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1.
Wiad Lek ; 74(3 cz 1): 492-497, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33813456

RESUMEN

OBJECTIVE: The aim: To study the dietary peculiarities of Ukrainian adolescents with obesity and to identify the eating disorders on the background of metabolic syndrome. PATIENTS AND METHODS: Materials and methods: A survey on the nutrition of Ukrainian adolescents was conducted at O. Yaremenko Ukrainian Institute for Social Research within the framework of the international project Health and Behavioral Orientations of Student Youth (HBSC), 2018. As a result, a sample of 200 adolescents with obesity (age 14-18 years: 100 boys and 100 girls) was formed, with the following examination by the Institute of Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine. RESULTS: Results: A survey conducted revealed the problem of irrational and unbalanced diet in Ukrainian adolescents. Thus, irregular and unbalanced diet naturally causes digestive disorders and contributes to the formation of comorbid pathologies such as obesity and metabolic syndrome. The general analysis of the DEBQ survey results revealed that patients with metabolic syndrome were twice as likely to have abnormalities in eating behavior (71.8 ± 3.7)% than in patients without them (39.4 ± 4.1)%, (φ < 0.05). Adolescents with obesity experienced significant zinc and magnesium deficiency in the body (φ < 0.05). CONCLUSION: Conclusions: Modification of eating behaviour through healthy balanced nutrition and psychological support is one of the most important tasks in the treatment of patients with obesity and metabolic syndrome.


Asunto(s)
Dieta , Síndrome Metabólico , Adolescente , Índice de Masa Corporal , Femenino , Humanos , Masculino , Síndrome Metabólico/epidemiología , Encuestas Nutricionales , Estado Nutricional , Obesidad/epidemiología , Ucrania
2.
Wiad Lek ; 74(2): 313-316, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33813493

RESUMEN

OBJECTIVE: The aim: To evaluate anthropometric, hemodynamic parameters, as well as changes in blood and leptin lipid spectrum in children and adults with overweight and obesity. PATIENTS AND METHODS: Materials and methods: We examined 68 overweight children and 90 patients with obesity in combination with stage 2, grade 2 AH who were electively inpatient. The control group consisted of practically healthy individuals - 20 adults and 55 children. RESULTS: Results: Obesity in childhood isaccompanied by the development of dyslipidemia, hypercholesterolemia, hyperleptinemia and hypertension, and in adulthood may be an additional risk factor for cardiovascular disease, in particular AH. According to the study, total leptin level in overweight children was significantly higher compared to the control group (p<0.01). The concentration of leptin in patients with hypertension in combination with obesity was 3 times higher compared to the control group (p<0.01). CONCLUSION: Conclusions: Thus, obesity or overweight, accompanied by hyperleptinemia and an increase in the proatherogenic fractions of the blood lipid spectrum, is an important problem that needs to be addressed in childhood to prevent cardiovascular disease in adulthood.


Asunto(s)
Hipertensión , Síndrome Metabólico , Obesidad Pediátrica , Adulto , Índice de Masa Corporal , Niño , Humanos , Hipertensión/epidemiología , Leptina , Síndrome Metabólico/complicaciones , Síndrome Metabólico/epidemiología , Sobrepeso/complicaciones , Sobrepeso/epidemiología , Obesidad Pediátrica/complicaciones , Obesidad Pediátrica/epidemiología , Factores de Riesgo
3.
Top Spinal Cord Inj Rehabil ; 27(1): 1-10, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33814879

RESUMEN

Individuals with a spinal cord injury (SCI) have a unique physiology characterized by sarcopenia, neurogenic osteoporosis, neurogenic anabolic deficiency, sympathetic dysfunction, and blunted satiety associated with their SCI, all of which alter energy balance and subsequently body composition. The distinct properties of "neurogenic obesity" place this population at great risk for metabolic dysfunction, including systemic inflammation, hyperglycemia, dyslipidemia, and hypertension. The purpose of this article is to demonstrate the relationship between neurogenic obesity and the metabolic syndrome after SCI, highlighting the mechanisms associated with adipose tissue pathology and those respective comorbidities. Additionally, representative studies of persons with SCI will be provided to elucidate the severity of the problem and to prompt greater vigilance among SCI specialists as well as primary care providers in order to better manage the epidemic from a public health perspective.


Asunto(s)
Síndrome Metabólico/etiología , Obesidad/complicaciones , Obesidad/fisiopatología , Traumatismos de la Médula Espinal/complicaciones , Traumatismos de la Médula Espinal/fisiopatología , Humanos
4.
Top Spinal Cord Inj Rehabil ; 27(1): 75-83, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33814885

RESUMEN

The prevalence of obesity and of neuropathic pain are both estimated at above 50% in the population of people with chronic spinal cord injury (SCI). These secondary consequences of SCI have significant negative impact on physical functioning, activities of daily living, and quality of life. Investigations of relationships between weight or body composition and chronic neuropathic pain in people with SCI are lacking, but investigations in non-SCI cohorts suggest an association between obesity and the presence and severity of neuropathic pain conditions. In the present article, we present a review of the literature linking obesity and neuropathic pain and summarize findings suggesting that metabolic syndrome and chronic, systemic inflammation due to excess adiposity increase the risk for neuropathic pain after an SCI.


