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1.
Crit Rev Oncog ; 29(4): 33-42, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38989736

RESUMEN

Particulate matter (PM) imposes a significant impact to environmental health with deleterious effects on the human pulmonary and cardiovascular systems. Macrophages (Mφ), key immune cells in lung tissues, have a prominent role in responding to inhaled cells, accommodating inflammation, and influencing tissue repair processes. Elucidating the critical cellular responses of Mφ to PM exposure is essential to understand the mechanisms underlying PM-induced health effects. The present review aims to give a glimpse on literature about the PM interaction with Mφ, triggering the cellular events causing the inflammation, oxidative stress (OS) and tissue damage. The present paper reviews the different pathways involved in Mφ activation upon PM exposure, including phagocytosis, intracellular signaling cascades, and the release of pro-inflammatory mediators. Potential therapeutic strategies targeting Mφ-mediated responses to reduce PM-induced health effects are also discussed. Overall, unraveling the complex interplay between PM and Mφ sheds light on new avenues for environmental health research and promises to develop targeted interventions to reduce the burden of PM-related diseases on global health.


Asunto(s)
Macrófagos , Material Particulado , Humanos , Material Particulado/efectos adversos , Macrófagos/metabolismo , Macrófagos/inmunología , Estrés Oxidativo , Salud Ambiental , Animales , Inflamación , Exposición a Riesgos Ambientales/efectos adversos , Fagocitosis , Transducción de Señal , Contaminantes Atmosféricos/efectos adversos
2.
Rev Med Suisse ; 20(881): 1317-1319, 2024 Jul 03.
Artículo en Francés | MEDLINE | ID: mdl-38961783
3.
Rev Esc Enferm USP ; 58: e20240026, 2024.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-38949513

RESUMEN

The aim is to conduct theoretical reflection on the inseparability among public health, planetary health and the nursing process in light of complexity thinking, with the aim of contributing to healthy and sustainable development. Study with a theoretical-reflexive approach that accessed bibliographical sources from contemporary authors who defend the inseparability between public health and planetary health and, at the same time, provide theoretical-systemic support to the nursing process, under an inductive critical bias. The nursing process is conceived as a complex phenomenon, which comprises interdependent dynamics, dialogical approaches, critical-reflective perception and prospective leadership. Theoretical reflection on the nursing process and sustainable development raises an expanded, contextualized and interdependent look at the role of nursing professionals in different health contexts, in order not to compromise well-being and environmental health.


Asunto(s)
Salud Global , Proceso de Enfermería , Salud Pública , Desarrollo Sostenible , Humanos , Proceso de Enfermería/organización & administración , Salud Ambiental , Rol de la Enfermera
4.
Multimedia | Recursos Multimedia, MULTIMEDIA-SMS-SP | ID: multimedia-13318

RESUMEN

O Programa em Saúde Ambiental relacionado a populações expostas à poluição do ar do Município de São Paulo (VIGIAR) tem por objetivo desenvolver ações de vigilância em saúde ambiental, para populações expostas aos poluentes atmosféricos, de forma a orientar medidas de prevenção, promoção da saúde e de atenção integral, conforme preconizado pelo Sistema Único de Saúde (SUS).


Asunto(s)
Contaminación del Aire/efectos adversos , Salud Ambiental
5.
Environ Health ; 23(1): 59, 2024 Jun 28.
Artículo en Inglés | MEDLINE | ID: mdl-38943149

RESUMEN

An under-recognised aspect of the current humanitarian catastrophe in Gaza is the impact of the war on the environment and the associated risks for human health. This commentary contextualises these impacts against the background of human suffering produced by the overwhelming violence associated with the use of military force against the general population of Gaza. In calling for an immediate cessation to the violence, the authors draw attention to the urgent need to rebuild the health care system and restore the physical and human infrastructure that makes a liveable environment possible and promotes human health and well-being, especially for the most vulnerable in the population. Environmental remediation should therefore form one of the most important parts of international efforts to assist reconstruction, through which we hope Palestinians and Israelis will achieve lasting peace, health, and sustainable development, all as part of accepted international human rights obligations.


Asunto(s)
Salud Pública , Humanos , Medio Oriente , Violencia/estadística & datos numéricos , Restauración y Remediación Ambiental , Salud Ambiental
6.
Environ Health Perspect ; 132(6): 64002, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38916968

RESUMEN

Most tools that measure environmental health literacy are broad in nature. Researchers have now developed a tool specific to phthalate awareness and behaviors as they relate to reproductive health.


