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1.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 55(11): 825-830, 2020 Nov 09.
Artículo en Chino | MEDLINE | ID: mdl-33171554

RESUMEN

Passive fit is a key prerequisite for successful implant-supported restorations, especially for full-arch implant-supported fixed restoration. The precise passive fit comes from the fine control of the entire manufacturing process of resorations. Intraoral welding directly connects the metal framework and the upper abutment in the mouth, which can ensure precise and stable passive fit. This article will explain the definition, necessity, influencing factors and clinical control methods of passive fit, in order to provide guidance for achieving precise passive fit in implant-supported full-arch prostheses.


Asunto(s)
Implantes Dentales , Soldadura , Prótesis Dental de Soporte Implantado
2.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi ; 38(10): 790-794, 2020 Oct 20.
Artículo en Chino | MEDLINE | ID: mdl-33142391

RESUMEN

Welding is an important industrial activity worldwide which involving millions of practitioners. Due to the influence of welding method, welding dust concentration, ventilation, weather and other factors, the exposure of the welder is different. And resulting in different respiratory symptoms, including decreased lung function, welder's pneumoconiosis and even lung cancer, which seriously affects the life quality of the worker. Through referring to literatures, the research status of welding dust and respiratory diseases was summarized to provide direction for future research.


Asunto(s)
Contaminantes Ocupacionales del Aire , Exposición Profesional , Neumoconiosis , Soldadura , Contaminantes Ocupacionales del Aire/análisis , Polvo , Gases , Humanos , Pulmón , Exposición Profesional/análisis
3.
Artículo en Chino | MEDLINE | ID: mdl-33036541

RESUMEN

Objective: To investigate the distribution and intensity of noise and ultraviolet radiation of welding posts in a refrigeration equipment manufacturing enterprise, in conjunction with the health status of welding workers, providing scientific evidence for the prevention and control of occupational diseases in this type of post. Methods: In May 2019, a cross-sectional survey method was used to select 576 welding workers in the pressure vessel workshop and the unit assembly workshop of a refrigeration complete equipment manufacturer from 2016 to 2018 as the research objects. The occupational hygiene survey and occupational hazard factor measurement were carried out in the workplace, and the measurement data and occupational health examination results were statistically analyzed. Results: The over standard rate of individual Lex in pressure vessel workshop was 82.2% (37/45) . Compared with the unit assembly workshop, the individual Lex of welding workers in pressure vessel workshop was higher than that in unit assembly workshop (t=13.43, P= 0.00) ; the effective irradiance exceeding rate of welding workers in pressure vessel workshop and unit assembly workshop was 33.3% (4/12) and 25.0% (3/12) , The meacurement of ovradiation in the moskment the occupational exposure limit. The deaf rate and hearing loss rate in pressure vessel workshop were 1.5% (5/336) 20.5% (69/336) , respectively, significantly higher than that in umit assembly workshop (P<0.05) . The detection rate of hearing loss of pressure vessel workshop workers increased year by year, and the difference was statistically significant (χ(2trend)=22.42, P<0.01) ; compared with the unit assembly workshop from 2016 to 2018, the detection rates of lens opacity, corneal cloudiness and hearing loss of pressure vessel workshop workers were statistically significant (χ(2)=9.45, 14.80, 55.99, P<0.01) . Conclusion: Welding workers exposed to noise and ultraviolet radiation are easy to be ignored. The enterprise management department should attach great importance to it and take comprehensive measures to protect the health of welding workers.


Asunto(s)
Ruido en el Ambiente de Trabajo , Enfermedades Profesionales , Exposición Profesional , Soldadura , Estudios Transversales , Humanos , Exposición Profesional/análisis , Refrigeración , Rayos Ultravioleta
4.
Cent Eur J Public Health ; 28 Suppl: S31-S36, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-33069178

RESUMEN

This study presents the results of pilot measurement, where the exposure of fine and ultrafine particulate matter was monitored. The measurement was performed in welding workplace, where these particles are produced unintentionally. The measurement consisted of collecting information and measuring the concentration of particles in the workplace, where data collection was focused only on inhalation exposure. During welding, primarily 300 nm size particles are produced, and their concentration is strongly influenced by the welding material, type of welding and suction. The particles are amorphous in terms of morphology and contain manganese, iron and silicon, which can cause neurodegenerative diseases. Furthermore, the results indicate the importance of monitoring oral exposure.