Asunto(s)
Neuralgia/etiología , Obesidad/complicaciones , Traumatismos de la Médula Espinal/complicaciones , Humanos , Síndrome Metabólico/etiología , Neuralgia/metabolismo , Factores de Riesgo
5.
Top Spinal Cord Inj Rehabil ; 27(1): 84-91, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33814886

RESUMEN

Spinal cord injury (SCI) substantially increases the risk of neurogenic obesity, diabetes, and metabolic syndrome. Much like in the general population, a discussion of these syndromes in SCI would be incomplete without acknowledging the association of SCI with sleep-disordered breathing (SDB). This article will outline the interplay between obesity and obstructive sleep apnea (OSA), discussing the pathophysiology of obesity in OSA both for the general population and SCI population. The role of insulin resistance in SDB and SCI will also be examined. The epidemiology and pathophysiology of OSA and central sleep apnea in SCI are discussed through an examination of current evidence, followed by a review of central sleep apnea in SCI. Principles of diagnosis and management of SDB will also be discussed. Because sleep deprivation in itself can be a risk factor for developing obesity, the significance of comorbid insomnia in SCI is explored. Ultimately, a thorough sleep history, testing, and treatment are key to improving the sleep of individuals with SCI and to potentially reducing the impact of neurogenic obesity and metabolic syndrome.


Asunto(s)
Obesidad/complicaciones , Síndromes de la Apnea del Sueño/etiología , Traumatismos de la Médula Espinal/complicaciones , Adulto , Humanos , Resistencia a la Insulina , Síndrome Metabólico/etiología , Síndromes de la Apnea del Sueño/metabolismo , Síndromes de la Apnea del Sueño/fisiopatología
6.
Kardiologiia ; 61(3): 36-41, 2021 Mar 30.
Artículo en Ruso, Inglés | MEDLINE | ID: mdl-33849417

RESUMEN

Aim        To study the psychological continuum in elderly patients with arterial hypertension associated with metabolic syndrome during the chronotherapy with a fixed combination (FC) of amlodipine, lisinopril, and rosuvastatin.Material and methods        In the inpatient conditions, 63 patients aged 60-74 years with arterial hypertension associated with metabolic syndrome were treated with chronotherapy with a FC of amlodipine, lisinopril, and rosuvastatin (5 / 10 / 10 mg/day in the evening). These patients composed the main group. The control group (58 patients aged 60-74 years with arterial hypertension associated with metabolic syndrome) was treated with the FC of amlodipine, lisinopril, and rosuvastatin at the same dose of 5 / 10 / 10 mg/day in the morning.Results   At one year, the disorders of psychological continuum were significantly decreased with the chronotherapy (evening dosing) with the antihypertensive FC of amlodipine, lisinopril, and rosuvastatin compared to the traditional treatment (morning dosing) at the same dose of 5 / 10 / 10 mg/day in both groups. With the chronotherapeutic approach, the dynamic of cognitive disorders in patients aged 60-74 years with arterial hypertension associated with metabolic syndrome was characterized by a significant increase in the Mini-Mental-State-Examination scale score from 17.8±0.3 at baseline to 23.5±0.4 with the evening dosing (р<0.001) vs. the increase from 16.9±0.3 to 20.4±0.4 (р<0.001) with the morning dosing. The situational anxiety score decreased from 40.0±2.2 to 30.6±1.8 (р<0.05) and from 40.8±2.5 to 33.5±1.9  (р<0.05), and the trait anxiety score decreased from 48.8±2.0 to 26.4±1.9 (р<0.001) and from 44.9±1.9 to 30.7±1.7  (р<0.01) with the evening and morning dosing, respectively. Depressive disorders slightly decreased with the chronotherapy by 14.1 % vs. 7.7 % with the traditional regimen; nevertheless, they were consistent with depressive spectrum disorders in both groups.Conclusion            The study results showed a higher effectiveness of the chronotherapeutic treatment compared to the traditional treatment with FC of amlodipine, lisinopril, and rosuvastatin in arterial hypertension with metabolic syndrome.


