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1.
Recurso de Internet en Portugués | LIS - Localizador de Información en Salud | ID: lis-LISBR1.1-47414

RESUMEN

A ACT Promoção da Saúde e outras organizações assinam nota conjunta sobre estudo que sugeriu um suposto efeito protetor da nicotina no combate ao COVID-19. A nota destaca que o estudo em questão não foi revisado por pares e que ao menos um dos autores do estudo já foi financiado no passado pela indústria do tabaco.


Asunto(s)
Tabaquismo , Tabaco , Virus del SRAS , Coronavirus , Nicotina
2.
Pestic Biochem Physiol ; 165: 104523, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32359551

RESUMEN

Tobacco black shank (TBS) caused by Phytophthora nicotianae is destructive to almost all tobacco cultivars and is widespread in many tobacco-growing countries. Through lab study and field test, we isolated plant growth-promoting rhizobacteria (PGPR) strain Ba168 which is a promising biocontrol strain of TBS. Ba168 was isolated from 168 soil samples and identified as Bacillus velezensis by its genetic and phenotypic characteristics. A susceptibility test indicated that the P. nicotianae antagonistic materials of Ba168 in extracellular metabolites were composed of effective and stable proteins/peptides. P. nicotianae's growth was suppressed by the ammonium sulfate precipitation of Ba168 culture filtrates (ASPBa) at a minimum inhibitory concentration of 5 µg/mL. Extracellular conductivity, pH, and the wet/dry weights of P. nicotianae's mycelia, along with scanning electron microscope analysis, suggested that Ba168-derived proteins/peptides could effectively inhibit P. nicotianae by causing irreversible damage to its cell walls and membranes. Protein identification of ASPBa supported these results and identified many key proteins responsible for various biocontrol-related pathways. Field assays of TBS control efficacy of many PGPRs and agrochemicals showed that all PGPR preparations reduced the disease index of tobacco, but Ba168 was the most effective. These results demonstrated the importance of Bacillus-derived proteins/peptides in the inhibition of P. nicotianae through irreversible damage to its cell wall and membrane; and the effectiveness of PGPR strain B. velezensis Ba168 for biocontrol of the soil-borne disease caused by P. nicotianae.


Asunto(s)
Bacillus , Phytophthora , Enfermedades de las Plantas , Tabaco
3.
Pestic Biochem Physiol ; 166: 104449, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32448412

RESUMEN

Tobacco mosaic virus helicase (TMV-Hel) plays important roles in viral multiplication. TMV-Hel is a potential target of anti-TMV agents. Our previous studies expressed and purified TMV-Hel as target protein for cytosinpeptidemycin. In this study, we preform molecular docking to study the binding sites of commercial antiviral agents with TMV-Hel. Then we verify the interactions between the potential anti-TMV agents and TMV-Hel in vitro using Microscale Thermophoresis experiment and study the inhibiting expression of TMV-Hel with the potential anti-TMV agents in vivo using Western-blot (WB) method. The results showed that ribavirin bound to TMV-Hel with a dissociation constant of 1.55 µM by direct interaction with eight binding sites, which was consistent with the docking studies. Ribavirin inhibited the expression of TMV-Hel in Nicotiana benthamiana. Docking studies combined Microscale Thermophoresis and WB experiment provided a new method to screen anti-TMV agents targeting TMV-Hel.


Asunto(s)
Antivirales , Virus del Mosaico del Tabaco , Simulación del Acoplamiento Molecular , Tabaco
5.
Sheng Wu Gong Cheng Xue Bao ; 36(4): 700-706, 2020 Apr 25.
Artículo en Chino | MEDLINE | ID: mdl-32347064

RESUMEN

The responsibility of root is absorbing water and nutrients, it is an important plant tissue, but easily to be affected by biotic and abiotic stresses, affecting crop growth and yield. The design of a synthetic root-specific promoter provides candidate promoters for the functional analysis and efficient expression of stress-related genes in crop roots. In this study, a synthetic root-specific module (pro-SRS) was designed using tandem four-copies of root specific cis-acting elements (OSE1ROOTNODULE, OSE2ROOTNODULE, SP8BFIBSP8AIB, and ROOTMOTIFAPOX1), and fused with minimal promoter from the CaMV 35S promoter to synthesize an artificially synthetic SRSP promoter. The SRSP promoter was cloned in pCAMBIA2300.1 by replacing CaMV 35S promoter so as to drive GUS expression. The constructs with SRSP promoter were transformed in tobacco by Agrobacterium-mediated method. SRSP promoter conferred root-specific expression in transgenic tobacco plants through Real-time PCR (RT-PCR) analysis and GUS histochemical staining analysis. It is indicated that the repeated arrangement of cis-acting elements can realize the expected function of the promoter. This study laid a theoretical foundation for the rational design of tissue-specific promoters.