Asunto(s)
Contaminantes Ocupacionales del Aire , Material Particulado/análisis , Soldadura , Contaminantes Ocupacionales del Aire/análisis , Humanos , Lugar de Trabajo
5.
Toxicol Lett ; 334: 60-65, 2020 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-32961271

RESUMEN

Iron oxides are Group 3 (not classifiable as to its carcinogenicity to humans) according to the International Agency for Research on Cancer (IARC). Occupational exposures during iron and steel founding and hematite underground mining as well as other iron predominant exposures such as welding are Group 1 (carcinogenic to humans). The objective of this study was to investigate the potential of iron as iron (III) oxide (Fe2O3) to initiate lung tumors in A/J mice, a lung tumor susceptible strain. Male A/J mice were exposed by oropharyngeal aspiration to suspensions of Fe2O3 (1 mg) or calcium chromate (CaCrO4; 100 µg; positive control) for 26 weeks (once per week). Shams were exposed to 50 µL phosphate buffered saline (PBS; vehicle). Mice were euthanized 70 weeks after the first exposure and lung nodules were enumerated. Both CaCrO4 and Fe2O3 significantly increased gross-observed lung tumor multiplicity in A/J mice (9.63 ± 0.55 and 3.35 ± 0.30, respectively) compared to sham (2.31 ± 0.19). Histopathological analysis showed that bronchiolo-alveolar adenomas (BAA) and carcinomas (BAC) were the primary lung tumor types in all groups and were increased in the exposed groups compared to sham. BAC were significantly increased (146 %) in the CaCrO4 group and neared significance in the Fe2O3 group (100 % increase; p = 0.085). BAA and other histopathological indices of toxicity followed the same pattern with exposed groups increased compared to sham control. In conclusion, evidence from this study, in combination with our previous studies, demonstrate that exposure to iron alone may be a potential risk factor for lung carcinogenesis.


Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Compuestos de Calcio/toxicidad , Carcinogénesis/efectos de los fármacos , Cromatos/toxicidad , Compuestos Férricos/toxicidad , Neoplasias Pulmonares/inducido químicamente , Animales , Susceptibilidad a Enfermedades , Relación Dosis-Respuesta a Droga , Hiperplasia/inducido químicamente , Hiperplasia/patología , Pulmón/efectos de los fármacos , Pulmón/patología , Neoplasias Pulmonares/patología , Masculino , Ratones , Ratones Endogámicos , Soldadura
6.
Ecotoxicol Environ Saf ; 202: 110920, 2020 Oct 01.
Artículo en Inglés | MEDLINE | ID: mdl-32800255

