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1.
Ulus Travma Acil Cerrahi Derg ; 28(3): 328-335, 2022 Mar.
Article in English | MEDLINE | ID: mdl-35485551

ABSTRACT

BACKGROUND: A total of 412 patients who applied to our clinic after a thoracic trauma between March 2010 and December 2019 were examined retrospectively In this study, late complications that developed as a result of blunt and penetrating thoracic traumas were evaluated and it was aimed to present a prediction for the management of these complications to physicians who are dealing with trauma. METHODS: Among the 412 thoracic trauma cases, 62 cases (15.04%) who developed late-term complications which constituted the main theme of this study were evaluated in terms of age, gender, the type of trauma, the cause of trauma, thorax, and concomitant organ pathologies that developed when the trauma first occurred, the late-term complications, and the treatment methods for them while considering mortality. RESULTS: Of 62 patients with late complications due to thoracic trauma, 47 (75.80%) were male, 15 (24.20%) were female, and the average age was 56.98±21.22. When the trauma type of the patients who developed posttraumatic late-term complications was evaluated, blunt traumas were seen in 90.33% (n=56) of the cases, whereas penetrating traumas were seen in 9.47% (n=6). Traffic accidents were the most common cause in blunt trauma cases (66.07%), whereas pointed and sharp-edged weapon injuries were the most common in penetrating traumas (83.33%). The most common thorax pathology is pulmonary contusion (75%) in blunt traumas and hemopneumothorax in penetrating traumas (66.66%). When the groups were analyzed separately, the most common late-term complication for penetrating traumas was retained hemothorax (66.66%), while pneumonia was the most common (41.07%) in blunt trauma cases. Video-assisted thoracoscopic surgery was performed in seventeen patients with retained post-traumatic hemothorax and thoracotomy was performed in eight cases. Seven patients with post-traumatic empyema underwent thoracoscopy, and four patients underwent decortication with thoracotomy. Six of the patients who developed late-term complications died. The mortality rate is 9.67%. Pneumonia was detected as a late complication type in 83.33% of cases with mortality. CONCLUSION: It will be appropriate for the physicians who are interested in trauma to determine the treatment modalities of the patients by considering many factors such as the age of the patient and the trauma type in terms of the late complications that they will not be able to detect at first glance.


Subject(s)
Thoracic Injuries , Wounds, Nonpenetrating , Wounds, Penetrating , Adult , Aged , Female , Hemothorax/epidemiology , Hemothorax/etiology , Humans , Male , Middle Aged , Retrospective Studies , Thoracic Injuries/surgery , Wounds, Nonpenetrating/surgery , Wounds, Penetrating/complications , Wounds, Penetrating/surgery
2.
Acta Trop ; 206: 105451, 2020 Jun.
Article in English | MEDLINE | ID: mdl-32201196

ABSTRACT

Cystic echinococcosis (CE) is a zoonotic infection and could lead to significant public health problems. The genetic diversity of CE includes five species: E. granulosus sensu stricto (s.s.) (G1-G3), Echinococcus equinus (G4), Echinococcus ortleppi (G5), Echinococcus canadensis genotypic cluster (G6, G7, G8 and G10, with the doubtful G9) and the Echinococcus felidis (lion strain). The species are important in epidemiology, pathology, control, prevention measures and vaccine/drug designs. The aim of the present study was to determine the E. granulosus genotypes in humans in the Van province in east of Turkey. In total, 102 echinococcal cysts were collected from operated patients. Genomic analyses were conducted with PCR-RFLP of the rDNA internal transcribed spacer 1 (ITS1) fragment and partial PCR sequencing of the cytochrome c oxidase subunit 1 (cox1) mitochondrial DNA gene region. In total, DNAs of 96 isolates could be extracted, unfortunately six extractions failed. The PCR-RFLP analysis findings were identical in all isolates. Two bands were observed at approximately 300 bp and 600 bp. All profiles corresponded to the G1-G3 strain. Also, 446 bp amplified gene regions were observed for cox1. Out of 20 samples, alignment of 16 sequences exhibited a total identification (100%) of granulosus sensu stricto (G1/G3). Of 16 samples, 8 were obtained in the lung and 12 were obtained in the liver; 8 belonged to male and 12 belonged to female patients. Other four samples exhibited one nucleotide substitution at different positions. Four samples had one nucleotide substitution at different positions. We detected single nucleotide variations in TRH1, TRH67, TRH85 and TRH89 isolates at the positions C240T; G330T; G211A and T157C, respectively. In conclusion, the present study was the first comprehensive molecular investigation on genetic characterization of human CE isolates in Van region. The findings demonstrated that E. granulosus s.s. was the dominant species, which indicated that the sheep-dog cycle was the source in human infections. And, probably, it would be possible to describe these mutations as "Turkey" or "lung" variants. In addition to contributing molecular epidemiological data, the present results should be considered when designing and implementing E. granulosus control programs.


