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1.
Int. j. morphol ; 38(2): 458-460, abr. 2020.
Artículo en Inglés | LILACS | ID: biblio-1056462

RESUMEN

The study of the temporomandibular joint (TMJ) through imaging, is useful for the analysis of intra-articular procedures in view of its complex anatomy. Precise knowledge of the depth at which the TMJ is located is required to achieve an ideal puncture technique. The aim of this study was to measure the depth of the TMJ through magnetic resonance imaging (MRI) in patients with temporomandibular disorders (TMD). A cross-sectional study was conducted, selecting 150 MRI of patients who attended the Polyclinic for TMD and Orofacial Pain. The variables analyzed were: 1) Depth of the right and left TMJ; 2) Age of the patients; and 3) Sex of the patients. Of the total MR, 114 corresponded to women with a median age of 23 years. The median depth of the right TMJ was 17.16 mm and median on the left side was 16.98 mm, there was no statistically significant difference (p> 0.05) but there was a strong correlation (r = 0.842). There were no differences between the depths and the sex of the patients in both the right and left TMJ. There was no correlation between age and depth of TMJ. In conclusion the depth of the right and left condyle are highly correlated, being approximately 17 mm according to the population studied. There is no association between patient age and condylar depth, and there are no differences in average according to sex.


El estudio por imágenes de la articulación temporomandibular (ATM) es útil para el análisis de procedimientos intra-articulares debido a la compleja anatomía que presenta. Se requiere un conocimiento preciso de la profundidad a la cual se encuentra la ATM para una adecuada técnica de punción. El objetivo de este estudio fue medir la profundidad de laATM en relación a la piel a través de resonancia magnética (RM) en pacientes con trastornos temporomandiblaes (TTM). Se realizó un estudio transversal, seleccionando 150 RM de pacientes que asistieron al Policlínico de TTM y Dolor Orofacial. La variables analizadas fueron: 1) Profundidad de la ATM derecha e izquierda; 2) Edad de los pacientes; y 3) Sexo de los pacientes. Del total de RM, 114 correspondían a mujeres con una mediana de edad de 23 años. La mediana de la profundidad de la ATM derecha fue de 17,16 mm y la mediana del lado izquierdo fue de 16,98 mm, no hubo una diferencia estadísticamente significativa (p>0,05) pero si una fuerte correlación (r=0,842). No hubo diferencias entre las profundidades y el sexo de los pacientes tanto en la ATM derecha como en la izquierda. No hubo correlación entre la edad y la profundidad de la ATM. La profundidad de los cóndilos derecho e izquierdo están altamente correlacionados, siendo 17 mm aproximadamente en la población estudiada. No existe asociación entre la edad de los pacientes y la profundidad condilar, y no hay diferencias en promedios por sexo.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Imagen por Resonancia Magnética , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Cóndilo Mandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/patología , Estudios Transversales
2.
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 68-72, Jan.-Mar. 2020. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1090546

RESUMEN

Abstract Introduction The prevalence of tinnitus is higher in individuals with temporoman- dibular joint disorder (TMD) than in the general population. Magnetic resonance imaging (MRI) of the temporomandibular joint (TMJ) is the method of choice for investigation, and it has been hypothesized that specific MRI findings might be observed in TMD with comorbid tinnitus. Objective To comparatively describe MRI findings in patients with TMD with and without tinnitus, identifying the most common TMJ alterations and determining whether a correlation exists between severity of TMD and tinnitus. Methods A cross-sectional study of 53 adult patients with bilateral or unilateral TMD (30 with and 23 without tinnitus). The association between tinnitus and morphological aspects of TMD (changes in condylar morphology, articular eminence morphology, and disc morphology), disc displacement (with/without reduction), condylar translation, and intra-articular effusion was analyzed on MRI images. Results The mean patient age was 46.12 ± 16.1 years. Disc displacement was the most common finding in both groups (24 patients with tinnitus versus 15 without; p = 0.043). Only the frequency of disc displacement with reduction was significantly different between groups. Conclusion Additional imaging techniques should be explored to detect specific aspects of the relationship between tinnitus and TMD.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Articulación Temporomandibular/diagnóstico por imagen , Acúfeno/diagnóstico por imagen , Imagen por Resonancia Magnética , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Audiometría de Respuesta Evocada , Audiometría de Tonos Puros , Articulación Temporomandibular/patología , Acúfeno/diagnóstico , Acúfeno/etiología , Índice de Severidad de la Enfermedad , Trastornos de la Articulación Temporomandibular/complicaciones , Trastornos de la Articulación Temporomandibular/patología , Estudios Transversales
3.
Clin Oral Investig ; 24(1): 221-227, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31079244