Asunto(s)
Regulación de la Expresión Génica de las Plantas , Raíces de Plantas , Regiones Promotoras Genéticas , Tabaco , Agrobacterium/genética , Clonación Molecular , Raíces de Plantas/genética , Plantas Modificadas Genéticamente , Regiones Promotoras Genéticas/genética , Estrés Fisiológico , Tabaco/genética , Tabaco/crecimiento & desarrollo , Transformación Genética
6.
Wiad Lek ; 73(3): 517-520, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32285825

RESUMEN

OBJECTIVE: The aim: To study the effect of drug addiction and smoking on the status of periodontal tissues in patients with hepatobiliary pathology. PATIENTS AND METHODS: Materials and methods: 58 smokers, 63 drug addicts with hepatobiliary pathology were examined and 92 persons of comparison group (with inflammatory periodontal diseases affected by hepatobiliary pathology, without addiction). Examination of patients included determination of iodine number by Svrakov, S-L and Stallard hygiene indices, PMA index and index PBI. RESULTS: Results: The results of examination of smokers are worse in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov - 1,4 times and 1,3 times higher, PMA index - 1,7 times and 1,4 times worse, in accordance). The results of the study showed that drug addicts patients are worse values in patients with cirrhosis than in patients with chronic toxic hepatitis and non-alcoholic steatohepatitis and also the results of these two groups was significantly worse than that of the comparison group (iodine number by Svrakov - 1,5 times and 1,4 times higher, PMA index - 1,7 times and 1,5 times worse, in accordance). CONCLUSION: Conclusions: Presence of hepatobiliary pathology in smokers and drug addicts increases the risk of periodontal diseases.


Asunto(s)
Trastornos Relacionados con Sustancias , Humanos , Enfermedades Periodontales , Índice Periodontal , Fumar , Tabaco
7.
Pestic Biochem Physiol ; 164: 40-46, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32284135

RESUMEN

Plant viral diseases cause severe economic losses in agricultural production. Development of microorganism-derived antiviral agents provides an alternative strategy to efficiently control plant viral diseases. In this study, the antiviral effect and mechanism of a combined biological agent Cytosinpeptidemycin and Chitosan oligosaccharide (CytPM-COS) were investigated. CytPM-COS effectively inhibited tobacco mosaic virus (TMV) in Nicotiana glutinosa, suppressed viral RNA and CP accumulation in BY-2 protoplast and affected the subcellular localization as well as punctate formation of TMV MP in N. benthamiana leaves. In addition, CytPM-COS triggered reactive oxygen species (ROS) production and induced up-regulation of various defense responsive genes including PR-1, PR-5, FLS2, Hsp70. Our results indicated that CytPM-COS can potentially act as a pesticide for integrated control of plant viruses in the future.


Asunto(s)
Antivirales , Quitosano , Virus del Mosaico del Tabaco , Factores Biológicos , Citosina/análogos & derivados , Oligosacáridos , Enfermedades de las Plantas , Hojas de la Planta , Tabaco
8.
Nat Rev Cancer ; 20(4): 199, 2020 04.
Artículo en Inglés | MEDLINE | ID: mdl-32112043
9.
Gene ; 741: 144522, 2020 May 30.
Artículo en Inglés | MEDLINE | ID: mdl-32145329

RESUMEN

Virus-induced gene silencing (VIGS) is a transient based reverse genetic tool used to elucidate the function of novel gene in N. benthamiana. In current study, 14 UDP-D-glucuronate 4-epimerase (GAE) family members were identified and their gene structure, phylogeny and expression pattern were analyzed. VIGS system was optimized for the functional characterization of NbGAE6 homologous genes in N. benthamiana. Whilst the GAE family is well-known for the interconversion of UDP-D-GlcA and UDP-D-GalA during pectin synthesis. Our results revealed that the downregulation of these genes significantly reduced the amount of GalA in the homogalacturunan which is the major component of pectin found in primary cell wall. Biphenyl assay and high performance liquid chromatography analysis (HPLC) depicted that the level of 'GalA' monosaccharide reduced to 40-51% in VIGS plants as compared to the wild type plants. Moreover, qRT-PCR also confirmed the downregulation of the NbGAE6 mRNA in VIGS plants. In all, this is the first comprehensive study of the optimization of VIGS system for the provision of rapid silencing of GAE family members in N. benthamiana, eliminating the need of stable transformants.