Subject(s)
Echinococcosis, Hepatic/parasitology , Echinococcosis, Pulmonary/parasitology , Echinococcus/genetics , Animals , Echinococcus/classification , Female , Humans , Male
3.
Tuberk Toraks ; 67(2): 146-148, 2019 Jun.
Article in English | MEDLINE | ID: mdl-31414647

ABSTRACT

The Ewing's sarcoma family of tumors (ESFT) incorporates both the wellrecognized primary bone and the extraskeletal soft tissue sarcomas. Primitive neuroectodermal tumors (PNET) and ESFT have a similar neural phenotype and can be considered in the same entity. Here, we will present 28 years old patient with Ewing Sarcoma. Patient was admited chest pain. Chest radiograph showed a suspicious lesion in the left paracardiac area. Computed tomography (CT) scan and positron emission tomography (PET)/CT result were compatible with malignant tumor. The patient was underwent surgical resection as the bronchoscopic result couldn't a malignant finding and pathological finding was detected as Ewing's sarcoma. Ewing's sarcoma should be considered in patients who are very fast growing in the lungs, are properly confined and suspected of malignancy in FDG-PET/CT.


Subject(s)
Lung Neoplasms/diagnostic imaging , Sarcoma, Ewing/diagnostic imaging , Adult , Diagnosis, Differential , Humans , Lung Neoplasms/pathology , Male , Neuroectodermal Tumors, Primitive/diagnostic imaging , Positron Emission Tomography Computed Tomography , Radiography , Sarcoma, Ewing/pathology , Tomography, X-Ray Computed
5.
Gen Thorac Cardiovasc Surg ; 67(6): 530-536, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30604240

ABSTRACT

OBJECTIVE: Destroyed lung is whole lung destruction secondary to chronic or recurrent lung infections. This clinical condition can result in irreversible changes in the lung parenchyma. In this study, we aimed to evaluate patients undergoing pneumonectomy with a diagnosis of lung destruction in terms of surgical technique, post-operative morbidity and mortality, and long-term outcomes. METHODS: A total of 32 patients that underwent pneumonectomy due to a destroyed lung between 2005 and 2017 were retrospectively reviewed. Age, gender, presenting symptoms, etiologies, localization of the destruction, pre-operative medical history, pre- and post-operative respiratory function tests, intraoperative complications and bleeding volume, morbidity and mortality, length of hospital stay, and long-term follow-up outcomes were reviewed for each patient. RESULTS: The study included 32 patients with a mean age of 31.7 ± 10.8 years. All the patients presented with persistent cough, whereas sputum production was presented by 25, hemoptysis by 18, and chest pain by 11 patients. The underlying primary diseases included nonspecific bronchiectasis in 20 (62.5%), tuberculosis in 9 (28.1%), left pulmonary hypoplasia accompanied by Bochdalek hernia in 2 (6.2%), and aspiration of a foreign body lodged in the left main bronchus in 1 (3.1%) patient. Mean operative time was 220.6 ± 40.2 min and mean perioperative bleeding was 450.9 ± 225.7 ml. Post-operative complications occurred in 14.2% of the patients, most commonly including atelectasis associated with stasis of secretions and wound site infection. Mean post-operative hospital stay was 11.8 ± 2.8 days and mean follow-up period was 35.5 ± 28.3 months. A significant clinical improvement was observed in 81.2% of the patients post-operatively. CONCLUSIONS: Favorable long-term outcomes were obtained in our patients through careful patient selection and appropriate pre-operative work-up and surgical technique.


