Lichen planus is a chronic inflammatory, immunologically mediated mucocutaneous dermatosis. Lichen planus mucosae predominantly affects the oral cavity. Various trigger factors such as bacterial or viral infections, drugs or physical stimuli are discussed in the development of the disease. An association with human papillomavirus infections has also been described, but is not sufficiently proven. Lichen planus mucosae is considered as a premalignant condition, but the malignant transformation rate is low. The risk of malignant transformation is significantly increased in patients with oral lichen planus who smoke, drink alcohol or have hepatitis C. We describe two patients with locally advanced squamous cell carcinoma that developed on a longstanding oral lichen planus. Both cases were successfully treated with radical tumor resection, subsequent tissue reconstruction, and adjuvant radiation/radiochemotherapy.
Carcinoma, Squamous Cell , Lichen Planus, Oral , Lichen Planus , Mouth Neoplasms , Precancerous Conditions , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/therapy , Humans , Lichen Planus/diagnosis , Lichen Planus, Oral/diagnosis , Precancerous Conditions/diagnosis
Bendamustine Hydrochloride/administration & dosage , Debridement , Intraepithelial Lymphocytes/pathology , Lymphoma, T-Cell, Cutaneous/therapy , Skin/pathology , Administration, Cutaneous , Biopsy , Chemotherapy, Adjuvant/methods , Drug Administration Schedule , Humans , Lymphoma, T-Cell, Cutaneous/complications , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Necrosis/diagnosis , Necrosis/etiology , Necrosis/pathology , Necrosis/therapy , Neoplasm Staging , Receptors, Antigen, T-Cell, gamma-delta/analysis , Receptors, Antigen, T-Cell, gamma-delta/metabolism , Skin/diagnostic imaging , Treatment Outcome
is missing (Short communication).
Carcinoma in Situ/virology , Carcinoma, Squamous Cell/virology , Human papillomavirus 16/isolation & purification , Papillomavirus Infections/virology , Skin Neoplasms/virology , Adult , Aged , Biomarkers, Tumor/analysis , Carcinoma in Situ/chemistry , Carcinoma in Situ/pathology , Carcinoma in Situ/surgery , Carcinoma, Squamous Cell/chemistry , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Cyclin-Dependent Kinase Inhibitor p16/analysis , Female , Human Papillomavirus DNA Tests , Human papillomavirus 16/genetics , Humans , Immunohistochemistry , Papillomavirus Infections/pathology , Papillomavirus Infections/surgery , Skin Neoplasms/chemistry , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Skin Transplantation , Toes , Treatment Outcome
