RESUMEN
Novel biomedical materials provide a new horizon for the diagnosis/treatment of diseases and tissue repair in medical engineering. As the most abundant biomass polymer on earth, cellulose is characterized by natural biocompatibility, good mechanical properties, and structure-performance designability. Owing to these outstanding features, cellulose as a biomacromolecule can be designed as functional biomaterials via hydrogen bonding (H-bonding) interaction or chemical modification for human tissue repair, implantable tissue organs, and controlling drug release. Moreover, cellulose can also be used to construct medical sensors for monitoring human physiological signals. In this study, the structural characteristics, functionalization approaches, and advanced biomedical applications of cellulose are reviewed. The current status and application prospects of cellulose and its functional materials for wound dressings, drug delivery, tissue engineering, and electronic skin (e-skin) are discussed. Finally, the key technologies and methods used for designing cellulosic biomaterials and broadening their application prospects in biomedical fields are highlighted.
Asunto(s)
Materiales Biocompatibles , Celulosa , Humanos , Materiales Biocompatibles/química , Celulosa/química , Ingeniería de Tejidos , Prótesis e Implantes , Hidrogeles/químicaRESUMEN
Electronic skin (e-skin), a new generation of flexible electronics, has drawn interest in soft robotics, artificial intelligence, and biomedical devices. However, most existing e-skins involve complex preparation procedures and are characterized by single-sensing capability and insufficient scalability. Here, we report on a one-step strategy in which a thermionic source is used for the in situ molecularization of bacterial cellulose polymeric fibers into molecular chains, controllably constructing an ionogel with a scalable mode for e-skin. The synergistic effect of a molecular-scale hydrogen bond interweaving network and a nanoscale fiber skeleton confers a robust tensile strength (up to 7.8 MPa) and high ionic conductivity (up to 62.58 mS/cm) on the as-developed ionogel. Inspired by the tongue to engineer the perceptual patterns in this ionogel, we present a smart e-skin with the perfect combination of excellent ion transport and discriminability, showing six stimulating responses to pressure, touch, temperature, humidity, magnetic force, and even astringency. This study proposes a simple, efficient, controllable, and sustainable approach toward a low-carbon, versatile, and scalable e-skin design and structure-performance development.
RESUMEN
With the forthcoming of the post-COVID-19 and the ageing era, the novel biomaterials and bioelectronic devices are attracting more and more attention and favor. Cellulose as one of the most globe-abundant natural macromolecules has multiple merits of biocompatibility, processability, carbon neutral feature and mechanical designability. Due to its progressive advancement of multi-scale design from macro to micro followed by new cognitions, cellulose shows a promising application prospect in developing bio-functional materials. In this review, we briefly discuss the role of cellulose from the "top-down" perspective of macro-scale fibers, micro-scale nanofibers, and molecular-scale macromolecular chains for the design of advanced cellulose-based functional materials. The focus then turns to the construction and development of emerging cellulose-based flexible bioelectronic devices including biosensors, biomimetic electronic skins, and biological detection devices. Finally, the dilemma and challenge of cellulose-based bioelectronic materials and their application prospects in basic biology and medical care have been prospected.