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1.
Bioresour Technol ; 304: 123061, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32127245

RESUMEN

Selection of indigenous and potential algal strain with high lipid content is paramount challenge in the avenues of microalgal biodiesel production. Particularly, hyper lipid producing algae with maximal triacyglycerols (TAGs) content and preferable fatty acid composition is of interest for sustainable biodiesel. Hence, the present study on comparative assessment of Chlorella vulgaris, Scenedesmus sp. and Synechococcus sp. was done in terms of cell density, lipid, TAGs and fatty acid. Higher biomass yield was obtained in Chlorella vulgaris (0.54 gL-1) on 13th day while maximal lipid content of 36% was observed in Scenedesmus sp. followed by Chlorella vulgaris (33%). Lipidomic analysis revealed higher non-polar lipids inChlorella vulgaris (57%) and Scenedesmus sp. (54%), whereas in Synechococcus sp. 69% polar lipids were present. In fatty acid profile, C24:0 (22.11%) was predominant in Chlorella vulgaris, while C20:0 (31.72%) and C18:2 (22.26%) was prevalent in Scenedesmus sp. and Synechococcus sp. respectively.


Asunto(s)
Bioprospección , Chlorella vulgaris , Microalgas , Biocombustibles , Biomasa , Recuento de Células , Ácidos Grasos , Selección de Paciente
2.
Urology ; 137: 23-24, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-32115067
3.
Urology ; 137: 24, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-32115068
4.
Medicine (Baltimore) ; 99(11): e19367, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32176058

RESUMEN

INTRODUCTION: This systematic review protocol aims to provide the methods used to assess the total benefits and side effects in all cancer patients and their respective benefits and side effects in different cancers. METHODS AND ANALYSIS: The following electronic bibliographic databases will be selected without any language restriction: PubMed, EMBASE, The Cochrane Library, Scopus and Web of Science without an upper-limit date until July 12, 2019. Searches will also be performed in the following trials registers: ClinicalTrials.gov (www.ClinicalTrials.gov), the ISRCTN registry (www.isrctn.com), the WHO International Clinical Trials Registry Platform (www.who.int/trialsearch/Default.aspx) and the EU Clinical Trials Register (www.clinicaltrialsregister.eu). All randomized controlled trials related to the combination of nivolumab and ipilimumab for cancer patients will be included. Outcomes will include curative effect, chemotherapeutic response rate, adverse events. Study inclusion, data extraction and quality assessment will be performed independently by two reviewers. Assessment of risk of bias and data synthesis will be performed using Review Manager software. ETHICS AND DISSEMINATION: Ethics approval is not required because individual patients' data are not included. The findings of this systematic review will be disseminated through peer-reviewed publication. PROSPERO REGISTRATION NUMBER: CRD42018109732.


Asunto(s)
Antineoplásicos Inmunológicos/uso terapéutico , Ipilimumab/uso terapéutico , Neoplasias/tratamiento farmacológico , Neoplasias/patología , Nivolumab/uso terapéutico , Antineoplásicos Inmunológicos/efectos adversos , Quimioterapia Combinada , Femenino , Humanos , Ipilimumab/efectos adversos , Masculino , Nivolumab/efectos adversos , Selección de Paciente , Pronóstico , Ensayos Clínicos Controlados Aleatorios como Asunto , Medición de Riesgo , Resultado del Tratamiento
5.
Medicine (Baltimore) ; 99(10): e19499, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32150112

