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1.
Chemosphere ; 279: 130923, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34134442

RESUMEN

Historical use of organochlorine pesticides (OCPs) in the Republic of Moldova could pose a potential risk for the aquatic environment due to the persistence, bioaccumulation and toxic properties of these environmental pollutants. However, knowledge on environmental concentrations of legacy OCPs in Moldova is limited. In this study, surface sediment from the two main rivers; Dniester (8 sites, n = 15) and Prut (6 sites, n = 12), and two tributary rivers; Bîc (11 sites, n = 11) and Raut (6 sites, n = 6), were collected during 2017-2018 and analyzed for hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs) and their transformation products (DDDs and DDEs) using gas chromatography coupled to mass spectrometry (GC-MS/MS). Sediment concentrations of Æ©6DDX (1.9-140 ng g-1 dry weight (dw)) and Æ©4HCHs (n.d-2.5 ng g-1 dw) were found. In the big rivers, the average Æ©6DDX concentration (18 ng g-1 dw) were 35 times higher than Æ©4HCHs (0.51 ng g-1 dw). Whereas, in the small rivers the average Æ©6DDX concentration (32 ng g-1 dw) was approximately 41 times higher than Æ©4HCHs (0.77 ng g-1 dw). Compared to previous studies from Eastern Europe, the sediment levels were generally similar as found in Moldova's neighboring countries (Romania and Ukraine). Overall, the contamination profile indicates long-term ageing of OCPs used in the past in the agricultural sector. Less than half of the sites (45%) had levels that pose a potential risk for benthic organisms. Hence, further work is needed to determine the bioaccumulation of OCPs in the aquatic food web in this region and the associated risks to ecosystems and human health.


Asunto(s)
Hidrocarburos Clorados , Plaguicidas , Contaminantes Químicos del Agua , China , Ecosistema , Monitoreo del Ambiente , Europa Oriental , Cromatografía de Gases y Espectrometría de Masas , Sedimentos Geológicos , Humanos , Hidrocarburos Clorados/análisis , Moldavia , Plaguicidas/análisis , Ríos , Rumanía , Espectrometría de Masas en Tándem , Ucrania , Contaminantes Químicos del Agua/análisis
2.
Medicina (Kaunas) ; 57(5)2021 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-34063545

RESUMEN

Background and Objectives: Mycosis fungoides (MF) and large plaque parapsoriasis (LPP) evolution provide intriguing data and are the cause of numerous debates. The diagnosis of MF and LPP is associated with confusion and imprecise definition. Copy number alterations (CNAs) may play an essential role in the genesis of cancer out of genes expression dysregulation. Objectives: Due to the heterogeneity of MF and LPP and the scarcity of the cases, there are an exceedingly small number of studies that have identified molecular changes in these pathologies. We aim to identify and compare DNA copy number alterations and gene expression changes between MF and LPP to highlight the similarities and the differences between these pathologies. Materials and Methods: The patients were prospectively selected from University Clinic of Dermatology and Venereology Timișoara, Romania. From fresh frozen skin biopsies, we extracted DNA using single nucleotide polymorphism (SNP) data. The use of SNP array for copy number profiling is a promising approach for genome-wide analysis. Results: After reviewing each group, we observed that the histograms generated for chromosome 1-22 were remarkably similar and had a lot of CNAs in common, but also significant differences were seen. Conclusions: This study took a step forward in finding out the differences and similarities between MF and LPP, for a more specific and implicitly correct approach of the case. The similarity between these two pathologies in terms of CNAs is striking, emphasizing once again the difficulty of approaching and differentiating them.


Asunto(s)
Micosis Fungoide , Parapsoriasis , Enfermedades de la Piel , Neoplasias Cutáneas , ADN , Variaciones en el Número de Copia de ADN/genética , Humanos , Micosis Fungoide/genética , Parapsoriasis/genética , Rumanía , Neoplasias Cutáneas/genética
3.
Medicina (Kaunas) ; 57(5)2021 May 03.
Artículo en Inglés | MEDLINE | ID: mdl-34063702

RESUMEN

Background and Objectives: COVID-19 pandemic severely impacted public health services worldwide, determining a significant decrease of elective cardiovascular (CV) procedures, especially in patients with associated chronic diseases such as diabetes mellitus (DM). Materials and Methods: This study was first started in 2019 in the western of Romania, to analyze the differences regarding the implantations of intra-cardiac devices such as permanent pacemakers (PPM), cardiac resynchronization therapy (CRT), or implantable cardioverter-defibrillators (ICD) in 351 patients with and without DM and the situation was reanalyzed at the end of 2020. Results: of the first 351 patients with and without DM. 28.20% of these patients had type 2 DM (p = 0.022), exceeding more than twice the prevalence of DM in the general population (11%). Patients with DM were younger (p = 0.022) and required twice as often CRT (p = 0.002) as non-diabetic patients. The state of these procedures was reanalyzed at the end of 2020, a dramatic decrease of all new device implantations being observed, both in non-diabetic and in patients with type 2 DM (79.37%, respectively 81.82%). Conclusions: COVID-19 pandemic determined a drastic decrease, with around 75% reduction of all procedures of new intra-cardiac devices implantation, both in non-diabetics, this activity being reserved mostly for emergencies.


