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1.
Molecules ; 26(17)2021 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-34500744

RESUMEN

Cannabis use has been growing recently and it is legally consumed in many countries. Cannabis has a variety of phytochemicals including cannabinoids, which might impair the peripheral systems responses affecting inflammatory and immunological pathways. However, the exact signaling pathways that induce these effects need further understanding. The objective of this study is to investigate the serum proteomic profiling in patients diagnosed with cannabis use disorder (CUD) as compared with healthy control subjects. The novelty of our study is to highlight the differentially changes proteins in the serum of CUD patients. Certain proteins can be targeted in the future to attenuate the toxicological effects of cannabis. Blood samples were collected from 20 male individuals: 10 healthy controls and 10 CUD patients. An untargeted proteomic technique employing two-dimensional difference in gel electrophoresis coupled with mass spectrometry was employed in this study to assess the differentially expressed proteins. The proteomic analysis identified a total of 121 proteins that showed significant changes in protein expression between CUD patients (experimental group) and healthy individuals (control group). For instance, the serum expression of inactive tyrosine protein kinase PEAK1 and tumor necrosis factor alpha-induced protein 3 were increased in CUD group. In contrast, the serum expression of transthyretin and serotransferrin were reduced in CUD group. Among these proteins, 55 proteins were significantly upregulated and 66 proteins significantly downregulated in CUD patients as compared with healthy control group. Ingenuity pathway analysis (IPA) found that these differentially expressed proteins are linked to p38MAPK, interleukin 12 complex, nuclear factor-κB, and other signaling pathways. Our work indicates that the differentially expressed serum proteins between CUD and control groups are correlated to liver X receptor/retinoid X receptor (RXR), farnesoid X receptor/RXR activation, and acute phase response signaling.


Asunto(s)
Cannabis/química , Trastorno Depresivo/tratamiento farmacológico , Fitoquímicos/uso terapéutico , Proteínas Tirosina Quinasas/sangre , Proteómica , Proteína 3 Inducida por el Factor de Necrosis Tumoral alfa/sangre , Enfermedad Aguda , Trastorno Depresivo/sangre , Trastorno Depresivo/diagnóstico , Humanos , Masculino , Fitoquímicos/sangre , Fitoquímicos/química
2.
Sci Rep ; 11(1): 13596, 2021 06 30.
Artículo en Inglés | MEDLINE | ID: mdl-34193938

RESUMEN

Depression is a common psychiatric disorder. Although many risk factors for depression have been reported, the associations of biochemical and anthropometric indices with depressive disorder remain unclear. The objective of this study was to assess whether there are significant associations of depressive disorder with biochemical and obesity indices. This study was based on data from the Korea National Health and Nutrition Examination Survey from 2007 to 2018, and logistic regression was performed to examine the association of depression with biochemical and obesity indices. A total of 33,993 subjects were included in the analyses. Study subjects consisted of 13,178 men in the control group (mean age of 51.12 years), 509 men in the depression group (53.67), 18,279 women in the control group (50.5), and 2027 women in the depression group (55.39). Among men, the depression group was significantly more likely to have a lower height and weight than the control group. Compared to the control group, the depression group was more likely to have higher triglyceride levels and tended to have lower hematocrit and blood urea nitrogen (BUN) levels. Among women, the depression group was more likely to have higher triglyceride, aspartate aminotransferase (AST), BUN, and creatinine levels and lower high-density lipoprotein cholesterol (HDL-C), hematocrit, and red blood cell counts. Several biochemical and anthropometric indices used in this study were associated with depressive disorder, but these associations may differ according to sex.


Asunto(s)
Estatura , Peso Corporal , Trastorno Depresivo , Caracteres Sexuales , Adulto , Anciano , Aspartato Aminotransferasas/sangre , Nitrógeno de la Urea Sanguínea , HDL-Colesterol/sangre , Trastorno Depresivo/sangre , Trastorno Depresivo/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Triglicéridos/sangre
3.
Biochemistry (Mosc) ; 86(6): 773-783, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34225599

RESUMEN

The review summarizes the results of our own studies and published data on the biological markers of psychiatric disorders, with special emphasis on the activity of platelet monoamine oxidase. Pharmacotherapy studies in patients with the mixed anxiety-depressive disorder and first episode of schizophrenia have shown that the activity of platelet monoamine oxidase could serve as a potential biomarker of the efficacy of therapeutic interventions in these diseases.


