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1.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(5): 491-493, 2020 May 06.
Artículo en Chino | MEDLINE | ID: mdl-32388947

RESUMEN

The epidemiological history and clinical characteristics of 7 cases of COVID-19 and 1 case of close contact in the first family aggregation epidemic of COVID-19 in Gansu Province were analyzed. The first patient A developed on January 22, 2020, with a history of residence in Wuhan, and confirmed severe cases of NCP on January 24, 2020; patient B, on January 23, 2020, diagnosed on January 31, severe cases; patient C, asymptomatic, diagnosed on January 27; patient D, asymptomatic, diagnosed on January 27; patient E, on January 24, diagnosed on January 28; patient F, asymptomatic, diagnosed on January 31; Patient G was asymptomatic and was diagnosed on January 31. In close contact, H was asymptomatic, PCR test was negative and asymptomatic, and he was discharged early. Among the 7 patients, 1 case died of (B) aggravation, and the other patients' condition was effectively controlled after active treatment. Except for the discharged cases, 5 cases were positive for COVID-19 specific IgM antibody and 1 case was negative. In this clustering outbreak, 4 patients remained asymptomatic, but PCR and IgM antibodies were positive, indicating that asymptomatic patients may be the key point to control the epidemic. Specific IgM antibody screening for patients whose pharyngeal swab nucleic acid test is negative but with ground glass-like lung lesions is very important for early detection and early isolation.


Asunto(s)
Infecciones Asintomáticas , Infecciones por Coronavirus/diagnóstico , Salud de la Familia , Neumonía Viral/diagnóstico , Anticuerpos Antivirales/sangre , Betacoronavirus , China , Humanos , Inmunoglobulina M/sangre , Masculino , Pandemias
2.
BMJ Case Rep ; 13(5)2020 May 04.
Artículo en Inglés | MEDLINE | ID: mdl-32371416

RESUMEN

The coronavirus disease (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, in late 2019 and has affected more than 1 270 000 people worldwide. The numbers of reported cases continue to rise and threaten global health. Transmissions among family members are frequently observed, although the route of transmission is partially known. Here we report three cases of SARS-CoV-2 infection within one family. Sequencing of the S gene of the viral genome showed 100% identity among samples, suggesting that the same strain caused the infection. Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. Our observations suggest the importance of preventing family transmission and the efficacy of current integrated treatment for mild/moderate pneumonia in COVID-19 cases.


Asunto(s)
Infecciones por Coronavirus , Pandemias , Neumonía Viral , Glicoproteína de la Espiga del Coronavirus , Adulto , Antivirales/uso terapéutico , Betacoronavirus/genética , Betacoronavirus/aislamiento & purificación , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/tratamiento farmacológico , Infecciones por Coronavirus/transmisión , Salud de la Familia , Femenino , Genoma Viral , Humanos , Masculino , Metilprednisolona/uso terapéutico , Persona de Mediana Edad , Oseltamivir/uso terapéutico , Neumonía Viral/diagnóstico , Neumonía Viral/tratamiento farmacológico , Neumonía Viral/transmisión , Reacción en Cadena en Tiempo Real de la Polimerasa , Glicoproteína de la Espiga del Coronavirus/genética , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
6.
Artículo en Inglés | MEDLINE | ID: mdl-32244498

RESUMEN

Our study aimed to investigate the immediate impact of the COVID-19 pandemic on mental health and quality of life among local Chinese residents aged ≥18 years in Liaoning Province, mainland China. An online survey was distributed through a social media platform between January and February 2020. Participants completed a modified validated questionnaire that assessed the Impact of Event Scale (IES), indicators of negative mental health impacts, social and family support, and mental health-related lifestyle changes. A total of 263 participants (106 males and 157 females) completed the study. The mean age of the participants was 37.7 ± 14.0 years, and 74.9% had a high level of education. The mean IES score in the participants was 13.6 ± 7.7, reflecting a mild stressful impact. Only 7.6% of participants had an IES score ≥26. The majority of participants (53.3%) did not feel helpless due to the pandemic. On the other hand, 52.1% of participants felt horrified and apprehensive due to the pandemic. Additionally, the majority of participants (57.8-77.9%) received increased support from friends and family members, increased shared feeling and caring with family members and others. In conclusion, the COVID-19 pandemic was associated with mild stressful impact in our sample, even though the COVID-19 pandemic is still ongoing. These findings would need to be verified in larger population studies.


