Esquizofrenia/diagnóstico por imagen , Esquizofrenia/tratamiento farmacológico , Tomografía de Coherencia Óptica , Adulto , Femenino , Humanos , Mácula Lútea/diagnóstico por imagen , Mácula Lútea/efectos de los fármacos , Masculino , Fibras Nerviosas/efectos de los fármacos
9.
Sensors (Basel) ; 20(24)2020 Dec 11.
Artículo en Inglés | MEDLINE | ID: mdl-33322285

RESUMEN

Computational ghost imaging (CGI), with the advantages of wide spectrum, low cost, and robustness to light scattering, has been widely used in many applications. The key issue is long time correlations for acceptable imaging quality. To overcome the issue, we propose parallel retina-like computational ghost imaging (PRGI) method to improve the performance of CGI. In the PRGI scheme, sampling and reconstruction are carried out by using the patterns which are divided into blocks from designed retina-like patterns. Then, the reconstructed image of each block is stitched into the entire image corresponding to the object. The simulations demonstrate that the proposed PRGI method can obtain a sharper image while greatly reducing the time cost than CGI based on compressive sensing (CSGI), parallel architecture (PGI), and retina-like structure (RGI), thereby improving the performance of CGI. The proposed method with reasonable structure design and variable selection may lead to improve performance for similar imaging methods and provide a novel technique for real-time imaging applications.


Asunto(s)
Diagnóstico por Imagen , Procesamiento de Imagen Asistido por Computador , Retina/diagnóstico por imagen , Humanos
10.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1360-1363, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018241

RESUMEN

Registration of multimodal retinal images is of great importance in facilitating the diagnosis and treatment of many eye diseases, such as the registration between color fundus images and optical coherence tomography (OCT) images. However, it is difficult to obtain ground truth, and most existing algorithms are for rigid registration without considering the optical distortion. In this paper, we present an unsupervised learning method for deformable registration between the two images. To solve the registration problem, the structure achieves a multi-level receptive field and takes contour and local detail into account. To measure the edge difference caused by different distortions in the optics center and edge, an edge similarity (ES) loss term is proposed, so loss function is composed by local cross-correlation, edge similarity and diffusion regularizer on the spatial gradients of the deformation matrix. Thus, we propose a multi-scale input layer, U-net with dilated convolution structure, squeeze excitation (SE) block and spatial transformer layers. Quantitative experiments prove the proposed framework is best compared with several conventional and deep learningbased methods, and our ES loss and structure combined with Unet and multi-scale layers achieve competitive results for normal and abnormal images.


Asunto(s)
Algoritmos , Retina , Fondo de Ojo , Retina/diagnóstico por imagen , Tomografía de Coherencia Óptica
11.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1592-1595, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018298

RESUMEN

Clinically, the Fundus Fluorescein Angiography (FA) is a more common mean for Diabetic Retinopathy (DR) detection since the DR appears in FA much more contrasty than in Color Fundus Image (CF). However, acquiring FA has a risk of death due to the fluorescent allergy. Thus, in this paper, we explore a novel unpaired CycleGAN-based model for the FA synthesis from CF, where some strict structure similarity constraints are employed to guarantee the perfectly mapping from one domain to another one. First, a triple multi-scale network architecture with multi-scale inputs, multi-scale discriminators and multi-scale cycle consistency losses is proposed to enhance the similarity between two retinal modalities from different scales. Second, the self-attention mechanism is introduced to improve the adaptive domain mapping ability of the model. Third, to further improve strict constraints in the feather level, quality loss is employed between each process of generation and reconstruction. Qualitative examples, as well as quantitative evaluation, are provided to support the robustness and the accuracy of our proposed method.


