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1.
Braz. j. biol ; 83: e252656, 2023. tab, graf
Artículo en Inglés | MEDLINE, LILACS, VETINDEX | ID: biblio-1345534

RESUMEN

Abstract The genus Artemisia L. of the family Asteraceae is systematically very complex. The aim of this study was to evaluate taxonomic positions of taxa of the subgenus Artemisia belonging to the genus Artemisia in Turkey using some molecular techniques. In this molecular study, 44 individuals belong to 14 species of the subgenus Artemisia were examined. Analyses were performed on the combined dataset using maximum parsimony, maximum likelihood and Bayesian inference and Molecular parameters obtained from co-evaluations of sequences of the psbA-trnH, ITS and ETS regions of examined individuals were used in the phylogenetic tree drawing. According to the results of this study, two molecular groups have been formed based on the DNA sequence similarity of the species, but there are no obvious morphological characters corresponding to two molecular groups. There is no also agreement between the two molecular groups and the two morphological groups formed according to the hairiness condition of the receptacle of species. Due to the lack of molecular significance of their receptacles with or without hair, dividing of the subgenus Artemisia species into new subgenera or sections was not considered appropriate. Likewise, it has been found that with or without hair on the corolla lobes of the central hermaphrodite disc flowers have no molecular significance. It was found that there were no gene flow and hybridization between the 14 species of the subgenus Artemisia and these 14 species were found completed their speciation. This study is important as it is the first molecular based study relating with belong to subgenus Artemisia species growing naturally in Turkey. In addition, new haplotypes related to the populations of Turkey belonging to the subgenus Artemisia taxa were reported by us for the first time and added to the GenBank database.


Resumo O gênero Artemisia L. da família Asteraceae é sistematicamente muito complexo. O objetivo deste estudo foi avaliar as posições taxonômicas de táxons do subgênero Artemisia pertencentes ao gênero Artemisia na Turquia usando algumas técnicas moleculares. Neste estudo molecular, 44 indivíduos pertencentes a 14 espécies do subgênero Artemisia foram examinados. As análises foram realizadas no conjunto de dados combinado usando máxima parcimônia, máxima verossimilhança e inferência bayesiana e parâmetros moleculares obtidos a partir de coavaliações de sequências das regiões psbA-trnH, ITS e ETS de indivíduos examinados foram usados ​​no desenho da árvore filogenética. De acordo com os resultados deste estudo, dois grupos moleculares foram formados com base na similaridade da sequência de DNA das espécies, mas não há caracteres morfológicos óbvios correspondentes a dois grupos moleculares. Também não há concordância entre os dois grupos moleculares e os dois grupos morfológicos formados de acordo com a condição de pilosidade do receptáculo da espécie. Devido à falta de significado molecular de seus receptáculos com ou sem cabelo, a divisão das espécies do subgênero Artemisia em novos subgêneros ou seções não foi considerada apropriada. Da mesma forma, verificou-se que com ou sem cabelo nos lobos da corola das flores do disco hermafrodita central não tem significado molecular. Constatou-se que não houve fluxo gênico e hibridização entre as 14 espécies do subgênero Artemisia e essas 14 espécies concluíram sua especiação. Este estudo é importante porque é o primeiro estudo de base molecular relacionado com espécies pertencentes ao subgênero Artemisia crescendo naturalmente na Turquia. Além disso, novos haplótipos relacionados às populações da Turquia pertencentes ao subgênero Artemisia taxa foram relatados por nós pela primeira vez e adicionados ao banco de dados do GenBank.


Asunto(s)
Humanos , Artemisia/genética , Filogenia , Turquia , Teorema de Bayes , Hibridación Genética
2.
Braz. j. biol ; 83: e244494, 2023. tab, graf
Artículo en Inglés | MEDLINE, LILACS, VETINDEX | ID: biblio-1285607

RESUMEN

Abstract Since water is one of the essentials for life, the presence and quality of water in the habitat is extremely important. Therefore, water quality change and management of Lake Aygır was investigated in this study. For this, water samples collected from the lake and the irrigation pool between May 2015 and May 2016 were analyzed monthly. Spectrophotometric, titrimetric and microbiological methods were used to determine the water quality. According to some water quality regulations, HCO3, NH4, Cu, Mo, Br, fecal coliform and total suspended solid (TSS) values were found above the limit values. The other 29 parameters comply with Turkish national and international legislations. Lake Aygır was negatively affected by the surrounding settlements and agricultural activities. It is thought that the water resource should be monitored periodically and remedial studies should be done to prevent parameters exceeding the limits. However, Lake Aygır was generally suitable for drinking, use, fishing and irrigation.