Asunto(s)
Salud Ambiental , Alfabetización en Salud , Ácidos Ftálicos , Salud Reproductiva , Humanos , Conocimientos, Actitudes y Práctica en Salud , Exposición a Riesgos Ambientales , Femenino , Contaminantes Ambientales
7.
Environ Geochem Health ; 46(7): 242, 2024 Jun 07.
Artículo en Inglés | MEDLINE | ID: mdl-38849707

RESUMEN

Emerging from the shadow of the COVID-19 pandemic, it is time to ground ourselves and retrospectively assess the recent achievements of SEGH over the past years. This editorial serves as a comprehensive report on the progress made in comparison to the aspirations and goals set by the society's board in 2019 (Watts et al., Environ Geochem Health 42:343-347, 2019) (Fig. 1) and reflects on the state of the SEGH community as it reached its 50th anniversary at the close of 2021 (Watts et al. Environ Geochem Health 45:1165-1171, 2023). The focus lies on how the SEGH community navigated through the extraordinary challenges posed by the COVID-19 pandemic since early 2020, and to what extent the 2023 targets have been met.


Asunto(s)
COVID-19 , COVID-19/epidemiología , Humanos , Salud Ambiental , Sociedades Científicas , Estudios Retrospectivos , SARS-CoV-2
8.
Cell Genom ; 4(7): 100591, 2024 Jul 10.
Artículo en Inglés | MEDLINE | ID: mdl-38925123

RESUMEN

Understanding the complex interplay of genetic and environmental factors in disease etiology and the role of gene-environment interactions (GEIs) across human development stages is important. We review the state of GEI research, including challenges in measuring environmental factors and advantages of GEI analysis in understanding disease mechanisms. We discuss the evolution of GEI studies from candidate gene-environment studies to genome-wide interaction studies (GWISs) and the role of multi-omics in mediating GEI effects. We review advancements in GEI analysis methods and the importance of large-scale datasets. We also address the translation of GEI findings into precision environmental health (PEH), showcasing real-world applications in healthcare and disease prevention. Additionally, we highlight societal considerations in GEI research, including environmental justice, the return of results to participants, and data privacy. Overall, we underscore the significance of GEI for disease prediction and prevention and advocate for integrating the exposome into PEH omics studies.


Asunto(s)
Salud Ambiental , Interacción Gen-Ambiente , Medicina de Precisión , Humanos , Medicina de Precisión/métodos , Estudio de Asociación del Genoma Completo , Exposición a Riesgos Ambientales/efectos adversos
9.
Lancet Public Health ; 9(7): e411, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38878782
10.
Sci Total Environ ; 942: 173628, 2024 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-38848924

RESUMEN

Air quality (AQ) significantly impacts human health, influenced by both natural phenomena and human activities. In 2021, heightened awareness of AQ's health impacts prompted the revision of the World Health Organization (WHO) guidelines, advocating for stricter pollution standards. However, research on AQ has predominantly focused on high-income countries and densely populated cities, neglecting low- and middle-income countries, particularly Pacific Island Countries, Territories, and States (PICTS). This systematic review compiles existing peer-reviewed literature on AQ research in PICTS to assess the current state of knowledge and emphasize the need for further investigation. A systematic literature search yielded 40 papers from databases including Web of Science, Scopus, and Embase. Among the 26 PICTS, only 6 (Hawai'i, Fiji, Papua New Guinea, New Caledonia, Republic of Marshall Islands, and Pacific) have been subject to AQ-related research, with 4 considering the World Health Organization (WHO) parameters and 26 addressing non-WHO parameters. Analysis reveals AQ parameters often exceed 2021 WHO guidelines for PM2.5, PM10, SO2, and CO, raising concerns among regional governments. Studies primarily focused on urban, agricultural, rural, and open ocean areas, with 15 based on primary data and 14 on both primary and secondary sources. Research interests and funding sources dictated the methods used, with a predominant focus on environmental risks over social, economic, and technological impacts. Although some papers addressed health implications, further efforts are needed in this area. This review underscores the urgent need for ongoing AQ monitoring efforts in PICTS to generate spatially and temporally comparable data. By presenting the current state of AQ knowledge, this work lays the foundation for coordinated regional monitoring and informs national policy development.