Asunto(s)
Plaquetas/enzimología , Trastornos Mentales/sangre , Monoaminooxidasa/sangre , Trastorno Depresivo/sangre , Trastorno Depresivo/tratamiento farmacológico , Humanos , Trastornos Mentales/tratamiento farmacológico , Esquizofrenia/sangre , Esquizofrenia/tratamiento farmacológico , Resultado del Tratamiento
4.
Basic Clin Pharmacol Toxicol ; 128(5): 677-685, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33470005

RESUMEN

According to previous studies, R-(-)-venlafaxine (VEN) has higher enantioselectivity than S-(+)-VEN, and the plasma concentration of R-(-)-VEN varies depending on CYP2D6 activity. Therefore, we examined the pharmacokinetic effects of CYP2D6*10 genotypes on the steady-state concentrations of the enantiomers of VEN. The individuals were 71 Japanese depressed patients treated with racemic VEN. The concentrations of the enantiomers of VEN and O-desmethylvenlafaxine (ODV) were measured. Polymerase chain reaction (PCR) was used to determine the CYP2D6*10 genotypes. The plasma concentrations of S-(+)-VEN were approximately 1.9-fold higher than those of R-(-)-VEN. The plasma concentrations of S-(+)-VEN and R-(-)-VEN seemed to be higher in individuals with two mutant alleles of CYP2D6*10, although no significant differences were found in the plasma levels of S-(+)-VEN and R-(-)-VEN between CYP2D6*10 genotypes. The number of mutant alleles of CYP2D6*10 was a significant factor associated with the R-(-)-ODV/R-(-)-VEN ratio (P = .004) in multiple regression analysis. This suggests that CYP2D6*10 mutations affect the metabolism of R-(-)-VEN and S-(+)-VEN. Further studies are needed to examine how these findings affect clinical practice.


Asunto(s)
Antidepresivos de Segunda Generación/farmacocinética , Citocromo P-450 CYP2D6/genética , Trastorno Depresivo/tratamiento farmacológico , Clorhidrato de Venlafaxina/farmacocinética , Adulto , Anciano , Anciano de 80 o más Años , Alelos , Antidepresivos de Segunda Generación/administración & dosificación , Antidepresivos de Segunda Generación/química , Citocromo P-450 CYP2D6/metabolismo , Trastorno Depresivo/sangre , Femenino , Humanos , Japón , Masculino , Persona de Mediana Edad , Variantes Farmacogenómicas , Estereoisomerismo , Clorhidrato de Venlafaxina/administración & dosificación , Clorhidrato de Venlafaxina/química , Adulto Joven
6.
Fluids Barriers CNS ; 17(1): 67, 2020 Nov 11.
Artículo en Inglés | MEDLINE | ID: mdl-33176794

RESUMEN

BACKGROUND: The importance of cerebrospinal fluid (CSF) diagnostics for psychiatry is growing. The CSF/blood albumin quotient (QAlb) is considered to be a measure of the blood-CSF barrier function. Recently, systematically higher QAlb in males than in females was described in neurological patients. The aim of this study was to investigate whether a sex difference could also be detected in a well-characterized psychiatric cohort. METHODS: The patient cohort comprised 989 patients, including 545 females and 444 males with schizophreniform and affective syndromes who underwent CSF diagnostics, including QAlb measurement. The basic CSF findings and antineuronal autoantibody data of this cohort have already been published. This re-analysis employed analysis of covariance with age correction for QAlb mean values and chi2-testing for the number of increased age-corrected QAlb levels to investigate sex differences in QAlb. RESULTS: The QAlb levels were elevated above reference levels by 18% across all patients, and a comparison between male and female patients revealed a statistically significant sex difference, with increased values in 26% of male patients and a corresponding rate of only 10% in female patients (chi2 = 42.625, p < 0.001). The mean QAlb values were also significantly higher in males (6.52 ± 3.69 × 10-3) than in females (5.23 ± 2.56 × 10-3; F = 52.837, p < 0.001). DISCUSSION: The main finding of this study was a significantly higher QAlb level in male compared to female patients with psychiatric disorders, complementing previously described sex differences in neurological patient cohorts. This result indicates bias from some general factors associated with sex and could be partly explained by sex differences in body height, which is associated with spine length and thus a longer distance for CSF flow within the subarachnoid space down the spine from the occipital area to the lumbar puncture site in males compared to females. Hormonal influences caused by different estrogen levels and other sex-specific factors could also play a relevant role. The significance of the study is limited by its retrospective design, absence of a healthy control group, and unavailability of exact measures of spine length.