Resumo Como a água é um dos elementos essenciais para a vida, a presença e a qualidade da água no habitat são extremamente importantes. Portanto, a mudança da qualidade da água e a gestão do lago Aygır foram investigadas neste estudo. Para isso, amostras de água coletadas no lago e na piscina de irrigação entre maio de 2015 e maio de 2016 foram analisadas mensalmente. Métodos espectrofotométricos, titulométricos e microbiológicos foram usados para determinar a qualidade da água. De acordo com alguns regulamentos de qualidade da água, os valores de HCO3, NH4, Cu, Mo, Br, coliformes fecais e total sólido suspenso (TSS) foram encontrados acima dos valores limite. Os outros 29 parâmetros estão em conformidade com as legislações nacionais e internacionais turcas. O lago Aygır foi afetado negativamente pelos assentamentos e atividades agrícolas ao redor. Pensa-se que o recurso hídrico deve ser monitorado periodicamente e estudos corretivos devem ser feitos para evitar que os parâmetros ultrapassem os limites. No entanto, o lago Aygır era geralmente adequado para beber, usar, pescar e irrigar.


Asunto(s)
Contaminantes Químicos del Agua/análisis , Lagos , Turquia , Calidad del Agua , Monitoreo del Ambiente , Explotaciones Pesqueras
3.
J Korean Med Sci ; 37(18): e142, 2022 May 09.
Artículo en Inglés | MEDLINE | ID: mdl-35535370

RESUMEN

BACKGROUND: Retraction is a process for correcting the literature and provides a barrier to the dissemination of publications that include major faults or false-misleading data. The aim of this study was to examine the characteristics of retracted articles in the biomedical field sourced from Turkey. METHODS: In this descriptive cross-sectional study, all retracted publications from Turkey on PubMed were listed without date restriction. Data covering the article title, authors, publication date, retraction date, time between publication and retraction dates (in months), journal, article type, country of the corresponding author, peer review timeline (in days), reason for retraction, and subject area of the retracted item were recorded. Citation data were obtained using the Scopus database. The altmetric attention scores of the articles were recorded. RESULTS: A total of 102 articles were listed and after the implementation of exclusion criteria, 86 articles were included for analysis. The first retracted article was published in 2000 (n = 1), while the most retracted articles were published in 2020 (n = 11). The median time lag between publication and retraction was 10.33 (0.73-144.06) months. The main factors causing retraction were plagiarism (n = 23), duplication (n = 22) and error (n = 17). The total number of citations was 695. A total of 224 citations were in the pre-retraction period and 471 citations were in the post-retraction period. CONCLUSION: The retracted article counts showed a rising trend over the years. The leading causes of retraction for articles from Turkey were plagiarism, duplication, and error. It was found that the articles continued to be cited after the retraction. Researchers in Turkey should be educated on retraction, particularly plagiarism and duplication. Strategies should be developed to prevent articles from being cited after retraction.


Asunto(s)
Investigación Biomédica , Mala Conducta Científica , Estudios Transversales , Humanos , Revisión por Pares , Plagio , Turquia
4.
J Wound Ostomy Continence Nurs ; 49(3): 226-232, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35523237

RESUMEN

PURPOSE: The purpose of this study was to assess the effectiveness of a pressure injury prevention care bundle. DESIGN: Prospective interventional study. SUBJECTS AND SETTING: Participants were 13 nurses and 104 patients cared for in the intensive care unit for at least 24 hours in a university hospital in Ankara, Turkey. METHODS: The study was conducted in 2 stages: the pre-care and post-care bundle stages. In the pre-care bundle stage, the pressure injury incidence of the patients was followed by the nurses. At the end of the third month, the researcher held a 1-day training program for the nurses about the care bundle use to promote correct implementation. In the post-care bundle stage, the nurses provided care according to the bundle. Compliance with the care bundle was assessed. Pressure injury incidence rates in the pre- and post-care bundle stages were compared. RESULTS: The incidence of stage 1 pressure injury was 15.11 (1000 patient-days) in the pre-care bundle stage and 6.79 (1000 patient-days) in the post-care bundle stage; this reduction was not statistically significant. CONCLUSIONS: A pressure injury prevention bundle was implemented in an intensive care unit, resulting in a decline in stage 1 pressure injuries.


Asunto(s)
Paquetes de Atención al Paciente , Humanos , Incidencia , Unidades de Cuidados Intensivos , Paquetes de Atención al Paciente/métodos , Estudios Prospectivos , Turquia/epidemiología
5.
BMC Infect Dis ; 22(1): 421, 2022 May 02.
Artículo en Inglés | MEDLINE | ID: mdl-35501702

RESUMEN

BACKGROUND: Immunization plays a vital role in child health and survival. Zero-dose children are coming increasingly into focus as part of the global Immunization Agenda 2030. Although the percentage of zero-dose children has decreased in Turkey over time, regional/socioeconomic inequalities persist. This study aims to analyze the trend in zero-dose children and the factors associated with this problem in Turkey in light of regional inequalities. METHODS: Six data sets (1993, 1998, 2003, 2008, 2013, and 2018) were pooled from the last six Turkey Demographic and Health Surveys (TDHSs). The vaccination module for children aged 12-35 months and variables related to household characteristics, socio-economic, cultural characteristics of parents, bio-demographic/health-related factors were taken from the DHS data. Binary logistic regression analyses were carried out by taking into account the complex sample design of surveys for Turkey in general, the East region, and other regions. RESULTS: Significant progress has been made in reducing the number of zero-dose children in Turkey over the last three decades, as it has dropped from 3.2 to 0.9%. The results of multivariate analyses revealed that survey year, household wealth, the mother's level of education, payment of bride price, mother's native language, place of delivery, and the number of antenatal care visits are associated with zero-dose children. Factors associated with zero-dose children also differ between the East region, and other regions. CONCLUSION: Public health programs targeting uneducated parents, poor households, lack of social security, Kurdish-speaking mothers, older mothers and those without antenatal care should be implemented to promote childhood immunization.