RESUMEN

BACKGROUND: The general consensus regarding a rational choice among various treatment strategies for medial meniscus posterior root tears (MMPRTs) has yet to be clearly established. The purpose of this systematic review was to analyze patient selection criteria based on index arthrosis, as well as clinical and radiological outcomes after repair or nonrepair treatment in patients with MMPRTs. METHODS: A systematic electronic search was performed with established medical databases. Data from the selected studies which were assessed using the modified Coleman methodology score were analyzed in terms of index arthrosis and degree of lower limb alignment, functional and radiologic outcomes after meniscus repair, partial meniscectomy, and conservative treatment. RESULTS: In total, 17 studies and 655 patients (665 cases) were enrolled in this study, of which 42% (279 cases) underwent MMPRT repair and 58% (386 cases) were treated using a nonrepair strategy. The mean age and the mean follow-up period were 54.7 years and 32.5 months in the repair group, respectively, and 57.0 years and 49.3 months in the nonrepair group, respectively. Based on the clinical data available in this study, most of the MMPRT repairs were performed in patients with mild arthrosis, mild varus alignment, and mild chondral injury. Although data were limited, the percentage of patients with mild chondral injury was only 40% in the nonrepair group, implying that the nonrepair group may have more advanced arthrosis at the baseline. Based on the available Lysholm score across the studies, good functional outcomes were obtained in the repair group, whereas the results of the nonrepair treatment exhibited fair functional outcomes that were somewhat heterogenous. The radiologic outcomes of the mean 5 years' follow-up study showed that arthritic change could not be prevented by either nonrepair or repair treatment. CONCLUSIONS: In general, MMPRT repair led to significant improvement in clinical outcomes. On the contrary, the nonrepair group also showed symptomatic relief in some selected cases, despite the somewhat heterogenous results. Given the subgroup analysis for the functional results reported in this review, strict patient selection is important to obtain satisfactory clinical outcomes, regardless of the treatment option selected.


Asunto(s)
Técnicas de Apoyo para la Decisión , Selección de Paciente , Lesiones de Menisco Tibial/terapia , Artroplastia de Reemplazo de Rodilla , Artroscopía , Humanos , Lesiones de Menisco Tibial/diagnóstico por imagen
6.
Instr Course Lect ; 69: 575-582, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32017752

RESUMEN

Shoulder arthroplasty has traditionally been viewed as an inpatient procedure because of the inherent medical comorbidities associated with an aging population and the need for postoperative pain control. Recent studies have shown that in appropriately selected patients, shoulder arthroplasty procedures can be safely done as outpatient procedures and can deliver economic value in today's cost-conscious health care environment. Several factors help ensure a successful surgical outcome, including cooperation from the ambulatory anesthesia service, proper patient selection, and perioperative pain control. Postoperatively, provider availability is vital to complete a seamless patient experience. With appropriate algorithms and care plans in place, outpatient shoulder arthroplasty can be a safe and cost-efficient procedure. The advances pioneered by outpatient shoulder arthroplasty will also serve to benefit inpatient shoulder arthroplasty patients via improved pain control, perioperative education, and potentially decreased length of stay.


Asunto(s)
Artroplastía de Reemplazo de Hombro , Anciano , Procedimientos Quirúrgicos Ambulatorios , Artroplastia , Humanos , Tiempo de Internación , Pacientes Ambulatorios , Selección de Paciente
7.
J Environ Manage ; 260: 110147, 2020 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-32090839

RESUMEN

Sustainable development assessment has been conducted considering its various dimensions, such as environmental, social, cultural and economic. In this paper, the representation of such dimensions is undertaken from the perspective of the natural, social and built capitals. These dimensions are usually represented by indicators, indexes and systems of indicators, but their abundance in the technical and scientific literatures without adequate analytical structures can impair assessment quality and speed. This study aimed to propose a structure for sustainable development assessment whereby key aspects and indicators can be identified, prioritised and meaningfully used from the perspective of sustainable development capitals. Content analysis of selected international papers and technical reports was undertaken to identify relevant analysis elements and their hierarchical order. This has led to a four-tier framework composed of three capitals, seven categories, 19 subcategories and 52 attributes, each of which can be measured with the aid of one or more locally relevant indicator(s) in the context of sustainable development assessment. Selection criteria for such indicators were compiled from the literature and are presented in terms of their political, management, data quality and economic relevance. This study may contribute to the development and refinement of structured sustainable development indicator systems with less analytical ambiguity, overlapping and gaps, and hence improve the representativeness of future assessment efforts.


Asunto(s)
Conservación de los Recursos Naturales , Desarrollo Sostenible , Selección de Paciente
8.
Medicine (Baltimore) ; 99(5): e18935, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32000408