Asunto(s)
COVID-19 , Desfibriladores Implantables , Diabetes Mellitus , Diabetes Mellitus/epidemiología , Diabetes Mellitus/terapia , Humanos , Pandemias , Rumanía/epidemiología , SARS-CoV-2
4.
Medicina (Kaunas) ; 57(5)2021 May 11.
Artículo en Inglés | MEDLINE | ID: mdl-34064607

RESUMEN

Background and Objectives: Sarcopenia is a recognized prognostic factor for both complications and survival in cancer patients. This study aims to analyze the relationship between sarcopenia measured by psoas muscle index on computer tomography scans and the presence of postoperative complications in colorectal cancer surgery. Materials and Methods: In a prospective study we recorded data from 51 patients who underwent colorectal cancer surgery in the Mures County Clinical Hospital, Romania. Total psoas muscle area and psoas density were measured at the level of the third lumbal vertebra (L3) for further index calculation. We also evaluated the general characteristics and laboratory analyses to obtain more information about status of the patients. Short-term postoperative complications were scored according to the Clavien-Dindo classification. Results: The majority of the 51 patients were male (61%) and the median age was 65 years. More than half of the cancer was located in the rectum (56.9%), a quarter in the right colon (25.5%), the rest in the sigmoid (11.8%), and the left colon (5.9%). Twenty-one patients (41.2%) developed a complication, five (9.8%) of these were Clavien-Dindo grade 3, 4 or 5 (high grade) and sixteen (31.3%) grade 1 or 2 (low grade). The low- and high-grade groups showed a significantly lower right psoas muscle area, left psoas muscle area, total psoas muscle area, and psoas muscle index (p < 0.001 in all cases). Among laboratory analyses, a significantly lower perioperative hematocrit, hemoglobin, and albumin level were found in patients who developed complications. Furthermore we observed that an elevated serum C-reactive protein level was associated with a higher grade of complication (p < 0.043). Conclusions: The psoas muscle index (PMI) influence on the postoperative outcome is an important factor in our single center prospective study and it appears to be a good overall predictor in colorectal surgery. A lower PMI is directly associated with a low or high grade complication by Clavien-Dindo classification. Perioperative inflammatory and nutritional status evidenced by serum C-reactive protein (CRP) and albumin level influences the presence of postoperative complications.


Asunto(s)
Neoplasias Colorrectales , Músculos Psoas , Anciano , Neoplasias Colorrectales/diagnóstico por imagen , Neoplasias Colorrectales/cirugía , Computadores , Femenino , Humanos , Masculino , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/epidemiología , Estudios Prospectivos , Músculos Psoas/diagnóstico por imagen , Estudios Retrospectivos , Rumanía
5.
Artículo en Inglés | MEDLINE | ID: mdl-34064469

RESUMEN

Due to the impact of the Covid-19 pandemic on dental treatments, the present research aimed to assess the infection rate among dental practitioners from Romania and to analyze the economic impact of Covid-19 on dental offices. We designed a web-based survey distributed to dental practitioners from Romania. The survey included questions that assessed demographic data from the dentists who completed the questionnaire, along with economic aspects and epidemiological aspects related to the impact of the COVID-19 pandemic on dental practitioners. Five hundred and seven dentists completed the survey. Three-quarters of the assessed dental offices reported a decrease in the income and patient volume compared to 2019. More than half of the patients visiting the dental office paid more attention to the risk of infection and to prevention methods. Most dental offices implemented specific protective equipment for doctors. Three thousand seven hundred thirty-five dental practitioners were working in the 507 assessed dental offices, and among them, 238 COVID-19 cases of contamination were recorded. High contamination rates were registered in October (48, 20.1%), November (66, 27.7%), and December 2020 (52, 21.85%). Contamination mostly took place at home (114 cases, 47.8%) or resulted from event attendance. This study underlines an overall greater level of safety and an increased patient addressability in dental offices.


