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Adv Exp Med Biol ; 1223: 17-30, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32030683


Erythropoietin (EPO), the primary cytokine of erythropoiesis, stimulates both proliferation and differentiation of erythroid progenitors and their maturation to red blood cells. Basal EPO levels maintain the optimum levels of circulating red blood cells. However, during hypoxia, EPO secretion and its expression is elevated drastically in renal interstitial fibroblasts, thereby increasing the number of erythroid progenitors and accelerating their differentiation to mature erythrocytes. A tight regulation of this pathway is therefore of paramount importance. The biological response to EPO is commenced through the involvement of its cognate receptor, EPOR. The receptor-ligand complex results in homodimerization and conformational changes, which trigger downstream signaling events and cause activation or inactivation of critical transcription factors that promote erythroid expansion. In recent years, recombinant human EPO (rEPO) has been widely used as a therapeutic tool to treat a number of anemias induced by infection, and chemotherapy for various cancers. However, several studies have uncovered a tumor promoting ability of EPO in man, which likely occurs through EPOR or alternative receptor(s). On the other hand, some studies have demonstrated a strong anticancer activity of EPO, although the mechanism still remains unclear. A thorough investigation of EPOR signaling could yield enhanced understanding of the pathobiology for a variety of disorders, as well as the potential novel therapeutic strategies. In this chapter, in addition to the clinical relevance of EPO/EPOR signaling, we review its anticancer efficacy within various tumor microenvironments.

Eritropoyetina/metabolismo , Salud , Neoplasias/metabolismo , Receptores de Eritropoyetina/metabolismo , Transducción de Señal , Microambiente Tumoral , Eritropoyesis , Humanos
Food Chem ; 307: 125548, 2020 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-31654949


Due to their high content of ß-glucan, the consumption of oat products can contribute to a healthy diet. Roasting may improve sensory properties but could also affect the nutritional value of oat products. Therefore, the aim of the present study was to analyse the impact of different roasting conditions (140-180 °C, approx. 20 min) on sensory quality, health-related compounds (e.g. acrylamide, ß-glucan) and viscosities of oat kernels and flakes. Roasting resulted in oat flakes with improved sensory properties. Acrylamide formation increased with higher roasting temperatures in kernels, thin and thick flakes. Contents of fat, protein, starch and ß-glucan were not affected by roasting, whereas dietary fibre fractions were marginally modulated. Viscosities were significantly reduced with increasing roasting temperatures. The results indicate that roasting up to 160 °C is a processing technique with potential to generate oat products with improved sensory quality and favourable nutritional composition.

Avena/química , Acrilamida/química , Avena/metabolismo , Fibras de la Dieta , Salud , Calor , Almidón/química , Almidón/metabolismo , Viscosidad , beta-Glucanos/química , beta-Glucanos/metabolismo
J Sci Food Agric ; 100(2): 483-499, 2020 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-31472019


There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter-individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre-clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry.

Ácidos Cumáricos/metabolismo , Animales , Disponibilidad Biológica , Ácidos Cumáricos/análisis , Frutas/química , Frutas/metabolismo , Microbioma Gastrointestinal , Salud , Humanos , Verduras/química , Verduras/metabolismo , Granos Enteros/química , Granos Enteros/metabolismo
J Agric Food Chem ; 67(51): 14007-14018, 2019 Dec 26.
Artículo en Inglés | MEDLINE | ID: mdl-31789029


Debate on the hazards of advanced glycation end products (AGEs) in food has continued for many years as a result of their uncertain bioavailability and ability to bind to their receptors (RAGEs) in vivo. There are increasing evidence that free and bound AGEs have many differences in gastrointestinal digestion, intestinal absorption, binding with RAGEs, in vivo circulation, and renal clearance. Therefore, this paper compares these aspects between free and bound AGEs by summarizing the available knowledge. On the basis of the current knowledge, we conclude that it is time to differentiate free AGEs from bound AGEs in food in future studies, because they vary in many aspects that are closely related to their influence on human health. Several perspectives were proposed at the end of this review for further exploring the difference between free and bound AGEs in food.

Análisis de los Alimentos , Productos Finales de Glicación Avanzada/metabolismo , Digestión , Productos Finales de Glicación Avanzada/química , Salud , Humanos
Med Probl Perform Art ; 34(3): 169, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31800675


This issue of MPPA raises awareness once more of the highly specific needs of performing artists, and the specialised kind of support or assessment that will be required to optimally manage their health care needs. As reported in this issue, Kawano et al. concluded that highly expressive task-specific movements are often a normal part of the technical requirements for a dance routine, and analysing whether dancers are safe to perform these manoeuvres requires a highly trained eye and experience. Not only that, but their beliefs on how such movements affect their risk of injury may be influenced by perspectives within the dance culture (Hendry et al.). To be able to assess dancers and their injury risk requires health professionals to have substantial experience, as general health assessment measures are unlikely to be adequate to meet their highly complex performance demands (Clarke et al.). Similar experience is required in understanding the complex demands of the wide spectrum of musical performance, acting, and other artistic pursuits, including understanding strategies to help performing artists manage their workloads. Problems are highlighted with the impact of fatigue on circus (Decker et al.) and dance activities (Jarvis et al.), with work and training loads playing a role in affecting movement patterns and health status. Further research may clarify other factors contributing to fatigue in performing artists, as many issues such as travel, diet, and mood will contribute to feelings of fatigue.