Asunto(s)
Hipertensión , Síndrome Metabólico , Anciano , Amlodipino/farmacología , Antihipertensivos/uso terapéutico , Ansiedad , Presión Sanguínea , Cronoterapia , Humanos , Hipertensión/tratamiento farmacológico , Lisinopril , Síndrome Metabólico/complicaciones , Síndrome Metabólico/tratamiento farmacológico , Persona de Mediana Edad , Rosuvastatina Cálcica
7.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(3): 359-364, 2021 Mar 06.
Artículo en Chino | MEDLINE | ID: mdl-33730828

RESUMEN

Objective: To investigate the relationship between metabolic syndrome (MS) and the risk of breast cancer in Chinese females. Methods: From May 2006 to December 2015, based on the Kailuan Women's Dynamic Cohort,a total of 25 618 female employees and retirees of the Kailuan Group were included and followed. Questionnaire surveys, physical measurements and laboratory tests were used to collect baseline sociodemographic characteristics, height, weight, blood glucose, blood lipids, blood pressure, tumor incidence and outcome information. Cox proportional hazards regression models were used to analyze the relationship between MS and its components (body mass index, blood pressure, blood glucose and blood lipid) and the risk of breast cancer in females. Results: The age of 25 618 women was (47.65±12.02) years old and median follow-up time was 8.78 years; 235 new cases of breast cancer were detected, and the incidence density was 113.19/100 000 person-years. After adjusting for age, education, income, smoking status, drinking status and other factors, people who were overweight or obese had a higher risk of breast cancer, with HR (95%CI) about 1.47 (1.12-1.93), than those with normal body mass index. Compared with those without MS abnormal components, women with two MS abnormal components had an increased risk of breast cancer (HR=1.70, 95%CI: 1.16-2.50). With the increase of the number of MS abnormal components, the risk of breast cancer increased gradually (Ptrend value<0.05). Conclusion: Overweight/obesity and the number of abnormal components of MS can increase the risk of breast cancer in women.


Asunto(s)
Neoplasias de la Mama , Síndrome Metabólico , Adulto , Índice de Masa Corporal , Neoplasias de la Mama/epidemiología , China/epidemiología , Femenino , Humanos , Incidencia , Síndrome Metabólico/epidemiología , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Estudios Prospectivos , Factores de Riesgo
8.
Klin Lab Diagn ; 66(2): 75-79, 2021 Mar 13.
Artículo en Inglés | MEDLINE | ID: mdl-33734639

RESUMEN

The presence of metabolic syndrome (MS) significantly increases the risk of developing cardiovascular diseases that lead to chronic heart failure (CHF). The values of NT-proBNP, ST-2, and CRP markers and their mutual correlations were studied in 37 patients with chronic heart failure (CHF) without metabolic syndrome (MS) (group 1) and 37 patients with CHF with MS (group 2). The aim of the study was to determine the features of their changes in patients with CHF complicated by MS, and to rank patients by assigning a rank value to the values of NTproBNP, ST2, and CRP concentrations. The average ST2 level was 51±24 ng/ml in group 1 and 62±27 ng/ml in group 2. The average values of CRP in group 1 were 23.1±5.3 mg/l, in group 2-33.0±4.4 mg/l (p<0.05). The NTproBNP level was 2413±1586 PG/ml and 2721±1635 PG/ml in groups 1 and 2, respectively. Correlations between the values of NTproBNP and ST2, NTproBNP and CRP were demonstrated. In the group of CHF with MS, compared with the group of CHF, there were significantly more patients with the most pronounced pathological levels of damage markers: the number of patients with a General rank of 6-9 in the group of CHF with MS was 59%, in the group of CHF without MS-38% (p<0.05). Of the 18 patients who died, 17 were among those who had an overall rank of 6 to 9, only 1 patient who died after hospitalization had an overall rank of 5. At the same time, among 22 patients who had improved CHF in the outcome of hospitalization, 18 patients had a total rank from 0 to 5, and in 4 patients of this category, the clinical manifestations of CHF remained virtually unchanged. The results of ranking the level of the studied laboratory markers indicate that they can be used as a predictor of various outcomes of CHF.


Asunto(s)
Insuficiencia Cardíaca , Síndrome Metabólico , Biomarcadores , Enfermedad Crónica , Humanos , Laboratorios , Síndrome Metabólico/complicaciones , Péptido Natriurético Encefálico , Fragmentos de Péptidos , Pronóstico
9.
Molecules ; 26(4)2021 Feb 11.
Artículo en Inglés | MEDLINE | ID: mdl-33670177

RESUMEN

For centuries, natural medicines have represented the only option for treating human diseases and, nowadays, plant phytochemicals are considered as promising compounds to treat or prevent chronic conditions. Among them, hop flowers (Humulus lupulus L.), typically used in brewing industries to give the typical aroma and flavor to beer, have attracted particular attention for their health promoting properties. Several in vivo/vitro studies and human interventional trials have demonstrated the beneficial effects of these molecules on weight gain, lipid metabolism, glucose homeostasis, insulin sensitivities, and inflammation by acting on different targets. All these activities suggest a possible role of bitter hop acid in preventing metabolic syndrome and its related diseases. A systematic quest on PubMed and Scopus databases was performed to identify pre-clinical and clinical studies focusing on this topic. This systematic review summarizes the results obtained by different cell lines, animal models, and human interventional trials to propose iso-α-acids as medical nutrition therapy to treat or prevent metabolic syndrome and its related disorders as diabetes, dislipidemia inflammation, etc.