RESUMEN

Advanced glycation end products (AGE) and the receptor for AGE (RAGE) have been found to be pivotal biomarkers to predict the risk of inflammation and oxidative stress. Limited evidence focuses on the influence of occupational exposure to polycyclic aromatic hydrocarbon (PAH) and metal fumes on AGE and RAGE in shipyard welders. Our aim was to determine the relationships among PAH, metal exposure, and inflammatory biomarkers. From September 1 to December 31, 2017, 53 welding workers (exposed group) and 29 office workers (control group) were enrolled in the study. Comprehensive workups included demographic characteristics, laboratory data, AGE, RAGE, Interleukin-6 (IL-6), tumor necrosis factor-α, PAH, and urinary metal concentrations. RAGE levels were measured by flow cytometric analysis. Urinary 1-hydroxypyrene (1-OHP) was used as a biomarker of exposure to PAH. Several metals were elevated in the personal fine particulate matter (PM2.5) samples, including Mn, Fe, V, Co, Zn, and Cu. The exposed group had significantly higher exposure to PM2.5 (p = 0.015), RAGE (p = 0.020), IL-6 (p = 0.008) than the control group. After adjusting for pertinent variables, there was still a significant and positive association between Ni level and AGE (ß = 0.101; 95% CI, 0.031-0.172). Significant relationship between Cr and Cd levels and RAGE was observed (ß = 0.173; 95% CI, 0.017-0.329; ß = 0.084; 95% CI, 0.011-0.157, respectively). Participants with elevated 1-OHP level had higher odds of high RAGE level in the model 1 (OR = 3.466, 95% CI, 1.053-11.412) and model 2 (OR = 3.454, 95% CI, 1.034-11.536). The RAGE expression of participants was significantly associated with IL-6 levels in the fully adjusted model (ß = 0.294; 95% CI, 0.083-0.732). Our findings highlighted that urinary metal levels and PAH were associated with increased AGE and RAGE formation in shipyard workers. Elevated serum RAGE might induce the production of proinflammatory cytokines and trigger ensuing inflammatory cascades.


Asunto(s)
Contaminantes Ocupacionales del Aire/análisis , Metales/análisis , Exposición Profesional/análisis , Hidrocarburos Policíclicos Aromáticos/análisis , Receptor para Productos Finales de Glicación Avanzada/metabolismo , Contaminantes Ocupacionales del Aire/toxicidad , Biomarcadores/orina , Gases/análisis , Productos Finales de Glicación Avanzada/sangre , Humanos , Inflamación , Masculino , Metales/toxicidad , Estrés Oxidativo , Material Particulado/análisis , Hidrocarburos Policíclicos Aromáticos/toxicidad , Factor de Necrosis Tumoral alfa , Soldadura
7.
Wiad Lek ; 73(4): 638-641, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32731689

RESUMEN

OBJECTIVE: The aim of the study was to conduct a comparative evaluation of the effectiveness of surgical treatment of acute ascending thrombophlebitis of the great saphenous vein using the endovascular high-frequency welding technique and traditional phlebectomy. PATIENTS AND METHODS: Materials and methods: Two groups were formed in the conducted study. Group I included patients (n=42) with the acute ascending thrombophlebitis of the great saphenous vein, in whom their thrombosed great saphenous vein was removed using the endovascular high-frequency welding technique. As a source of current, an EK300M1 Svarmed electric welding machine (Ukraine) was used. Electric welding of a thrombosed vein segment was carried out using the endovenous electric welding catheter. Group II included patients (n=31) with the acute ascending thrombophlebitis of the great saphenous vein, who underwent the traditional phlebectomy of the thrombosed great saphenous vein according to Babcock's technique. RESULTS: Results: In group I no patient revealed presence of pain syndrome with significant intensity during the postoperative period. An infiltrate along the coagulated segments ofnthe great saphenous vein, postoperative oedema and paresthesiae were observed in considerably fewer cases from group I versus group II (р=0.0005, р=0.0001, р=0.0018). During their follow-up for more than 12 months, 2 (4.76 %) of 42 patients from group I revealed partial recanalization of the great saphenous vein (р=0.632). In group I the postoperative inpatient period was 1.3±0.1 days. In group II the above period averaged 4.8±0.8 days (p<0.001). Absence of an intense pain syndrome in group I was caused by a gentle effect of high-frequency electric current itself on the venous wall and paravasal structures. A significant reduction of side effects and complications with a shorter stay of patients in hospital versus the traditional phlebectomy was achieved owing to reduction in the extent of injury of the surgical operation itself with the use of endovascular high-frequency welding. CONCLUSION: Conclusions: The technique of endovascular high-frequency welding in treatment of acute ascending thrombophlebitis of the great saphenous vein makes it possible to reduce the extent of injury of the surgical operation versus the traditional phlebectomy, results in a significant decrease in the number of side effects and complications and shortens the period of the patient's stay in hospital.