Arte , Estilo de Vida , Trabajo , Prestación de Atención de Salud , Salud , Humanos
N Engl J Med ; 381(23): 2279-2280, 2019 12 05.
Artículo en Inglés | MEDLINE | ID: mdl-31801006
N Engl J Med ; 381(23): 2280, 2019 12 05.
Artículo en Inglés | MEDLINE | ID: mdl-31801007
N Engl J Med ; 381(23): 2280-2281, 2019 12 05.
Artículo en Inglés | MEDLINE | ID: mdl-31801008
RECIIS (Online) ; 13(4): 935-951, out.-dez. 2019. ilus
Artículo en Portugués | LILACS | ID: biblio-1047680


Este artigo é resultado do trabalho de pesquisa sobre a produção das campanhas antitabagistas de governo e sobre a forma com que foram apropriados pela população. Nosso objetivo foi avaliar como essas campanhas foram pensadas em relação aos princípios de comunicação e saúde pressupostos pelo Sistema Único de Saúde. A expectativa foi problematizar a questão numa perspectiva interdisciplinar. Analisamos documentos a partir dos preceitos teóricos e metodológicos da Semiologia dos Discursos Sociais. Concluiu-se que foram criadas campanhas alarmistas, pautadas na imputação do medo e na vigília moral, que acabaram por se distanciar da ideia de uma comunicação em saúde pública dialógica, informativa e participativa.

This article is the result of a research on the use of the concept of aversion in the production of government anti-smoking campaigns and how they were appropriated by the population. Our objective was to evaluate how these campaigns were conceived in relation to the principles of communication and health presupposed by the Unified Health System. The expectation was to problematize the issue from an interdisciplinary perspective. We analyze documents from the theoretical and methodological precepts of Semiology of Social Discourses. It was concluded that alarmist campaigns were created, based on the imputation of fear and on moral vigilance, which eventually distanced these actions from the principles of communication in dialogic, informative and participatory public health.

Este artículo es el resultado del trabajo de investigación sobre la utilización del concepto de aversión en la producción de las campañas antitabaco de gobierno y sobre la forma en que fueron apropiados por la población. Nuestro objetivo fue evaluar cómo estas campañas fueron pensadas en relación a los principios de comunicación y salud presupuestados por el Sistema Único de Salud. La expectativa fue problematizar la cuestión desde una perspectiva interdisciplinaria. Analizamos documentos a partir de los preceptos teóricos y metodológicos de la Semiología de los Discursos Sociales. Se concluyó que se crearon campañas alarmistas, pautadas en la imputación del miedo y en la vigilia moral, que acabaron por distanciarse de la idea de una comunicación en salud pública dialógica, informativa y participativa.

Humanos , Tabaquismo , Medios de Comunicación , Publicidad como Asunto , Promoción de la Salud , Estilo de Vida , Propaganda , Política Pública , Sistema Único de Salud , Salud , Comercialización de Productos Derivados del Tabaco , Fumar Cigarrillos , Prevención del Hábito de Fumar/historia , Neoplasias
RECIIS (Online) ; 13(4): 952-958, out.-dez. 2019. ilus
Artículo en Portugués | LILACS | ID: biblio-1047681


Análise do documentário Saúde! Velho Chico, de Stella Oswaldo Cruz Penido e Eduardo Vilela Thielen, tomando-o como registro, a um só tempo, dos padrões históricos de interação com o Rio São Francisco e de alternativas capazes de construir uma relação mais sinérgica e sustentável com as águas fluviais. O filme contrapõe as metanarrativas do desenvolvimento ­ legitimadoras de intervenções como hidrelétricas, barragens, projetos de irrigação para a agricultura industrial e o controverso projeto de sua transposição ­ a formas de relação estabelecidas pelas diversas populações ribeirinhas, das quais a vida, o corpo e as culturas são construídos em estreita simbiose com o rio.

This review analyzes the documentary Saúde! Velho Chico, scripted and directed by Stella Oswaldo Cruz Penido and Eduardo Vilela Thielen, taking it as a record of the historical patterns of interaction with the Rio São Francisco (São Francisco River) and at the same time of alternatives based on the building of more synergistic and sustainable relationships with river waters. In this sense, the film contrasts the metanarratives of development ­ which legitimize interventions such as hydroelectric dams, irrigation projects for industrial agriculture as well as the controversial transfer of the São Francisco River project ­ with relationships established by the riverside populations, who have a close symbiosis between their life, body and cultures and the river.