Asunto(s)
Diabetes Mellitus/tratamiento farmacológico , Humulus/química , Inflamación/tratamiento farmacológico , Síndrome Metabólico/tratamiento farmacológico , Ácidos/química , Ácidos/uso terapéutico , Cerveza , Flores/química , Humanos , Metabolismo de los Lípidos/efectos de los fármacos , Fitoquímicos/química , Fitoquímicos/farmacología
11.
Pan Afr Med J ; 38: 21, 2021.
Artículo en Francés | MEDLINE | ID: mdl-33777289

RESUMEN

Introduction: the aim of this study was to correlate the metabolic syndrome with the level of the physical activity in a population from Marrakech, Morocco. Methods: the study was conducted at Ibn Zohr Regional Hospital in Marrakech. The body mass index (BMI) was calculated to assess the degree of obesity of each subject. To determine the level of physical activity, we used the short version of the IPAQ (International Physical Activity Questionnaire); Blood parameters were measured by a Biochemistry Automaton. All statistical analyzes were performed using SPSS software. Results: a total of 300 subjects participated in the study, which 57.3% were female and 42.7% were male with a sex ratio of 0.74. The average age of our population was 51.6± 13.42 years old. Seventy-nine of the participants (26.3%) had a metabolic syndrome, with a predominance of female: 60 women (34.9%) and 19 men (14.8%). There is a significant relationship between level of physical activity and the presence of metabolic syndrome (P = 0.002), between physical activity level and BMI and waist circumference (p < 0.001) and (p = 0.003) respectively. Conclusion: the result shows a significant association between obesity, metabolic syndrome and the level of the physical activity, which would encourage us to encourage the application of lifestyle rules, including physical activity, which remains one of the best preventive actions against this pathology.


Asunto(s)
Ejercicio Físico , Estilo de Vida , Síndrome Metabólico/epidemiología , Obesidad/epidemiología , Adulto , Anciano , Índice de Masa Corporal , Femenino , Humanos , Masculino , Persona de Mediana Edad , Marruecos , Encuestas y Cuestionarios , Circunferencia de la Cintura
12.
Life Sci ; 273: 119290, 2021 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-33662430

RESUMEN

The current study examined the role of sex differences in the development of risk factors associated with obesity and its comorbidities using models that differ in their susceptibility to develop obesity, obesity-resistant S5B/Pl (S5B) and obesity-prone Osborne-Mendel (OM) rats. Male and female rats were fed a low fat or high fat diet (HFD) and markers of metabolic syndrome (MetSyn) and expression of inflammatory cytokines/chemokines in visceral and subcutaneous adipose depots were measured. We hypothesized that male and female OM and S5B rats would exhibit differential responses to the consumption of HFD and that females, regardless of susceptibility to develop obesity, would display decreased obesity-related risk factors. Results suggested that consumption of HFD increased adiposity and fasting glucose levels in male OM and S5B rats, decreased circulating adiponectin levels in male S5B rats, and increased body weight and triglyceride levels in male OM rats. The consumption of HFD increased body weight and adiposity in female OM rats, not female S5B rats. Overall, female rats did not meet criteria for MetSyn, while male rats consuming HFD met criteria for MetSyn. Visceral and subcutaneous adipose tissue inflammation was higher in male rats. In visceral adipose tissue, HFD consumption differentially altered expression of cytokines in male and female S5B and OM rats. These findings suggest that resistance to obesity in males may be overridden by chronic consumption of HFD and lead to increased risk for development of obesity-related comorbidities, while female rats appear to be protected from the adverse effects of HFD consumption.


Asunto(s)
Tejido Adiposo/patología , Biomarcadores/metabolismo , Dieta Alta en Grasa/efectos adversos , Inflamación/patología , Síndrome Metabólico/patología , Obesidad/complicaciones , Tejido Adiposo/metabolismo , Animales , Peso Corporal , Femenino , Inflamación/etiología , Inflamación/metabolismo , Leptina/metabolismo , Masculino , Síndrome Metabólico/etiología , Síndrome Metabólico/metabolismo , Ratas , Factores Sexuales , Aumento de Peso
13.
Pol Merkur Lekarski ; 49(289): 32-34, 2021 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-33713090