Asunto(s)
Tromboflebitis , Insuficiencia Venosa , Soldadura , Humanos , Vena Safena , Resultado del Tratamiento , Ucrania
8.
Artículo en Chino | MEDLINE | ID: mdl-32629568

RESUMEN

Objective: To explore the skin damage, oxidative damage and DNA damage of welding workers caused by ultra violet. Methods: From 1 May to 30 June 2017, 125 welding workers were selected as the contact group, which was divided into 2, 4, 6, 8 and 10-year-working age groups with 25 workers in each group and 25 healthy volunteers as the control group. The workers in the contact group were investigated with questionnaires on the distribution and wearing of protective equipment; the subjects in the two groups were examined in dermatology, and the peripheral blood was collected to detect the total antioxidant capacity (T-AOC) and DNA damage of mononuclear cells, and the influence of ultraviolet on the above indexes was analyzed. Results: The distribution rates of welding mask, dust mask and goggles were 100.0% (125/125) , 96.0% (120/125) , 98.4% (123/125) , respectively, and the distribution rates of welding gloves were 64.8% (81/125) ; the wearing rates of welding mask and goggles were 100.0% (125/125) , 90.4% (113/125) , and the wearing rates of dust mask and welding gloves were 89.6% (112/125) and 64.0% (80/125) , respectively. The acute skin injuries such as hand and face peeling and skin pruritus were serious in the 2-year-working age group, and the chronic skin injuries such as insensitive and numbness and verrucous vegetations were the main manifestations in the 10-year-working age group. Compared with the control group, T-AOC in peripheral blood of workers exposed to 6, 8 and 10 years decreased significantly, and DNA content in comet tail of workers exposed to various working years increased significantly (P<0.05) , while DNA content in comet tail increased with working years (F=1501.130, P<0.05) . Conclusion: UV welding can cause skin damage, reduce the antioxidant capacity of the body, and increase DNA damage with the increase of working age.


Asunto(s)
Exposición Profesional/análisis , Soldadura , Antioxidantes/metabolismo , ADN , Daño del ADN , Humanos
9.
J Occup Health ; 62(1): e12122, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32515891

RESUMEN

OBJECTIVES: Welders demonstrate a significant prevalence of work-related musculoskeletal disorders as indicated by high rates of illness-related absenteeism. The aim of the study was to investigate the effects of a 24-week exercise program on workload, physical performance, and overall health in welders. METHODS: Seventy-seven professional welders were assigned to either a control group (CG), an endurance training group (ETG), or a strength training group (STG). Both groups conducted a 24-week, standardized and progressive endurance or resistance exercise training program. Before (TP1) and after training (TP2) all participants performed an experimental welding task (EWT) in order to test the hypothesis that training would reduce the relative load (%MVC) of eight skeletal muscles measured by surface electromyography. Secondary outcome measures included further EWT-induced stress parameters and a series of health-related outcome measures. RESULTS: Results revealed a lower muscle load in participants of the ETG and STG for trapezius muscle at TP2 compared to T1 (P < .05 vs CG). Rate of perceived exertion and visual analogue scale were decreased, while increase of maximum EWT duration was found in participants of the ETG and STG after training (P < .05 vs CG). At T2, body fat (%) decreased and physical performance (bicycle exercise test, isometric strength of core muscles) increased in ETG and STG (P < .05). CONCLUSION: Both regular endurance and strength training represent effective strategies for reducing workload and improving physical performance of welders. The results emphasize the importance of physical fitness for welders and might motivate health professionals in steel-industry to offer access to exercise training programs.