Asunto(s)
Inmunización , Madres , Niño , Escolaridad , Femenino , Humanos , Embarazo , Factores Socioeconómicos , Turquia/epidemiología
6.
Artículo en Inglés | MEDLINE | ID: mdl-35506980

RESUMEN

Eleven Gram-negative, curved and S-shaped, oxidase activity positive, catalase activity negative bacterial isolates recovered from faeces of Anatolian ground squirrel (Spermophilus xanthoprymnus) in the city of Kayseri, Turkey, were subjected to a polyphasic taxonomic study. Results of a genus-specific PCR revealed that these isolates belonged to the genus Helicobacter. The 16S rRNA gene sequence analysis revealed that the 11 isolates had over 99 % sequence identity with each other and were most closely related to Helicobacter ganmani CMRI H02T with 97.0-97.1 % identity levels and they formed a novel phylogenetic line within the genus Helicobacter. Faydin-H64 and Faydin-H70T strains were subjected to gyrA and atpA gene and whole genome sequence analyses. These two Helicobacter strains formed separate phylogenetic clades, divergent from other known Helicobacter species. The DNA G+C content and genome size of the strain Faydin-H70T were 35.3 mol% and 1.7 Mb, respectively. Average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strain Faydin-H70T and its close phylogenetic neighbour H. winghamensis ATCC BAA-430T were determined as 81.7 and 34.9 %, respectively. Pairwise sequence comparison showed that it was closely related to H. ganmani CMRI H02T however it shared the highest ANI and dDDH values with H. winghamensis ATCC BAA-430T. The data obtained from the polyphasic taxonomy approach, including phenotypic characterization and whole-genome sequences, revealed that these strains represent a novel species within the genus Helicobacter, for which the name Helicobacter turcicus sp. nov., is proposed with Faydin-H70T as the type strain (=DSM 112556T=LMG 32335T).


Asunto(s)
Helicobacter , Sciuridae , Animales , Técnicas de Tipificación Bacteriana , Composición de Base , Catalasa/genética , ADN Bacteriano/genética , Ácidos Grasos/química , Hibridación de Ácido Nucleico , Filogenia , ARN Ribosómico 16S/genética , Sciuridae/genética , Análisis de Secuencia de ADN , Turquia
7.
PLoS One ; 17(5): e0265684, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35512025

RESUMEN

The primary aim of this paper is to provide fresh evidence by testing the linkage between renewable energy consumption, financial development, and external debts in Turkey, using the Bootstrap ARDL test (McNown et al. 2018). The Bootstrap ARDL test is desired over traditional co-integration tests due to its ability to predict when resolving power and size limitation issues, and its corresponding features, which have not been addressed by traditional co-integration tests. The ARDL testing model is employed to investigate the coefficients amongst the selected variables. The findings from the ARDL test illustrate that there is a positive linkage between renewable consumption and Turkey's financial development. Furthermore, the outcomes illustrate that the coefficient of external debt is negative and significant. The results indicate that policymakers in Turkey must use the growth of the financial sector to minimize environmental degradation by promoting investment in energy and production through renewable energy sources. Furthermore, the research suggested that Turkey's policy-makers should reformulate the external debt policy to reduce the negative influence of external debt on sustainable energy development. This could potentially be achieved by removing any restrictions on international capital flow or barriers on foreign capital and foreign investment. Hence, the findings of this paper provide valuable conclusions and recommendations for Turkey heading to sustainable and green financial sector.


Asunto(s)
Dióxido de Carbono , Desarrollo Económico , Dióxido de Carbono/análisis , Deuda Externa , Energía Renovable , Turquia
8.
East Mediterr Health J ; 28(4): 272-280, 2022 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-35545908

RESUMEN

Background: Childhood road traffic injuries (RTIs) are a major public health problem worldwide. Reliable and valid information on childhood RTIs is essential to reduce the number of deaths. Aims: To determine the burden of deaths from RTIs in children aged 0-14 years from 2006 to 2019 in Turkey. Methods: This descriptive study examined the change in road traffic fatalities in children according to age, gender, road user type, and place. The necessary data for this study were obtained from the Turkish Statistical Institute. We used Microsoft Excel to analyse data from 4614 children who died from RTIs in 2006-2019 in Turkey. Results: The fatality rate from RTIs per 100 000 children aged 0-14 years increased from 1.41 in 2006 to 2.13 in 2019. The fatality rate for boys aged 0-9 and 10-14 years was higher than that for girls of the same age. The fatality rate for girls aged 0-9 years was higher than that for girls aged 10-14 years. The fatality rate for boys aged 10-14 years was higher than that for boys aged 0-9 years. Among the children who died from RTIs, 6.65% were drivers, 41.31% pedestrians and 52.04% passengers. Children lost their lives mostly as pedestrians on urban roads and as passengers on rural roads. Conclusion: The death of children due to RTIs is a significant health burden in Turkey.