Asunto(s)
Infecciones por Coronavirus/psicología , Miedo , Salud Mental , Pandemias , Neumonía Viral/psicología , Calidad de Vida , Estrés Psicológico , Adulto , Ansiedad/epidemiología , Grupo de Ascendencia Continental Asiática , Betacoronavirus , China/epidemiología , Infecciones por Coronavirus/complicaciones , Estudios Transversales , Emociones , Familia , Salud de la Familia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neumonía Viral/complicaciones , Apoyo Social , Encuestas y Cuestionarios , Adulto Joven
10.
Recenti Prog Med ; 111(4): 223-230, 2020 Apr.
Artículo en Italiano | MEDLINE | ID: mdl-32319444

RESUMEN

The pandemic infection caused by the virus SARS-CoV-2 has determined a severe imbalance between demand and actual supply of intensive care. The shortage of intensive care units (ICU) beds and ventilators for the treatment of patients with severe respiratory failure produced angst in the clinicians/intensivists who have to decide which patients admit to ICU and in which patients to implement palliative care. They have to apply specific clinical and ethical criteria, in emergency conditions. Proportionality and appropriateness criteria should be integrated with equity, equality, utility criteria, widening the distributive justice concept from the right of the patient to receive all available therapies to a right resources allocation during shortage, guided by public health ethic. The clinical criteria should include the disease severity, the number and severity of comorbidities, frailty, the organ failures and their stage, the patient's age, the functional autonomy and cognitive status. Consequently the first come-first served rule to ICU admission should not be applied. The patients not admitted to ICU due to clinical reasons and advanced stage diseases should receive a high quality palliative care, to obtain a good symptoms control (mainly dyspnea, anxiety and delirium) and to implement palliative sedation at the end of life. Finally particular attention should be paid to the bereavement management of the family/caregivers and in the right approach of psychological problems and Post-Traumatic Stress Disorder of health workers involved in the pandemia.


Asunto(s)
Infecciones por Coronavirus , Cuidados Críticos , Toma de Decisiones , Cuidados Paliativos , Pandemias , Neumonía Viral , Asignación de Recursos , Aflicción , Betacoronavirus , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/psicología , Infecciones por Coronavirus/terapia , Cuidados Críticos/ética , Salud de la Familia , Equidad en Salud , Recursos en Salud , Capacidad de Camas en Hospitales , Humanos , Italia , Cuidados Paliativos/ética , Neumonía Viral/epidemiología , Neumonía Viral/psicología , Neumonía Viral/terapia , Respiración Artificial , Índice de Severidad de la Enfermedad
12.
Pediatr Pulmonol ; 55(6): E6-E9, 2020 06.
Artículo en Inglés | MEDLINE | ID: mdl-32243729

RESUMEN

In December 2019, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbroke in Wuhan, the capital city of Hubei province, China. The disease rapidly spread to other areas in China due to a huge population movement during the New Year Festival. Here, a 7-year-old child with SARS-CoV-2 infection in Chongqing, outside of Wuhan, Hubei province, was reported. This case suggested that children infected with SARS-CoV-2 are more likely to present milder manifestations than adults. The continuous positive real-time reverse transcription-polymerase chain reaction assay for SARS-CoV-2 in the child's throat swab sample indicated the isolation period for suspected child cases should be longer than 14 days.


Asunto(s)
Betacoronavirus/aislamiento & purificación , Infecciones por Coronavirus/prevención & control , Transmisión de Enfermedad Infecciosa/prevención & control , Pandemias/prevención & control , Neumonía Viral/prevención & control , Adulto , Betacoronavirus/genética , Niño , China/epidemiología , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/tratamiento farmacológico , Infecciones por Coronavirus/transmisión , Salud de la Familia , Humanos , Control de Infecciones/métodos , Interferón-alfa/administración & dosificación , Masculino , Oseltamivir/administración & dosificación , Neumonía Viral/diagnóstico , Neumonía Viral/tratamiento farmacológico , Neumonía Viral/transmisión , Reacción en Cadena en Tiempo Real de la Polimerasa , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Tomografía Computarizada por Rayos X
13.
Arch Iran Med ; 23(4): 255-264, 2020 04 01.
Artículo en Inglés | MEDLINE | ID: mdl-32271599