Asunto(s)
Retinopatía Diabética , Retina , Atención , Retinopatía Diabética/diagnóstico , Angiografía con Fluoresceína , Fondo de Ojo , Humanos , Retina/diagnóstico por imagen
12.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1863-1866, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018363

RESUMEN

The deterioration of the retina center could be the main reason for vision loss. Older people usually ranging from 50 years and above are exposed to age-related macular degeneration (AMD) disease that strikes the retina. The lack of human expertise to interpret the complexity in diagnosing diseases leads to the importance of developing an accurate method to detect and localize the targeted infection. Approaching the performance of ophthalmologists is the consistent main challenge in retinal disease segmentation. Artificial intelligence techniques have shown enormous achievement in various tasks in computer vision. This paper depicts an automated end-to-end deep neural network for retinal disease segmentation on optical coherence tomography (OCT) scans. The work proposed in this study shows the performance difference between convolution operations and atrous convolution operations. Three deep semantic segmentation architectures, namely U-net, Segnet, and Deeplabv3+, have been considered to evaluate the performance of varying convolution operations. Empirical outcomes show a competitive performance to the human level, with an average dice score of 0.73 for retinal diseases.


Asunto(s)
Enfermedades de la Retina , Tomografía de Coherencia Óptica , Anciano , Anciano de 80 o más Años , Inteligencia Artificial , Humanos , Redes Neurales de la Computación , Retina/diagnóstico por imagen , Enfermedades de la Retina/diagnóstico por imagen
13.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1867-1870, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018364

RESUMEN

Automatic detection of age-related macular degeneration (AMD) from optical coherence tomography (OCT) images is often performed using the retinal layers only and choroid is excluded from the analysis. This is because symptoms of AMD manifest in the choroid only in the later stages and clinical literature is divided over the role of the choroid in detecting earlier stages of AMD. However, more recent clinical research suggests that choroid is affected at a much earlier stage. In the proposed work, we experimentally verify the effect of including the choroid in detecting AMD from OCT images at an intermediate stage. We propose a deep learning framework for AMD detection and compare its accuracies with and without including the choroid. Results suggest that including the choroid improves the AMD detection accuracy. In addition, the proposed method achieves an accuracy of 96.78% which is comparable to the state-of-the-art works.


Asunto(s)
Degeneración Macular , Tomografía de Coherencia Óptica , Coroides/diagnóstico por imagen , Humanos , Degeneración Macular/diagnóstico por imagen , Retina/diagnóstico por imagen
14.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1958-1961, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018386

RESUMEN

Detailed extraction of retinal vessel morphology is of great significance in many clinical applications. In this paper, we propose a retinal image segmentation method, called MAU-Net, which is based on the U-net structure and takes advantages of both modulated deformable convolution and dual attention modules to realize vessels segmentation. Specifically, based on the classic U-shaped architecture, our network introduces the Modulated Deformable Convolutional (MDC) block as encoding and decoding unit to model vessels with various shapes and deformations. In addition, in order to obtain better feature presentations, we aggregate the outputs of dual attention modules: the position attention module (PAM) and channel attention module (CAM). On three publicly available datasets: DRIVE, STARE and CHASEDB1, we have achieved superior performance to other algorithms. Quantitative and qualitative experimental results show that our MAU-Net can effectively and accurately accomplish the retinal vessels segmentation task.


Asunto(s)
Procesamiento de Imagen Asistido por Computador , Vasos Retinianos , Algoritmos , Retina/diagnóstico por imagen , Vasos Retinianos/diagnóstico por imagen , Manejo de Especímenes
15.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1980-1983, 2020 07.
Artículo en Inglés | MEDLINE | ID: mdl-33018391

RESUMEN

Symmetry can be defined as uniformity, equivalence or exact similarity of two parts divided along an axis. While our left and right eyes clearly have a high degree of external bilateral symmetry, it is less obvious to what degree they have internal bilateral symmetry. In this paper, we try to find approximate-bilateral symmetry in retina, one of the internal parts of our eye, which plays a vital role in our vision and also can be used as a powerful biometric. Contrary to previous works, we study interretinal symmetry from a biometric perspective. In other words, we study whether the left and right retinal symmetry is strong enough to reliably tell whether a pair of the left and right retinas belongs to a single person. For this, we focus on overall symmetry of the retinas rather than specific attributes such as length, area, thickness, or the number of blood vessels. We evaluate and analyse the performance of both human and neural network based bilateral retina verification on fundus photographs. By experimenting on a publicly available data set, we confirm interretinal symmetry.