Subject(s)
Lung Diseases/surgery , Pneumonectomy/methods , Adolescent , Adult , Bronchiectasis/diagnosis , Child , Female , Hemoptysis/diagnosis , Humans , Length of Stay , Lung Diseases/diagnosis , Male , Middle Aged , Postoperative Complications/etiology , Postoperative Period , Pulmonary Atelectasis/diagnosis , Respiratory Function Tests , Retrospective Studies , Young Adult
6.
Turk Gogus Kalp Damar Cerrahisi Derg ; 27(2): 206-211, 2019 Apr.
Article in English | MEDLINE | ID: mdl-32082854

ABSTRACT

BACKGROUND: This study aims to assess the prolidase activity, nitric oxide levels, and oxidative status in patients with esophageal squamous cell carcinoma. METHODS: The study included 30 patients with esophageal squamous cell carcinoma (11 males, 19 females; mean age 61±3 years; range, 28 to 77 years) and 30 healthy controls (10 males, 20 females; mean age 58±5 years; range, 31 to 73 years). Serum prolidase activity, total antioxidant capacity, total oxidant status, and nitric oxide levels were measured. In addition, the oxidative stress index was calculated. RESULTS: Prominently elevated serum prolidase activity, oxidative stress index values, total oxidant status, and nitric oxide levels were detected in the patient group (p<0.05). Lower total antioxidant capacity levels were observed in the patient group (p<0.05). CONCLUSION: Increased oxidant status with increased nitric oxide levels and prolidase activity were found in esophageal squamous cell carcinoma patients. Impairment of antioxidant mechanism with increased prolidase activity and nitric oxide levels may have a crucial role in the etiopathogenesis of esophageal squamous cell carcinoma.

7.
Arch Med Sci ; 14(6): 1404-1415, 2018 Oct.
Article in English | MEDLINE | ID: mdl-30393496

ABSTRACT

INTRODUCTION: The effective control of malignant pleural effusion (MPE) is of paramount importance in the treatment of patients with disseminated cancer. In this study, we compared two different approaches (early pleurodesis versus late pleurodesis) to MPE. MATERIAL AND METHODS: Patients (188 cases) whose primary tumor type was known and who were confirmed to have MPE, were included in the study and were separated into two groups. One group consisted of patients who were asymptomatic and who underwent early phase pleurodesis (group I, n = 79). The other group (group II, n = 109) was composed of patients who were symptomatic and whose pleurodesis was performed later. In all cases, pleural effusion was evaluated by means of direct radiography. Computed tomography was performed with the goal of confirming the parenchymal or mediastinal lesions accompanying the pleural fluid. RESULTS: The rate of complete success in group I cases was observed to be higher, while the rate of recurrence was lower (p = 0.001 and p = 0.002, respectively) than group II. In multiple logistic regression analysis, co-morbidities and the group that patient belong were found to be significant in terms of pleurodesis success (p = 0.02 and p = 0.03). There was a significant difference in survival time between group I and group II, with group I exhibiting longer average survival time (log rank test p < 0.001). CONCLUSIONS: We observed that the success rate was lower and the rate of recurrence higher in the late pleurodesis group, whose members already had greater volumes of pleural effusion.