RESUMEN

OBJECTIVES: To characterize the relationship between radiographic and clinical characteristics of patients with temporomandibular joint (TMJ) osseous changes. MATERIALS AND METHODS: TMJ cone beam computed tomography (CBCT) images of 73 patients (142 joints) with changes in osseous component of TMJ were included in this study. Based on both clinical and radiographic findings, each TMJ was diagnosed as either non-degenerative joint disease (non-DJD) or degenerative joint disease (DJD) according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) criteria. The DJD group was further classified into two subgroups of osteoarthritis and osteoarthrosis. The data were analyzed using t test and Pearson's correlation. Level of statistical significance was set at 0.05. RESULTS: Statistically significant relationships were found between TMJ crepitation sound and 4 radiographic characteristics of DJD. DJD group demonstrated statistically significant higher CBCT bone change score (BCS) and age. In contrast, there was no significant difference of BCS between osteoarthrosis and osteoarthritis groups within the DJD group. CONCLUSIONS: Crepitation sounds and osseous changes in TMJ radiograph are confirmed to be important diagnostic criteria for TMJ DJD. However, degree of TMJ osseous changes does not correlate significantly with clinical pain symptom. CLINICAL RELEVANCE: For TMJ DJD diagnosis, dentists should consider both clinical examination for TMJ crepitation and radiographic assessment for TMJ bony changes.


Asunto(s)
Osteoartritis , Trastornos de la Articulación Temporomandibular , Tomografía Computarizada de Haz Cónico , Humanos , Cóndilo Mandibular , Articulación Temporomandibular , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/patología
4.
J Craniomaxillofac Surg ; 47(12): 1903-1912, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31812309

RESUMEN

OBJECTIVE: Temporomandibular joint ankylosis (TMJa) is a debilitating condition that causes difficulty in mastication, speech and mouth opening. Its treatment poses surgical and rehabilitative challenges along with a high incidence of reankylosis. This study was designed to assess the long-term outcomes with a new two phase physiotherapy protocol following conservative resection of the ankylotic mass. MATERIALS AND METHODS: 143 patients who were treated for TMJa were initially recruited, among whom 98 were inducted into the study and retrospectively evaluated using clinical records and 3-dimensional computed tomography. All the patients underwent a minimal pre auricular incision and conservative interpositional gap arthroplasty with collagen membrane. This was followed by the new two phase physiotherapy protocol with the use of a bite block. The primary outcome measures were the maximum interincisal distance, vertical ramus height and complications. The patients were followed up at monthly intervals during the first year, quarterly intervals during the second year, and at intervals of 6 months during subsequent follow-up years. The mean follow up period was 6.38 ± 2.36 years after ankylotic release. Paired student t test was used for statistical analysis. RESULTS: The mean scores for mouth opening at T1, T2 and T3 were statistically significantly different at all intervals (p < 0.0005). The mean scores for ramal length were statistically significantly different at T1 and T2 interval (p < 0.0005) and insignificant at T2 and T3 interval. No reankylosis was observed in patients who followed the physiotherapy protocol. CONCLUSIONS: In the management of TMJa, the success of the conservative surgical technique with interpositional arthroplasty is less dependent on the longevity and rigidity of the interpositional material but more indebted to the patient compliance in following the proposed physiotherapy protocol.