Asunto(s)
Trastornos Psicóticos Afectivos/metabolismo , Albúminas/líquido cefalorraquídeo , Trastorno Bipolar/metabolismo , Trastorno Depresivo/metabolismo , Esquizofrenia/metabolismo , Albúmina Sérica Humana/metabolismo , Caracteres Sexuales , Adolescente , Adulto , Trastornos Psicóticos Afectivos/sangre , Trastornos Psicóticos Afectivos/líquido cefalorraquídeo , Anciano , Anciano de 80 o más Años , Trastorno Bipolar/sangre , Trastorno Bipolar/líquido cefalorraquídeo , Trastorno Depresivo/sangre , Trastorno Depresivo/líquido cefalorraquídeo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Esquizofrenia/sangre , Esquizofrenia/líquido cefalorraquídeo , Punción Espinal , Adulto Joven
7.
Nutrients ; 12(11)2020 Nov 23.
Artículo en Inglés | MEDLINE | ID: mdl-33238615

RESUMEN

Several conditions are risk factors for iron deficiency (ID), some of which are highly prevalent in older individuals. Despite the amount of evidence pointing for a role of ID in cognition, mood and physical functional ability, the research addressing these associations in older individuals is still scarce. In the present study, 162 older community-dwelling individuals (29.53% classified as ID) were enrolled in a cross-sectional analysis and characterized regarding cognition, mood, functional ability, general nutritional intake and iron status. Assessment of iron status was performed using several blood biomarkers. Storage and erythropoiesis dimensions were positively associated with memory, along with an interaction (moderator effect) between iron storage and nutritional status. A more depressed mood was negatively associated with (iron) transport, transport saturation and erythropoiesis dimensions, and functional tiredness was positively associated with the erythropoiesis dimension. These observations indicate that lower iron status is associated with depressive mood, functional tiredness and poorer memory ability, with the latter moderated by nutritional status. These findings suggest that using iron as a continuous variable may be useful in finding associations with iron homeostasis, eventually missed when iron levels are considered within the usual classification groups.


Asunto(s)
Actividades Cotidianas , Afecto , Anemia Ferropénica/epidemiología , Trastorno Depresivo/epidemiología , Hierro/sangre , Trastornos de la Memoria/epidemiología , Anciano , Anemia Ferropénica/sangre , Causalidad , Comorbilidad , Estudios Transversales , Trastorno Depresivo/sangre , Femenino , Humanos , Masculino , Trastornos de la Memoria/sangre , Portugal/epidemiología
8.
Biomolecules ; 10(10)2020 10 08.
Artículo en Inglés | MEDLINE | ID: mdl-33050072

RESUMEN

Depressive disorder (DD) is a psychiatric disorder whose molecular basis is not fully understood. It is assumed that reduced consumption of fish and omega-3 fatty acids (FA) is associated with DD. Other lipids such as total cholesterol (TCH), LDL-, and HDL-cholesterols (LDL-CH, HDL-CH) also play a role in depression. The primary endpoint of the study was the effect of omega-3 FA on the severity of depression in children and adolescents. This study aimed to investigate the secondary endpoint, relationship between depressive disorder symptoms and lipid profile, LDL- and HDL-cholesterol subfractions, Paraoxonase 1 (PON1) activities, and erythrocyte membrane fluidity in 58 depressed children and adolescents (calculated by the statistical program on the effect size), as well as the effect of omega-3 FA on the monitored parameters. Depressive symptoms were assessed by the Children's Depression Inventory (CDI), lipid profile by standard biochemical procedures, and LDL- and HDL-subfractions by the Lipoprint system. Basic biochemical parameters including lipid profile were compared with levels in 20 healthy children and were in the physiological range. Improvement of symptoms in the group supplemented with a fish oil emulsion rich in omega-3 FA in contrast to omega-6 FA (emulsion of sunflower oil) has been observed. We are the first to report that omega-3 FAs, but not omega-6 FA, increase large HDL subfractions (anti-atherogenic) after 12 weeks of supplementation and decrease small HDL subfractions (proatherogenic) in depressed children. We found a negative correlation between CDI score and HDL-CH and the large HDL subfraction, but not LDL-CH subfractions. CDI score was not associated with erythrocyte membrane fluidity. Our results suggest that HDL-CH and its subfractions, but not LDL-CH may play a role in the pathophysiology of depressive disorder. The study was registered under ISRCTN81655012.


Asunto(s)
Trastorno Depresivo/dietoterapia , Ácidos Grasos Omega-3/uso terapéutico , Lípidos/sangre , Fluidez de la Membrana/fisiología , Adolescente , Antidepresivos/uso terapéutico , Análisis Químico de la Sangre , Fraccionamiento Químico , Niño , Trastorno Depresivo/sangre , Trastorno Depresivo/tratamiento farmacológico , Trastorno Depresivo/patología , Suplementos Dietéticos , Método Doble Ciego , Membrana Eritrocítica/química , Membrana Eritrocítica/fisiología , Ácidos Grasos Omega-3/farmacología , Femenino , Humanos , Lípidos/análisis , Lipoproteínas/análisis , Lipoproteínas/sangre , Masculino , Índice de Severidad de la Enfermedad , Eslovaquia
9.
Int J Mol Sci ; 21(18)2020 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-32927845

RESUMEN

Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (µCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.