RESUMEN

Obesity is one of the most serious and common risk factors for cardiovascular disease that increases the risk of type 2 diabetes. AIM: The aim of the study was to analyze the features of disorders of diastolic function of the left ventricle and the oxygenation of arterial and venous blood in patients with diabetic foot syndrome and metabolic syndrome with diastolic dysfunction of the left ventricle in its complex treatment with the using a course of hyperbaric oxygen therapy. MATERIALS AND METHODS: An examination of 32 patients with diabetic foot syndrome, neuro-ischemic form (I stage - 8 patients, II stage - 24 patients) and metabolic syndrome, to determine an assessment was made of diastolic function of the left ventricle, determination of saturation of arterial and venous blood, oxygen content in arterial and venous blood, arterio-venous difference in oxygen. The control group consisted of 20 healthy individuals. These indicators were determined before starting the course of hyperbaric oxygen therapy and after completing the full course used 100 % oxygen, with the following parameters: working pressure of 1.7-1.8 at, with periods of compression and decompression of 10 minutes, isopression - 40-60 minutes. The total number of sessions was 8-10. RESULTS: The ratio peak rates of early- and late diastolic filling of the patients in the study group was significantly lower by 24.48 % (p <0.05) compared to the control group. Iso-volumetric relaxation and slowing of early diastolic filling also increased: by 21.02 % and by 7.26 % (p <0.05), respectively. Saturation of arterial blood after hyperbaric oxygenation sessions was 4.1% higher than the initial data. Saturation of venous blood before and after oxygen therapy was 52.64 ± 0.08 % and 58.25 ± 0.02 %, respectively. Oxygen content in arterial and venous blood before the start of the course was 121.57 ± 0.85 ml· L-1 and 127.20 ± 3.5 ml·L-1, respectively, and after treatment respectively 135.61 ± 0.06 ml·L-1 and 82.13 ± 0.01 ml·L-1. In addition, the volume of oxygen consumed by body tissues increased from 46.85 ± 0.84 ml·L-1 to 57.83 ± 4.3 ml·L-1. CONCLUSIONS: The use of the course of the hyperbaric oxygen therapy contributed to the reduction of signs of diastolic heart failure and increased oxygenation rates of arterial and venous blood, the alignment of oxygen metabolism, contributed to the elimination of both systemic oxygen deficiency and local tissue hypoxia, due to which a complex therapeutic effect revealed.


Asunto(s)
Diabetes Mellitus Tipo 2 , Pie Diabético , Síndrome Metabólico , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/terapia , Pie Diabético/terapia , Diástole , Ventrículos Cardíacos , Humanos , Síndrome Metabólico/complicaciones , Síndrome Metabólico/terapia
14.
Epidemiol Health ; 43: e2021016, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33677859

RESUMEN

With the introduction of life-course epidemiology, researchers realized the importance of identifying risk factors in early life to prevent chronic diseases. This led to the establishment of the Ewha Birth and Growth Study in 2001; the study is a prospective birth cohort designed to provide evidence of early life risk factors for a child's growth and health. Participants were recruited from those who visited Ewha Womans University Mokdong Hospital (a tertiary hospital in southwest Seoul, Korea) for prenatal care at 24-28 weeks of gestation. In total, 891 mothers enrolled in this study between 2001 and 2006 and their offspring (n=940) were followed-up. Regular check-up examinations of offspring were conducted at 3 years, 5 years, and 7 years of age and every year thereafter. To consider age-related health issues, extensive data were collected using questionnaires and measurements. In 2021, the study subjects will reach 19 years of age, and we are planning a check-up examination for early adulthood. About 20 years have passed since the cohort data were collected, and we have published results on childhood health outcomes associated with prenatal and birth characteristics, genetic and epigenetic characteristics related to childhood metabolism, the effects of exposure to endocrine disruptors, and dietary patterns in childhood. Recently, we started reporting on topics related to adolescent health. The findings will facilitate identification of early life risk factors for chronic diseases and the development of interventions for diseases later in life.


Asunto(s)
Desarrollo Infantil , Salud del Niño , Adolescente , Niño , Preescolar , Estudios de Cohortes , Femenino , Humanos , Recién Nacido , Masculino , Síndrome Metabólico/epidemiología , República de Corea/epidemiología
15.
Int J Mol Sci ; 22(4)2021 Feb 17.
Artículo en Inglés | MEDLINE | ID: mdl-33671459

RESUMEN

Metabolic syndrome (MetS) and infertility are two afflictions with a high prevalence in the general population. MetS is a global health problem increasing worldwide, while infertility affects up to 12% of men. Despite the high prevalence of these conditions, the possible impact of MetS on male fertility has been investigated by a few authors only in the last decade. In addition, underlying mechanism(s) connecting the two conditions have been investigated in few preclinical studies. The aim of this review is to summarize and critically discuss available clinical and preclinical studies on the role of MetS (and its treatment) in male fertility. An extensive Medline search was performed identifying studies in the English language. While several studies support an association between MetS and hypogonadism, contrasting results have been reported on the relationship between MetS and semen parameters/male infertility, and the available studies considered heterogeneous MetS definitions and populations. So far, only two meta-analyses in clinical and preclinical studies, respectively, evaluated this topic, reporting a negative association between MetS and sperm parameters, testosterone and FSH levels, advocating, however, larger prospective investigations. In conclusion, a possible negative impact of MetS on male reproductive potential was reported; however, larger studies are needed.