Asunto(s)
Peatones , Heridas y Lesiones , Accidentes de Tránsito , Niño , Femenino , Humanos , Masculino , Turquia/epidemiología
9.
Clin Lab ; 68(5)2022 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-35536077

RESUMEN

BACKGROUND: It is critical to determine the importance of laboratory tests on the mortality of Covid-19 disease. Our aim is to search the effect of D-dimer, C-reactive protein (CRP), ferritin, and lymphocyte count in the algorithm organized by our Ministry of Health in the diagnosis and treatment of Covid-19 on mortality. METHODS: Two hundred forty-five patients admitted to the emergency department (ED) with a diagnosis of Covid-19 pneumonia between March 15, 2020, and May 15, 2020. CRP, D-dimer, ferritin, and lymphocyte count included in the algorithm of the Ministry of Health. The relationship between demographic, clinical, and laboratory characteristics of the patients and their thirty-day mortality was examined. RESULTS: A statistically significant difference was only found in coronary artery disease between the mortality rates and underlying diseases of the patients included in the study. When the diagnostic contribution of laboratory values to the mortality estimation was evaluated, the areas under the curve were the highest for CRP 0.782 (95% Cl 0.68 - 0.88), ferritin 0.740 (95% Cl 0.60 - 0.88), and D-dimer 0.738 (95% Cl 0.58 - 0.89). CONCLUSIONS: An increased serum CRP, D-dimer, ferritin levels, and low lymphocyte count as shown by Turkish Ministry of Health in Turkey are significant predictors of COVID-19 mortality.


Asunto(s)
COVID-19 , Biomarcadores , Proteína C-Reactiva/análisis , COVID-19/diagnóstico , Ferritinas , Productos de Degradación de Fibrina-Fibrinógeno , Humanos , Linfocitos/metabolismo , Pronóstico , Estudios Retrospectivos , Turquia/epidemiología
10.
JAMA Netw Open ; 5(5): e2211489, 2022 May 02.
Artículo en Inglés | MEDLINE | ID: mdl-35536574

RESUMEN

Importance: The cost-effectiveness of the Self-Help Plus (SH+) program, a group-based, guided, self-help psychological intervention developed by the World Health Organization for people affected by adversity, is unclear. Objective: To investigate the cost-utility of providing the SH+ intervention combined with enhanced usual care vs enhanced usual care alone for Syrian refugees or asylum seekers hosted in Turkey. Design, Setting, and Participants: This economic evaluation was performed as a prespecified part of an assessor-blinded randomized clinical trial conducted between October 1, 2018, and November 30, 2019, with 6-month follow-up. A total of 627 adults with psychological distress but no diagnosed psychiatric disorder were randomly assigned to the intervention group or the enhanced usual care group. Interventions: The SH+ program was a 5-session (2 hours each), group-based, stress management course in which participants learned self-help skills for managing stress by listening to audio sessions. The SH+ sessions were facilitated by briefly trained, nonspecialist individuals, and an illustrated book was provided to group members. Th intervention group received the SH+ intervention plus enhanced usual care; the control group received only enhanced usual care from the local health care system. Enhanced usual care included access to free health care services provided by primary and secondary institutions plus details on nongovernmental organizations and freely available mental health services, social services, and community networks for people under temporary protection of Turkey and refugees. Main Outcomes and Measures: The primary outcome measure was incremental cost per quality-adjusted life-year (QALY) gained from the perspective of the Turkish health care system. An intention-to-treat analysis was used including all participants who were randomized and for whom baseline data on costs and QALYs were available. Data were analyzed September 30, 2020, to July 30, 2021. Results: Of 627 participants (mean [SD] age, 31.3 [9.0] years; 393 [62.9%] women), 313 were included in the analysis for the SH+ group and 314 in the analysis for the enhanced usual care group. An incremental cost-utility ratio estimate of T£6068 ($1147) per QALY gained was found when the SH+ intervention was provided to groups of 10 Syrian refugees. At a willingness to pay per QALY gained of T£14 831 ($2802), the SH+ intervention had a 97.5% chance of being cost-effective compared with enhanced usual care alone. Conclusions and Relevance: This economic evaluation suggests that implementation of the SH+ intervention compared with enhanced usual care alone for adult Syrian refugees or asylum seekers hosted in Turkey is cost-effective from the perspective of the Turkish health care system when both international and country-specific willingness-to-pay thresholds were applied.