RESUMEN

The effect of frailty on short and long term results of interventional treatment of coronary heart disease is not well defined. The evaluation of frailty may be helpful in appointment of most suitable treatment option and timing of patient follow-up. The frailty syndrome in daily practice of interventional cardiology ward (FRAPICA) study objective is to evaluate prognostic capability of the Fried frailty scale and instrumental activities of daily living scale (IADL) in elderly patients with symptomatic coronary heart disease.This is a single center, prospective, observational study. Patients aged ≥65 years are eligible. The objectives are to report Fried frailty scale and IADL scale dispersion before hospital discharge and to assess predictive impact of both scores. The endpoints are: success of interventional treatment, its complications (procedure related myocardial infarction, dye-induced renal function deterioration, loss of blood), 3-year mortality, either all-cause and cardiovascular, re-infarction, re-intervention, stroke, new-onset heart failure, any hospital readmission, and a combination of all above mentioned. Secondary analyses will focus on distinct clinical patient presentations, sub-classifications of frailty for modeling of long-term risk.FRAPICA trial will improve understanding of the associations between frailty syndrome, cardiovascular system diseases, their invasive treatment, and short and long-term outcomes. It will allow for more individualized assessment of risk and will identify new goals for interventions. (ClinicalTrials.gov Identifier NCT03209414).


Asunto(s)
Enfermedad Coronaria/diagnóstico , Fragilidad/diagnóstico , Estudios Observacionales como Asunto , Actividades Cotidianas , Anciano , Enfermedad Coronaria/complicaciones , Enfermedad Coronaria/mortalidad , Enfermedad Coronaria/terapia , Anciano Frágil , Fragilidad/complicaciones , Fragilidad/mortalidad , Fragilidad/terapia , Evaluación Geriátrica , Humanos , Selección de Paciente
9.
Medicine (Baltimore) ; 99(5): e18955, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32000419

RESUMEN

BACKGROUND: Obesity is associated with metabolic syndrome, a condition that increases one's risk for heart disease and other conditions. The prevalence of obesity and associated diseases have steadily increased among Korean adults. The effect of the herbal medicines Daesiho-tang (DSHT) and Chowiseungcheng-tang (CST) on obesity have been reported. The purpose of this study is to evaluate the efficacy and safety of Daesiho-tang and Chowiseungcheng-tang on obese Korean women with high risk for metabolic syndrome. METHODS/DESIGN: This study is a randomized, double-blinded, placebo-controlled, multi-center, 3-arm, parallel group clinical trial. A total of 120 participants will be enrolled and randomly assigned to the Daesiho-tang group, the Chowiseungcheng-tang group, or the placebo group in a 1:1:1 ratio using an internet-based randomization system at visit 2. Each group will be administered DSHT, CST, or placebo 3 times per day for 12 weeks. The primary outcome is to evaluate the changes in mean body weight of participants in the DSHT and CST groups and compare with those in the placebo group, and determine their statistical significance, if any, after 12 weeks. The secondary outcomes are the following: changes in body fat percentage and body fat mass, changes in waist circumference, waist-to-hip ratio, and body mass index, changes in serum lipids, fasting blood sugar, blood pressure, and C-reactive proteins (CRP) levels between visit 1 and visit 5 measurements. Changes in visceral fat volume determined through abdominal computed tomography, patient-reported health outcomes surveys-the Korean version of the Obesity-related Quality of Life and the Korean version of Eating Attitudes Test. DISCUSSION: This study will provide research methodologies for evaluating the efficacy and safety of Daesiho-tang and Chowiseungcheng-tang on obese Korean women with high risk for metabolic syndrome. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02651454. Registered on 11 January 2016.Protocol version: The final approved version of the trial protocol is V1.3.(2017.11.10).


Asunto(s)
Medicina Tradicional Coreana , Síndrome Metabólico/tratamiento farmacológico , Estudios Multicéntricos como Asunto , Obesidad/tratamiento farmacológico , Fitoterapia , Ensayos Clínicos Controlados Aleatorios como Asunto , Adolescente , Adulto , Anciano , Fármacos Antiobesidad/uso terapéutico , Femenino , Humanos , Síndrome Metabólico/complicaciones , Síndrome Metabólico/epidemiología , Persona de Mediana Edad , Obesidad/complicaciones , Obesidad/epidemiología , Selección de Paciente , Proyectos Piloto , República de Corea , Factores de Riesgo , Resultado del Tratamiento , Adulto Joven
10.
Bull Cancer ; 107(3): 333-343, 2020 Mar.
Artículo en Francés | MEDLINE | ID: mdl-32037013

RESUMEN

INTRODUCTION: Health researchers often face difficulties related to participants' recruitment for their research. However, a new strategy emerges: offering patients-but also citizens who are not ill-the possibility to volunteer as participants to hasten research processes. The French platform "Seintinelles" aims to fulfill this goal and bring together citizens who volunteered to participate to cancer related research. The "Seintinelles Barometer" aims to describe these volunteers' profile. METHODS: The Seintinelles Barometer data were collected through a web-based auto-questionnaire proposed to the "Seintinelles" members from June 2017 to November 2018. RESULTS: The sample presents a high level of overrepresentation of women. Participants are characterized by a high level of education. About a third of the participants had suffered from cancer. Two profile of volunteers emerged: the « patients ¼ and the « supportive citizens ¼. DISCUSSION: The Seintinelles Barometer participants manifest a strong wish to be involved in cancer related research. Therefore, this platform seems to be a promising tool for the development of community-based research in the field of cancer.