Asunto(s)
Anquilosis/cirugía , Artroplastia , Modalidades de Fisioterapia , Trastornos de la Articulación Temporomandibular/cirugía , Adolescente , Adulto , Anquilosis/patología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Cooperación del Paciente , Recuperación de la Función , Estudios Retrospectivos , Articulación Temporomandibular , Trastornos de la Articulación Temporomandibular/patología
5.
Am J Vet Res ; 80(12): 1107-1113, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31763947

RESUMEN

OBJECTIVE: To describe histologic changes in the temporomandibular joints (TMJs) of horses of various ages. SAMPLE: 22 TMJs from cadavers of 11 horses. PROCEDURES: Horses were categorized into 3 age groups (group 1, 2 to 10 years old [n = 3]; group 2, 11 to 20 years old [3]; and group 3, > 20 years old [5]). Each TMJ was sectioned into 5-mm slices, preserved in formalin, decalcified in formic acid, and routinely processed for histologic analysis. Joints were systematically assessed by use of previously described methods. Multilevel mixed-effects models were used to examine the data. RESULTS: The number of changes was significantly fewer and degree of changes was significantly less within the TMJs of group 1 horses, compared with those of group 3 horses. Comparison among groups revealed that the combination of temporal and mandibular scores for group 1 was significantly lower than for groups 2 or 3. Disk score did not differ significantly between groups 1 and 2, but disk scores of groups 1 and 2 were significantly lower than the disk score of group 3. CONCLUSIONS AND CLINICAL RELEVANCE: The assessed lesions were associated with osteoarthritis, and they accumulated in the TMJs as horses aged. In the absence of signs of pain manifested as changes in mastication, behavior, or performance, it would be difficult to determine the point at which accrued pathological changes represented the onset of clinically important osteoarthritis of the TMJs.


Asunto(s)
Caballos , Osteoartritis/veterinaria , Trastornos de la Articulación Temporomandibular/patología , Articulación Temporomandibular/patología , Factores de Edad , Animales , Femenino , Masculino , Osteoartritis/patología , Articulación Temporomandibular/anatomía & histología
6.
PLoS One ; 14(10): e0223244, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31603905

RESUMEN

The temporomandibular joint (TMJ) is a fibrocartilaginous tissue critical for chewing and speaking. In patients with temporomandibular disorders (TMDs), permanent tissue loss can occur. Recapitulating the complexity of TMDs in animal models is difficult, yet critical for the advent of new therapies. Synovial fluid from diseased human samples revealed elevated levels of tumor necrosis factor alpha (TNF-alpha). Here, we propose to recapitulate these findings in mice by subjecting murine TMJs with TNF-alpha or CFA (Complete Freund's Adjuvant) in mandibular condyle explant cultures and by local delivery in vivo using TMJ intra-articular injections. Both TNF-alpha and CFA delivery to whole mandibular explants and in vivo increased extracellular matrix deposition and increased cartilage thickness, while TNF-alpha treated explants had increased expression of inflammatory cytokines and degradative enzymes. Moreover, the application of TNF-alpha or CFA in both models reduced cell number. CFA delivery in vivo caused soft tissue inflammation, including pannus formation. Our work provides two methods of chemically induced TMJ inflammatory arthritis through a condyle explant model and intra-articular injection model that replicate findings seen in synovial fluid of human patients, which can be used for further studies delineating the mechanisms underlying TMJ pathology.


Asunto(s)
Artritis Experimental/inmunología , Cartílago Articular/inmunología , Matriz Extracelular/inmunología , Trastornos de la Articulación Temporomandibular/inmunología , Articulación Temporomandibular/inmunología , Proteína ADAMTS5/genética , Proteína ADAMTS5/inmunología , Adolescente , Adulto , Anciano , Animales , Artritis Experimental/inducido químicamente , Artritis Experimental/genética , Cartílago Articular/efectos de los fármacos , Cartílago Articular/patología , Colágeno Tipo II/genética , Colágeno Tipo II/inmunología , Colágeno Tipo X/genética , Colágeno Tipo X/inmunología , Modelos Animales de Enfermedad , Matriz Extracelular/efectos de los fármacos , Matriz Extracelular/patología , Femenino , Adyuvante de Freund/administración & dosificación , Expresión Génica/efectos de los fármacos , Expresión Génica/inmunología , Humanos , Interleucinas/genética , Interleucinas/inmunología , Masculino , Cóndilo Mandibular/efectos de los fármacos , Cóndilo Mandibular/inmunología , Cóndilo Mandibular/patología , Ratones , Ratones Endogámicos C57BL , Persona de Mediana Edad , Líquido Sinovial/inmunología , Articulación Temporomandibular/efectos de los fármacos , Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/genética , Trastornos de la Articulación Temporomandibular/patología , Técnicas de Cultivo de Tejidos , Factor de Necrosis Tumoral alfa/administración & dosificación
7.
Am J Orthod Dentofacial Orthop ; 156(4): 531-544, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31582125