Asunto(s)
Síndrome Metabólico/fisiopatología , Reproducción/fisiología , Animales , Dieta Alta en Grasa , Humanos , Infertilidad Masculina/complicaciones , Masculino , Síndrome Metabólico/complicaciones , Síndrome Metabólico/epidemiología , Prevalencia , Semen
16.
Medicine (Baltimore) ; 100(13): e25303, 2021 Apr 02.
Artículo en Inglés | MEDLINE | ID: mdl-33787620

RESUMEN

ABSTRACT: This study aimed to investigate the association between mean platelet volume (MPV) and metabolic syndrome (MetS) in patients with type 2 diabetes mellitus (T2DM). Data for 1240 patients with T2DM admitted to the Department of Endocrinology at the First Affiliated Hospital of Guangxi Medical University between January 1, 2017 and June 1, 2020 were collected retrospectively via electronic medical records, including demographic information, complete blood count, lipid profile, and glucose metabolism indexes. MetS was defined according to the Chinese Diabetes Society. Among the 1240 patients enrolled, 873 (70.40%) had MetS. MPV was significantly higher in patients with MetS (P < .001). For individual MetS components, MPV was significantly higher in the presence of abdominal obesity (P = .013) and hypertriglyceridemia (P = .026), but did not differ in the presence of elevated blood pressure (P = .330) or low high-density lipoprotein cholesterol (P = .790). Moreover, MPV was independently associated with MetS after adjustment for sex, smoking, alcohol drinking, white blood cell count, fasting C-peptide, and body mass index (odds ratio 1.174, 95% confidence interval 1.059-1.302). The odds ratio for MetS in the highest tertile, compared with the lowest MPV tertile, was 1.724 (95% confidence interval 1.199-2.479, P for trend = .003) after multiple adjustment. In stratified analyses, the positive correlation of MPV with MetS was significant only in patients who were older, male, or overweight, or who had poor glycemic control. In conclusion, high MPV was positively associated with the presence of MetS in patients with T2DM, particularly older, male, or overweight patients, or those with poor glycemic control.


Asunto(s)
Diabetes Mellitus Tipo 2/sangre , Volúmen Plaquetario Medio , Síndrome Metabólico/sangre , Adulto , Factores de Edad , Anciano , Recuento de Células Sanguíneas , Glucemia , Presión Sanguínea , Índice de Masa Corporal , China , Diabetes Mellitus Tipo 2/complicaciones , Femenino , Humanos , Lípidos/sangre , Masculino , Síndrome Metabólico/etiología , Persona de Mediana Edad , Sobrepeso/sangre , Sobrepeso/complicaciones , Estudios Retrospectivos , Factores Sexuales
17.
Medicine (Baltimore) ; 100(12): e24574, 2021 Mar 26.
Artículo en Inglés | MEDLINE | ID: mdl-33761635

RESUMEN

BACKGROUND: Metabolic syndrome (MS) is a common chronic disease in modern society, and the etiology and pathogenesis of it is still unknown. For its main symptoms: disorder of glucose and lipid metabolism, the usual treatment is applying statin and hypoglycemic drugs. Comparing to the long-term application of these drugs which may cost great side effects, Dendrobium Nobile Lindl (DN) has been proved for its hypoglycemic and lipid-lowering effects without obvious side effects. So this trial is aim to evaluate the efficacy and safety of DN-powder in intervention of MS, and to explore the mechanism of action of DN through multi-group correlation analysis. METHODS: This clinical trial is a single-arm, non-randomized, open, exploratory trial. A total of 30 participants who are suffering from MS will be assigned into therapy group (n = 30). The treatment course will last for 8 weeks, and a follow-up period for 4 weeks. The participants will receive DN-powder for 6 g, twice a day during the study period. The primary outcome will be the change of lipid and glucose metabolism. Other outcomes will be the body weight and body mass index (BMI) which will be assessments record in every 2 weeks. Participants who quit the trial due to untolerable reactions or uncontrollable conditions will enter into a follow-up period after the last treatment. All participants will enter into a follow-up period for 4 weeks after the last treatment. Adverse events will be recorded during the whole study. DISCUSSION: The results of the trial are aim to provide evidence of the safety and efficacy of DN-powder in intervention of MS which may be potential to become an important alternative therapy for certain patients. TRIAL REGISTRATION: It has been registered at http://www.chictr.org.cn/showprojen.aspx?proj=55914. (Identifier: ChiCTR2000034550), Registered 9 July 2020.


Asunto(s)
Dendrobium/química , Medicamentos Herbarios Chinos/efectos adversos , Hipoglucemiantes/efectos adversos , Hipolipemiantes/efectos adversos , Síndrome Metabólico/tratamiento farmacológico , Adolescente , Adulto , Anciano , Glucemia/análisis , Glucemia/efectos de los fármacos , Glucemia/metabolismo , Índice de Masa Corporal , Peso Corporal/efectos de los fármacos , Medicamentos Herbarios Chinos/administración & dosificación , Femenino , Estudios de Seguimiento , Humanos , Hipoglucemiantes/administración & dosificación , Hipolipemiantes/administración & dosificación , Metabolismo de los Lípidos/efectos de los fármacos , Lípidos/sangre , Masculino , Síndrome Metabólico/sangre , Síndrome Metabólico/diagnóstico , Persona de Mediana Edad , Adulto Joven
18.
Medicine (Baltimore) ; 100(10): e24600, 2021 Mar 12.
Artículo en Inglés | MEDLINE | ID: mdl-33725823