Asunto(s)
Refugiados , Adulto , Análisis Costo-Beneficio , Femenino , Humanos , Masculino , Años de Vida Ajustados por Calidad de Vida , Refugiados/psicología , Siria , Turquia
11.
Sci Rep ; 12(1): 6814, 2022 Apr 26.
Artículo en Inglés | MEDLINE | ID: mdl-35474245

RESUMEN

Plant genetic resources constitute the most valuable assets of countries. It is of great importance to determine the genetic variation among these resources and to use the data in breeding studies. To determine the genetic diversity among genotypes of Cucurbita pepo L. species of pumpkin, which is widely grown in Erzincan, 29 different pumpkin genotypes collected were examined based on the morphological parameters and molecular characteristics. SSR (Simple Sequence Repeat) markers were used to determine genetic diversity at the molecular level. The analysis of morphological characterization within genotypes showed a wide variability in morphological traits of plant, flower, fruit, and leaf. In the evaluation performed using SSR markers, all primers exhibited polymorphism rate of %100. Seven SSR markers yielded a total of 15 polymorphic bands, the number of alleles per marker ranged from 2 to 3, and the mean number of alleles was 2.14. Polymorphic information content (PIC) ranged from 0.06 (GMT-M61) to 0.247 (GMT-P41), and the mean PIC value per marker was 0.152. Cluster analysis using Nei's genetic distance determined that 29 genotypes were divided into 4 major groups. The present findings have revealed the genetic diversity among pumpkin genotypes collected from Erzincan province and may form the basis for further breeding studies in pumpkin.


Asunto(s)
Cucurbita , Cucurbita/genética , Genotipo , Repeticiones de Microsatélite/genética , Fitomejoramiento , Turquia
12.
Artículo en Inglés | MEDLINE | ID: mdl-35470223

RESUMEN

OBJECTIVES: This study aimed to determine the COVID-19 risk perceptions, vaccination intentions and predictive factors of family physicians and family healthcare staff working in primary care in Üsküdar. DESIGN: A cross-sectional study was performed using an online questionnaire to determine the demographic and general characteristics of the participants and their willingness to be vaccinated. SETTING: An online questionnaire was applied to family physicians and family health workers working in primary care family health centres in Üsküdar between 25 and 29 December 2020. Multivariate analysis was performed to identify independent predictors of the willingness of individuals to be vaccinated. PARTICIPANTS: Out of 323 health workers working in 44 family health centres in the district, a total of 276 health workers were reached, including 126 physicians (n=158, 79.7%) and 150 midwives/nurses (n=165, 90.9%) (response rate 85.4%). RESULTS: 50.4% (n=139) of the healthcare workers were willing to have the COVID-19 vaccine, 29% (n=80) were undecided and 20.7% (n=57) refused the vaccine. The rate of acceptance to be vaccinated was higher in physicians, in men and in those who had not received a seasonal influenza vaccination regularly each year. CONCLUSIONS: Half of the primary healthcare workers, one of the high-risk groups in the pandemic, were hesitant or refused to be vaccinated for COVID-19. Knowing the factors affecting the vaccine acceptance rates of healthcare professionals can be considered one of the most strategic moves in reaching the target of high community vaccination rates. For evidence-based planning in vaccination studies, there is a need to investigate the reasons for COVID-19 vaccine acceptance by healthcare workers at all levels.


Asunto(s)
COVID-19 , Vacunas contra la Influenza , Gripe Humana , COVID-19/prevención & control , Vacunas contra la COVID-19/uso terapéutico , Estudios Transversales , Personal de Salud , Humanos , Gripe Humana/prevención & control , Masculino , Turquia
13.
Mikrobiyol Bul ; 56(2): 288-303, 2022 Apr.
Artículo en Turco | MEDLINE | ID: mdl-35477231

RESUMEN

Additional or different test procedures can be applied to maximize transfusion safety by reducing the risk of transfusion-transmitted infections. Antibodies to hepatitis B core antigen (anti-HBc) is one of the most commonly used serologic marker in this context. The aim of the study was to analyse anti-Hbc test results performed within the scope of routine screening tests in our center and to examine the effect of the donor re-entry protocol established. A total of 57191 people who applied to Gülhane Regional Blood Center to donate blood between 2014-2019 were included in the study. All blood donations were screened for anti-HBc by chemiluminescense immunoassay (Architect i2000 SR, AXSYM, Abbott, IL, USA). Hepatitis B surface antibody (anti-HBs) and hepatitis B virus (HBV) deoxyribonucleic acid (DNA) (ABI Prism 7500 Real time PCR system, Applied Biosystems, USA) tests were performed in accordance with the donor recovery protocol for those who could be reached among those with positive for anti-HBc test results. Samples with > 100 IU/ml of anti-HBs levels and negative for HBV DNA test were included in the donor pool. Of the 57 191 blood donors involved in the study, 5125 (8.5%) were found as positive for anti-HBc. Of the donors, 54 035 (94.4%) were male and 3156 (5.5%) were female. The difference was found to be statistically significant in terms of gender distribution between the years of the study (p<0.001). The highest anti-HBc positivity rate (35.7%) was in the age group of 60 years and over while the lowest positivity rate (3.8%) was in the age group of 18-30 years (r= 0.549, p= 0.0001). The year with the highest anti-HBc seroprevalance (10.1%) was 2017, while the year with the lowest (7.9%) was 2014. The distribution of seropositivity over the years was statistically significant (p<0.001). In the study, anti-HBs and HBV-DNA test results of 439 donors were accessible and of which 301 (68.5%) were considered eligible to donate again according to the re-entry protocol. The isolated anti-HBc positivity and HBV-DNA positivity rates were 7.5% (33/430) and 0.2% (1/439) respectively,in blood donors to whom re-entry protocol was performed. The seroprevalance of anti-HBc below 10% during the six-year period in which the study was conducted is a critical data for the evaluation of this test within the scope of routine microbiological screening tests. Moreover, we have observed that donor losses due to the antiHBc testing can be significantly reduced with the implementation of donor re-entry protocols. Anti-HBc screening strategy should be decided by considering of HBV epidemiology, cost-effectivity and possible blood donor losses.