Asunto(s)
Entrenamiento Aeróbico/métodos , Rendimiento Físico Funcional , Entrenamiento de Resistencia/métodos , Soldadura , Carga de Trabajo , Adulto , Electromiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Músculo Esquelético/fisiología
10.
Artículo en Inglés | MEDLINE | ID: mdl-32512868

RESUMEN

Workplace exposure in various occupational and industrial sectors is an emerging health concern worldwide. This study aimed to investigate the nexus between workplace exposure for wood, welding, motor mechanic, and oil refinery workers and the prevalence of prediabetes and type 2 diabetes mellitus. Initially, 2500 male volunteers who were wood, welding, motor mechanic, and oil refinery workers were interviewed. After an examination of their demographics and medical history, 1408 non-smoking wood (158), welding (560), motor mechanic (272), and oil refinery workers (217), along with 201 control subjects, were selected. The participants' mean age was 36.59 ± 0.29 years and the mean body mass index was 26.14 ± 0.11 kg/m2. The selected industry workers had been exposed to their respective wood, welding, motor mechanic, and oil refinery workplaces for 8 h per day, six days per week. The American Diabetic Association (ADA)-based glycated hemoglobin (HbA1c) criterion was used to diagnose prediabetes and type 2 diabetes mellitus. Subjects with an HbA1c of less than 5.7% were regarded as non-diabetics, subjects with an HbA1c of 5.7%-6.4% were considered prediabetics, and subjects with an HbA1c of more than 6.4% were considered diabetics. In wood industry workers, the prevalence of prediabetes (PD) was 64 (40.50%) and in type 2 diabetes mellitus (T2DM), it was 21 (13.29%); in welding workers, the prevalence of prediabetes was 261 (46.60%), and for T2DM, it was 90 (16.07%); in motor mechanic workers, the prevalence of prediabetes was 110 (40.44%), and for T2DM, it was 126 (46.32%); and in oil refinery workers, the prevalence of prediabetes was 80 (36.86%), and for T2DM, it was 35 (16.12%). However; the combined prevalence of prediabetes and T2DM among wood, welding, motor mechanic, and oil refinery workers was 421 (34.79%) and 515 (42.66%), respectively. The prevalence of prediabetes and T2DM among workers increased with the duration of working exposure in the wood, welding, motor mechanic, and oil refinery industries. A one-year working exposure in these industries caused an increase of 0.03% in HbA1c. Workplace exposure in wood, welding, motor mechanic, and oil refinery industries increased the risk of prevalence of prediabetes and T2DM among the workers and affected the diabetes etiology.


Asunto(s)
Diabetes Mellitus Tipo 2 , Exposición Profesional , Estado Prediabético , Soldadura , Lugar de Trabajo , Adulto , Diabetes Mellitus Tipo 2/epidemiología , Hemoglobina A Glucada , Humanos , Masculino , Estado Prediabético/epidemiología , Prevalencia , Madera
11.
Toxicol Lett ; 329: 47-55, 2020 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-32380127

RESUMEN

The aim of the study was to determine the concentration of hexavalent and trivalent chromium, nickel, manganese, and iron in welding fumes (WFs) and to evaluate the significant association between the concentration of metals in the biological material of welders. The studies were conducted in welders (n = 67) and controls (n = 52). Stainless steel WFs were continuously collected in the workers' breathing zone during a shift. The serum and urine concentrations of Cr and Ni were determined by ICP-MS. The content of Mn in the whole blood was determined using ET-AAS. The content of Cr in the erythrocytes was determined using ICP-MS. The Cr concentration in the welders' urine positively correlated with a work environment concentration of Cr (R = 0.59, p < 0.0001), Cr(VI) (R = 0.58, p < 0.0001), and Cr(III) (R = 0.64, p < 0.0001) in the inhalable fraction. The Ni concentration in the welders' urine positively correlated with the Ni concentration in the inhalable and respirable fraction (R = 0.34, p < 0.005 and R = 0.44, p < 0.002). The correlation between the Mn concentration in the work environment air and the Mn concentration in the welders' whole blood (R = 0.46, p < 0.0001) was observed.