RESUMEN

ABSTRACT: To understand the adverse association of short sleep duration and insufficient fruit and vegetable intake (FVI) with and their combined effect on metabolic syndrome (MetS) in Chinese adults.This cross-sectional study analyzed 7052 adults aged 18∼64 years old in 2009, with fasting blood samples collected. Participants were divided into short/normal/long sleep duration groups and sufficient/insufficient FVI groups in accordance with self-reported information. Metabolic syndrome was defined by National Cholesterol Education Program's Adult Treatment Panel III criteria.The prevalence of MetS among the study subjects was 21.74%. Participants were classified into short (<7 h/d), normal (7∼9 h/d), and long (>9 h/d) groups according to their daily sleep duration. Participants with less than 500 g of FVI per day was considered as insufficient FVI. After adjusting for confounders, the negative effect of short sleep duration on MetS was statistically significant, with an OR of 1.29 (95%CI = 1.06∼1.56); and high fasting glucose levels were significantly associated with insufficient FVI. Compared with subjects with normal sleep duration and sufficient FVI, participants with short sleep time and insufficient FVI had the highest risk of MetS (OR = 1.37, 95% CI: 1.04-1.66).This study revealed that insufficient FVI and short sleep duration were significantly associated with an increased risk of MetS among Chinese adults. Increasing FVI and normal sleep duration during Chinese adults could be significant targets for reducing the prevalence of MetS.


Asunto(s)
Conducta Alimentaria/fisiología , Frutas , Síndrome Metabólico/epidemiología , Sueño/fisiología , Verduras , Adolescente , Adulto , Glucemia/análisis , China/epidemiología , Estudios Transversales , Ayuno/sangre , Femenino , Humanos , Masculino , Síndrome Metabólico/sangre , Síndrome Metabólico/fisiopatología , Síndrome Metabólico/prevención & control , Persona de Mediana Edad , Prevalencia , Medición de Riesgo , Factores de Riesgo , Autoinforme/estadística & datos numéricos , Factores de Tiempo , Adulto Joven
19.
Nutr. hosp ; 38(1): 36-42, ene.-feb. 2021. tab, graf
Artículo en Inglés | IBECS | ID: ibc-198838

RESUMEN

INTRODUCTION: human growth is the result of an interaction between genetic, hormonal, nutritional, and environmental factors. It is not yet fully understood what is predominant and decisive in determining an individual's weight and height. OBJECTIVE: the aim of this study was to evaluate the cardiometabolic profile of exclusively breastfed children born small for gestational age (SGA). METHODS: this is a prospective cohort study of children born at term who were classified as SGA, and as appropiate for gestational age (AGA), who were followed up to pre-school age. Anthropometric measures and body composition parameters were obtained. Breastfeeding duration was calculated in days, and achievement of catch up of weight was considered an increase in Z-score ≥ 0.67. The cardiometabolic profile was evaluated in the first month of life and repeated at pre-school age. At pre-school age, fasting blood glucose, insulin, HOMA-IR, and blood pressure were measured. RESULTS: twenty SGA and 12 AGA children were studied. The mean duration of exclusive breastfeeding (EBF) was 180 days in both groups. Of SGA children, 85 % had recovery anthropometric parameters for age within the first six months, with a speed of weight gain significantly higher than the that of AGAs (p < 0.001). SGAs continued to be thinner and smaller than AGAs at pre-school age. There was no diagnosis of overweight or obesity in the studied sample, and no differences were foun between groups in laboratory tests. CONCLUSION: these findings suggest that EBF may confer protection until pre-school age in children born SGA, who are considered at higher risk for chronic non-communicable diseases


INTRODUCCIÓN: el crecimiento humano es el resultado de la interacción de factores genéticos, hormonales, nutricionales y ambientales. Todavía no se comprende completamente lo que es predominante y decisivo para determinar el peso y la altura del individuo. OBJETIVO: el objetivo de este estudio fue evaluar el perfil cardiometabólico de niños alimentados con lactancia materna exclusivamente y que nacieron pequeños para la edad gestacional (PEG). MÉTODOS: este es un estudio de cohortes prospectivo con niños nacidos a término, unos clasificados como PEG y otros como apropiados para la edad gestacional (AEG). Se hizo un seguimiento de estos niños hasta la edad preescolar. Se realizaron medidas antropométricas y de la composición corporal. La duración de la lactancia materna se calculó en días y el éxito en la recuperación del peso se consideró como un aumento de la puntuación Z ≥ 0,67. El perfil cardiometabólico se evaluó en el primer mes de vida y se repitió en la edad preescolar. En la edad preescolar se midieron la glucosa en sangre en ayunas, la insulina, el HOMA-IR y la presión arterial. RESULTADOS: el grupo del estudio estaba formado por veinte niños PEG y doce niños AEG. La duración media de la lactancia materna exclusiva (LME) fue de 180 días en ambos grupos. De los niños PEG, el 85 % tenían parámetros antropométricos de recuperación para la edad en los primeros seis meses, siendo la velocidad del aumento de peso significativamente mayor que en los AEG (p < 0,001). Aun así, los niños PEG continuaron siendo más delgados y pequeños que los AEG en la edad preescolar. No hubo diagnóstico de sobrepeso u obesidad en la muestra estudiada, y no hay diferencia entre los grupos relativos a las pruebas de laboratorio. CONCLUSIÓN: estos hallazgos sugieren que la LME puede conferir protección hasta la edad preescolar en los niños nacidos PEG, que se consideran en mayor riesgo de contraer enfermedades crónicas no transmisibles


Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Edad Gestacional , Leche Humana/metabolismo , Recién Nacido Pequeño para la Edad Gestacional/metabolismo , Recién Nacido Pequeño para la Edad Gestacional/fisiología , Síndrome Metabólico/prevención & control , Estudios de Cohortes , Recién Nacido Pequeño para la Edad Gestacional/crecimiento & desarrollo , Sobrepeso/prevención & control , Estudios Prospectivos , Presión Sanguínea , Enfermedades Cardiovasculares/prevención & control
20.
Nutr. hosp ; 38(1): 67-72, ene.-feb. 2021. tab
Artículo en Inglés | IBECS | ID: ibc-198842

RESUMEN

INTRODUCTION: obesity often leads to deregulation and disrupting of the function of adipokines, which leads to various altered conditions, including metabolic syndrome (MetS). Adiponectin is one of the main adipokines secreted by adipocytes. The ADIPQ gene polymorphism rs266729 (-11377 C>G) is significantly associated with metabolic alterations related to obesity in different populations. Mexico has a high prevalence of obesity and risk factors associated with MetS. We investigated the association of the ADIPQ gene polymorphism rs266729 (-11377 C>G) with MetS in a Mexican population of western Mexico. METHODS: a total of 101 MetS patients and 70 unrelated healthy subjects were genotyped for ADIPQ polymorphism rs266729 using the restriction fragment length polymorphism method. RESULTS: we found a higher frequency of the minor allele G in MetS patients, as compared to that observed in the control group (OR = 2.17; 95 % CI, 1.26-3.70; p = 0.003). Also, the GG genotype was significantly associated with MetS risk under codominant (OR = 4.0; 95 % CI, 1.32-11.71; p = 0.014), dominant (OR = 2.16; 95 % CI, 1.12-4.03; p = 0.018), and recessive (OR = 3.33; 95 % CI, 1.14-9.45; p = 0.033) genetic models. CONCLUSION: our findings suggest that the minor allele G in the ADIPQ gene polymorphism rs266729 constitutes a risk factor for the development of MetS in a Mexican population of western Mexico


INTRODUCCIÓN: la obesidad frecuentemente tiene como consecuencia una desregulación y disrupción de la función de las adipocinas, que dan lugar a varias alteraciones, incluyendo el síndrome metabólico (SM). La adiponectina es una de las principales adipocinas secretadas por los adipocitos. El polimorfismo rs266729 (-11377 C>G) del gen ADIPOQ se ha asociado significativamente con alteraciones metabólicas relacionadas con la obesidad en diferentes poblaciones. México tiene una alta prevalencia de obesidad y de factores de riesgo asociados al SM. En el presente estudio investigamos la asociación del polimorfismo rs266729 (-11377 C>G) del gen ADIPOQ con el SM en una población mexicana del occidente de México. Metodos: a un total de 101 pacientes con SM y 70 sujetos sanos no relacionados se les identificó el polimorfismo rs266729 por el método de la PCR-RFLP. RESULTADOS: encontramos una mayor frecuencia del alelo menor G en los pacientes con SM, en comparación con la frecuencia observada en el grupo de control (OR = 2,17; IC 95 %: 1,26-3,70; p = 0,003). Asimismo, el genotipo GG se asoció significativamente con el SM bajo los modelos genéticos codominante (OR = 4,0; IC 95 %: 1,32-11,71; p = 0,014), dominante (OR = 2,16; IC 95 %: 1,12-4,03; p = 0,018) y recesivo (OR = 3,33; IC 95 %: 1,14-9,45; p = 0,033). CONCLUSIÓN: nuestros resultados sugieren que el alelo menor G del polimorfismo rs266729 (-11377 C>G) del gen ADIPOQ representa un factor de riesgo para el desarrollo de SM en la población mexicana del occidente de México


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano , Polimorfismo Genético , Síndrome Metabólico/epidemiología , Síndrome Metabólico/genética , Obesidad/epidemiología , Protocolos Clínicos , Adipoquinas/sangre , Adiponectina/sangre , México/epidemiología , Adipoquinas/análisis , Adipoquinas/genética , Adiponectina/genética , Estudios Transversales , Antropometría
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