8.
J Pak Med Assoc ; 68(8): 1193-1198, 2018 Aug.
Article in English | MEDLINE | ID: mdl-30108385

ABSTRACT

OBJECTIVE: To compare the frequency of oesophageal foreign bodies during the month of Eid-ul-Adha with other months. METHODS: This retrospective study was conducted at YüzüncüYil University Hospital, Van, Turkey, during 2012-16, and comprised individuals who were treated for bone and/or meat fragments lodged in the oesophagus. The number of hospital admissions with diagnosis of oesophageal foreign bodies during Eid-ul-Adha episodes were extricated and compares with similar date for the other months.Minitab 13 was used for statistical computations. RESULTS: Among the 289 cases in the study, a pronounced increase in the number of patients was observed during Eid-ul-Adha, with the most frequent symptoms in 263(91%) patients being dysphagia and odynophagia. The number of patients with oesophageal foreign bodies diagnosed during Eid-ul-Adha were significantly higher than the other months (p<0.05). CONCLUSIONS: An increase in cases of oesophageal foreign bodies was found during Eid-ul-Adha.


Subject(s)
Esophagus , Foreign Bodies/etiology , Islam , Meat/adverse effects , Aged , Deglutition Disorders/etiology , Female , Foreign Bodies/complications , Foreign Bodies/epidemiology , Holidays/statistics & numerical data , Humans , Male , Middle Aged , Retrospective Studies , Turkey/epidemiology
9.
Dis Markers ; 2018: 3610239, 2018.
Article in English | MEDLINE | ID: mdl-29849819

ABSTRACT

OBJECTIVE: Elevated serum Mac 2-binding protein (M2BP) levels have been observed in some cancers. As far as we know, its importance has not been investigated in esophageal squamous cell carcinoma (ESCC). The investigated problem of this study was to evaluate whether there was a difference between ESCC patients and the control group in terms of M2BP. Also, we evaluated the diagnostic performance of serum M2BP alone or in combination with the CEA for patients with ESCC. MATERIAL AND METHODS: Blood serum samples were collected from 50 healthy donors and 150 patients with ESCC. M2BP levels of all 200 samples were quantified by ELISA (enzyme-linked immunosorbent assay). Patients who had been diagnosed with ESCC and did not have any other malignancies were enrolled to study. RESULTS: The two groups did not significantly differ in terms of age (p > 0.05). In the control group, the mean serum M2BP level was 14.97 ± 3.46 ng/mL. The mean serum M2BP level of the ESCC patients was 176.65 ± 22.14 ng/mL. The serum M2BP level was significantly higher in patients with ESCC than in the control group (p < 0.001). Gender was also comparable in both groups (p = 0.695). CONCLUSIONS: Our analysis demonstrated that this marker may be associated with the mechanism of the disease. Despite that serum M2BP is not a specific marker for ESCC, it can be used as an adjuvant biomarker for the diagnosis of ESCC.


Subject(s)
Antigens, Neoplasm/blood , Biomarkers, Tumor/blood , Carcinoma, Squamous Cell/blood , Esophageal Neoplasms/blood , Adult , Aged , Carcinoma, Squamous Cell/pathology , Case-Control Studies , Esophageal Neoplasms/pathology , Female , Humans , Male , Middle Aged
10.
Turkiye Parazitol Derg ; 39(3): 209-11, 2015 Sep.
Article in Turkish | MEDLINE | ID: mdl-26470927

ABSTRACT

OBJECTIVE: This study was performed in order to contribute the data on the prevalence of cystic echinococcosis (CE) in Turkey and to reveal this parasitosis problem in Van province. METHODS: Blood samples of 2642 patients (1214 men, 1428 women; 506 of them 0-13 age, 2136 of them 14 and over age group), which were sent with suspected CE to Parasitology Laboratory from various policlinics of Yüzüncü Yil University Medical Faculty, between the dates of 01.09.2005 and 01.09.2013, were evaluated for CE by using Enzyme-Linked Immunosorbent Assay (ELISA) (R-Biopharm, Germany; IgG) method. RESULTS: 801 (30.3%) of examined blood samples of these patients were found positive for this parasitosis. Seropositivity was found 31.9% of men, 29% of women; 33.4% of 0-13 age group, 29.6% of 14 and over age group in the study. Cysts, which were obtained from operated seropositive patients, were confirmed that unilocular cysts as pathological. CONCLUSION: As a result, it was seen that CE is continued to be a major public health problem in Van province and it was appear that comprehensive protection and control programs should be carry out to struggle this disease.