Asunto(s)
Experiencias Adversas de la Infancia , Huesos/metabolismo , Colágeno Tipo I/sangre , Trastorno Depresivo/sangre , Osteocalcina/sangre , Fragmentos de Péptidos/sangre , Péptidos/sangre , Procolágeno/sangre , Absorciometría de Fotón , Animales , Densidad Ósea , Huesos/diagnóstico por imagen , Huesos/inervación , Trastorno Depresivo/diagnóstico por imagen , Femenino , Homeostasis , Humanos , Masculino , Ratones Endogámicos C57BL , Estudios Retrospectivos , Microtomografía por Rayos X
10.
Nutrients ; 12(9)2020 Aug 26.
Artículo en Inglés | MEDLINE | ID: mdl-32858873

RESUMEN

The purpose of this study to estimate cumulative vitamin D doses from solar ultraviolet and dietary intakes in patients with depression and compare it to healthy controls. Using a case-control research design, a sample of 96 patients with depression were age- and sex-matched with 96 healthy controls. Dietary vitamin D dose was estimated from diet analysis. Vitamin D-weighted ultraviolet solar doses were estimated from action spectrum conversion factors and geometric conversion factors accounting for the skin type, the fraction of body exposed, and age factor. Patients with depression had a lower dose of vitamin D (IU) per day with 234, 153, and 81 per day from all sources, sunlight exposure, and dietary intake, respectively. Controls had a higher intake of vitamin D (IU) per day with 357, 270, and 87 per day from all sources, sunlight exposure, and dietary intake, respectively. Only 19% and 30% met the minimum daily recommended dose of ≥400 IU per day for cases and controls, respectively. The sensitivity, specificity, percentage correctly classified and receiver operating characteristic (ROC) Area for the estimated vitamin D against serum vitamin D as reference were 100%, 79%, 80%, and 89%. Physical activity level was the only predictor of daily vitamin D dose. Vitamin D doses are lower than the recommended dose of ≥400 IU (10 mcg) per day for both cases with depression and healthy controls, being much lower in the former.


Asunto(s)
Trastorno Depresivo/sangre , Dieta/métodos , Luz Solar , Rayos Ultravioleta , Vitamina D/administración & dosificación , Vitamina D/sangre , Adulto , Estudios de Casos y Controles , Trastorno Depresivo/psicología , Relación Dosis-Respuesta a Droga , Femenino , Humanos , Masculino , Persona de Mediana Edad , Vitaminas/administración & dosificación , Vitaminas/sangre , Adulto Joven
11.
Psychiatry Res ; 292: 113320, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32717709

RESUMEN

Suicide is devastating with a high incidence in patients with depressive disorder (PDDs). Although some studies have explored underlying associations between C-reactive protein (CRP) levels and suicidal behavior in PDDs, consistent results have not been reached. Therefore, the aim of this meta-analysis was to explore the differences of peripheral blood CRP concentrations between suicidal and non-suicidal PDDs, and between suicidal PDDs and healthy controls (HCs). To this end, PubMed, Embase, and Web of science were searched for eligible studies, and pooled effect sizes from eligible studies were calculated by random-effect models. Furthermore, sensitivity and meta-regression analyses were performed to explain the causes of heterogeneity. Eventually, 7 studies with 2,108 participants were included. Our statistical results suggested that the concentrations of peripheral CRP may be significantly increased for suicidal PDDs, both compared with non-suicidal PDDs and HCs, respectively. The differences of detection methods may be linked with the sources of heterogeneity. In short, our findings showed both compared with non-suicidal PDDs and HCs, peripheral blood CRP levels may be significantly increased in suicidal PDDs, while more studies with large sample sizes are needed to validate our findings.


Asunto(s)
Proteína C-Reactiva/metabolismo , Trastorno Depresivo/sangre , Trastorno Depresivo/diagnóstico , Ideación Suicida , Biomarcadores/sangre , Estudios de Casos y Controles , Trastorno Depresivo/psicología , Humanos , Suicidio/prevención & control , Suicidio/psicología
12.
Psychoneuroendocrinology ; 116: 104655, 2020 06.
Artículo en Inglés | MEDLINE | ID: mdl-32247203

