[Relationship between histologic type and location of gastric adenocarcinoma in the Rebagliati Hospital]. / Relación entre tipo histológico y la localización del adenocarcinoma gástrico en el Hospital Rebagliati.

INTRODUCTION: There is epidemiologic evidence that suggest the relation between the histological type and location of gastric adenocarcinoma. Knowing that there is a predominance of Helicobacter pylori infection in the antral region and this is considered an environmental factor; make us suppose that there is a relation among intestinal type and distal location. OBJECTIVE: The aim of this study is to investigate the relation among histological type and location of gastric cancer, using the Lauren classification and the Japanese Gastric Cancer Association classification. METHOD: During the period between January 1st 2007 and December 31th 2010, 460 patients with the proven diagnostic of adenocarcinoma were admitted for surgical treatment at the gastric cancer specialized ward of Rebagliati National Hospital, Lima, Peru. RESULTS: Female was more frequent in diffuse type (39% vs. 33%; p: 0,153), the mean age among intestinal type is greater than diffuse type (70,7 vs. 62,6 años; p<0,001). There is association among poorly differentiated with upper location (22% vs. 12,7%; p = 0,009), signet cell with middle location (50% vs. 32,5%; p: 0,006), tubular type with distal location (57,6% vs. 42,8%; p: 0,002), intestinal type with distal location (58,3% vs. 44,1%; p: 0,004), and diffuse type with upper location (19,3% vs. 12,5%; p: 0,049). CONCLUSION: Adenocarcinomas histologically differentiated or intestinal type are associated with distal location. Poorly differentiated type and signet ring cell type are associated with upper and middle location respectively.

[Colon and rectum signet-ring cell carcinoma in the National Institute of Neoplastic Diseases]. / Carcinoma de celulas en anillo de sello del colon y recto en el Instituto Nacional de Enfermedades Neoplasicas.

OBJECTIVE: Primary signet ring cell carcinoma of the colon and rectum is a rare form of adenocarcinoma of the large intestine. The purpose of this study was define the incidence, natural history and relation with hereditary nonpolyposis colorectal cancer (HNPCC). METHODS: We reviewed the medical records and pathology of 28 patients with primary signet ring cell carcinoma of the colon and rectum seen at the Instituto de Enfermedades Neoplasicas (INEN), between 1991 and 2002. RESULTS: In the present study the incidence was 5.09% of large bowel adenocarcinoma. Most patients present with late stage disease (Dukes stage C and D). In most cases the signet ring cells diffusely infiltrated through all layers of the intestinal wall (Borrmann IV). Male to female ratio was of 1 : 1.5, mean age was 55.5 and median age was 57 years (range 11 - 83 years). CONCLUSIONS: Comparison of our data with the literature showed some differences that could be related with biological characteristics of our people and different applied inclusion criteria. We couldn't define the relation between HNPCC and primary signet ring cell carcinoma of the colon and rectum.

[Signet ring cell carcinoma of sigmoid colon in an adolescent patient. Report of a case]. / Carcinoma de Células en anillo de sello del Colon en Adolecentes.

We report the case of a female patient, sixteen years old who was diagnosed of signet ring cell carcinoma of sigmoid colon. We discuss the clinical presentation outstanding the early presentation of this unusual cancer.