Asunto(s)
Contaminación del Aire Interior , Monitoreo Biológico/métodos , Exposición Profesional , Acero Inoxidable , Soldadura , Adulto , Humanos , Metales Pesados/sangre , Persona de Mediana Edad
13.
Artículo en Inglés | MEDLINE | ID: mdl-32276440

RESUMEN

(1) Background: Welding fumes (WFs) are composed of fine and ultrafine particles, which may reach the distal airways and represent a risk factor for respiratory diseases. (2) Methods: In vitro and in vivo studies to understand WFs pathogenesis were selected. Epidemiological studies, original articles, review, and meta-analysis to examine solely respiratory disease in welders were included. A systematic literature search, using PubMed, National Institute for Occupational Safety and Health Technical Information Center (NIOSHTIC), and Web of Science databases, was performed. (3) Results: Dose, time of exposure, and composition of WFs affect lung injury. Inflammation, lung defense suppression, oxidative stress, DNA damage, and genotoxic effects were observed after exposure both to mild and stainless steel WFs. (4) Conclusions: The detection of lung diseases associated with specific occupational exposure is crucial as complete avoidance or reduction of the exposure is difficult to achieve. Further studies in the area of particle research may aid the understanding of mechanisms involved in welding-related lung disease and to expand knowledge in welding-related cardiovascular diseases.


Asunto(s)
Enfermedades Pulmonares , Soldadura , Contaminantes Ocupacionales del Aire/toxicidad , Estudios Transversales , Humanos , Estudios Longitudinales , Enfermedades Pulmonares/inducido químicamente , Enfermedades Pulmonares/epidemiología , Enfermedades Profesionales , Exposición Profesional/efectos adversos , Factores de Riesgo
14.
Sci Total Environ ; 720: 137549, 2020 Jun 10.
Artículo en Inglés | MEDLINE | ID: mdl-32135282

RESUMEN

The occupational exposure of toxic metals is an important concern, because of its potential accumulation in living organisms, leading to long term toxic effects. The occupational and environmental contacts of toxic metals, cadmium (Cd) and lead (Pb) have been evaluated by determination of them in biological samples (blood and scalp hair) of adolescent and adults, workers of battery recycling and welding workshops. The age matched adolescent and adult residing in nonindustrial areas were also selected, termed as referent/control subjects. The blood and scalp hair samples of workers and controls were analyzed for Cd and Pb using graphite furnace atomic absorption spectrometry previously decomposed the matrices using acid mixture. The biochemical parameters of workers of both age groups were also evaluated. The average concentrations of Cd and Pb in blood and scalp hair samples of adolescent workers were three fold higher as compared with control subjects. The drinking water in containers of both workshops contained Pb and Cd in two to four and five to thirteen folds, respectively, higher than recommended permissible limits of WHO. The significant correlations between the blood lead levels and hemoglobin (%) in adolescent (r = -0.78). The positive correlation was observed among incidence of blood pressure with Pb and Cd concentrations in biological samples of workers (adults) (r = 0.65 to 0.83). These findings suggest that occupational exposure of toxic metals might be created adverse impacts on workers due to ill management of workshops.


Asunto(s)
Exposición Profesional , Soldadura , Adolescente , Adulto , Cadmio , Humanos , Plomo , Reciclaje
15.
Georgian Med News ; (298): 13-16, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32141840