Asunto(s)
Selección de Donante , Hepatitis B , Adolescente , Adulto , ADN Viral/análisis , Femenino , Hepatitis B/diagnóstico , Hepatitis B/epidemiología , Hepatitis B/prevención & control , Anticuerpos contra la Hepatitis B , Humanos , Masculino , Persona de Mediana Edad , Turquia , Adulto Joven
14.
Mikrobiyol Bul ; 56(2): 339-348, 2022 Apr.
Artículo en Turco | MEDLINE | ID: mdl-35477235

RESUMEN

Leishmaniasis is a vector-borne disease that is caused by the protozoa of Leishmania genus. Leishmaniasis is endemic in tropical, subtropical, and large areas of the Mediterranean basin, and covers a total of 98 countries worldwide. It is estimated, according to the World Health Organization (WHO) data, that approximately 350 million people are at risk in these areas, and approximately 12 million people are infected. Increased drug resistance has been documented lately, in the treatment of leishmaniasis which causes almost 1.2 million new cases annually. Thus, interest in plant-derived active substances has increased in recent years, and new anti-leishmanial agents are investigated with in vitro studies. The aim of the present study was to investigate the anti-leishmanial effects of Prangos ferulacea and Ferula orientalis plant extracts collected from the rural areas of Sirnak province against Leishmania tropica. The water, chloroform, and ethanol extracts of the roots, stems, and fruits of P.ferulaceae and F.orientalis plants were obtained, and the cytotoxic activity tests of the extracts were performed. L.tropica isolate obtained from the Parasite Bank in Manisa Celal Bayar University in Turkey (MHOM/TR/2012/CBCL-LT) was grown on NNN and RPMI 1640 broth medium. The cytotoxicity of each extract on the L.tropica isolate was evaluated with the XTT test. Amphotericin B (AmpB) was used as the positive control, and the IC50 values were determined. The lowest IC50 values of the plant extracts were found to be as follows: P.ferulaceae root chloroform extract 36 µg/ml and fruit chloroform extract 20 µg/ml, F.orientalis root ethanol extract 2.5 µg/ml, and fruit ethanol extract 48 µg/ml, stem chloroform extract 24 µg/ml, and fruit chloroform extract 3.1 µg/ml. It was also determined in our study that only P.ferulaceae root ethanol extract showed cytotoxic activity on the WI-38 fetal lung fibroblast cell line at 65.19 µg/ml at 72 hours. This is the first study that assessed the anti-leishmanial activities of P.ferulaceae and F.orientalis plants that grow in high altitude areas of our country. It was determined that P.ferulaceae root ethanol extract and fruit chloroform extract had the lowest IC50 values among the 18 plant extracts that we examined for their anti-leishmanial activities. The outcomes of this study will be useful in further studies for the determination of active compounds in P.ferulaceae and F.orientalis plant extracts.


Asunto(s)
Antiprotozoarios , Ferula , Leishmania tropica , Leishmaniasis , Antiprotozoarios/farmacología , Antiprotozoarios/uso terapéutico , Cloroformo/farmacología , Cloroformo/uso terapéutico , Etanol/farmacología , Etanol/uso terapéutico , Humanos , Leishmaniasis/tratamiento farmacológico , Leishmaniasis/parasitología , Extractos Vegetales/farmacología , Extractos Vegetales/uso terapéutico , Turquia
15.
Anatol J Cardiol ; 26(4): 260-268, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35435837

RESUMEN

BACKGROUND: The Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study trial has been the largest study ever conducted among patients in Turkey regarding aspirin treatment. In the subgroup analysis of the hypertensive group of the Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study trial, we aimed to evaluate the physicians' adherence to current guidelines regarding their aspirin treatment preferences. METHODS: The Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study trial is a cross-sectional and multicenter study conducted among 5007 consecutive patients aged ≥18 years. The study population consisted of outpatients on aspirin treatment (80-300 mg). The patient data were obtained from 30 different cardiology clinics of 14 cities from all over Turkey. In this subgroup analysis, patients were divided into 2 groups: the hypertensive group (n=3467, 69.3%) and the group without hypertension (n=1540, 30.7%) according to the 2018 European Society of Cardiology/ European Society of Hypertension Guidelines for the Management of Arterial Hypertension. RESULTS: Aspirin use for primary prevention was higher in patients with hypertension compared to patients without hypertension [328 (21.3%); 1046 (30.2%); P < .001]. Treatment with a dose of 150 mg aspirin (n=172, 5%) was mostly preferred by internists for hypertensive patients (n =226, 6.5%); however, a daily dose of 80-100 mg aspirin therapy (n=1457, 94.6%) was mostly prescribed by cardiologists (n=1347, 87.5%) for patients without hypertension. CONCLUSION: Aspirin was found to be used commonly among patients with hypertension for primary prevention despite the current European Society of Cardiology Arterial Hypertension Guideline not recommending aspirin for primary prevention in patients with hypertension.