Asunto(s)
Contaminación del Aire , Humanos , Contaminantes Atmosféricos/análisis , Contaminación del Aire/estadística & datos numéricos , Exposición a Riesgos Ambientales/estadística & datos numéricos , Salud Ambiental , Monitoreo del Ambiente/métodos , Islas del Pacífico , Organización Mundial de la Salud
11.
BMJ ; 385: q1241, 2024 06 10.
Artículo en Inglés | MEDLINE | ID: mdl-38857922
12.
J Toxicol Environ Health B Crit Rev ; 27(5-6): 189-211, 2024 Aug 17.
Artículo en Inglés | MEDLINE | ID: mdl-38743482

RESUMEN

Globally, national regulatory authorities are both responsible and accountable for health and environmental decisions related to diverse products and risk decision contexts. These authorities provided regulatory oversight and expedited market authorizations of vaccines and other therapeutic products during the COVID-19 pandemic. Regulatory decisions regarding such products and situations depend upon well-established risk assessment and management steps. The underlying processes supporting such decisions were outlined in frameworks describing the complex interactions between factors including risk assessment and management steps as well as principles which help guide risk decision-making. In 2022, experts in risk science proposed a set of 10 guiding principles, further examining the intersection and utility of these principles using 10 diverse risk contexts, and inviting a broader discourse on the application of these principles in risk decision-making. To add to this information, Canadian regulatory practitioners responsible for evaluating health and environmental risks and establishing policies convened at a Health Canada workshop on Principles for Risk Decision-Making. This review reports the results derived from this interactive engagement and provides a first pragmatic analysis of the relevance, importance, and feasibility of such principles for health and environmental risk decision-making within the Canadian regulatory context.


Asunto(s)
COVID-19 , Toma de Decisiones , Humanos , Medición de Riesgo , COVID-19/prevención & control , Canadá , SARS-CoV-2 , Pandemias/prevención & control , Salud Ambiental
13.
Environ Sci Pollut Res Int ; 31(26): 37963-37987, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38780845

RESUMEN

Exposure to heavy metals in various populations can lead to extensive damage to different organs, as these metals infiltrate and bioaccumulate in the human body, causing metabolic disruptions in various organs. To comprehensively understand the metal homeostasis, inter-organ "traffic," and extensive metabolic alterations resulting from heavy metal exposure, employing complementary analytical methods is crucial. Metabolomics is pivotal in unraveling the intricacies of disease vulnerability by furnishing thorough understandings of metabolic changes linked to different metabolic diseases. This field offers exciting prospects for enhancing the disease prevention, early detection, and tailoring treatment approaches to individual needs. This article consolidates the existing knowledge on disease-linked metabolic pathways affected by the exposure of diverse heavy metals providing concise overview of the underlying impact mechanisms. The main aim is to investigate the connection between the altered metabolic pathways and long-term complex health conditions induced by heavy metals such as diabetes mellitus, cardiovascular diseases, renal disorders, inflammation, neurodegenerative diseases, reproductive risks, and organ damage. Further exploration of common pathways may unveil the shared targets for treating associated pathological conditions. In this article, the role of metabolomics in disease susceptibility is emphasized that metabolomics is expected to be routinely utilized for the diagnosis and monitoring of diseases and practical value of biomarkers derived from metabolomics, as well as determining their appropriate integration into extensive clinical settings.


Asunto(s)
Exposición a Riesgos Ambientales , Salud Ambiental , Metabolómica , Metales Pesados , Humanos , Biomarcadores/metabolismo
14.
Ecotoxicol Environ Saf ; 280: 116513, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-38820820

RESUMEN

In Canada, every day, contaminants of emerging concern (CEC) are discharged from waste treatment facilities into freshwaters. CECs such as pharmaceutical active compounds (PhACs), personal care products (PCPs), per- and polyfluoroalkyl substances (PFAS), and microplastics are legally discharged from sewage treatment plants (STPs), water reclamation plants (WRPs), hospital wastewater treatment plants (HWWTPs), or other forms of wastewater treatment facilities (WWTFs). In 2006, the Government of Canada established the Chemicals Management Plan (CMP) to classify chemicals based on a risk-priority assessment, which ranked many CECs such as PhACs as being of low urgency, therefore permitting these substances to continue being released into the environment at unmonitored rates. The problem with ranking PhACs as a low priority is that CMP's risk management assessment overlooks the long-term environmental and synergistic effects of PhAC accumulation, such as the long-term risk of antibiotic CEC accumulation in the spread of antibiotic resistance genes. The goal of this review is to specifically investigate antibiotic CEC accumulation and associated environmental risks to human and environmental health, as well as to determine whether appropriate legislative strategies are in place within Canada's governance framework. In this research, secondary data on antibiotic CEC levels in Canadian and international wastewaters, their potential to promote antibiotic-resistant residues, associated environmental short- and long-term risks, and synergistic effects were all considered. Unlike similar past reviews, this review employed an interdisciplinary approach to propose new strategies from the perspectives of science, engineering, and law.