RESUMEN

BACKGROUND: Placental endocrine insufficiency may increase the risk of depression and anxiety during pregnancy and/or after birth. This study investigated the association between serum human placental lactogen (hPL) and measures of perinatal mental health, accounting for selective serotonin-reuptake inhibitor (SSRI) usage. METHOD: Caucasian women with singleton, term pregnancies recruited at their pre-surgical appointment prior to an elective caesarean section (ELCS) were studied. Serum hPL levels were measured by ELISA in maternal blood collected at the pre-surgical appointment. Depression and anxiety scores were derived from Edinburgh Postnatal Depression Scale (EPDS) and the trait subscale of the State-Trait Anxiety Inventory (STAI) questionnaires completed at recruitment and three postnatal time points. Data was analysed by unadjusted and adjusted multiple linear regression. RESULTS: In adjusted linear regressions, term maternal serum hPL levels were negatively associated with postnatal EPDS and STAI score ten weeks postnatal for mothers who had girls (B= -.367, p = .022, 95% CI -.679, -.056; and B= -.776, p = .030, 95% CI -1.475, -.077 respectively). Excluding women prescribed SSRIs strengthened the relationship at 10 weeks and uncovered an earlier association between hPL and mood scores within one week of delivery (EPDS B= -.357, p = .041, 95 % CI -.698, -.015; and STAI B= -.737, p = .027, 95 % CI -1.387, -.086). In mothers who had boys, there were no associations between hPL and mood scores at any time point. CONCLUSION: Low hPL at term associated with postnatal depression and anxiety symptoms exclusively in mothers of girls. Insufficiency in hPL may contribute to maternal mood symptoms.


Asunto(s)
Trastornos de Ansiedad/sangre , Trastorno Depresivo/sangre , Lactógeno Placentario/sangre , Trastornos Puerperales/sangre , Adulto , Cesárea , Depresión Posparto/sangre , Femenino , Humanos , Lactante , Recién Nacido , Embarazo , Factores Sexuales
13.
Child Adolesc Ment Health ; 25(4): 249-255, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32304285

RESUMEN

BACKGROUND: Depression is a heterogeneous disorder and is thought to develop as a result of complex interactions between genetic and environmental factors. One-carbon metabolism that includes vitamin B12, folic acid, and homocysteine has been investigated in psychiatric disorders like depression. In recent years, vitamin D has also been considered to contribute to psychiatric disorders. In this study, serum levels of folate, vitamin B12, and homocysteine related to one-carbon metabolism and vitamin D were investigated in children and adolescents with depression and to assess possible roles in depression pathogenesis. METHODS: The study included 89 children and adolescents with depression (69 female, 20 male; mean age ± SD = 15.08 ± 1.46) and 43 control subjects (31 female, 12 male; mean age ± SD = 14.41 ± 2.32) without any DSM-5 diagnosis. Each subject completed a sociodemographic form, Childhood Depression Inventory, State-Trait Anxiety Inventory 1-2 and measured serum folate, vitamin B12, homocysteine, and 25-OH vitamin D levels. RESULTS: There was no significant difference between the groups in terms of folate levels (p = .052). In the patient group, the vitamin B12 and vitamin D levels were clearly low (p values for both levels were <.001), while homocysteine levels were found to be remarkably high (p < .001). In addition, there was a negative correlation between depression severity and vitamin B12 and vitamin D, while a positive correlation was found with homocysteine. CONCLUSIONS: The results of the study show that vitamin B12 deficiency or insufficiency and elevated homocysteine may contribute to the etiopathogenesis of depression. Additionally, it was shown that lower vitamin D levels may be associated with depression. KEY PRACTITIONER MESSAGE: Depression of children and adolescents is associated with the interaction of environmental and genetic factors. Homocysteine, vitamin B12, and folate related to one-carbon metabolism are associated with psychiatric disorders such as depression in adulthood. Vitamin D also contributes to psychiatric disorders pathogenesis. There are not enough studies in the literature about these parameters in children with depression. Low vitamin B12 and vitamin D levels and increased homocysteine levels may play a role in the pathogenesis of depression in children and adolescents. Investigation of vitamin B12, folate, homocysteine, and vitamin D levels are recommended in children and adolescents with depression.


Asunto(s)
Trastorno Depresivo/sangre , Trastorno Depresivo/fisiopatología , Ácido Fólico/sangre , Homocisteína/sangre , Vitamina B 12/sangre , Vitamina D/sangre , Adolescente , Niño , Trastorno Depresivo/etiología , Femenino , Deficiencia de Ácido Fólico/complicaciones , Humanos , Masculino , Índice de Severidad de la Enfermedad , Deficiencia de Vitamina B 12/complicaciones
14.
Biomarkers ; 25(3): 228-234, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32116029