RESUMEN

Acute thrombophlebitis of the superficial veins is an urgent problem as it can spread to the deep veins with the subsequent development of pulmonary embolism. The social implications of varicotrombophlebitis are the long-term disability of most patients up to complete disability, so finding the least invasive methods of correction of the discussed disease is a pressing issue of modern phlebology. The research objective is to carry out a comparative analysis of the quality of life of patients with acute ascending thrombophlebitis of the great sapheneous vein after treatment with high-frequency endovenous welding and standard phlebectomy. The results of treatment of 63 patients with acute ascending thrombophlebitis of great saphenous vein (GSV) with III and IV class of thrombophlebitis, who were hospitalized in the surgical wards of the Municipal Clinical Hospital No. 8 of Kyiv from 2017 to 2018, were analyzed. Welding of the thrombotic vein segment was performed using an endovenous welding catheter (WC). Quality of life (QOL) results were assessed using CIVIQ2 (Chronic Venous Insufficiency Questionnaire). According to ultrasound duplex scanning, complete vein ablation occurred in 97.22% of patients after endovenous welding (EW) of thrombotic GSV. In all patients of Group I already on day 2, the total rate of QOL by all factors (pain, physical, social, psychological) significantly (p<0.05) exceeded the presurgery values and was 79.3%, when before treatment this indicator was 4.3% higher. At follow-up, QOL values continued to improve over all observation periods compared to the previous term (p <0.05). Quality of life restriction in connection with pain, social and psychological factors after EW decreased 2.1 times(p<0.05), when in control group patients - only 1.2 times. The revealed advantages of the method of high-frequency endovenous welding by all indicators of quality of life over standard phlebectomy allow recommending this method for wide practical application.


Asunto(s)
Ablación por Catéter , Terapia por Láser , Calidad de Vida/psicología , Vena Safena/cirugía , Tromboflebitis/cirugía , Insuficiencia Venosa/cirugía , Soldadura , Humanos , Tromboflebitis/psicología , Resultado del Tratamiento , Insuficiencia Venosa/complicaciones , Insuficiencia Venosa/diagnóstico
17.
Sci Rep ; 10(1): 2795, 2020 02 17.
Artículo en Inglés | MEDLINE | ID: mdl-32066756

RESUMEN

Welding generates and releases fumes that are hazardous to human health. Welding fumes (WFs) are a complex mix of metallic oxides, fluorides and silicates that can cause or exacerbate health problems in exposed individuals. In particular, WF inhalation over an extended period carries an increased risk of cancer, but how WFs may influence cancer behaviour or growth is unclear. To address this issue we employed a quantitative analytical framework to identify the gene expression effects of WFs that may affect the subsequent behaviour of the cancers. We examined datasets of transcript analyses made using microarray studies of WF-exposed tissues and of cancers, including datasets from colorectal cancer (CC), prostate cancer (PC), lung cancer (LC) and gastric cancer (GC). We constructed gene-disease association networks, identified signaling and ontological pathways, clustered protein-protein interaction network using multilayer network topology, and analyzed survival function of the significant genes using Cox proportional hazards (Cox PH) model and product-limit (PL) estimator. We observed that WF exposure causes altered expression of many genes (36, 13, 25 and 17 respectively) whose expression are also altered in CC, PC, LC and GC. Gene-disease association networks, signaling and ontological pathways, protein-protein interaction network, and survival functions of the significant genes suggest ways that WFs may influence the progression of CC, PC, LC and GC. This quantitative analytical framework has identified potentially novel mechanisms by which tissue WF exposure may lead to gene expression changes in tissue gene expression that affect cancer behaviour and, thus, cancer progression, growth or establishment.


Asunto(s)
Aprendizaje Automático , Redes y Vías Metabólicas/efectos de los fármacos , Neoplasias/genética , Soldadura , Contaminantes Ocupacionales del Aire/toxicidad , Biología Computacional , Gases/toxicidad , Regulación Neoplásica de la Expresión Génica/efectos de los fármacos , Humanos , Exposición por Inhalación/efectos adversos , Redes y Vías Metabólicas/genética , Proteínas de Neoplasias/genética , Neoplasias/inducido químicamente , Neoplasias/patología
18.
Occup Environ Med ; 77(5): 293-300, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-31959638

RESUMEN

OBJECTIVE: To investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study. METHODS: Analyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos. RESULTS: Welding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend <0.01) and the weighted duration (p-trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer. CONCLUSION: Our findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.