Asunto(s)
Proteínas de Arabidopsis/genética , Carbohidrato Epimerasas/genética , Pared Celular/metabolismo , Pectinas/genética , Tabaco/genética , Arabidopsis/genética , Pared Celular/genética , Pared Celular/virología , Regulación de la Expresión Génica de las Plantas , Silenciador del Gen , Vectores Genéticos/genética , Monosacáridos/metabolismo , Pectinas/biosíntesis , Péptidos , Virus de Plantas/genética , ARN Mensajero/genética , Tabaco/virología
11.
Plant Mol Biol ; 103(1-2): 185-196, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32124178

RESUMEN

As a key integrator of shoot branching, BRANCHED 1 (BRC1) coordinates and is orchestrated by endogenous and environmental signals involved in the regulation of axillary bud outgrowth. In the present study, we characterized the regulatory roles of five BRC gene members in tobacco (Nicotiana tabacum L.) using CRISPR site-directed mutagenesis and overexpression assays. It was shown that lateral branching was negatively regulated by NtBRC1A-1, 1B-1, and 1B-2, but was unexpectedly promoted by NtBRC2A. Suppression of bud growth may be attained by direct binding of NtBRCs to the Tassels Replace Upper Ears 1 (TRU1) genes. It was speculated that NtBRC2A probably confers a dominant negative effect by interfering with the branching-inhibitory BRC1 genes. Our results suggested that highly homologous gene family members may function antagonistically in the same signaling pathway. However, the molecular mechanism underlying NtBRC2A-mediated outgrowth of axillary buds needs to be further addressed. KEY MESSAGE: Axillary bud outgrowth in general is negatively regulated by the BRANCHED gene. Here we show that the BRANCHED genes play opposing regulatory roles in tobacco lateral branching.


Asunto(s)
Genes de Plantas , Desarrollo de la Planta/genética , Tabaco/crecimiento & desarrollo , Sistemas CRISPR-Cas , Regulación hacia Abajo , Regulación de la Expresión Génica de las Plantas , Filogenia , Interferencia de ARN , Transducción de Señal , Tabaco/genética , Transcriptoma , Regulación hacia Arriba
12.
Asian Pac J Cancer Prev ; 21(3): 667-673, 2020 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-32212792

RESUMEN

BACKGROUND: Lung cancer coexisting with idiopathic pulmonary fibrosis (IPF) or chronic obstructive pulmonary disease (COPD) can lead to poor prognosis.  Telomere-related polymorphisms may be implicated in the pathogenesis of these three lung diseases.  As to elucidate the mechanism of lung cancer via IPF or COPD may enable early detection and early treatment of the disease, we firstly examined the association between telomere-related polymorphisms and the risk of IPF and COPD in a case-control study. MATERIALS AND METHODS: A total of 572 patients with IPF (n = 155) or COPD (n = 417), who were derived from our on-going cohort study, and controls (n = 379), who were derived from our previous case-control study, were included in this study.  Telomerase reverse transcriptase (TERT) rs2736100, telomere RNA component (TERC) rs1881984, and oligonucleotide/oligosaccharide-binding fold containing1 (OBFC1) rs11191865 were genotyped with real-time PCR using TaqMan fluorescent probes. Unconditional logistic regression was used to assess the adjusted odds ratios and 95% confidence intervals. RESULTS: TERT rs2736100 was significantly associated with the risk of IPF; increases in the number of this risk allele increased the risk of IPF (Ptrend = 0.008).  Similarly, TERT rs2736100 was associated with the risk of COPD.  In regard to the combined action of the three loci, increasing numbers of "at-risk" genotypes increased the risk of IPF in a dose-dependent manner (P trend=0.003). CONCLUSIONS: TERT rs2736100 was associated with the risks of both IPF and COPD in a Japanese population. A combination of the "at-risk" genotypes might be important to identify the population at risk for IPF more clearly.