Asunto(s)
Antibacterianos , Contaminantes Químicos del Agua , Antibacterianos/análisis , Canadá , Humanos , Contaminantes Químicos del Agua/análisis , Monitoreo del Ambiente/métodos , Medición de Riesgo , Salud Ambiental , Aguas Residuales/química , Eliminación de Residuos Líquidos/métodos
15.
Neuron ; 112(12): 1905-1910, 2024 Jun 19.
Artículo en Inglés | MEDLINE | ID: mdl-38723637

RESUMEN

This NeuroView assesses the interplay among exposome, One Health, and brain capital in health and disease. Physical and social exposomes affect brain health, and green brain skills are required for environmental health strategies. Ibanez et al. address current gaps and strategies needed in research, policy, and technology, offering a road map for stakeholders.


Asunto(s)
Encéfalo , Exposoma , Humanos , Encéfalo/fisiología , Salud Ambiental , Exposición a Riesgos Ambientales/efectos adversos
16.
Health Place ; 88: 103277, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38781859

RESUMEN

Residential segregation drives exposure and health inequities. We projected the mortality impacts among low-income residents of leveraging an existing 10% affordable housing target as a case study of desegregation policy. We simulated movement into newly allocated housing, quantified changes in six ambient environmental exposures, and used exposure-response functions to estimate deaths averted. Across 1000 simulations, in one year, we found on average 169 (95% CI: 84, 255) deaths averted from changes in greenness, 71 (49, 94) deaths averted from NO2, 9 (4, 14) deaths averted from noise, 1 (1, 2) excess death from O3, and 2 (1, 2) excess deaths from PM2.5, with rates of deaths averted highest among non-Hispanic Black and non-Hispanic White residents. Strengthening desegregation policy may advance environmental health equity.


Asunto(s)
Evaluación del Impacto en la Salud , Vivienda , Pobreza , Humanos , Connecticut , Exposición a Riesgos Ambientales/efectos adversos , Segregación Social , Salud Ambiental , Mortalidad/tendencias , Contaminación del Aire/efectos adversos
17.
Environ Int ; 188: 108776, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38810494

RESUMEN

OBJECTIVE: Headache is one of the most prevalent and disabling health conditions globally. We prospectively explored the urban exposome in relation to weekly occurrence of headache episodes using data from the Dutch population-based Occupational and Environmental Health Cohort Study (AMIGO). MATERIAL AND METHODS: Participants (N = 7,339) completed baseline and follow-up questionnaires in 2011 and 2015, reporting headache frequency. Information on the urban exposome covered 80 exposures across 10 domains, such as air pollution, electromagnetic fields, and lifestyle and socio-demographic characteristics. We first identified all relevant exposures using the Boruta algorithm and then, for each exposure separately, we estimated the average treatment effect (ATE) and related standard error (SE) by training causal forests adjusted for age, depression diagnosis, painkiller use, general health indicator, sleep disturbance index and weekly occurrence of headache episodes at baseline. RESULTS: Occurrence of weekly headache was 12.5 % at baseline and 11.1 % at follow-up. Boruta selected five air pollutants (NO2, NOX, PM10, silicon in PM10, iron in PM2.5) and one urban temperature measure (heat island effect) as factors contributing to the occurrence of weekly headache episodes at follow-up. The estimated causal effect of each exposure on weekly headache indicated positive associations. NO2 showed the largest effect (ATE = 0.007 per interquartile range (IQR) increase; SE = 0.004), followed by PM10 (ATE = 0.006 per IQR increase; SE = 0.004), heat island effect (ATE = 0.006 per one-degree Celsius increase; SE = 0.007), NOx (ATE = 0.004 per IQR increase; SE = 0.004), iron in PM2.5 (ATE = 0.003 per IQR increase; SE = 0.004), and silicon in PM10 (ATE = 0.003 per IQR increase; SE = 0.004). CONCLUSION: Our results suggested that exposure to air pollution and heat island effects contributed to the reporting of weekly headache episodes in the study population.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire , Exposición a Riesgos Ambientales , Exposoma , Cefalea , Humanos , Cefalea/epidemiología , Cefalea/inducido químicamente , Masculino , Femenino , Países Bajos/epidemiología , Persona de Mediana Edad , Estudios Prospectivos , Adulto , Exposición a Riesgos Ambientales/estadística & datos numéricos , Contaminantes Atmosféricos/análisis , Contaminación del Aire/estadística & datos numéricos , Contaminación del Aire/efectos adversos , Salud Ambiental , Estudios de Cohortes , Encuestas y Cuestionarios , Material Particulado/análisis , Población Urbana/estadística & datos numéricos
18.
Chemosphere ; 361: 142465, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38810805