Asunto(s)
COVID-19 , SARS-CoV-2 , Odontólogos , Humanos , Pandemias , Rol Profesional , Rumanía/epidemiología , Encuestas y Cuestionarios
6.
Artículo en Inglés | MEDLINE | ID: mdl-34069311

RESUMEN

All social and economic systems worldwide, including the educational one have been disrupted by escalating the global COVID-19 pandemic. One of the most impacted areas were the medical and dental education fields, due to the forced break from clinical practice during the lockdown, which affected both the educational part, as well as the patients. Thus, the main goal of our research was to investigate the impact of the COVID-19 pandemic on the dental students' education as related to their perceptions and evaluations, in Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. A cross-sectional study was conducted on 878 dental students who reported their perception of the psychological and educational impact of this period by completing a Google Forms questionnaire. Collected data were statistically analyzed using Stata/IC 16. There was a severe psychological impact among the respondents, the levels of stress being perceived as high and very high (33.83%, n = 297; 28.59%, n = 251), similar to high and very high anxiety feelings (26.54%, n = 233; 24.26%, n = 213). Very high educational impact from the point of view of the acquisition of practical skills (48.52%, n = 426) and future professional perspectives (38.95%, n = 342) were recorded. While online theoretical learning ability was principally low (37.93%, n = 333) despite consistently modified time allocated to the individual study (44.35%, n = 389), most of the students evaluated the efficiency of lecturers in online courses as neutral (41.12%, n = 361). New dentistry teaching programs will have to be adopted taking into account the dynamics of the pandemic and its strong impact on our students, in order to improve both their wellbeing and the sustainability of dental education.


Asunto(s)
COVID-19 , Pandemias , Control de Enfermedades Transmisibles , Estudios Transversales , Humanos , Rumanía/epidemiología , SARS-CoV-2 , Estudiantes de Odontología
7.
Medicina (Kaunas) ; 57(6)2021 May 27.
Artículo en Inglés | MEDLINE | ID: mdl-34071770

RESUMEN

Background and Objectives: The COVID-19 pandemic has globally affected health systems and services. Non-melanoma skin cancers (NMSCs) are the most common malignancies around the world. This study aimed to analyze the differences in the benign and malignant histopathological diagnoses performed on radical excision skin tumors and skin biopsies in the dermatopathology ward in Mures Clinical County Hospital, Targu Mures, Romania, 1 year prior to and during the COVID-19 pandemic, to emphasize the changes in the diagnostic process as per the new regulations. Materials and Methods: A total of 1168 histopathological diagnoses were included in the study-302 from the COVID-19 period and 866 from the non-COVID-19 period-considering the number, type, and frequency of the histopathological diagnoses as variables to be analyzed. Results: In the COVID-19 period, out of the 55 NMSC and melanoma histopathological diagnoses, 50.9% (n = 28) were BCCs, 20% (n = 11) were SCCs, 10.9% (n = 6) were basosquamous cell carcinomas, and 18.18% (n = 10) were melanoma cases. Regarding the non-COVID-19 period, out of the 173 NMSC and melanoma histopathological diagnoses, 46.82% (n = 81) were BCCs, 22.54% (n = 39) were SCCs, 7.51% (n = 13) were basosquamous cell carcinomas, and 23.12% (n = 40) were melanoma cases. Conclusions: During the COVID-19 pandemic, a decrease in histopathological diagnoses at the dermatopathology ward in our hospital was observed, for both benign and malignant pathologies, especially for NMSCs and melanomas, compared to the same period 1 year prior to the pandemic.


Asunto(s)
COVID-19 , Carcinoma de Células Escamosas , Melanoma , Neoplasias Cutáneas , Humanos , Melanoma/diagnóstico , Melanoma/epidemiología , Pandemias , Rumanía/epidemiología , SARS-CoV-2 , Neoplasias Cutáneas/epidemiología
8.
Artículo en Inglés | MEDLINE | ID: mdl-34063249

RESUMEN

Benzene, toluene, and total BTEX (benzene, toluene, ethylbenzene, and xylene) concentrations registered for one year (2016) have been determined every month for one high-density traffic area. The assessment was performed in Arad City, Romania, to evaluate these pollutants and their influence on the inhabitants' health. The contaminants were sampled using a static sampling method and analyzed by gas chromatography coupled with mass spectrometry. Benzene was the most dominant among the BTEX compounds-the average concentrations ranged from 18.00 ± 1.32 µg m-3 in December to 2.47 ± 0.74 µg m-3 in August. The average toluene concentration over the year was 4.36 ± 2.42 µg m-3 (with a maximum of 9.60 ± 2.39 µg m-3 in November and a minimum of 1.04 ± 0.29 µg m-3 in May). The toluene/benzene ratio (T/B) was around 0.5, indicating substantial contributions from mobile sources (vehicles). The emission and accumulation of different aromatic compounds (especially benzene) could deteriorate the urban air quality. The lifetime cancer risk (LTCR) for benzene was found to be more than 10-5 in winter, including the inhabitants in the "probable cancer risk" category.


