RESUMEN
Cytomegalovirus (CMV) is a member of the ß-herpesviruses and is ubiquitous, infecting 50%-99% of the human population depending on ethnic and socioeconomic conditions. CMV establishes lifelong, latent infections in their host. Spontaneous reactivation of CMV is usually asymptomatic, but reactivation events in immunocompromised or immunosuppressed individuals can lead to severe morbidity and mortality. Moreover, herpesvirus infections have been associated with several cardiovascular and post-transplant diseases (stroke, atherosclerosis, post-transplant vasculopathy, and hypertension). Herpesviruses, including CMV, encode viral G-protein-coupled receptors (vGPCRs) that alter the host cell by hijacking signaling pathways that play important roles in the viral life cycle and these cardiovascular diseases. In this brief review, we discuss the pharmacology and signaling properties of these vGPCRs, and their contribution to hypertension. Overall, these vGPCRs can be considered attractive targets moving forward in the development of novel hypertensive therapies.
Asunto(s)
Enfermedades Cardiovasculares , Infecciones por Citomegalovirus , Hipertensión , Humanos , Citomegalovirus/metabolismo , Transducción de Señal , Infecciones por Citomegalovirus/epidemiología , Receptores Acoplados a Proteínas G/metabolismoRESUMEN
Infants at higher risk of bronchopulmonary dysplasia had increased rates of survival free of cerebral palsy after postnatal corticosteroid treatment in a previous metaregression of data from 14 randomized controlled trials. The relationship persists and is stronger in an updated analysis with data from 20 randomized controlled trials.
Asunto(s)
Corticoesteroides/efectos adversos , Displasia Broncopulmonar/prevención & control , Parálisis Cerebral/epidemiología , Corticoesteroides/uso terapéutico , Displasia Broncopulmonar/mortalidad , Modificador del Efecto Epidemiológico , Humanos , Recien Nacido Prematuro , Medición de RiesgoAsunto(s)
Biología Molecular/educación , Genética Médica , Autoinmunidad/genética , Diagnóstico Prenatal , Hemofilia A , Neoplasias/genética , Autoinmunidad/fisiología , Virosis , Enfermedades Transmisibles , Expresión Génica , Proteínas Recombinantes/uso terapéutico , Inmunidad/genética , ADN/genética , ARN/genética , Proteínas/genéticaAsunto(s)
Autoinmunidad/genética , Biología Molecular/educación , Genética Médica , ADN , ARN , Autoinmunidad/fisiología , Diagnóstico Prenatal , Enfermedades Transmisibles , Expresión Génica , Hemofilia A , Inmunidad/genética , Neoplasias/genética , Proteínas Recombinantes/uso terapéutico , Proteínas/genética , VirosisAsunto(s)
Autoinmunidad , Biología Molecular , Neoplasias/genética , Citología , Genética , Medicina , Terapia GenéticaRESUMEN
VI Congreso Argentino de Perinatología.10-12 set 1998. Buenos Aires
Asunto(s)
Atención PerinatalRESUMEN
VI Congreso Argentino de Perinatología.10-12 set 1998. Buenos Aires