Asunto(s)
Técnicas de Diagnóstico Oftalmológico , Fotograbar , Biometría , Humanos , Procedimientos Quirúrgicos Oftalmológicos , Retina/diagnóstico por imagen
16.
Vestn Oftalmol ; 136(6): 50-56, 2020.
Artículo en Ruso | MEDLINE | ID: mdl-33084279

RESUMEN

PURPOSE: To determine the indications and assess the effectiveness of laser coagulation of the retina (RLC) after different types of surgeries for retinal detachment (RD), except vitrectomy. MATERIAL AND METHODS: The study included 160 patients (165 eyes) with various types of retinal detachment and retinoschisis who remained under observation for 11 years. RESULTS: In case of retinal tear with a slight local RD (less than one quadrant), we recommend the use of RLC as monotherapy. Such patients are indicated to undergo regular examinations (1 month, 3 months, 6 months, 1 year). Due to risk of tractional defects of the retina in the lower quadrants during the introduction of gas-air mixture into the vitreous cavity, in the presence of retinal pathology it is recommended to perform RLC before the pneumatic retinopexy stage. In large retinal tears, despite their upper localization, pneumatic retinopexy is not indicated due to the possibility of gas spilling over the edges of the tear under the retina, leading to an increase in the initial size of the tear and spread of RD. We noted the effectiveness of RLC monotherapy for retinal detachment of various localization. After sealing the sclera, retinal laser coagulation on the shaft along the seal is necessary to limit the tear along the edge, since over time the seal may shift causing a relapse of RD. CONCLUSION: The study has confirmed the effectiveness of laser coagulation of the retina as an independent method for the treatment of retinoschisis and retinal tears with local detachment.


Asunto(s)
Desprendimiento de Retina , Retinosquisis , Humanos , Coagulación con Láser , Retina/diagnóstico por imagen , Retina/cirugía , Desprendimiento de Retina/diagnóstico , Desprendimiento de Retina/etiología , Desprendimiento de Retina/cirugía , Retinosquisis/diagnóstico , Retinosquisis/etiología , Retinosquisis/cirugía , Vitrectomía
17.
Vestn Oftalmol ; 136(5): 39-45, 2020.
Artículo en Ruso | MEDLINE | ID: mdl-33056962

RESUMEN

PURPOSE: To study the long-term clinical and functional outcomes of retinopathy in extremely premature infants. MATERIAL AND METHODS: The study included 42 patients (84 eyes) with retinopathy of prematurity (ROP) at the age of 9-18 years. All patients underwent comprehensive ophthalmological examination, including morphometric (OCT), functional (ERG) and psycho-physical (computer perimetry) methods. RESULTS: A high occurrence of low vision (67%) was revealed in extremely premature children with ROP during school years and adolescence, which depended on the severity of active ROP and the formation of pronounced residual changes in the fundus during the cicatricial phase of the disease, a high occurrence of refractive errors (92%), including high degree myopia (46%), late complications that develop with ROP of any degree (68%), impaired retinal electrogenesis - due to both ROP and deep morphological and functional immaturity of the retina. CONCLUSION: Patients with any degree of cicatricial ROP born in the early stages of gestation and with extremely low body weight need regular complex ophthalmologic examination and lifelong follow-up.