Asunto(s)
Contaminantes Atmosféricos , Contaminantes Atmosféricos/análisis , Atmósfera/análisis , Benceno/análisis , Derivados del Benceno/análisis , Ciudades , Monitoreo del Ambiente , Cromatografía de Gases y Espectrometría de Masas , Rumanía , Tolueno/análisis , Xilenos/análisis
9.
Artículo en Inglés | MEDLINE | ID: mdl-34068563

RESUMEN

Romania is one of the countries severely affected by numerous natural hazards, where landslides constitute a very common geomorphic hazard with strong economic and social impacts. The analyzed area, known as the "Ciuperca Hill", is located in Oradea (NW part of Romania) and it has experienced a number of landsliding events in previous years, which have endangered anthropogenic systems. Our investigation, focused on the main causal factors, determined that landslide events have rather complex components, reflected in the joint climatological characteristics, properties of the geological substrate, and human activity that further contributed to the intensive change of landscape and acceleration of slope instability. Analysis of daily precipitation displays the occurrence and intensive distribution between May and September. Higher values of rainfall erosivity (observed for the 2014-2017 period), are occurring between April and August. Erosivity density follows this pattern and indicates high intensity events from April until October. SPI index reveals the greater presence of various wet classes during the investigated period. Geological substrate has been found to be highly susceptible to erosion and landsliding when climatological conditions are suitable. Accelerated urbanization and reduced vegetation cover intensified slope instability. The authors implemented adequate remote-sensing techniques in order to monitor and assess the temporal changes in landslide events at local level. Potential solutions for preventative actions are given in order to introduce and conduct qualitative mitigation strategies for shaping sustainable urban environments. Results from this study could have implications for mitigation strategies at national, regional, county, and municipality levels, providing knowledge for the enhancement of geohazard prevention and appropriate response plans.


Asunto(s)
Deslizamientos de Tierra , Ciudades , Monitoreo del Ambiente , Sistemas de Información Geográfica , Humanos , Conceptos Meteorológicos , Medición de Riesgo , Rumanía
10.
BMJ Open ; 11(5): e047126, 2021 05 05.
Artículo en Inglés | MEDLINE | ID: mdl-33952553

RESUMEN

OBJECTIVES: Most countries including Malaysia have set goals to incorporate a strong primary care into the healthcare system. The aim of this study was to evaluate the strength of service delivery process dimensions in Malaysia and compare it with England, the Netherlands, Spain, North Macedonia, Romania and Turkey which participated in the Quality and Costs of Primary Care (QUALICOPC) study. METHODS: This cross-sectional study utilised the QUALICOPC study data on primary care performance, which was conducted in 2011-2013 (QUALICOPC in Europe Australia, New Zealand and Canada) and 2015-2016 (Malaysia). A standardised questionnaire was completed by primary care practitioners from participating countries. Multilevel regression analysis and composite scores were constructed to compare the performance of primary care on four process dimensions: accessibility, comprehensiveness, continuity of care and coordination. RESULTS: The high-income countries with strong primary care performed better in comprehensiveness, continuity and coordination but poorer in accessibility to services compared with upper-middle-income countries. Among the upper-middle-income countries, Malaysia scored the best in comprehensiveness and coordination. None of the studied countries were having consistent performance over all indicators either in their respective best or worst primary care services delivery dimensions. CONCLUSIONS: There is a wide variation in primary care services delivery across and within the studied countries. The findings indicate room for quality improvement activities to strengthen primary healthcare services. This includes addressing current healthcare challenges in response to the population health needs which are essential for more integrated and efficient primary care services delivery.