Análisis del documental Saúde! Velho Chico, con guión y dirección de Stella Oswaldo Cruz Penido y Eduardo Vilela Thielen, entendido como un registro, al mismo tiempo, de los patrones históricos de interacción con el Rio São Francisco (río San Francisco) y de alternativas capaces de construir una relación más sinérgica y sostenible con las aguas de los ríos. La película contrasta las metanarrativas del desarrollo ­ que legitiman intervenciones como represas hidroeléctricas, proyectos de riego para la agricultura industrial y el controvertido proyecto de transposición del río ­ con formas de relación establecidas por las diversas poblaciones ribereñas, que tienen la vida, el cuerpo y las culturas en estrecha simbiosis con el río.

Humanos , Tecnología, Industria y Agricultura , Documentarios Cinematográficos , Ríos , Ambiente , Agricultura Sostenible , Población , Brasil , Salud Ambiental , Salud , Ecosistema , Recursos Naturales , Conservación de los Recursos Hídricos
Movimento (Porto Alegre) ; 25(1): e25026, jan.- dez. 2019.
Artículo en Portugués | LILACS | ID: biblio-1048001


Esta pesquisa realizou uma avaliação de desempenho em um polo do Programa Academia da Saúde em Belo Horizonte/MG. É uma pesquisa qualitativa, descritiva, do tipo estudo de caso. A escolha do polo e dos participantes foi intencional. Adotamos a entrevista em profundidade para a coleta dos dados, sendo que a amostra foi estipulada pela técnica de saturação. Para a interpretação das informações usamos a análise crítica do discurso. Os resultados indicam algumas lacunas existentes no programa, como aspectos logísticos adequados; inadequação da articulação entre polo e Unidade Básica de Saúde; ausência de metas definidas. Como aspectos positivos identificamos a satisfação dos profissionais em atuar no programa e dos alunos em participar das aulas. Concluímos que o modelo de avaliação adotado contribuiu para diagnosticar importantes condições operacionais executadas que podem auxiliar a tomada de decisões dos gestores quanto ao desenvolvimento do programa

This research conducted a performance evaluation on the Health Gym Program in Belo Horizonte, MG. It is a qualitative case study and the choice of Gym and participants was intentional. We used in-depth interview to collect data and the sample was set by saturation. To interpret the information, we used critical discourse analysis. The results point to some gaps in the program such as proper logistics, coordination between Gym and Basic Health Unit, and clear goals. As positive aspects we found professionals' satisfaction in working in the program and students' satisfaction in participating in the classes. We concluded that the evaluation model adopted contributed to finding important operational conditions that can help managers to make decisions regarding the development of the program

Esta investigación realizó una evaluación de desempeño en un polo del Programa Academia de la Salud en Belo Horizonte/MG. Se trata de una investigación cualitativa, descriptiva, del tipo estudio de caso. La elección del polo y de los participantes fue intencional. Se adoptó la entrevista en profundidad para la recolección de los datos, siendo que la muestra fue estipulada por la técnica de saturación. Para la interpretación de las informaciones usamos el análisis crítico del discurso. Los resultados indican algunas lagunas existentes en el programa, como: aspectos logísticos adecuados, inadecuación de la articulación entre polo y Unidad Básica de Salud; ausencia de metas definidas. Como aspectos positivos, identificamos la satisfacción de los profesionales en actuar en el programa y de los alumnos en participar de las clases. Concluimos que el modelo de evaluación adoptado contribuyó para diagnosticar importantes condiciones operacionales ejecutadas que pueden auxiliar en la toma de decisiones de los gestores en cuanto al desarrollo del programa

Humanos , Salud , Investigación Cualitativa , Programas de Gobierno , Efectividad , Eficacia , Eficiencia
Mem. Inst. Invest. Cienc. Salud (Impr.) ; 17(3): 41-48, dic.2019. tab
Artículo en Español | LILACS, BDNPAR | ID: biblio-1047798