Subject(s)
Antibodies, Helminth/blood , Echinococcosis/epidemiology , Echinococcus granulosus/immunology , Adolescent , Adult , Age Distribution , Animals , Child , Child, Preschool , Echinococcosis/immunology , Enzyme-Linked Immunosorbent Assay/methods , Female , Hospitals, University , Humans , Infant , Male , Prevalence , Retrospective Studies , Sex Distribution , Turkey/epidemiology , Young Adult
11.
European J Pediatr Surg Rep ; 3(1): 15-7, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26171308

ABSTRACT

Percutaneous nephrolithotomy (PNL) is the first-line treatment in large, multiple stones and lower calyceal stones. Majority of complications associated with PNL are minor and clinically insignificant. It was seen that distal piece (2 cm in size) of ureter catheter observed at pelvis was found at the parenchyma of left lung on the perioperative fluoroscopy in the patient undergoing PNL for right kidney stone. We presented this complication to stress that a foreign body can pass into circulation presumably through venous injury and can migrate to the lung.

12.
Turk Thorac J ; 16(4): 180-184, 2015 Oct.
Article in English | MEDLINE | ID: mdl-29404100

ABSTRACT

OBJECTIVES: Hydatid cysts are sometimes confused with different pathologies, and problems arise in their diagnosis and treatment. In this study, cases that are followed up with a diagnosis of lung malignancy and that are detected to have hydatid cysts were retrospectively examined. MATERIAL AND METHODS: Seven patients with hydatid cysts whose clinical and radiological features were consistent with lung malignancy were retrospectively examined between 2010 and 2014 regarding sex, age, symptoms, diagnostic methods, surgical procedures performed, and postoperative complications. In the diagnosis of the patients, radiological diagnostic methods such as chest radiography, thoracic computed tomography (TCT), and positron emission tomography+computed tomography (PET-CT) as well as invasive diagnostic methods such as bronchoscopy, fine-needle aspiration biopsy, thoracentesis, and video-assisted thoracoscopic surgery were used. RESULTS: The average diameter of the lesions was determined as 4.14±1.57 cm in TCT. Maximum standardized uptake value (SUV max) was measured as 8.77±3.41 (5.4-15.1) in the PET-CT analysis. Bronchoscopy, fine-needle aspiration biopsy, and thoracentesis yielded no results. Definitive diagnosis was established by performing thoracotomy and video-assisted thoracoscopic surgery. CONCLUSION: Pulmonary hydatid cysts can appear as malignant diseases such as lung cancer as well as infectious pathologies such as tuberculosis or benign pathologies. Radiologically, it should be kept in mind that pulmonary hydatid cysts can mimic many pulmonary pathologies, particularly malignancies. Necessary examinations towards its differential diagnosis must be performed in the preoperative period.

13.
Brain Res Bull ; 92: 84-8, 2013 Mar.
Article in English | MEDLINE | ID: mdl-21803127

ABSTRACT

This study was designed to investigate the effect of crush and axotomy on oxidative stress and some trace element levels in phrenic nerve of rats. Eighteen male Wistar-albino rats were divided randomly into three groups, each consisting of 6 rats. The animals in the first group were not crushed or axotomized and served as control. Phrenic nerves of the animals in the second and third groups were crushed and axotomized, respectively. Animals in all groups were sacrificed one week after the crush or axotomy, and degenerated phrenic nerves were harvested for the determination of tissue oxidative stress and trace element levels. Lipid peroxidation product malondialdehyde and antioxidant glutathione levels increased in both crushed and axotomized phrenic nerves. The activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase were lower in crushed and axotomized phrenic nerves than in controls. The levels of Fe, Pb, Mn, Cd and Co increased, and Mg and Cu levels decreased in crushed phrenic nerves. The levels of Fe and Mg decreased, Pb and Co levels increased in axotomized phrenic nerves. It was concluded that crushing or axotomizing the phrenic nerves may produce oxidative stress by increasing lipid peroxidation and decreasing antioxidant enzyme activities. It was also concluded that while crush to phrenic nerves causes accumulation of minerals, axotomizing phrenic nerves causes depletion of minerals in the tissues.