RESUMEN

Progressive condylar resorption, also known as idiopathic condylar resorption, is an uncommon, aggressive, degenerative disease of the temporomandibular joint (TMJ) seen mostly in adolescent girls and young women. This condition leads to loss of condylar bone mass, decrease of mandibular ramal height, steep mandibular and occlusal plane angles, and an anterior open bite. In 3 case reports, we review the pathogenesis of TMJ degenerative disease and the clinical management of TMJ arthrosis. We emphasize that TMJ arthritic disease should be discussed in dental circles as a pathologic entity in the same way that orthodontists discuss arthritic disease in orthopedic circles. Regarding the degenerative pathology of the TMJ, treatment goals include restored function and pain reduction. The treatment methods used to achieve these goals can range from noninvasive therapy to minimally invasive and invasive surgery. Most patients can be treated noninvasively, and the importance of disease prevention and conservative management in the overall treatment of TMJ disease must be acknowledged. The decision to manage TMJ osteoarthrosis surgically must be based on evaluation of the patient's response to noninvasive treatments, mandibular form and function, and effect of the condition on his or her quality of life.


Asunto(s)
Resorción Ósea/diagnóstico por imagen , Resorción Ósea/cirugía , Ortodoncia Correctiva/métodos , Procedimientos Quirúrgicos Ortognáticos/métodos , Osteoartritis/diagnóstico por imagen , Osteoartritis/cirugía , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/terapia , Adulto , Resorción Ósea/patología , Niño , Terapia Combinada , Progresión de la Enfermedad , Femenino , Humanos , Cóndilo Mandibular/patología , Cóndilo Mandibular/cirugía , Osteoartritis/patología , Calidad de Vida , Trastornos de la Articulación Temporomandibular/patología , Resultado del Tratamiento
8.
J Craniofac Surg ; 30(7): e597-e598, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31503121

RESUMEN

The calcification of the articular disc is an uncommon lesion, usually discovered in hips, elbows, and shoulders, but rarely in temporomandibular joints (TMJ). The TMJ disc calcification may be related to pain and limitation of the mandibular mobility, however, most of the patients were asymptomatic. A 61-year-old female was referred to our hospital after a maxillofacial fist injury, bilateral TMJ disc calcifications were found accidentally by radiological examination. Here the significance of image fusion of cone-beam computed tomography and magnetic resonance imaging (MRI) in the diagnosis of this lesion was emphasized.


Asunto(s)
Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Calcinosis , Tomografía Computarizada de Haz Cónico , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Persona de Mediana Edad , Rango del Movimiento Articular , Disco de la Articulación Temporomandibular/diagnóstico por imagen , Disco de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/patología
9.
J Radiol Case Rep ; 13(8): 31-39, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31558968

RESUMEN

Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of the synovium that usually involves joints, tendon sheaths, and bursae. It presents rarely, however, in the temporomandibular joints (TMJs). This paper reports a 59-year-old female patient with PVNS of the TMJ and its clinico-pathologic features are discussed. The patient was treated with surgery and postoperative radiotherapy (PORT). Follow-up was conducted, and there were no recurrences, metastases, skin changes or joint stiffness noted. The main treatment of PVNS is surgical resection. However, postoperative radiotherapy is important for local control of extensive tumors or positive margins. We conducted a literature review for postoperative radiotherapy case reports related to PVNS of the TMJ.