La investigación y la publicación científica son aspectos importantes dentro de la formación profesional en salud, pues permitirán practicar eficientemente una medicina basada en evidencias. El objetivo del trabajo fue describir a través de indicadores bibliométricos la producción científica relacionada con la formación de profesionales de la salud en Perú durante el periodo 2014-2018. Estudio bibliométrico sobre la totalidad de la producción científica peruana que trata de la formación de profesionales de la salud en el período 2014-2018, recuperada de la base de datos de Google Académico. Se calcularon los indicadores cienciométricos de 155 artículos filtrados por el software Harzing's Publish or Perish v. 6. Las variables estudiadas fueron: total de artículos, citas, promedio de citas por año, por artículos, por autores y por autores por año, promedio de artículos por autor, promedio de autores por artículo, índices h, g, h contemporáneo (hc), h individual (hI), hI normalizado, AWCR, AW, AWCRpA, e, hm, hI anual, amplitud H, amplitud, cantidad de autores, índice de colaboración, artículos más citados y distribución anual de los artículos, así como su publicador. Se obtuvo un total de 905 citas con un promedio de 181.00; 5.84 y 457.37 citas por año, artículos y autores respectivamente. Las publicaciones poseen un índice h de 16 y un índice g de 19. Destaca la producción anual del año 2015, con 41 publicaciones. La mayor cantidad de autores trabajan en parejas (48 artículos). Se totalizaron 458 autores en los 155 artículos, generando un índice de colaboración de 2.95. La producción científica relacionada con la formación de profesionales de la salud en Perú fue escasa en los últimos 5 años. Los indicadores cienciométricos muestran una tendencia decreciente(AU)

Research and scientific publication are important aspects of professional training in health, as they will allow efficient practice of evidence-based medicine. The objective was to describe through bibliometric indicators the scientific production related to the training of health professionals in Peru during the period 2014-2018 . Bibliometric study of the entire Peruvian scientific production that deals with the training of health professionals in the period 2014-2018, retrieved from the Google academic database. We calculated the scientometric indicators of 155 articles filtered by the Harzing's Publish or Perish v.6 software. The variables studied were: total number of articles, citations, average citations per year for articles, authors and authors per year, average articles per author, average number of authors per article, the h, g indexes contemporary h (hc), individual h (hI), standard hI, AWCR, AW, AWCRpA, e, hm, annual hI, amplitude H, amplitude, number of authors, index of collaboration, most-cited articles and annual distribution of articles, as well as their publishers. A total of 905 citations were obtained with an average of 181.00; 5.84 and 457.37 citations per year, articles and authors respectively. The publications have an H-index of 16 and a G-index of 19. The annual production of 2015, with 41 publications, stood out, the largest number of authors work in pairs (48 articles). A total of 458 authors were published in the 155 articles, generating a 2.95 collaboration rate. Scientific production related to the training of health professionals in Peru was scarce in the last 5 years. Scientometric indicators show a decreasing trend(AU)

Bibliometría , Indicadores de Producción Científica , Salud , Capacitación Profesional
Ann Agric Environ Med ; 26(4): 566-571, 2019 Dec 19.
Artículo en Inglés | MEDLINE | ID: mdl-31885229


INTRODUCTION: Air pollution is one of the most important issues of our times. Air quality assessment is based on the measurement of the concentration of substances formed during the combustion process and micro-particles suspended in the air in the form of an aerosol. Microscopic atmospheric particulate matters (PM) 2.5 and 10 are mixtures of organic and inorganic pollutants smaller than 2.5 and 10 µm, respectively. They are the main cause of negative phenomena in the earth's atmosphere of Earth and human health, especially on the respiratory and cardiovascular systems. Particulates have the ability to cause permanent mutations of tissue, leading to neoplasms and even premature deaths. Nitrogen dioxide (NO2) is one of the main pollutants which arises mainly during the burning of fossil fuels. Based on numerous scientific researches, it has been proved that long-term exposure to NO2 could increase morbidity of cancer due to inflammatory processes increasing abnormal mutations. MATERIAL AND METHODS: Data available in the Polish National Cancer Registry, Chief Inspectorate for Environmental Protection and Map of Health Needs in the Field of Oncology for Poland, WHO Air Quality Guidelines 2005 were analyzed. Air pollution was also evaluated: PM2.5, PM10, NO2, and compared with lung cancer morbidity. RESULTS AND CONCLUSIONS: Based on the available data and literature, it can be concluded that in 2009-2017, on average, each Pole smoked ten cigarettes a day +/- 2. Therefore, it can be estimated that after 60 years everyone had 30 package-years of smoking, leading to a high risk of lung cancer and other smoking related diseases. Additionally air quality in Poland is not satisfactory, exceeding the standards presented in the WHO Guidelines 2005. It can be assumed that this may translate into an additional, independent continuous increase in morbidity and mortality dependent on smoking.

Contaminantes Atmosféricos/efectos adversos , Contaminantes Atmosféricos/análisis , Contaminación del Aire/efectos adversos , Neoplasias Pulmonares/etiología , Productos de Tabaco/efectos adversos , Contaminación del Aire/análisis , Salud , Humanos , Neoplasias Pulmonares/epidemiología , Dióxido de Nitrógeno/efectos adversos , Dióxido de Nitrógeno/análisis , Material Particulado/efectos adversos , Material Particulado/análisis , Polonia/epidemiología , Productos de Tabaco/análisis