Subject(s)
Oxidative Stress/physiology , Peripheral Nervous System Diseases/metabolism , Peripheral Nervous System Diseases/pathology , Peripheral Nervous System Diseases/physiopathology , Phrenic Nerve/metabolism , Trace Elements/metabolism , Animals , Axotomy/methods , Catalase/metabolism , Disease Models, Animal , Glutathione/metabolism , Glutathione Peroxidase/metabolism , Lipid Peroxidation/physiology , Male , Malondialdehyde/metabolism , Nerve Crush/methods , Peripheral Nervous System Diseases/etiology , Rats , Rats, Wistar , Superoxide Dismutase/metabolism
14.
Turkiye Parazitol Derg ; 36(2): 65-70, 2012.
Article in Turkish | MEDLINE | ID: mdl-22801908

ABSTRACT

UNLABELLED: Common sociocultural behavior and common hygienic habits may lead lead to the existence of parasites in many people living in the same environment. The main objective of this study was to investigate the incidence of disease in individuals sharing the same living space. METHODS: A total of 102 individuals with no previous diagnosis of hydatid cyst and sharing the same living space with 40 patients and who were operated on between 2007 and 2011 were included in the study. All the patients were evaluated with chest radiography, abdominal ultrasonography and serological tests. RESULTS: Thirteen (12.74%) of the 102 individuals who were screened for hydatid cyst were found to have hydatidosis. One patient with pulmonary hydatid had false negative results in serological assays. IHA was negative in two patients, one with hepatic and splenic hydatid cyst, and one with isolated hepatic hydatid cyst; the diagnosis was confirmed by a positive ELISA in both cases. CONCLUSION: This study has aimed to demonstrate the risk of developing hydatid cyst in individuals sharing the same living space as patients with hydatid cysts, unlike the screening tests performed in endemic areas. A rate of 12.74% is considerable when applied to larger populations.


Subject(s)
Echinococcosis, Hepatic/diagnosis , Echinococcosis/diagnosis , Splenic Diseases/diagnosis , Adolescent , Adult , Animals , Echinococcosis/diagnostic imaging , Echinococcosis, Hepatic/diagnostic imaging , Echinococcus/immunology , Echinococcus/isolation & purification , Female , Humans , Lung/diagnostic imaging , Male , Middle Aged , Radiography, Thoracic , Serologic Tests , Splenic Diseases/diagnostic imaging , Ultrasonography , Young Adult
15.
Int J Clin Exp Med ; 5(1): 64-71, 2012.
Article in English | MEDLINE | ID: mdl-22328950

ABSTRACT

BACKGROUND: In this clinical retrospective study, we aimed to investigate our experinces and whether capitonnage is an effective therapy method for a pulmonary hydatid cyst or not. MATERIAL AND METHODS: A total of 412 patients with hydatid cyst operated in our hospitals were evaluated retrospectively between January 2003 and January 2011. In order to create a study group to compare the hydatid cyst operations with and without capitonnage in our department, 60 uncomplicated patients with the diagnosis of hydatid cyst who had undergone operations in the previous two years, were divided into two groups; while no capitonnage was performed and bronchial leaks were closed in one group, standard cystotomy plus the capitonnage operation was performed in the second group. All patients underwent surgery. RESULTS: In many patients, one or more symptoms were present on admission (339 cases, 82%). Perforated cysts/ nonperfore cysts rate was statistically significant (p = 0.001). There was no statistical difference between patients with or without capitonnage in terms of morbidity rates between patients with or without capitonnage (p = 0.041). However, morbidity rates were higher in the group without capitonnage. There were found statistically significant between capitonnage and non capitonnage groups in terms of length of hospital stay (p=0.001). CONCLUSIONS: In the surgical treatment, resection should be avoided as much as possible. An average time of 3-5 minutes should be allocated and capitonnage should be performed. Capitonnage should always be performed in the surgical treatment of hydatid cyst. We believe that povidone iodine per se provides sufficient disinfection.