Asunto(s)
Sinovitis Pigmentada Vellonodular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Femenino , Pérdida Auditiva/etiología , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Radioterapia Ayuvante , Sinovitis Pigmentada Vellonodular/patología , Sinovitis Pigmentada Vellonodular/terapia , Trastornos de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/terapia , Acúfeno/etiología
10.
Pan Afr Med J ; 32: 151, 2019.
Artículo en Francés | MEDLINE | ID: mdl-31303922

RESUMEN

Ankylosis of the temporomandibular joint (TMJ) is a joint stiffness with an oral aperture of less than 30 mm measured between the incisors, occurring because of a bony, fibrous or fibro-osseous fusion. Arthrosis is a rare cause of the ankylosis of the temporomandibular joint. We report a case of ankylosis of the TMJ due to osteoarthrosis, in order to highlight the diagnostic and therapeutic features of this quite uncommon disease.


Asunto(s)
Anquilosis/diagnóstico , Osteoartritis/diagnóstico , Trastornos de la Articulación Temporomandibular/diagnóstico , Anquilosis/patología , Femenino , Humanos , Persona de Mediana Edad , Osteoartritis/patología , Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/patología
12.
J Mol Histol ; 50(5): 459-470, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31302828

RESUMEN

Temporomandibular joint osteoarthritis (TMJOA) is a complex inflammatory condition with multiple factors and degenerative processes co-occurring. However, its pathogenesis remains uncertain. The purpose of the study was to observe the expression of Indian hedgehog (Ihh) signal related molecules in TMJOA induced by bite-raising and to study the effect and mechanism of Ihh signaling. Our research indicated that Ihh signaling pathway can be activated in condylar cartilage induced by bite-raising. The histological analysis showed TMJOA-like structural changes of condylar cartilage in experiment groups. Ihh, Smoothened (Smo), and Gli zinc finger transcription factors-1 (Gli-1) were activated in the experimental groups, and the expression levels increased significantly over time, whereas the sham control groups showed no fluctuation. Additionally, the expression levels of matrix metalloproteinase-13 (MMP-13) and cysteinyl aspartate specific proteinase-3 (Caspase-3) in the experiment groups increased in a time-dependent manner compared with the matched sham control groups. In conclusion, our results indicated that the Ihh signaling pathway may activate the occurrence of TMJOA by mediating the hypertrophy of chondrocytes, which may be an important regulatory mechanism and potential therapeutic target in the repair of condylar cartilage.


Asunto(s)
Mordeduras y Picaduras/metabolismo , Cartílago/metabolismo , Condrocitos/patología , Proteínas Hedgehog/metabolismo , Hipertrofia , Transducción de Señal , Envejecimiento , Animales , Huesos , Osteoartritis/etiología , Osteoartritis/patología , Ratas , Trastornos de la Articulación Temporomandibular/etiología , Trastornos de la Articulación Temporomandibular/patología
13.
J Craniofac Surg ; 30(7): e643-e645, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-31233003

RESUMEN

Pterygoid hamular bursitis is a rare craniofacial pain syndrome used to describe palatal and pharyngeal pain due to an enlarged pterygoid hamulus. The pterygoid hamulus is a hook-shaped bony process located bilaterally on each medial pterygoid plate of the sphenoid bone, posterior and medial to each maxillary tuberosity. These processes project downward and anterolaterally; serve as attachment for ligaments and a network of muscles. It can be palpated in patients with a finger palpating the posteromedial to maxillary tuberosity. The pathogenesis is elusive and varies from bursitis of tensor veli palatine, elongated pterygoid hamulus, persistent trauma to the mucosa overlying the pterygoid hamulus. The clinical features include strange chronic sensation, burning, swelling, and erythema of the pterygoid hamulus region. The pain often radiates to pharynx, ipsilateral face and sometimes radiating to temporal region making it difficult to diagnose from headache, temporomandibular disorders, and dental infections like pericoronitis. The anatomical neighboring structures in relation to oropharyngeal region may give a misleading diagnosis to dentist in case of pterygoid hamulus bursitis. The understanding of pterygoid hamulus anatomy and its relation to surrounding structures is necessary to get the correct diagnosis of the inflammatory or traumatic pain in oropharyngeal region.