RESUMEN

Objective: This study aims to review the alteration of plasma nesfatin-1 levels in patients with depression.Methods: Under the guidance of the latest PRISMA checklist, a systematic review and meta-analysis were conducted by searching English database (PubMed, Web of Science, EMDASE) and Chinese database for relevant studies up to August, 2019. Pooled standardised mean difference (SMD) with 95% confidence intervals (CI) was calculated with the random effects model.Results: Nine studies that reported the association between plasma levels of nesfatin-1 and the risk of depression with 567 patients and 447 control participants were included in the meta-analysis. Compared with the healthy controls, depressive patients had a higher plasma level of nesfatin-1 [SMD (95% CI):1.58(0.75, 2.41), Z = 3.74, p for Z < 0.001; I2 = 96.8%, p for I2 < 0.001]. The subgroup analyses and meta-regression failed to find the source of the heterogeneity. No evidence of publication bias was found either in Begg's test (p = 0.348) or the Egger's test (p = 0.523).Conclusion: The present meta-analysis indicated that a higher plasma level of nesfatin-1 was associated with an increased risk of depression.


Asunto(s)
Biomarcadores/sangre , Depresión/sangre , Trastorno Depresivo/sangre , Nucleobindinas/sangre , /estadística & datos numéricos , Depresión/diagnóstico , Depresión/etnología , Trastorno Depresivo/diagnóstico , Trastorno Depresivo/etnología , Humanos , Factores de Riesgo , Sensibilidad y Especificidad
15.
Psychiatry Res ; 287: 112911, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32179212

RESUMEN

Omega-3 fatty acids (FA) are a promising adjuvant therapy for depressive disorder (DD) in adults. The objective of this single-centre, randomized, double-blind and controlled study was to compare the efficacy of an omega-3 FA fish oil emulsion with a control oil emulsion alongside the standard treatment for depression in children and adolescents suffering from DD or mixed anxiety depressive disorder (MADD) and to analyse serum fatty acid levels and omega-6/omega-3 FA ratio before and after the intervention. 60 children were randomised 1:1 to the intervention (Om3) or active comparator (Om6) groups. Children's Depression Inventory (CDI) ratings were performed at the baseline, every 2 weeks for a 12-week intervention period. Significant reductions in CDI scores were observed after 6 and 12 weeks of intervention in the Om3 group and in the DD subgroup compared to the Om6 and MADD subgroup. Ratio of omega-6/omega-3 decreased in Om3 but not in Om6 from 24.2/1 to 7.6/1 after 6 weeks, EPA, omega-6/omega-3 ratio, but not DHA, correlated with severity symptoms at the baseline. An omega-3 fatty acid rich fish oil emulsion may be an effective adjuvant supplement during the treatment of depressive disorders in children. Trial registration: ISRCTN 81655012.


Asunto(s)
Trastorno Depresivo/sangre , Trastorno Depresivo/tratamiento farmacológico , Ácidos Grasos Omega-3/administración & dosificación , Ácidos Grasos Omega-3/sangre , Ácidos Grasos Omega-6/administración & dosificación , Ácidos Grasos Omega-6/sangre , Adolescente , Biomarcadores/sangre , Niño , Trastorno Depresivo/diagnóstico , Suplementos Dietéticos , Método Doble Ciego , Quimioterapia Combinada , Femenino , Humanos , Masculino , Resultado del Tratamiento
16.
Gen Hosp Psychiatry ; 64: 17-25, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32078857

RESUMEN

OBJECTIVE: To investigate serum neurofilament light (sNfL) levels in acute ischemic stroke and to assess whether sNfL are related to the severity of disease and a potential prognostic marker of post-stroke depression (PSD) during a 3-month follow-up period. METHODS: This was a single-center prospective cohort study. The sNfL concentration was measured in baseline samples using the Simoa platform- Single Molecule Array technology. A psychiatrist administered the Structural Clinical Interview for Diagnostic and Statistical Manual IV to all patients and made a diagnosis of PSD 3 months after stroke. The logistic regression was used to examine the association between sNfL and PSD. RESULTS: In total, 236 ischemic stroke cases were included and finished the follow-up. In the follow-up, 55 patients were defined as PSD, thus the incidence rate was 23.3% (95% confidence intervals [CI]: 17.9%-28.7%). Significant differences were observed between the sNfL levels in patients with PSD (124.8 pg/ml [interquartile range {IQR}: 59.6-159.2]) and in patients without PSD (35.9 pg/ml [IQR: 18.2-60.4]) levels (P < 0.001). After adjusting for age, family history of depression, marital status, National Institutes of Health and Stroke Scale score, C-reactive protein and homocysteine levels, sNfL levels independently predicted the development of post-stroke depression. The crude and adjusted odds ratios [OR] (and 95%CI) of PSD associated with an IQR increase for sNfL were 3.38(2.29, 4.98) and 2.65(1.59, 4.04), respectively. According to receiver operating characteristic curves (ROC) curves, the cut-off value of sNfL to predict PSD was 111.4 pg/ml with an area under the curve (AUC) of 0.84(95% CI, 0.78-0.90) and with the highest sensitivity (61.8%) and specificity (95.4%). CONCLUSIONS: In this study, elevated level of sNfL is associated with higher risk of 3-month depression in patients with ischemic stroke and makes early diagnoses of depression. The study needs replication to ensure the validity of our preliminary results.