Asunto(s)
Atención a la Salud , Atención Primaria de Salud , Australia , Canadá , Estudios Transversales , Inglaterra , Europa (Continente) , Humanos , Malasia , Países Bajos , Nueva Zelanda , Rumanía , España , Turquia
11.
Front Public Health ; 9: 583706, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33968871

RESUMEN

In managing the COVID-19 pandemic, several compelling narratives seem to have played a significant role in the decision-making processes regarding which risk mitigation and management measures to implement. Many countries were to a large extent unprepared for such a situation, even though predictions about a significant probability for a pandemic to occur existed, and national governments of several countries often acted in an uncoordinated manner, which resulted in many inconsistencies in the disaster risk reduction processes. Limited evidence has also made room for strategic narratives meant to persuade the public of the chosen set of actions, even though the degree of uncertainty regarding the outcomes of these was high, further complicating the situation. In this article, we assume a normative standpoint regarding rhapsodic decision making and suggest an integrated framework for a more elaborated decision analysis under the ambiguity of how to contain the virus spread from a policy point of view, while considering epidemiologic estimations and socioeconomic factors in a multi-stakeholder-multi-criteria context based on a co-creative work process for eliciting attitudes, perceptions, as well as preferences amongst relevant stakeholder groups. The framework, applied in our paper on Romania for demonstrative purposes, is used for evaluating mitigation measures for catastrophic events such as the COVID-19 situation, to mobilize better response strategies for future scenarios related to pandemics and other hazardous events, as well as to structure the production and analysis of narratives on the current pandemic effects.


Asunto(s)
COVID-19 , Pandemias , Humanos , Pandemias/prevención & control , Rumanía , SARS-CoV-2
12.
Medicine (Baltimore) ; 100(18): e25832, 2021 May 07.
Artículo en Inglés | MEDLINE | ID: mdl-33950993

RESUMEN

ABSTRACT: Tocilizumab (TCZ), a monoclonal recombinant antibody against IL-6 receptor, is currently used in managing the cytokine release syndrome (CRS) that occurred in coronavirus disease 2019 (COVID-19) selected cases. The primary objective of our study was to establish the effectiveness of TCZ in patients with severe or critical severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pneumonia.We retrospectively analyzed 25 consecutive patients, admitted in the Academic Emergency Hospital Sibiu, Romania from April 1, 2020 until May 25, 2020, all with confirmed SARS-CoV-2 infection and severe pneumonia. All patients were treated off-label with TCZ, beside their standard care. Adjuvant iron chelator was associated in 11 patients.Six female and 19 male patients admitted in our hospital all with confirmed SARS-CoV-2 infection and severe pneumonia as defined by Chinese Centers for Disease Control and Prevention were enrolled in this study. Seventeen of the 25 enrolled patients (68%) were seriously ill requiring noninvasive ventilation or oxygen mask, and 8 cases (32%) were critically ill requiring invasive mechanical ventilation. All patients received TCZ, and also received hydroxychloroquine, and lopinavir/ritonavir 200/50 mg for 10 days. Adjuvant iron chelator (deferasirox - marketed as Exjade) was associated in 11 patients who had ferritin serum levels above 1000 ng/mL. No side effects were encountered during infusions or after TCZ. We observed a rapid increase in arterial oxygen saturation for 20 of the 25 cases (80%) with a favorable evolution toward healing. Survivors were younger than 60 years old (80%), had less comorbidities (10% no comorbidities, 70% with 1 or 2 comorbidities), lower serum ferritin levels (30% under 1000 ng/mL), and 50% had no serum glucose elevation. Our patients with CRS had no response to corticosteroid therapy. Five out of the 25 patients had an unfavorable evolution to death. The off-label use of TCZ in patients with severe or critically ill form of SARS-CoV-2 infection had good results in our study.Off-label use of TCZ in severe and critical cases of COVID-19 pneumonia is effective in managing the "cytokine storm." Better outcomes were noted in younger patients. Associated adjuvant iron chelators may contribute to a good outcome and needs to be confirmed in larger studies.


Asunto(s)
Anticuerpos Monoclonales Humanizados/uso terapéutico , COVID-19/tratamiento farmacológico , Síndrome de Liberación de Citoquinas/tratamiento farmacológico , Deferasirox/uso terapéutico , Quelantes del Hierro/uso terapéutico , Neumonía Viral/tratamiento farmacológico , Adulto , Anciano , Anciano de 80 o más Años , Comorbilidad , Quimioterapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Uso Fuera de lo Indicado , Neumonía Viral/virología , Respiración Artificial , Estudios Retrospectivos , Rumanía , SARS-CoV-2
13.
Chirurgia (Bucur) ; 116(2 Suppl): 105-109, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33963700