Asunto(s)
Bursitis/diagnóstico por imagen , Dolor Facial/etiología , Enfermedades de la Boca/etiología , Hueso Esfenoides/patología , Trastornos de la Articulación Temporomandibular/patología , Bursitis/complicaciones , Femenino , Cefalea/etiología , Humanos , Persona de Mediana Edad
14.
Medicine (Baltimore) ; 98(22): e15830, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-31145325

RESUMEN

The purpose of this study was to evaluate the change in three-dimensional morphology and clinical symptoms of temporomandibular joint (TMJ) in class III dentofacial deformity patients postoperatively for 6 months after sagittal split ramus osteotomy (SSRO).Seventeen patients with skeletal Class III malocclusion and 10 asymptomatic volunteers (classified as Control group) were recruited for the study and underwent cone-beam computed tomography scanning. The geometries of the maxilla and mandible were reconstructed using MIMICS (Materialise, Leuven, Belgium). The morphologic measurements of the patients' TMJs were done before surgery and at 6-month follow-up - named as Pre and Post groups, respectively.The joint spaces (medial joint space, superior joint space, lateral joint space, anterior joint space, and posterior joint space) of the Control group were significantly greater than those of the Pre and Post groups (P < .05), and SSRO did not significantly change the TMJ morphology parameters. Five patients were found to have preoperative temporomandibular disorder (TMD) symptoms, and 3 of them were relieved at 6 months after surgery. Postoperative TMD symptom was observed in 1 patient without preoperative TMD symptom.SSRO did not markedly alter the TMJ morphology of the patients with mandibular prognathism. The effects of SSRO on TMD symptoms should be related to the type of deformity.


Asunto(s)
Maloclusión de Angle Clase III/cirugía , Osteotomía Sagital de Rama Mandibular/métodos , Adulto , Bélgica , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Maloclusión de Angle Clase III/complicaciones , Maloclusión de Angle Clase III/patología , Articulación Temporomandibular/anatomía & histología , Trastornos de la Articulación Temporomandibular/complicaciones , Trastornos de la Articulación Temporomandibular/patología , Adulto Joven
15.
Mol Med Rep ; 19(5): 4297-4305, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-30942403

RESUMEN

Traumatic temporomandibular joint ankylosis (TMJA) is a common disease and disorder of the temporomandibular joint (TMJ); however, its pathogenesis has yet to be completely elucidated. In the authors' previous studies, the lateral pterygoid muscle (LPM) was confirmed to exert a function in distraction osteogenesis (DO) during the healing of a condylar fracture, which resulted in the formation of excess bone. The aim of the present study was to investigate alterations in the expression of any associated genes via an Affymetrix GeneChip method. The traumatic TMJA model was fabricated by a condylar fracture in the TMJ area of sheep with either a dissected LPM (LPD) or normal (LPN). The untreated sheep served as a control. At 4­ and 12 weeks post­surgery, the condylar zone was isolated to perform the gene chip analysis, which was performed according to a standard Affymetrix protocol. The validated genes were further evaluated by reverse transcription­quantitative polymerase chain reaction (RT­qPCR). The gene chip analysis indicated that the LPN gene expression pattern was similar compared with the DO process, while LPD was similar to that of normal bone fracture healing. The validated genes were collagen type II α1 chain, C­type lectin domain family 3 member A, interleukin 1A, cartilage oligomeric matrix protein, chondromodulin (LECT1), calcitonin receptor (CALCR), transforming growth factor (TGF)­ß1, Fos proto­oncogene (FOS), bone γ­carboxyglutamate protein and bone morphogenic protein (BMP)7, among which, BMP7, LECT1, CALCR and FOS were confirmed by RT­qPCR. In conclusion, the present study demonstrated that LPM exerts a DO effect during the pathogenesis of traumatic TMJA, which may provide a novel target for preventing TMJA.


Asunto(s)
Anquilosis/etiología , Anquilosis/patología , Músculos Pterigoideos/metabolismo , Músculos Pterigoideos/patología , Trastornos de la Articulación Temporomandibular/etiología , Trastornos de la Articulación Temporomandibular/patología , Heridas y Traumatismos/complicaciones , Animales , Biología Computacional , Modelos Animales de Enfermedad , Perfilación de la Expresión Génica , Ontología de Genes , Análisis de Secuencia por Matrices de Oligonucleótidos , Reproducibilidad de los Resultados , Ovinos , Transcriptoma
16.
Dent Med Probl ; 56(1): 81-87, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30951623