RESUMEN

Modern environmental epidemiology benefits from a new generation of technologies that enable comprehensive profiling of biomarkers, including environmental chemical exposure and omic datasets. The integration and analysis of large and structured datasets to identify functional associations is constrained by computational challenges that cannot be overcome using conventional regression methods. Some extensions of Partial Least Squares (PLS) regression have been developed to efficently integrate multiple datasets, including Multiblock PLS (MB-PLS) and Sequential and Orthogonalized PLS; however, these approaches remain seldom applied in environmental epidemiology. To address that research gap, this study aimed to assess and compare the applicability of PLS-based multiblock models in an observational case study, where biomarkers of exposure to environmental chemicals and endogenous biomarkers of effect were simultaneously integrated to highlight biological links related to a health outcome. The methods were compared with and without sparsity coupling two metrics to support the variable selection: Variable Importance in Projection (VIP) and Selectivity Ratio (SR). The framework was applied to a case-study dataset mimicking the structure of 36 environmental exposure biomarkers (E-block), 61 inflammation biomarkers (M-block), and their relationships with the gestational age at delivery of 161 mother-infant pairs. The results showed an overall consistency in the selected variables across models, although some specific selection patterns were identified. The block-scaled concatenation-based approaches (e.g. MB-PLS) tended to select more variables from the E-block, while these methods were unable to identify certain variables in the M-block. Overall, the number of variables selected using the SR criterion was higher than using the VIP criterion, with lower predictive performances. The multiblock models coupled to VIP, appeared to be the methods of choice for identifying relevant variables with similar statistical performances. Overall, the use of multiblock PLS-based methods appears to be a good strategy to efficiently support the variable selection process in modern environmental epidemiology.


Asunto(s)
Biomarcadores , Exposición a Riesgos Ambientales , Biomarcadores/análisis , Humanos , Exposición a Riesgos Ambientales/estadística & datos numéricos , Análisis de los Mínimos Cuadrados , Salud Ambiental , Contaminantes Ambientales/análisis , Femenino
19.
World J Gastroenterol ; 30(16): 2191-2194, 2024 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-38690026

RESUMEN

This editorial explores the intricate relationship between microplastics (MPs) and gut microbiota, emphasizing the complexity and environmental health implications. The gut microbiota, a crucial component of gastrointestinal health, is examined in the context of potential microbial degradation of MPs. Furthermore, dysbiosis induced by MPs emerges as a consensus, disrupting the balance of gut microbiota and decreasing diversity. The mechanisms triggering dysbiosis, including physical interactions and chemical composition, are under investigation. Ongoing research addresses the consequences of MPs on immune fun-ction, nutrient metabolism, and overall host health. The bidirectional relationship between MPs and gut microbiota has significant implications for environmental and human health. Despite uncertainties, MPs negatively impact gut microbiota and health. Further research is essential to unravel the complex interactions and assess the long-term consequences of MPs on both environmental and human well-being.


Asunto(s)
Disbiosis , Microbioma Gastrointestinal , Microplásticos , Microplásticos/efectos adversos , Humanos , Microbioma Gastrointestinal/efectos de los fármacos , Microbioma Gastrointestinal/fisiología , Salud Ambiental , Exposición a Riesgos Ambientales/efectos adversos , Animales
20.
Soins ; 69(885): 24-27, 2024 May.
Artículo en Francés | MEDLINE | ID: mdl-38762228

RESUMEN

The healthcare system and the practice of health care have unprecedented impacts on our environment. High carbon footprint, pollution and its consequences on health, the picture is not glorious. Even if they rarely identify themselves as such, healthcare professionals are key actors in the drive towards more sustainable practices. Their numbers, skills and activities give them privileged access to the population, communities and individuals of all ages and backgrounds. Thanks to their increasingly specialized training, they are in a position to accompany people on their health journey, prevent illness and promote healthy behaviours. These aspects are central to sustainability in healthcare.


Asunto(s)
Cuidadores , Humanos , Cuidadores/psicología , Salud Ambiental
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