Asunto(s)
Hipertensión , Médicos , Adolescente , Adulto , Aspirina , Estudios Transversales , Humanos , Hipertensión/epidemiología , Turquia
16.
Anatol J Cardiol ; 26(4): 298-304, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35435841

RESUMEN

BACKGROUND: Silent cranial embolism due to carotid artery stenting has been demonstrated to cause dementia, cognitive decline, and even ischemic stroke. The purpose of this study was to compare the periprocedural asymptomatic cranial embolism rates of different stent designs used for extracranial carotid stenosis with diffusion-weighted magnetic resonance imaging. METHODS: A total of 507 consecutive patients who underwent carotid artery stenting at our center from December 2010 to June 2020 (mean age, 66.4 ± 9.5) were analyzed retrospectively. The patients were divided into 3 groups as open-cell stent (334 patients), closed-cell stent (102 patients), and hybrid-cell stent (71 patients) groups. Diffusionweighted magnetic resonance imaging was performed for the patients before and after carotid artery stenting and compared. The diffusion limitations of 3 stent groups on cranial diffusion-weighted magnetic resonance imaging were compared with one another. RESULTS: Periprocedural asymptomatic same-side microembolism, which was the primary endpoint of our study, was detected in 58 (17.4%) patients in the open-cell stent group, 6 (5.9%) patients in the closed-cell group, and 8 (11.3%) patients in the hybrid cell group, and overall in 72 (14.2%) patients. On diffusion-weighted magnetic resonance imaging, periprocedural asymptomatic same-side cranial embolism was found to be statistically significantly higher in the open-cell group compared to the other two groups (P=.011). CONCLUSIONS: The result of this study showed us that the rate of same-side cranial embolism detected on cranial diffusion-weighted magnetic resonance imaging after carotid artery stenting performed with open-cell stent was higher than those of the carotid artery stenting procedure performed with closed-cell and hybrid-cell stents.


Asunto(s)
Cardiología , Embolia , Accidente Cerebrovascular , Anciano , Arterias Carótidas , Hospitales , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Stents/efectos adversos , Accidente Cerebrovascular/etiología , Resultado del Tratamiento , Turquia/epidemiología
17.
BMC Pregnancy Childbirth ; 22(1): 340, 2022 Apr 19.
Artículo en Inglés | MEDLINE | ID: mdl-35439969

RESUMEN

OBJECTIVE: The aim of this study is to determine the frequency of neural tube defects (NTDs) and to examine the epidemiological characteristics of NTD related deaths in Turkey. METHODS: This nationwide descriptive study was included NTD related infant deaths, termination of pregnancy for fetal anomaly (ToPFA) and stillbirth cases registered in Death Notification System between 2014 and 2019, and patients diagnosed with NTD in the 2018 birth cohort. FINDINGS: In the 2018 birth cohort, there were 3475 cases of NTD at birth (27.5 per 10,000). The fatality rates for live-born babies with NTD in this cohort were 13.5% at first year, and 15.6% at the end of March, 2022. NTDs were associated with 11.7% of ToPFA cases, 2.5% of stillbirths and 2.8% of infant deaths in 2014-2019. NTD related stillbirth rate was 1.74 per 10,000 births, while NTD related ToPFA rate and infant mortality rate were 0.61 and 2.70 per 10,000 live births respectively. NTD-related stillbirth and infant mortality rate were highest in the Eastern region (3.64 per 10,000 births; 4.65 per 10,000 live births respectively), while ToPFA rate was highest in the North and West regions (1.17 and 0.79 per 10,000 live births respectively) (p < 0.05). Prematurity and low birth weight were the variables with the highest NTD related rates for stillbirths (11.26 and 16.80 per 10,000 birth), ToPFA (9.25 and 12.74) per 10,000 live birth), and infant deaths (13.91 and 20.11 per 10,000 live birth) (p < 0.05). CONCLUSION: NTDs are common and have an important place among the mortality causes in Turkey. Primary prevention through mandatory folic acid fortification should be considered both to reduce the frequency of NTD and related mortality rates.