RESUMEN

BACKGROUND: Temporomandibular disorders (TMD) are the most common reason of non-dental pain in the orofacial region. A clinical examination of the temporomandibular joint (TMJ) with additional imaging is the most recommended procedure for TMD diagnosis. OBJECTIVES: The objective of this study was to evaluate the association between TMD and the condylar position in the glenoid fossa by examining a group of patients suffering from TMD compared with a control group of patients without TMD. In this study, we used cone-beam computed tomography (CBCT) images for measurements. MATERIAL AND METHODS: Sixty-five symptomatic joints were selected from 48 patients with TMD. Sixtyfive joints were selected from a total of 96 asymptomatic joints in the control group. The superior, anterior and posterior area of the joint, and the steepness of the articular eminence were measured on the CBCT images. The data was analyzed using Pearson's χ2 test. RESULTS: The position of the condyle was significantly more posterior in the joints with TMD, and more anterior and centric in the asymptomatic joints. Statistically, the vertical position of the condyle and the steepness of the articular eminence had no significant relation with the occurrence of TMD. CONCLUSIONS: In this study, we observed that the posterior condylar position is more common in TMD patients, but it is not the reason for diagnosing TMD, and the reason of the posterior position of the condyle should be investigated before any decisions pertaining to treatment are made. In future, studies should focus on evaluating how the position of the condyle will change after the treatment of patients with TMD.


Asunto(s)
Cóndilo Mandibular , Trastornos de la Articulación Temporomandibular , Tomografía Computarizada de Haz Cónico , Humanos , Cóndilo Mandibular/diagnóstico por imagen , Articulación Temporomandibular/diagnóstico por imagen , Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/patología
17.
J Craniomaxillofac Surg ; 47(3): 438-442, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-30709759

RESUMEN

PURPOSE: Temporomandibular disorder (TMD) is a common problem in modern societies. Causes of TMD, as a consequence of condylar asymmetry index (CAI), are still a subject of controversy. The aim of the present study was to determine the possible correlations between the degree of condylar asymmetry and clinical dysfunction indices. MATERIALS AND METHODS: In this cross-sectional study, we used the Habets method to measure the CAI in 42 TMD patients. The participants' age and sex were matched in the control group. Patients were divided into mild, moderate and severe dysfunction groups based on Helkimo's clinical Di. The data were analyzed using Mann-Whitney U and Kruskal-Wallis tests. Also, the study attempted to assess the possibility of correlation between age and CAI. RESULTS: The CAI values of TMD patients were significantly higher than those of the control group (P = 0.001). However, CAI was not significantly different among TMD patients with different dysfunction index. There was no significant correlation between CAI and age (Spearman r = 0.655, P = 0.23). CONCLUSION: Based on the findings of the present study, patients with condylar asymmetry index are more susceptible to TMD. However, degree of the condylar asymmetry is not a criterion for TMD signs and symptoms.


Asunto(s)
Cóndilo Mandibular/anatomía & histología , Trastornos de la Articulación Temporomandibular/fisiopatología , Articulación Temporomandibular/fisiopatología , Adolescente , Adulto , Anciano , Tomografía Computarizada de Haz Cónico , Estudios Transversales , Femenino , Humanos , Masculino , Cóndilo Mandibular/diagnóstico por imagen , Cóndilo Mandibular/fisiopatología , Persona de Mediana Edad , Rango del Movimiento Articular , Trastornos de la Articulación Temporomandibular/patología , Adulto Joven
18.
PLoS One ; 14(1): e0209739, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30605460

RESUMEN

The purpose of this study was to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) for synovial chondromatosis (SC) of the temporomandibular joint (TMJ). In this study, 1415 patients (2109 joints) with temporomandibular joint disorders were collected between January 2012 and January 2017. All patients had a preoperative MRI examination and were treated by either arthroscopy or open surgery. On reviewing all MRI images, the number of "positive", "suspicious", and "negative" cases was collected afterwards, then the number of reported SC cases in operative data was recorded. The SPSS software was used to process all collected data. The kappa coefficient and ROC curve (AUC-index) with sensitivity and specificity were calculated to evaluate the consistency between MRI and arthroscopy/open surgery. Compared to 156 joints with SC detected by arthroscopy and open surgery, the results of MRI examination showed "positive" in 117 joints, and "negative" in 1938 joints. The number of "true positive", and "true negative" cases was 95, and 1897 respectively. The AUC-index was 0.86 (0.82-0.90) with a kappa coefficient of 0.74 (P < 0.05). In conclusion, the incidence of synovial chondromatosis diagnosed on MRI was in accordance with the arthroscopic and open surgery. Therefore, being a relatively non-invasive tool, MRI could be recommended as an effective diagnostic modality for SC.