RESUMEN

On March 11th 2020, the coronavirus outbreak was declared a pandemic by the WHO. One of the groups that is considered high risk in this pandemic are cancer patients as they are treated with a variety of immune system suppressor treatment modalities and this puts them in a great risk for infectious disease (including COVID-19). Therefore, cancer patients require higher level measures for preventing and treating infectious diseases. furthermore, cancer patients may bear additional risk due to the restriction of access to the routine diagnostic and therapeutic services during such epidemic. Since most of the attention of health systems is towards patients affected with COVID-19, the need for structured and unified approaches to COVID-19 prevention and care specific to cancer patients and cancer centers is felt more than ever. This article provides the recommendations and possible actions that should be considered by patients, their caregivers and families, physician, nurses, managers and staff of medical centers involved in cancer diagnosis and treatment. We pursued two major goals in our recommendations: first, limiting the exposure of cancer patients to medical environments and second, modifying the treatment modalities in a manner that reduces the probability of myelosuppression such as delaying elective diagnostic and therapeutic services, shortening the treatment course, or prolonging the interval between treatment courses.


Asunto(s)
Cuidadores , Infecciones por Coronavirus , Personal de Salud , Control de Infecciones , Neoplasias , Pandemias , Neumonía Viral , Betacoronavirus , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/prevención & control , Prestación de Atención de Salud , Salud de la Familia , Humanos , Irán , Neoplasias/complicaciones , Neoplasias/terapia , Pandemias/prevención & control , Neumonía Viral/complicaciones , Neumonía Viral/prevención & control
16.
J Med Syst ; 44(5): 95, 2020 Mar 19.
Artículo en Inglés | MEDLINE | ID: mdl-32193696

RESUMEN

In view of the contradiction between the medical service demand of elderly patients with hypertension and the ability of hospital, community and family medical service security, based on the optimization of the hospital community family edge network and personal medical resources, this paper designs an Internet intervention system for elderly patients with hypertension. Firstly, based on studying the process and problems of the three-dimensional medical and health management service of hospitals, communities and families, the multi-dimensional medical and health management service edge network is formed with the government and medical structure as the core and the community and family as the edge. Then, since ensuring the distributed balance of the edge network, according to the condition of individual patients, classified guidance is given to guarantee that severe patients and other patients can get timely and effective treatment, while minimizing hospital, community and family medical resources and resource wastage. Secondly, an Internet intervention system for elderly patients with hypertension and marginal network is designed by integrating the context of Internet intervention, multi-dimensional factors and the connotation of different interventions. The experimental results show that the resource optimization algorithm and the Internet intervention system have good performance in the implementation efficiency of the Internet intervention system, the optimization performance of personal medical resources, the multi-level efficiency of hospitals, communities and families, and the experience quality of elderly patients with hypertension.


Asunto(s)
Manejo de la Enfermedad , Hipertensión , Internet , Anciano , Salud de la Familia , Hospitales Comunitarios , Humanos , Hipertensión/diagnóstico , Hipertensión/terapia , Autonomía Personal
17.
Emerg Microbes Infect ; 9(1): 707-713, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-32208917

RESUMEN

This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. All the children were detected positive result after their families onset. Three children had fever (22.2%) or cough (11.2%) symptoms and six (66.7%) children had no symptom. Among the 14 adult patients, the major symptoms included fever (57.1%), cough (35.7%), chest tightness/pain (21.4%), fatigue (21.4%) and sore throat (7.1%). Nearly 70% of the patients had normal (71.4%) or decreased (28.6%) white blood cell counts, and 50% (7/14) had lymphocytopenia. There were 10 adults (71.4%) showed abnormal imaging. The main manifestations were pulmonary consolidation (70%), nodular shadow (50%), and ground glass opacity (50%). Five discharged children were admitted again because their stool showed positive result in SARS-CoV-2 PCR. COVID-19 in children is mainly caused by family transmission, and their symptoms are mild and prognosis is better than adult. However, their PCR result in stool showed longer time than their families. Because of the mild or asymptomatic clinical process, it is difficult to recognize early for pediatrician and public health staff.