Asunto(s)
Depresión , Trastorno Depresivo , Accidente Cerebrovascular Isquémico , Proteínas de Neurofilamentos/sangre , Anciano , Biomarcadores/sangre , Infarto Encefálico/patología , Depresión/sangre , Depresión/diagnóstico , Depresión/etiología , Depresión/fisiopatología , Trastorno Depresivo/sangre , Trastorno Depresivo/diagnóstico , Trastorno Depresivo/etiología , Trastorno Depresivo/fisiopatología , Femenino , Estudios de Seguimiento , Humanos , Ataque Isquémico Transitorio/sangre , Ataque Isquémico Transitorio/complicaciones , Ataque Isquémico Transitorio/patología , Ataque Isquémico Transitorio/fisiopatología , Accidente Cerebrovascular Isquémico/sangre , Accidente Cerebrovascular Isquémico/complicaciones , Accidente Cerebrovascular Isquémico/patología , Accidente Cerebrovascular Isquémico/fisiopatología , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Sensibilidad y Especificidad
17.
Int J Neurosci ; 130(11): 1136-1141, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-32053409

RESUMEN

Purpose: Depression, which affects about 52% of Alzheimer's disease (AD) patients, can worsen cognitive impairment and increase mortality and suicide rates. We hope to provide clinical evidence for the prevention and treatment of depression in AD patients by investigating related risk factors of depression in AD patients.Methods: 158 AD inpatients of the Department of Neurology, Daping Hospital from September 2017 to March 2019 were enrolled. General information, laboratory tests, cognitive and emotional function assessments of the inpatients were collected. Logistic regression was used to analyze the risk factors of depression in AD patients, and the relationship between 17 Hamilton depression scale scores and HbA1c levels in AD patients was further analyzed.Results: The prevalence of age, gender, hypertension, hyperlipidemia, Type 2 diabetes mellitus (T2DM), and white matter lesions (WML) in the AD with depression group was significantly different from without depression group. Hypertension, T2DM, and WML are independent risk factors for depression in AD patients. The depression scores of AD patients with HbA1c>6.5% were significantly higher than AD patients with HbA1c ≤ 6.5%, and there were significant difference in depression scale scores between using anti-diabetes drugs group and not using anti-diabetes drugs group whose HbA1c level is >6.5%, while no difference in depression scores between using anti-diabetes drugs group and not using anti-diabetes drugs group whose HbA1c level is ≤6.5%.Conclusion: T2DM is an independent risk factor for AD patients with depression. Increased HbA1c levels aggravate depression in AD patients, and controlling HbA1c levels and anti-diabetes drugs can reduce the severity of depression in AD patients.


Asunto(s)
Enfermedad de Alzheimer/epidemiología , Trastorno Depresivo/epidemiología , Trastorno Depresivo/etiología , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/epidemiología , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/sangre , China/epidemiología , Comorbilidad , Trastorno Depresivo/sangre , Trastorno Depresivo/tratamiento farmacológico , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/tratamiento farmacológico , Femenino , Hemoglobina A Glucada , Humanos , Hipoglucemiantes/uso terapéutico , Masculino , Persona de Mediana Edad , Factores de Riesgo , Índice de Severidad de la Enfermedad
18.
J Head Trauma Rehabil ; 35(1): 66-73, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31033745

RESUMEN

OBJECTIVE: To understand the relationships between traumatic brain injury (TBI), blood biomarkers, and symptoms of posttraumatic stress disorder (PTSD), depression, and postconcussive syndrome symptoms. DESIGN: Cross-sectional cohort study using multivariate analyses. PARTICIPANTS: One hundred nine military personnel and veterans, both with and without a history of TBI. MAIN MEASURES: PTSD Checklist-Civilian Version (PCL-C); Neurobehavioral Symptom Inventory (NSI); Ohio State University TBI Identification Method; Patient Health Questionnaire-9 (PHQ-9); Simoa-measured concentrations of tau, amyloid-beta (Aß) 40, Aß42, and neurofilament light (NFL). RESULTS: Controlling for age, sex, time since last injury (TSLI), and antianxiety/depression medication use, NFL was trending toward being significantly elevated in participants who had sustained 3 or more TBIs compared with those who had sustained 1 or 2 TBIs. Within the TBI group, partial correlations that controlled for age, sex, TSLI, and antianxiety/depression medication use showed that tau concentrations were significantly correlated with greater symptom severity, as measured with the NSI, PCL, and PHQ-9. CONCLUSIONS: Elevations in tau are associated with symptom severity after TBI, while NFL levels are elevated in those with a history of repetitive TBIs and in military personnel and veterans. This study shows the utility of measuring biomarkers chronically postinjury. Furthermore, there is a critical need for studies of biomarkers longitudinally following TBI.