Asunto(s)
Fibrosis Pulmonar Idiopática/genética , Neoplasias Pulmonares/genética , Polimorfismo de Nucleótido Simple , Enfermedad Pulmonar Obstructiva Crónica/genética , Telomerasa/genética , Femenino , Humanos , Masculino , Sistema de Registros , Factores de Riesgo , Tabaco/efectos adversos
13.
Washington, D.C.; PAHO; 2020-03-27. (PAHO/NMH/20-0004).
en Inglés | PAHO-IRIS | ID: phr-51952

RESUMEN

This scorecard has been developed by PAHO to highlight the country capacity for noncommunicable diseases and showcase regional results from the global NCD Progress Monitor 2020. It provides a snapshot of key NCD indicators across all countries in the Region of the Americas, and complements the country profiles published on the WHO 2020 Progress Monitor for Noncommunicable Diseases. The tool aims to promote understanding of the response to NCDs and assist decision-making for NCD program improvement. The WHO Progress Monitor 2020 for Noncommunicable Diseases (NCDs), the third of a series, provides information on the country capacity for NCDs, measured by the 19 indicators on NCDs. They include setting time-bound targets to reduce NCD deaths; developing all-of-government policies to address NCDs; implementing key tobacco demand reduction measures, measures to reduce harmful use of alcohol and unhealthy diets and promote physical activity; and strengthening health systems through primary health care and universal health coverage. Noncommunicable diseases (NCDs) and their risk factors are the leading causes of morbidity, mortality, and disability in the Americas, and they represent both a public health challenge and a serious threat to economic and social development. In the Region of the Americas, NCDs cause approximately 5.5 million deaths per year, representing 80.7% of all deaths in the region. Of the total deaths from NCDs, 38.9% are premature deaths occurring in people under 70 years of age.


Asunto(s)
Enfermedades no Transmisibles , Vigilancia , Aptitud Física , Ambientes Libres de Humo , Tabaco , Consumo de Bebidas Alcohólicas , Dieta Saludable , Programas y Políticas de Nutrición y Alimentación , Política para Fumadores , Política Ambiental
14.
Med Sci Monit ; 26: e920793, 2020 Mar 23.
Artículo en Inglés | MEDLINE | ID: mdl-32201430

RESUMEN

BACKGROUND Chronic obstructive pulmonary disease (COPD), a general airway disease, is featured by progressive and chronic immunoreaction in the lung. Increasing evidences have showed that cigarette smoking is the main reason in the COPD progression, and human pulmonary microvascular endothelial cell (HPMEC) apoptosis often be observed in COPD, while its pathogenesis is not yet fully described. Upregulation of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was observed in COPD patients, but the specific mechanism of lncRNA MEG3 in COPD remains unknown. The objective of this research was to explore the role of lncRNA MEG3 in cigarette smoke extract (CSE)-induced HPMECs. MATERIAL AND METHODS HPMECs were induced by a series of concentrations of CSE (0%, 0.1%, 1%, and 10%). Then cell apoptosis was analyzed by flow cytometry. Cell apoptosis related proteins were tested using western blot assay. Finally, we applied knockdown and over-expression system to explore the lncRNA MEG3 functions in CSE-induced HPMECs. RESULTS Our results indicated that various concentrations of CSE (0%, 0.1%, 1%, and 10%) significantly promoted cell apoptosis, augmented caspase-3 activity, upregulated Bax expression, decreased Bcl-2 expression, and enhanced lncRNA MEG3 level in HPMECs. LncRNA MEG3-plasmid transfection resulted in the upregulation of lncRNA MEG3, more apoptotic HPMECs, and higher caspase-3 activity. While lncRNA MEG3 knockdown presented the opposite effects. Further investigation suggested that all the effects of CSE treatment on HPMECs were markedly reversed by lncRNA MEG3-shRNA (short hairpin RNA). CONCLUSIONS Our study illustrated a protective effect of lncRNA MEG3-shRNA on CSE-induced HPMECs, indicting lncRNA MEG3 can be a new therapeutic approach for COPD treatment.