Asunto(s)
Defectos del Tubo Neural , Mortinato , Femenino , Ácido Fólico , Humanos , Lactante , Muerte del Lactante , Recién Nacido , Defectos del Tubo Neural/epidemiología , Defectos del Tubo Neural/prevención & control , Embarazo , Prevalencia , Mortinato/epidemiología , Turquia/epidemiología
18.
J Infect Dev Ctries ; 16(3): 462-468, 2022 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-35404851

RESUMEN

INTRODUCTION: Patients infected with SARS-CoV-2 may present with varying clinical pictures. This study aimed to examine the relationship between viral load cycle threshold value, clinical prognosis and other laboratory parameters in initial swab samples on the day of hospitalization. METHODOLOGY: This retrospective and cross-sectional study included 112 patients, who were diagnosed with SARS-CoV-2 via the Bio-Rad CFX96 TouchTM system. Cycle threshold values for the RdRp gene obtained from reverse transcriptase polymerase chain reaction positive patients were recorded. RESULTS: The mean age of the 112 patients was 47.57 ± 17 years. No relationship was found in symptoms, pneumonia, oxygen need, follow-up in intensive care unit, and mortality between patient groups with cycle threshold values of < 30 and ≥ 30. Frequencies of thrombocytopenia (50%) and elevated LDH levels were higher in patients with cycle threshold values of ≥ 30 (p = 0.02 and p = 0.04, respectively). There was a weak but significant correlation between cycle threshold values and CRP levels (Pearson's r = 0.207, p = 0.029). CONCLUSIONS: Symptoms or clinical prognosis were not significantly related to the SARS-CoV-2 viral load levels tested at admission or for the first time within the scope of this study. Thrombocytopenia and elevated LDH rates were higher in patients with cycle threshold values of ≥ 30. A weak but significant correlation was found between the viral load and CRP levels. Large-scale studies are needed to further elucidate this subject matter.


Asunto(s)
COVID-19 , Trombocitopenia , Adulto , Estudios Transversales , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , SARS-CoV-2 , Turquia/epidemiología , Carga Viral
19.
Turk Kardiyol Dern Ars ; 50(3): 182-191, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35450842

RESUMEN

OBJECTIVE: Cardiac resynchronization therapy is the guideline-directed treatment option in selected heart failure with reduced left ventricular ejection fraction patients. Data regarding the contemporary clinical practice of cardiac resynchronization therapy in Turkey have been published recently. This sub-study aims to compare clinical and periprocedural characteristics between cardiac resynchronization therapy upgrade and de novo implantations. METHODS: Turkish arm of the Cardiac Resynchronization Therapy Survey-II was conducted between October 1, 2015, and December 31, 2016, at 16 centers. All consecutive patients who underwent an upgrade to cardiac resynchronization therapy system (n=60) or de novo cardiac resynchronization therapy implantation (n=335) were eligible. RESULTS: Distribution of age, gender, and heart failure etiology were similar in the 2 groups. Atrial fibrillation, valvular heart disease, and chronic kidney disease were more common in cardiac resynchronization therapy upgrade patients. Narrow intrinsic QRS duration and left ventricular ejection fraction being 75% in both groups, and only beta-blockers were prescribed at rates of >90% in both groups. CONCLUSION: Cardiac resynchronization therapy upgrades are performed with high procedural success rates and without excess periprocedural complication risk. Feared complications of cardiac resynchronization therapy upgrades due to the pre-existing device should not delay the procedure if indicated.


Asunto(s)
Terapia de Resincronización Cardíaca , Desfibriladores Implantables , Insuficiencia Cardíaca , Dispositivos de Terapia de Resincronización Cardíaca/efectos adversos , Desfibriladores Implantables/efectos adversos , Electrónica , Insuficiencia Cardíaca/epidemiología , Insuficiencia Cardíaca/terapia , Humanos , Volumen Sistólico , Resultado del Tratamiento , Turquia/epidemiología , Función Ventricular Izquierda
20.
J Pediatr Endocrinol Metab ; 35(5): 663-668, 2022 May 25.
Artículo en Inglés | MEDLINE | ID: mdl-35405047

RESUMEN

Phenylketonuria (PKU) is an autosomal recessive disorder of phenylalanine metabolism, mostly caused by PAH gene variants. The aim of this study was to identify the frequency of PAH gene variants in Turkish population with PKU. In 433 patients with PKU, PAH gene was examined using next generation sequencing (NGS) method. IVS10- 11G>A, p.R261Q, p.A300S, p.A403V, and p.T380 variants, which are the most common variants in this study, constituted 45,9% of the variants in our study. Nine novel variants p.A34V, K73Qfs*4, R157H, R261S, p.T266I, p.S310P, T328A, p.F351I, and K363N were identified. This study determines the most common PAH variants in Turkey and shows that PKU can be screened before marriage with the screening kits. Identification of the PAH gene variant spectrum is important for early diagnosis, understanding molecular mechanisms, clinical follow-up, treatment, and genetic counseling. And the novel variants found this study are important for further studies.


Asunto(s)
Fenilalanina Hidroxilasa , Fenilcetonurias , Alelos , Humanos , Mutación , Fenilalanina Hidroxilasa/genética , Fenilcetonurias/diagnóstico , Fenilcetonurias/epidemiología , Fenilcetonurias/genética , Turquia/epidemiología
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