16.
Muscle Nerve ; 45(3): 412-5, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22334176

ABSTRACT

INTRODUCTION: In this study we investigated the effect of crush and axotomy of phrenic nerves on oxidative stress and antioxidant enzyme activities in rat diaphragm muscle. METHODS: The animals in the first group were not crushed or axotomized and served as controls. Phrenic nerves of the rats in the second and third groups were crushed or axotomized in the diaphragm muscle. RESULTS: The malondialdehyde level increased in diaphragm muscles after both crush and axotomy. The antioxidant enzymes, such as superoxide dismutase, glutathione peroxidase, carbonic anhydrase, and catalase, decreased in diaphragm muscles after both crush and axotomy. CONCLUSIONS: Crushing or axotomizing the phrenic nerves may produce oxidative stress in the diaphragm muscle of the rat by increasing lipid peroxidation and decreasing antioxidant enzyme activities.


Subject(s)
Axotomy , Diaphragm/physiopathology , Nerve Crush , Oxidative Stress/physiology , Peripheral Nervous System Diseases/pathology , Phrenic Nerve/physiopathology , Animals , Carbonic Anhydrases/metabolism , Catalase/metabolism , Diaphragm/pathology , Disease Models, Animal , Glutathione Peroxidase/metabolism , Male , Malondialdehyde/metabolism , Peripheral Nervous System Diseases/etiology , Rats , Rats, Wistar , Superoxide Dismutase/metabolism
17.
J Cardiothorac Surg ; 7: 10, 2012 Jan 24.
Article in English | MEDLINE | ID: mdl-22273539

ABSTRACT

BACKGROUND: This study investigated the results of the LigaSure Vessel Sealing System (LVSS), which has been routinely used in esophageal resections in our clinic since 2006. METHODS: For this purpose, 60 patients who underwent Ivor Lewis esophagectomy were included in the study. The results were compared with the patients who underwent stomach mobilising procedure and esophagectomy with conventional methods (conventional group) before 2006 and the patients who underwent LVSS (group of LigaSure) in surgical cases after 2006. The cases were compared particularly in terms of intraoperative bleeding, operative time, duration of postoperative hospital stay, intraoperative complications, mortality, and morbidity. RESULTS: Of the patients, 34 (% 56.6) were female and 26 (43.3%) were male, and the range of the age was between 33 and 78, and the mean age of the patients was 52.73 ± 11,617. While the amount of intraoperative bleeding was 321.864 ± 575.00 ml in the conventional group, this was found to be 370.31 ± 238.456 ml in the LigaSure group (p = 0.007). In the statistical evaluation of the operative time, the mean duration was determined as 310.00 ± 24.795 minutes in the conventional group, whereas it was determined as 265.16 ± 31.353 minutes in the LigaSure group (p = 0.001). CONCLUSIONS: The use of LVSS was associated with a significant reduction in the operative time and the rate of intra-operative complications.


Subject(s)
Electrocoagulation , Esophageal Neoplasms/surgery , Esophagectomy/methods , Adult , Aged , Female , Humans , Male , Middle Aged , Retrospective Studies
18.
Eurasian J Med ; 44(2): 79-83, 2012 Aug.
Article in English | MEDLINE | ID: mdl-25610214