Asunto(s)
Lesiones Traumáticas del Encéfalo/sangre , Lesiones Traumáticas del Encéfalo/psicología , Personal Militar/psicología , Veteranos/psicología , Proteínas tau/sangre , Adulto , Péptidos beta-Amiloides/sangre , Biomarcadores/sangre , Lesiones Traumáticas del Encéfalo/complicaciones , Estudios de Cohortes , Estudios Transversales , Trastorno Depresivo/sangre , Trastorno Depresivo/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proteínas de Neurofilamentos/sangre , Síndrome Posconmocional/sangre , Síndrome Posconmocional/etiología , Trastornos por Estrés Postraumático/sangre , Trastornos por Estrés Postraumático/etiología , Adulto Joven
19.
Biol Trace Elem Res ; 194(1): 76-83, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31147977

RESUMEN

Previous studies have reported an association between blood lead (BPb) levels and depressive symptoms in adults. However, the relationship between BPb levels and depression remains unclear in the old population. Our purpose was to investigate the association of BPb levels with depression among the old population. Data were gathered from 994 elderly persons in the Cohort Study of Elderly Health and Environmental Controllable Factors, which was created in Anhui, China. BPb was measured by inductively coupled plasma mass spectrometry. Our subjects were divided into four groups according to BPb quartiles. Multivariate logistic regressions were used to assess the association between BPb levels and depression. The median (25th-75th) BPb level was 26.94 µg/L (20.34 µg/L-36.13 µg/L). BPb levels in participants with depression were higher than those in participants without depression. The prevalence of depression was 27.64%. After multivariate adjustment for confounding factors, participants with BPb level in the highest quartile had 2.03 times higher risk of depression compared with those in the lowest quartile. In rural areas, the risk of depression in higher BPb quartile was higher than that in the lowest quartile. These findings suggest that higher BPb level was associated with increased odds of depression in the old population. This association was obvious among older people living in rural areas.


Asunto(s)
Trastorno Depresivo/sangre , Plomo/sangre , Anciano , Anciano de 80 o más Años , China/epidemiología , Estudios de Cohortes , Trastorno Depresivo/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo
20.
Psychol Med ; 50(1): 29-37, 2020 01.
Artículo en Inglés | MEDLINE | ID: mdl-30606276

RESUMEN

BACKGROUND: Few studies have examined the concurrent effects of physical disease and systemic inflammation on suicide risk in patients with depression. The authors investigated the independent contributions of chronic physical disease and systemic inflammation as indexed by C-reactive protein (CRP), on risk of suicide attempt. METHODS: In this case-control study, 1468 cases of suicide attempters and 14 373 controls, both aged 18-65 years with a diagnosis of depression during 2011-2015, were identified from the hospital-wide database. Regression models were implemented to identify separate effects of physical diseases and systemic inflammation indexed by CRP, on risk of suicide attempt. RESULTS: Compared with having no physical disease, having one, two, and three or more physical diseases was associated with a 3.6-, 6.4-, and 14.9-fold increase in odds of making a suicide attempt, respectively, after adjusting for age, sex, and race/ethnicity. In a sub-sample of cases and controls with available CRP values, patients with high CRP (>3 mg/L) had 1.9 times the odds of suicide attempt compared with patients with low CRP (<1 mg/L). This association was no longer significant when controlling for the effect of physical disease. CONCLUSIONS: The presence of physical disease is an important risk factor for suicide attempt among patients with depression. Systemic inflammation is likewise associated with increased risk for suicide attempt, however, this association appears to be accounted for by the presence of physical disease among patients receiving care in a medical center setting. Healthcare providers should consider the risk of suicide attempt in depressed patients burdened with multiple comorbidities.


Asunto(s)
Enfermedad Crónica/epidemiología , Enfermedad Crónica/psicología , Trastorno Depresivo/psicología , Inflamación/psicología , Intento de Suicidio/psicología , Intento de Suicidio/estadística & datos numéricos , Centros Médicos Académicos , Adolescente , Adulto , Anciano , Proteína C-Reactiva/análisis , Estudios de Casos y Controles , Comorbilidad , Trastorno Depresivo/sangre , Femenino , Hospitales , Humanos , Inflamación/sangre , Masculino , Persona de Mediana Edad , Factores de Riesgo , Adulto Joven
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