Asunto(s)
Condromatosis Sinovial/diagnóstico por imagen , Imagen por Resonancia Magnética/métodos , Articulación Temporomandibular/patología , Adolescente , Adulto , Anciano , Artroscopía/métodos , China , Femenino , Humanos , Masculino , Persona de Mediana Edad , Curva ROC , Estudios Retrospectivos , Sensibilidad y Especificidad , Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/patología
19.
J Craniofac Surg ; 30(1): e15-e17, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30439736

RESUMEN

Orthopedic functional appliances are usually used to correct patients with retrognathic mandible. However, a part of cases have a trend of relapse after splint treatment. The aim of this study was to explore the role of temporomandibular joint disc position in functional appliance treatment. This study included 8 patients who had 1 joint anterior disc displacement with reduction (ADDWR) and the other joint anterior disc displacement without reduction (ADDWoR) confirmed by magnetic resonance imaging (MRI). Only the ADDWR joint could return to its normal position after wearing the anterior repositioning appliances (ARAs). Condylar morphology, condylar height, and disc length were evaluated 6 months after ARA treatment. The MRI showed that new bone appeared on 7 joints with ADDWR and on 1 joint with ADDWoR. The condylar height has increased 1.4 mm in the ADDWR group, while 0.1 mm shorter in the ADDWoR group. Disc length has increased from 8.5 to 8.7 mm in the ADDWR group and 0.4 mm shorter in the ADDWoR group after wearing the ARA. Our results suggested that it is noneffective of functional appliance used for class II malocclusion adolescents with ADDWoR and only a normal disc-condyle relationship benefits condyle growth by functional appliance. Thus it is important to reposition the disc as soon as possible.


Asunto(s)
Luxaciones Articulares/terapia , Ortodoncia Correctiva/instrumentación , Retrognatismo/terapia , Disco de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/terapia , Adolescente , Niño , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Maloclusión de Angle Clase II/terapia , Cóndilo Mandibular/diagnóstico por imagen , Cóndilo Mandibular/patología , Ferulas Oclusales , Recurrencia , Disco de la Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen
20.
Auris Nasus Larynx ; 46(4): 609-617, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-30497770

RESUMEN

OBJECTIVE: Pigmented villonodular synovitis occurring in the region of the temporomandibular joint is a rare disease, requiring a review of the treatment method, follow-up period. METHOD: Refer to the past literature, along with a retrospective search. RESULTS: An excision, including the skull base bone, was performed in all cases; however, recurrence was found in one case on which fractional excision was performed. Past reports have also indicated that en bloc resection was considered desirable. CONCLUSION: It is necessary to perform en bloc resection on patients with pigmented villonodular synovitis occurring in the region of the temporomandibular joint. Furthermore, due to reported cases of recurrence after a long period of time, follow-up observations of about 10 years are considered necessary.


Asunto(s)
Neoplasias de la Base del Cráneo/cirugía , Sinovitis Pigmentada Vellonodular/cirugía , Trastornos de la Articulación Temporomandibular/cirugía , Adulto , Artralgia/etiología , Femenino , Pérdida Auditiva/etiología , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Neoplasias de la Base del Cráneo/complicaciones , Neoplasias de la Base del Cráneo/diagnóstico por imagen , Neoplasias de la Base del Cráneo/patología , Sinovitis Pigmentada Vellonodular/complicaciones , Sinovitis Pigmentada Vellonodular/diagnóstico por imagen , Sinovitis Pigmentada Vellonodular/patología , Trastornos de la Articulación Temporomandibular/complicaciones , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/patología , Tomografía Computarizada por Rayos X
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