Asunto(s)
Betacoronavirus , Infecciones por Coronavirus , Pandemias , Neumonía Viral , Adulto , Dolor en el Pecho , Niño , Preescolar , China , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/diagnóstico , Infecciones por Coronavirus/diagnóstico por imagen , Infecciones por Coronavirus/fisiopatología , Tos , Salud de la Familia , Heces/virología , Femenino , Fiebre , Humanos , Lactante , Pulmón/diagnóstico por imagen , Masculino , Neumonía Viral/diagnóstico , Neumonía Viral/diagnóstico por imagen , Neumonía Viral/fisiopatología , Reacción en Cadena de la Polimerasa , Pronóstico , Estudios Retrospectivos
18.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(4): 494-497, 2020 Apr 10.
Artículo en Chino | MEDLINE | ID: mdl-32133831

RESUMEN

Objective: To understand the possible transmission route of a family cluster of COVID-19 in Zhengzhou and the potential infectivity of COVID-19 in incubation period, and provide scientific evidence for the timely control of infectious source and curb the spread of the epidemic. Methods: Epidemiological investigation was conducted for a family cluster of COVID-19 (8 cases) with descriptive epidemiological method, and respiratory tract samples of the cases were collected for the nucleic acid detection of virus by RT-PCR. Results: Two primary cases, which occurred on 31 January and 1 February, 2020, respectively, had a common exposure history in Wuhan. The other six family members had onsets on 30 January, 31 January, 1 February (three cases) and 3 February, 2020. Conclusions: In this family cluster of COVID-19, six family members were infected through common family exposure to the 2 primary cases. Five secondary cases had onsets earlier than or on the same day as the primary cases, indicating that COVID-19 is contagious in incubation period, and the home isolation in the early phase of the epidemic might lead to the risk of family cluster of COVID-19.


Asunto(s)
Infecciones por Coronavirus/epidemiología , Salud de la Familia , Neumonía Viral/epidemiología , Betacoronavirus , China/epidemiología , Infecciones por Coronavirus/transmisión , Humanos , Periodo de Incubación de Enfermedades Infecciosas , Pandemias , Neumonía Viral/transmisión
19.
PLoS Negl Trop Dis ; 14(3): e0008173, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-32155158

RESUMEN

BACKGROUND: Several studies have shown that leprosy, podoconiosis and lymphatic filariasis impact individual quality of life. In contrast, family quality of life has not received as much attention despite evidence that families are also affected. This is especially relevant given the crucial role of the family in most societies around the world. This study looks at the impact of leprosy, podoconiosis and lymphatic filariasis on family quality of life. METHODOLOGY: The study used a cross-sectional design with a qualitative approach. Both semi-structured interviews and focus group discussions were conducted. Participants, persons affected and their family members, were selected by purposive sampling. Data were collected between August and November 2017 in Awi zone, Northwest Ethiopia and analysed by three independent researchers using open, inductive coding and content analysis. RESULTS: A total of 86 participants were included in this study: 56 participants in the in-depth interviews and 30 participants in the focus group discussions. We found that participation restrictions, reduced productivity and marginalisation were common. In addition, discrimination in the communities occurred often, often extending to family members of persons affected. Divorce and difficulties in finding a spouse were common for persons affected and their family members. Many persons affected reported mental health problems. While most people got social and physical support from their families, there were a few exceptions. In particular, persons with younger children seemed to lack social support. Having to provide for their affected family member sometimes caused stress, school dropouts and an additional workload. Financial problems and loss of livelihood were reported by almost all participants. CONCLUSION: This study revealed that leprosy, lymphatic filariasis and podoconiosis have an effect on several dimensions of family quality of life. Many problems reported related to stigma and poverty.


Asunto(s)
Filariasis Linfática/psicología , Elefantiasis/psicología , Salud de la Familia , Familia/psicología , Lepra/psicología , Calidad de Vida/psicología , Adolescente , Adulto , Anciano , Estudios Transversales , Etiopía , Femenino , Humanos , Entrevistas como Asunto , Masculino , Persona de Mediana Edad , Estigma Social , Adulto Joven
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