Asunto(s)
Neoplasias Laríngeas/epidemiología , Neoplasias de Células Escamosas/epidemiología , Enfermedades Profesionales/epidemiología , Exposición Profesional/efectos adversos , Neoplasias Faríngeas/epidemiología , Soldadura , Adolescente , Adulto , Anciano , Estudios de Casos y Controles , Francia/epidemiología , Neoplasias de Cabeza y Cuello , Humanos , Neoplasias Hipofaríngeas , Neoplasias Laríngeas/etiología , Neoplasias Laríngeas/patología , Modelos Logísticos , Masculino , Persona de Mediana Edad , Neoplasias de Células Escamosas/etiología , Neoplasias de Células Escamosas/patología , Enfermedades Profesionales/etiología , Enfermedades Profesionales/patología , Neoplasias Orofaríngeas , Neoplasias Faríngeas/etiología , Neoplasias Faríngeas/patología , Factores de Riesgo , Adulto Joven
19.
Arch Environ Occup Health ; 75(1): 56-59, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-30614391

RESUMEN

Interstitial pulmonary fibrosis is rare clinical entity related to welding usually associated with long term and heavy exposure to welding fumes. A 56-year-old asymptomatic male patient was referred to our clinic due to abnormal chest X-ray findings that was requested for regular controls. He has been working as a welder both indoor and outdoor settings for the last 25 years. The radiological findings were compatible with usual interstitial pneumonia on computed tomography of thorax. Pulmonary function tests, exercise capacity and laboratory results were within normal limits. Collagen tissue markers were negative. In order to confirm the relation of welding with pulmonary fibrosis, bronchoalveolar lavage was performed and stained with Prussian blue. The demonstration of hemosiderin-laden macrophages (25%) confirmed this association and allowed differential diagnosis. Besides it helped the patient decide to leave his job.


Asunto(s)
Lavado Broncoalveolar , Enfermedades Profesionales/diagnóstico , Siderosis/diagnóstico , Soldadura , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico por imagen , Fibrosis Pulmonar/etiología , Siderosis/diagnóstico por imagen , Turquia
20.
Environ Res ; 180: 108900, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-31711660

RESUMEN

Inhalation of welding fume (WF) can result in the deposition of toxic metals, such as manganese (Mn), in the brain and may cause neurological changes in exposed workers. Alterations in telomere length are indicative of cellular aging and, possibly, neurodegeneration. Here, we investigated the effect of WF inhalation on telomere length and markers of neurodegeneration in whole brain tissue in rats. Male Fischer-344 (F-344) rats were exposed by inhalation to stainless steel WF (20 mg/m3 x 3 h/d x 4 d/wk x 5 wk) or filtered air (control). Telomere length, DNA-methylation, gene expression of Trf1, Trf2, ATM, and APP, protein expression of p-Tau, α-synuclein, and presenilin 1 and 2 were assessed in whole brain tissue at 12 wk after WF exposure ended. Results suggest that WF inhalation increased telomere length without affecting telomerase in whole brain. Moreover, we observed that components of the shelterin complex, Trf1 and Trf2, play an important role in telomere end protection, and their regulation may be responsible for the increase in telomere length. In addition, expression of different neurodegeneration markers, such as p-Tau, presenilin 1-2 and α-synuclein proteins, were increased in brain tissue from the WF-exposed rats as compared to control. These findings suggest a possible correlation between epigenetic modifications, telomere length alteration, and neurodegeneration because of the presence of factors in serum after WF exposure that may cause extra-pulmonary effects as well as the translocation of potentially neurotoxic metals associated with WF to the central nervous system (CNS). Further studies are needed to investigate the brain region specificity and temporal response of these effects.


Asunto(s)
Contaminantes Ocupacionales del Aire , Regulación de la Expresión Génica/efectos de los fármacos , Exposición por Inhalación , Telómero , Soldadura , Contaminantes Ocupacionales del Aire/toxicidad , Animales , Encéfalo , Gatos , Metilación de ADN , Células Endoteliales , Humanos , Masculino , Ratas , Ratas Sprague-Dawley
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