RESUMEN

Introduction: Oncofertility represents a new field, dedicated to patients at childbearing age who are diagnosed with a neoplasic disease and who want to have a biologic child after they complete the oncological and surgical treatment. Because of new screening and treatment methods, most patients survive the disease, but the main long-term complication remains infertility. Young women with breast cancer are candidates for preserving their fertility mostly because of the risk of chemotherapy-related infertility due to the alkylating agent, causing dose-dependent destruction of oocytes and follicular depletion and thus bringing cortical fibrosis and ovarian blood-vessel damage (1). "Prof. Dr. Panait S #226;rbu" hospital is the first medical facility in Romania which performs oncofertility procedures among breast cancer patients within the program "Newborn Oncofertility". Material and Methods: Within the program run by our hospital 21 patients (13 men and 8 women) came for fertility preservation, including 5 patients diagnosed with breast cancer. Our specialists in reproductive medicine performed ovarian stimulation and oocyte pick-up, after which the genetic material was cryopreserved. The procedure could be performed only if the patients were under 35 years old, and provided the case had been previously discussed within the tumor board and the patient had received the oncological agreement. Disscution: There was a slight predominance of breast cancer patients who addressed the clinic with a view for preserving their fertility and those who met the conditions could start the procedure immediately, without any delay when it comes to oncological or surgical treatments. There were no side effects during ovarian stimulation treatment. Oocytes or embryos were cryopreserved using the method of vitrification.


Asunto(s)
Neoplasias de la Mama , Preservación de la Fertilidad , Neoplasias , Adulto , Neoplasias de la Mama/tratamiento farmacológico , Niño , Femenino , Hospitales , Humanos , Recién Nacido , Rumanía , Resultado del Tratamiento
14.
J Int Med Res ; 49(5): 3000605211016630, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-34034541

RESUMEN

OBJECTIVE: In 2018, colorectal cancer (CRC) was the second most frequent malignancy in Romania after lung cancer. Although CRC is typically encountered in patients >50 years old, CRC's global incidence among younger adults has been increasing. We aimed to compare the disease characteristics of patients with CRC aged ≤50 years with those >50 years old. METHODS: We retrospectively evaluated data from patients with CRC who underwent standard surgery at "Pius Brinzeu" Emergency County Hospital, Timisoara, Romania. Patients were divided into two groups: Group 1 (patients ≤50 years old) and Group 2 (patients >50 years old). Six parameters were analyzed (sex, residence location, age, tumor localization, microscopic findings, pathological staging). RESULTS: Data on age-related CRC were available for 1380 patients treated from January 2012 to December 2018. Group 1 included 120 patients while group 2 included 1260 patients. Significantly more Group 1 patients presented with advanced CRC compared with Group 2 patients (94.2% vs. 87.4%). Furthermore, CRC in younger adults was more likely to be diagnosed at an advanced stage. CONCLUSIONS: Monitoring the CRC incidence in younger adults is essential to assess whether screening practices require changes and to raise awareness among clinicians of the increasing CRC incidence among younger patients.


Asunto(s)
Neoplasias Colorrectales , Adulto , Neoplasias Colorrectales/diagnóstico , Neoplasias Colorrectales/epidemiología , Neoplasias Colorrectales/patología , Humanos , Incidencia , Tamizaje Masivo , Persona de Mediana Edad , Estadificación de Neoplasias , Estudios Retrospectivos , Rumanía/epidemiología
15.
J Environ Radioact ; 234: 106626, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-33940545

RESUMEN

Romania is on the first place in Europe with an annual production of honey of 30.9 thousand tons in 2018, while the European Union is on the second place in the world with a total of 283 thousand tons. The most part of the honey production from Romania is exported. The aim of this study was to estimate internal radiation doses and lifetime cancer risk from honey ingestion sampled from several locations on the Romanian territory. The activity concentration of 137Cs and 238U is found to be below the detection limit of the method. The activity of 226Ra ranged from lower than the minimum detectable value (<1.08 Bq·kg-1) to 7.35 ± 1.73 Bq·kg-1. For 232Th and 40K the average recorded values were 1.51 ± 0.74 and 24.08 ± 4.37 Bq·kg-1, respectively. The annual effective dose due to the intake of 232Th, 226Ra, 40K has been assessed ranging from 0.08 to 0.47 (µSv·y-1), 0.35 to 1.65 (µSv·y-1) and 0.04 to 0.33 (µSv·y-1), respectively. 26Ra gives the largest contribution (56-82%) to the total annual effective dose due to ingestion received by consumption of honey, in the samples where it was identified. In the other samples (where 226Ra was below the detection limit), the largest contribution to annual effective dose is due to 232Th (45-85%). The values obtained from the lifetime cancer risk calculation range in the domain from 2.85·10-7 to 1.78·10-6 for 232Th, 1.33·10-6 to 6.22·10-6 for 226Ra and 1.38·10-7 to 1.25·10-6 for 40K. For 137Cs, only one value was recorded 2.20·10-8. The 232Th, 226Ra, 40K and 137Cs activities measured in the present work were comparable with completion of others activated values of honey samples around Europe.