Asunto(s)
Escolaridad , Neoplasias , Desarrollo de Programa , Sujetos de Investigación , Adulto , Factores de Edad , Salud de la Familia , Femenino , Francia , Voluntarios Sanos/educación , Voluntarios Sanos/psicología , Voluntarios Sanos/estadística & datos numéricos , Humanos , Masculino , Estado Civil/estadística & datos numéricos , Persona de Mediana Edad , Motivación , Neoplasias/epidemiología , Ocupaciones/estadística & datos numéricos , Selección de Paciente , Densidad de Población , Sujetos de Investigación/educación , Sujetos de Investigación/psicología , Sujetos de Investigación/estadística & datos numéricos , Factores Sexuales , Encuestas y Cuestionarios
12.
Anticancer Res ; 40(2): 999-1006, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32014945

RESUMEN

BACKGROUND/AIM: We aimed to evaluate the efficacy of high-dose-rate brachytherapy techniques selected according to pre-brachytherapy magnetic resonance imaging (MRI) findings in asymmetrical cervical cancer (ACC). PATIENTS AND METHODS: We analyzed 33 ACC patients. Asymmetric tumors were defined as those in which the difference between the distance from the cervical canal to the farthest end of the tumor [long distance (LD)] and the distance from the cervical canal to the contralateral tumor edge [short distance (SD)] is equal to or greater than 2 cm on the basis of MRI prior to treatment. On pre-treatment and pre-brachytherapy MRI, the median LDs were 40 mm and 21 mm, respectively. Patients with LD≥2 cm and LD - SD≥1 cm on pre-brachytherapy MRI received non-conventional intracavitary brachytherapy (ICBT). RESULTS: Sixteen patients (48%) received non-conventional ICBT. There was no significant difference in 3-year local control between the two treatment groups (100% vs. 81.2%, p=0.07); two patients had grade 2 radiation proctitis. CONCLUSION: Brachytherapy techniques selected according to pre-brachytherapy MRI findings were effective for ACC treatment.


Asunto(s)
Braquiterapia , Dosificación Radioterapéutica , Neoplasias del Cuello Uterino/mortalidad , Neoplasias del Cuello Uterino/radioterapia , Adulto , Anciano , Braquiterapia/efectos adversos , Braquiterapia/métodos , Femenino , Humanos , Estimación de Kaplan-Meier , Imagen por Resonancia Magnética/métodos , Persona de Mediana Edad , Estadificación de Neoplasias , Selección de Paciente , Resultado del Tratamiento , Neoplasias del Cuello Uterino/diagnóstico
17.
Urology ; 137: 173-177, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-31945380

RESUMEN

Rhabdomyosarcoma is the most common sarcoma diagnosed in childhood and adolescence, arising from the bladder/prostate in only 5%-10% of cases. Treatment-induced cytodifferention of tumor cells into mature rhabdomyoblasts has been reported following chemoradiation and is thought to suggest a more favorable outcome. We report a case of embryonal rhabdomyosarcoma of the bladder/prostate that exhibited extensive cytodifferentiation with downregulation of myogenin and MyoD1 gene expression in rhabdomyoblasts following treatment with chemoradiation therapy. The downregulation of myogenin and MyoD1 expression in rhabdomyoblasts following chemoradiation treatment has not previously been described in the literature and its significant remains uncertain.