Asunto(s)
Enfermedad Pulmonar Obstructiva Crónica/metabolismo , ARN Largo no Codificante , Transducción de Señal/fisiología , Tabaco/efectos adversos , Apoptosis/fisiología , Células Cultivadas , Células Endoteliales/metabolismo , Regulación de la Expresión Génica , Regulación del Desarrollo de la Expresión Génica , Humanos , Humo/efectos adversos
15.
Nature ; 578(7794): 224-226, 2020 02.
Artículo en Inglés | MEDLINE | ID: mdl-32042085
16.
PLoS One ; 15(2): e0228069, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32053603

RESUMEN

BACKGROUND: Standardised packaging for factory made (FM) and roll your own (RYO) tobacco was fully implemented in the UK in May 2017. Around the same time, several changes to the tax system were applied (a Minimum Excise Tax (MET) for FM products and tax increases weighted towards RYO products). The tobacco industry claims that standardised packaging will lower prices (a disincentive for quitting) by commoditising the product, yet had itself taken advantage of the previous tax regime to achieve large profits from premium brands while also keeping some products' prices relatively low. Here we evaluate the impact of standardised packaging, the MET and the RYO focussed tax changes on price and industry profitability. METHODS AND FINDINGS: Nielsen electronic point of sale (EPOS) data (May 2015 to April 2018) were used to calculate real (inflation adjusted) monthly price per stick overall, by cigarette type (FM and RYO) and by seven market segments. Trend estimation, using additive mixed models, assessed weighted average price (weighted by volume of sales) and tobacco industry net revenue changes. The beginning and end of the data series were compared in terms of: (a) average monthly price growth, (b) average monthly net revenue growth, and (c) undershifting and overshifting patterns after tax changes. FM and RYO real prices changed little over the 3-year period-overall prices rose by about 1p per stick. There was no evidence of commoditisation with prices of all FM segments (but not RYO) rising faster after the implementation of standardised packaging than immediately beforehand. The prices of the cheapest FM brands rose with the implementation of the MET. RYO price increases did not close the gap to FM pricing levels despite RYO focussed tax increases. Tax changes following the implementation of standardised packaging and the MET were more widely and quickly passed on to smokers in the form of higher prices than the tax change pre-implementation. The main limitations are first that because we do not know the exact mechanism by which Nielsen scales up sample data to provide UK estimates, we could only use data for a set three year period during which the same adjustments are made. Second, the tax and standardised packaging events were sometimes too close in time to separate their consequences statistically. Third, tobacco prices may also be affected by external factors such as changes in smokers' disposable income or availability of electronic nicotine delivery systems. CONCLUSIONS: There was no long-term lowering of tobacco prices after the implementation of standardised packaging as predicted by the industry. The introduction of the MET was successful in increasing the price of the cheapest FM cigarettes and narrowing the price gap between FM brands. The RYO tax increases were, however, insufficient to narrow the price gap between RYO and FM. Overall, undershifting became less extensive indicating that tobacco industry manipulation of the tax system which had previously kept cheap products available had declined. This suggests that standardised packaging and a MET will likely contribute to further declines in UK tobacco use.


Asunto(s)
Embalaje de Productos/economía , Impuestos/estadística & datos numéricos , Tabaco , Análisis Multivariante , Estándares de Referencia , Industria del Tabaco/economía , Reino Unido
17.
PLoS One ; 15(2): e0229256, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32084204

RESUMEN

Cigarette smoke (CS) contains multiple gaseous and particulate materials that can cause lung inflammation, and smoking is the major cause of chronic obstructive pulmonary disease (COPD). We sought to determine the mechanisms of how CS triggers lung inflammation. Nur77, a nuclear hormone receptor belonging to the immediate-early response gene family, controls inflammatory responses, mainly by suppressing the NF-κB signaling pathway. Because it is unknown if Nur77's anti-inflammatory role modulates COPD, we assessed if and how Nur77 expression and activity are altered in CS-induced airway inflammation. In lung tissues and bronchial epithelial cells from COPD patients, we found Nur77 was downregulated. In a murine model of CS-induced airway inflammation, CS promoted lung inflammation and also reduced Nur77 activity in wild type (WT) mice, whereas lungs of Nur77-deficient mice showed exaggerated CS-induced inflammatory responses. Our findings in in vitro studies of human airway epithelial cells complemented those in vivo data in mice, together showing that CS induced threonine-phosphorylation of Nur77, which is known to interfere with its anti-inflammatory functions. In summary, our findings point to Nur77 as an important regulator of CS-induced inflammatory responses and support the potential benefits of Nur77 activation for COPD treatment.