Asunto(s)
Miel , Neoplasias , Monitoreo de Radiación , Contaminantes Radiactivos del Suelo , Radioisótopos de Cesio , Europa (Continente) , Humanos , Rumanía , Contaminantes Radiactivos del Suelo/análisis
16.
Stud Health Technol Inform ; 281: 734-738, 2021 May 27.
Artículo en Inglés | MEDLINE | ID: mdl-34042673

RESUMEN

The paper analyzes the evolution of COVID-19 cases in Romanian counties over a period of 10 months, to highlight possible similarities that may contribute to a better understanding of the spreading pattern. The study uses the numbers of active cases for each county in Romania, as well as Bucharest and the whole country, reported daily by the Romanian Ministry of Health (https://datelazi.ro) between April 2nd, 2020 and January 25th, 2021. We compared the disease's evolution in Suceava county (the first outbreak of spread) with other counties in Romania in order to highlight the gaps between them. We calculated the cross-correlations between counties, interpreted as time series. The recorded lags varied between 1-15 days, the most counties having a lag of 6-7 days compared with Suceava. Therefore, on long term there are no important discrepancies between the regions in Romania regarding the evolution of the disease, which shows that the intervention efforts of the medical staff were uniform in efficiency. The existence of a lag of only one day between Suceava and the whole country shows that on long term, even in this county the situation is not very discrepant, belonging to the general evolution.


Asunto(s)
COVID-19 , Brotes de Enfermedades , Grupos Étnicos , Humanos , Rumanía/epidemiología , SARS-CoV-2
17.
Environ Monit Assess ; 193(6): 340, 2021 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-33991242

RESUMEN

The cross-border rivers management is a challenge for the involved countries, especially if they do not have the same type of legislation. The negative effects on water quality are quantified by using environmental impact assessment tools. Thus, the quantification of impacts that could affect the human health, ecosystem equilibrium, and biodiversity is based on monitoring of the water quality indicators. An increased attention should be paid to the toxic pollutants resulted from various activities that may affect the aquatic environment and human health on short and long term. This study approaches the cross-border impact assessment of heavy metals, organic, and nutrient pollution in the case of two countries (Romania and Republic of Moldova), the Prut River being the natural border. The methodology considered a specific area of the Prut River on both river sides, based on specific water quality indicators. The studied area covers sampling points from North to South within Iasi County and Republic of Moldova, in the Prut River cross-border section. To assess the pollutants' impacts, the improved Leopold Matrix and the Rapid Impact Assessment Matrix were adapted and applied. The results offered an overview on water pollution level and impacts on the Prut River cross-border area, for the 5-year period (2015-2019). There is a major negative impact generated in the Southern part of the studied area, in the case of the following indicators: copper, selenium, organic substances, with an increased level of pollution recorded in the last 2 years (2018, 2019). The conclusion of this research is that even if both countries follow the international protocols concerning cross-border pollution, they still have to comply to different environmental standards which approach differently the pollution levels and the significant impacts on water quality.


Asunto(s)
Metales Pesados , Contaminantes Químicos del Agua , Ecosistema , Monitoreo del Ambiente , Humanos , Metales Pesados/análisis , Ríos , Rumanía , Contaminantes Químicos del Agua/análisis
18.
Medicine (Baltimore) ; 100(20): e25944, 2021 May 21.
Artículo en Inglés | MEDLINE | ID: mdl-34011073

RESUMEN

ABSTRACT: At present, various researches presented how subtypes of hematological malignancies are related to stages of the immune response, because the activated immune system represents a promising form in cancer treatment. This study explores the relationship between the adaptive immune system (T cells), and the coagulation system (platelets, platelet membrane glycoproteins, platelets derivate microparticles) which seems to play an important role in host immune defense of patients with acute myeloblastic leukemia (AML) or B cell lymphoma (BCL), 2 of the most common hematological malignancies subtypes.Blood samples (n = 114) obtained from patients with AML or BCL were analyzed for platelet membrane glycoproteins (CD42b, CD61), glycoprotein found on the surface of the T helper cells (CD4+), protein complex-specific antigen for T cells (CD3+), platelet-derived microparticles (CD61 PMP) biomarkers by flow cytometry, and hematological parameters were quantified by usual methods.In patients with AML, the means of the percentage of the expressions of the molecules on platelet surfaces (CD61 and CD42b, P < .01; paired T test) were lower as compared to both control subgroups. The expression of cytoplasmic granules content (CD61 PMP) had a significantly higher value in patients with AML reported to controlling subgroups (P < .01; paired T test), which is suggesting an intravascular activation of platelets.The platelet activation status was presented in patients with low stage BCL because CD61 and CD42b expressions were significantly higher than control subgroups, but the expression of CD 61 PMP had a significantly decreased value reported to control subgroups (all P < .01; paired T test). T helper/inducer lineage CD4+ and T lymphoid lineage CD3+ expressions presented significant differences between patients with AML or low stage BCL reported to control subgroups (all P < .01; paired T test).Platelet-lymphocyte interactions are involved in malignant disorders, and CD61, CD42b present on platelet membranes, as functionally active surface receptors mediate the adhesion of active platelets to lymphocytes, endothelial cells, and cancer cells.