Asunto(s)
Miopía , Errores de Refracción , Retinopatía de la Prematuridad , Adolescente , Niño , Humanos , Lactante , Recien Nacido Extremadamente Prematuro , Recién Nacido , Retina/diagnóstico por imagen , Retinopatía de la Prematuridad/diagnóstico , Retinopatía de la Prematuridad/epidemiología
18.
Artículo en Ruso | MEDLINE | ID: mdl-33081441

RESUMEN

OBJECTIVE: To study the relationship between cognitive deficits and retinal neuroarchitectonics in Alzheimer's disease, vascular dementia, and glaucoma based on optical coherence tomography. MATERIAL AND METHODS: A comprehensive examination of 90 patients with Alzheimer's disease, vascular dementia and glaucoma was conducted. The patients were divided into three groups of 30 people each. The groups were comparable by gender and age and initial socio-economic status. All patients underwent a comprehensive neurological and neuropsychological study as well as optical coherence tomography. RESULTS AND CONCLUSION: The results of optical coherence tomography in Alzheimer's disease and glaucoma reveal retinal changes in the perifocal region in the upper and lower quadrants. In patients with vascular dementia, the process is observed in the foveal (central) region of the retina, which can be considered as a potential biomarker of the neurodegenerative damage. The severity of cognitive deficit in the Alzheimer's disease group correlates with the degree of degeneration in the layers of the peripapillary layer of the nerve fibers of the retina of the temporal region, the perifocal region of the lower quadrant of the retina, ganglion cells, and the inner plexiform layers of the retina. In the vascular dementia group, the severity of cognitive deficit positively correlates with the degree of cell degeneration in the foveal region of the inner plexiform retinal layer.


Asunto(s)
Enfermedad de Alzheimer , Disfunción Cognitiva , Enfermedad de Alzheimer/complicaciones , Enfermedad de Alzheimer/diagnóstico por imagen , Disfunción Cognitiva/diagnóstico por imagen , Humanos , Fibras Nerviosas , Retina/diagnóstico por imagen , Tomografía de Coherencia Óptica
19.
Klin Monbl Augenheilkd ; 237(10): 1187-1193, 2020 Oct.
Artículo en Inglés, Alemán | MEDLINE | ID: mdl-33059378

RESUMEN

In recent years, an increasing incidence of laser pointer-associated retinal injuries has been observed, likely due to easy access to incorrectly classified laser pointers, their labelling as toys, and lack of awareness concerning the associated risk. Laser pointer exposure can lead to irreversible retinal damage and associated vision loss, depending on the wavelength, radiation power, duration of exposure, localization, and spot size. Pronounced retinal laser damage is especially seen in children and teenagers. The structural appearance of retinal laser pointer damage varies and, in some cases, may be a diagnostic challenge. Besides often subtle findings on optical coherence tomography examination, characteristic alterations on near-infrared autofluorescence imaging may be valuable for the diagnosis of retinal laser pointer injuries and for differentiating other retinal lesions with similar appearance. The increase in laser pointer injuries indicates that regulatory actions and increased public awareness are required regarding the dangers of laser pointers.


Asunto(s)
Retina , Enfermedades de la Retina , Adolescente , Niño , Humanos , Rayos Láser , Retina/diagnóstico por imagen , Enfermedades de la Retina/etiología , Tomografía de Coherencia Óptica , Agudeza Visual
20.
Klin Monbl Augenheilkd ; 237(10): 1225-1229, 2020 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-33059379

RESUMEN

One of the most controversial discussions in retinal surgery is currently being held about the importance of intraoperative OCT (iOCT). The background is the desire to combine the 2-dimensional fundus view of the surgeon with the layered depth information of OCT to achieve a 4-dimensional "augmented reality" (3-D plus change over time). This should help to visualise fine structures, which have been hidden from the surgeon's view. Therefore, retinal surgery seems to be predestined for the use of iOCT. The great hope is that a dynamic live 3-D image with real-time feedback will provide the surgeon with additional information and improve safety. Although fascinating at the first glance, in the surgical routine, however, iOCT technology is disappointing, especially in macular surgery. It rarely provides substantial information that would not be obtainable without iOCT or that would not be available in much better quality through preoperative diagnostic testing. Only some special indications remain, particularly related to subretinal surgery.


Asunto(s)
Retina , Tomografía de Coherencia Óptica , Fondo de Ojo , Procedimientos Quirúrgicos Oftalmológicos , Retina/diagnóstico por imagen , Retina/cirugía , Cuerpo Vítreo
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