Asunto(s)
Regulación hacia Abajo/efectos de los fármacos , Miembro 1 del Grupo A de la Subfamilia 4 de Receptores Nucleares/genética , Enfermedad Pulmonar Obstructiva Crónica/genética , Humo/efectos adversos , Tabaco/química , Animales , Células Epiteliales/efectos de los fármacos , Células Epiteliales/metabolismo , Humanos , Inflamación/genética , Pulmón/patología , Ratones , Fosforilación/efectos de los fármacos , Enfermedad Pulmonar Obstructiva Crónica/patología , Treonina/metabolismo
18.
Nucleic Acids Res ; 48(6): 3379-3394, 2020 04 06.
Artículo en Inglés | MEDLINE | ID: mdl-32083668

RESUMEN

Synthetic biology has advanced from the setup of basic genetic devices to the design of increasingly complex gene circuits to provide organisms with new functions. While many bacterial, fungal and mammalian unicellular chassis have been extensively engineered, this progress has been delayed in plants due to the lack of reliable DNA parts and devices that enable precise control over these new synthetic functions. In particular, memory switches based on DNA site-specific recombination have been the tool of choice to build long-term and stable synthetic memory in other organisms, because they enable a shift between two alternative states registering the information at the DNA level. Here we report a memory switch for whole plants based on the bacteriophage ϕC31 site-specific integrase. The switch was built as a modular device made of standard DNA parts, designed to control the transcriptional state (on or off) of two genes of interest by alternative inversion of a central DNA regulatory element. The state of the switch can be externally operated by action of the ϕC31 integrase (Int), and its recombination directionality factor (RDF). The kinetics, memory, and reversibility of the switch were extensively characterized in Nicotiana benthamiana plants.


Asunto(s)
ADN/genética , Siphoviridae/genética , Biología Sintética , Tabaco/genética , Escherichia coli/genética , Integrasas/genética , Cinética , Recombinación Genética/genética , Tabaco/virología , Proteínas Virales/genética
19.
Cell Host Microbe ; 27(3): 405-417.e6, 2020 Mar 11.
Artículo en Inglés | MEDLINE | ID: mdl-32101702

RESUMEN

In certain plant hybrids, immunity signaling is initiated when immune components interact in the absence of a pathogen trigger. In Arabidopsis thaliana, such autoimmunity and cell death are linked to variants of the NLR RPP7 and the RPW8 proteins involved in broad-spectrum resistance. We uncover the molecular basis for this autoimmunity and demonstrate that a homolog of RPW8, HR4Fei-0, can trigger the assembly of a higher-order RPP7 complex, with autoimmunity signaling as a consequence. HR4Fei-0-mediated RPP7 oligomerization occurs via the RPP7 C-terminal leucine-rich repeat (LRR) domain and ATP-binding P-loop. RPP7 forms a higher-order complex only in the presence of HR4Fei-0 and not with the standard HR4 variant, which is distinguished from HR4Fei-0 by length variation in C-terminal repeats. Additionally, HR4Fei-0 can independently form self-oligomers, which directly kill cells in an RPP7-independent manner. Our work provides evidence for a plant resistosome complex and the mechanisms by which RPW8/HR proteins trigger cell death.


Asunto(s)
Proteínas de Arabidopsis/inmunología , Arabidopsis/inmunología , Muerte Celular , Inmunidad de la Planta , Regulación de la Expresión Génica de las Plantas , Plantas Modificadas Genéticamente , Multimerización de Proteína , Tabaco/inmunología
20.
Adv Exp Med Biol ; 1225: 53-69, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32030647

RESUMEN

Tobacco smoke is a multicomponent mixture of chemical, organic, and inorganic compounds, as well as additive substances and radioactive materials. Many studies have proved the carcinogenicity of various of these compounds through the induction of DNA adducts, mutational potential, epigenetic changes, gene fusions, and chromosomal events. The tumor microenvironment plays an important role in malignant tumor formation and progression through the regulation of expression of key molecules which mediate the recruitment of immune cells to the tumor site and subsequently regulate tumor growth and metastasis. In this chapter, we discuss the effects of inhaled tobacco smoke in the tumor microenvironment of the respiratory tract. The mechanisms underlying these effects as well as their link with tumor progression are analyzed.


Asunto(s)
Neoplasias Pulmonares/patología , Humo/efectos adversos , Tabaco , Microambiente Tumoral/efectos de los fármacos , Progresión de la Enfermedad , Humanos , Tabaco/efectos adversos , Contaminación por Humo de Tabaco/efectos adversos
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