Asunto(s)
Biomarcadores de Tumor/sangre , Plaquetas/metabolismo , Leucemia Mieloide Aguda/inmunología , Linfoma de Células B/inmunología , Linfocitos T Colaboradores-Inductores/metabolismo , Anciano , Biomarcadores de Tumor/metabolismo , Plaquetas/inmunología , Complejo CD3/sangre , Adhesión Celular/inmunología , Micropartículas Derivadas de Células , Femenino , Citometría de Flujo , Humanos , Integrina beta3/sangre , Leucemia Mieloide Aguda/sangre , Activación de Linfocitos , Recuento de Linfocitos , Linfoma de Células B/sangre , Masculino , Persona de Mediana Edad , Activación Plaquetaria/inmunología , Recuento de Plaquetas , Complejo GPIb-IX de Glicoproteína Plaquetaria/análisis , Rumanía , Linfocitos T Colaboradores-Inductores/inmunología
19.
Nutrients ; 13(5)2021 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-33925066

RESUMEN

Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely related to GPx activity, would result in an increased risk of reproductive dysfunction in individuals. We retrospectively investigated the serum selenium (SeS) concentrations of 1264 apparently healthy people, aged 16-89 years, from Western Romania. The general analysis revealed a non-normal SeS distribution with a median SeS of 100.26 ± 18.32 µg/L and a significant difference in SeS levels between age groups. The analysis of the young group (16-35 years) revealed that up to 50% of individuals did not reach the SeS threshold corresponding to maximum GPx activity (80 µg/L), and a significant imbalance between the genders was apparent when looking at SeS values outside the range. Our results correlated with the general diminished reproductive ability registered in Romania during the last few years. Serum selenium content proves to offer a proper reflection of the fertility competence of the young population, and its monitoring is important for guiding dietary adjustments and attaining normal reproductive function.


Asunto(s)
Selenio/sangre , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Rumanía , Factores Sexuales , Adulto Joven
20.
Sci Total Environ ; 784: 147145, 2021 Aug 25.
Artículo en Inglés | MEDLINE | ID: mdl-33901961

RESUMEN

BACKGROUND: Few studies have simultaneously assessed the health impact of school and home environmental factors on children, since handling multiple highly correlated environmental variables is challenging. In this study, we examined indoor home and school environments in relation to health outcomes using machine learning methods and logistic regression. METHODS: We used the data collected by the SINPHONIE (Schools Indoor Pollution and Health: Observatory Network in Europe) project in Romania, a multicenter European research study that collected comprehensive information on school and home environments, health symptoms in children, smoking, and school policies. The health outcomes were categorized as: any health symptoms, asthma, allergy and flu-like symptoms. Both logistic regression and random forest (RF) methods were used to predict the four categories of health outcomes, and the methods prediction performance was compared. RESULTS: The RF method we employed for analysis showed that common risk factors for the investigated categories of health outcomes, included: environmental tobacco smoke (ETS), dampness in the indoor school environment, male gender, air freshener use, residence located in proximity of traffic (<200 m), stressful schoolwork, and classroom noise (contributions ranged from 7.91% to 23.12%). Specificity, accuracy and area under the curve (AUC) values for most outcomes were higher when using RF compared to logistic regression, while sensitivity was similar in both methods. CONCLUSION: This study suggests that ETS, dampness in the indoor school environment, use of air fresheners, living in proximity to traffic (<200 m) and noise are common environmental risk factors for the investigated health outcomes. RF pointed out better predictive values, sensitivity and accuracy compared to logistic regression.


Asunto(s)
Contaminación del Aire Interior , Contaminación del Aire Interior/análisis , Niño , Europa (Continente) , Humanos , Masculino , Evaluación de Resultado en la Atención de Salud , Factores de Riesgo , Rumanía/epidemiología , Instituciones Académicas
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