Asunto(s)
Diferenciación Celular , Quimioradioterapia , Proteína MioD/genética , Miogenina/genética , Neoplasias de la Próstata , Rabdomiosarcoma Embrionario , Neoplasias de la Vejiga Urinaria , Biomarcadores de Tumor/análisis , Biomarcadores de Tumor/genética , Biopsia/métodos , Diferenciación Celular/efectos de los fármacos , Diferenciación Celular/efectos de la radiación , Quimioradioterapia/efectos adversos , Quimioradioterapia/métodos , Diagnóstico Diferencial , Regulación hacia Abajo , Expresión Génica , Humanos , Inmunohistoquímica , Lactante , Masculino , Proteína MioD/análisis , Miogenina/análisis , Selección de Paciente , Pronóstico , Neoplasias de la Próstata/diagnóstico por imagen , Neoplasias de la Próstata/genética , Neoplasias de la Próstata/patología , Neoplasias de la Próstata/terapia , Rabdomiosarcoma Embrionario/diagnóstico por imagen , Rabdomiosarcoma Embrionario/genética , Rabdomiosarcoma Embrionario/patología , Rabdomiosarcoma Embrionario/terapia , Neoplasias de la Vejiga Urinaria/diagnóstico por imagen , Neoplasias de la Vejiga Urinaria/genética , Neoplasias de la Vejiga Urinaria/patología , Neoplasias de la Vejiga Urinaria/terapia
19.
BMJ ; 368: l6744, 2020 01 06.
Artículo en Inglés | MEDLINE | ID: mdl-31907166

RESUMEN

OBJECTIVE: To determine, in critically ill patients, the relative impact of proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), sucralfate, or no gastrointestinal bleeding prophylaxis (or stress ulcer prophylaxis) on outcomes important to patients. DESIGN: Systematic review and network meta-analysis. DATA SOURCES: Medline, PubMed, Embase, Cochrane Central Register of Controlled Trials, trial registers, and grey literature up to March 2019. ELIGIBILITY CRITERIA FOR SELECTING STUDIES AND METHODS: We included randomised controlled trials that compared gastrointestinal bleeding prophylaxis with PPIs, H2RAs, or sucralfate versus one another or placebo or no prophylaxis in adult critically ill patients. Two reviewers independently screened studies for eligibility, extracted data, and assessed risk of bias. A parallel guideline committee (BMJ Rapid Recommendation) provided critical oversight of the systematic review, including identifying outcomes important to patients. We performed random-effects pairwise and network meta-analyses and used GRADE to assess certainty of evidence for each outcome. When results differed between low risk and high risk of bias studies, we used the former as best estimates. RESULTS: Seventy two trials including 12 660 patients proved eligible. For patients at highest risk (>8%) or high risk (4-8%) of bleeding, both PPIs and H2RAs probably reduce clinically important gastrointestinal bleeding compared with placebo or no prophylaxis (odds ratio for PPIs 0.61 (95% confidence interval 0.42 to 0.89), 3.3% fewer for highest risk and 2.3% fewer for high risk patients, moderate certainty; odds ratio for H2RAs 0.46 (0.27 to 0.79), 4.6% fewer for highest risk and 3.1% fewer for high risk patients, moderate certainty). Both may increase the risk of pneumonia compared with no prophylaxis (odds ratio for PPIs 1.39 (0.98 to 2.10), 5.0% more, low certainty; odds ratio for H2RAs 1.26 (0.89 to 1.85), 3.4% more, low certainty). It is likely that neither affect mortality (PPIs 1.06 (0.90 to 1.28), 1.3% more, moderate certainty; H2RAs 0.96 (0.79 to 1.19), 0.9% fewer, moderate certainty). Otherwise, results provided no support for any affect on mortality, Clostridium difficile infection, length of intensive care stay, length of hospital stay, or duration of mechanical ventilation (varying certainty of evidence). CONCLUSIONS: For higher risk critically ill patients, PPIs and H2RAs likely result in important reductions in gastrointestinal bleeding compared with no prophylaxis; for patients at low risk, the reduction in bleeding may be unimportant. Both PPIs and H2RAs may result in important increases in pneumonia. Variable quality evidence suggested no important effects of interventions on mortality or other in-hospital morbidity outcomes. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019126656.


Asunto(s)
Enfermedad Crítica/terapia , Hemorragia Gastrointestinal , Antagonistas de los Receptores Histamínicos H2/farmacología , Inhibidores de la Bomba de Protones/farmacología , Hemorragia Gastrointestinal/etiología , Hemorragia Gastrointestinal/prevención & control , Humanos , Selección de Paciente , Ajuste de Riesgo/métodos
20.
J Thorac Cardiovasc Surg ; 159(3): 865-896, 2020 03.
Artículo en Inglés | MEDLINE | ID: mdl-31983522
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