ABSTRACT

OBJECTIVE: Hydatid cyst disease, endemic in Eastern region of Turkey, is a significant parasitic public health problem. In this study, pleural complications of hydatid cysts were presented in 76 cases. MATERIALS AND METHODS: In our study, of the 412 pulmonary hydatid cyst cases operated on between 2003 and 2011, 76 cases had ruptured into the pleura for various reasons, and the different clinicoradiological presentations were evaluated retrospectively. The age distribution of the cases was between 7 and 56 years, and the mean age was 26.20±13.04. RESULTS: The most frequent symptom due to pleural rupture in patients was dyspnea (44 cases, 57.8%). Etiologically, iatrogenic perforation was detected in four cases and thoracic trauma in nine cases (six car accidents and three falls from a height). An anthelmintic drug use history was found in three cases of ruptured pleura. Spontaneous perforation was detected in the other 60 (78.9%) cases. Two cases that were admitted to the emergency unit and were immediately administered a tube thoracostomy developed tension pneumothorax. In addition, 21 cases had hydropneumothorax, 17 had pneumothorax, and 36 had pleurisy. Morbidity was observed in 30 cases (39.4%). Atelectasis was the most frequent cause of morbidity in these patients (10 cases). The mean duration of hospitalization was determined to be 12.26±2.90 days. CONCLUSION: This disease can progress asymptomatically for a long time and can sometimes lead to life-threatening emergency situations, such as tension pneumothorax. The delayed admission of a patient to a physician causes the disease to become more complicated and to increase the morbidity and mortality rates. Treatment of the disease is in the form of surgery. Possible parenchymal protection should be applied in surgical treatment, and anatomic resection should not be performed unless necessary.

19.
Asian Pac J Cancer Prev ; 12(6): 1399-403, 2011.
Article in English | MEDLINE | ID: mdl-22126471

ABSTRACT

OBJECTIVES: Early diagnosis and prevention is very important for lung cancer patients. Previous studies have emphasized that the level of coenzyme Q10 (CoQ10), present primarily in mitochondria, decreases with age and is low in patients with chronic diseases. Our goal was to find out if there is any relationship between lung cancer and CoQ10 and lipid peroxidation levels. DESIGN AND METHODS: Blood samples from lung cancer patients were collected. Total and oxide CoQ10 levels, 8-OHdG (product of DNA damage), and malondialdehyde (MDA) levels (lipid peroxidation) were analyzed with high performance liquid chromatography (HPLC). RESULTS: The MDA level (P<0.001) and DNA damage rate (8-OHdG) (P<0.001) was higher in cancer patients than in the control group; in contrast, theCoQ10 enzyme level was significantly lower (P<0.001). CONCLUSION: The results suggest that the aforementioned parameters can be useful for lung cancer risk assessment.


Subject(s)
Biomarkers, Tumor/blood , DNA Damage , Lipid Peroxidation , Lung Neoplasms/diagnosis , Ubiquinone/analogs & derivatives , 8-Hydroxy-2'-Deoxyguanosine , Case-Control Studies , Deoxyguanosine/analogs & derivatives , Deoxyguanosine/blood , Humans , Malondialdehyde/blood , Mitochondria/enzymology , Mitochondria/metabolism , Oxidative Stress , Risk Assessment/methods , Ubiquinone/blood
20.
J Cardiothorac Surg ; 6: 161, 2011 Dec 11.
Article in English | MEDLINE | ID: mdl-22152759

ABSTRACT

BACKGROUND: Although the prevalence of bronchiectasis decreased significantly in developed countries, in less developed and in developing countries, it still represents a significant cause of morbidity and mortality. The aim of this retrospective study is to present our surgical experiences, the morbidity and mortality rates and outcome of surgical treatment for bronchiectasis. METHODS: We reviewed the medical records of 129 patients who underwent surgical resection for bronchiectasis between April 2002 and April 2010, at Van Training and Research Hospital, Thoracic Surgery Department. Variables of age, sex, symptoms, etiology, and surgical procedures, mortality, morbidity and the result of surgical therapy were analyzed retrospectively. RESULTS: Mean age was 21.8 year (the eldest was 67 year, the youngest was 4 years-old). Male/female ratio was 1.86 and 75% of all patients were young population under the age of 40. Bilateral involvement was 14.7%, left/right side ratio according to localization was 2.1/1. The most common reason for bronchiectasis was recurrent infection. Surgical indications were as follows: recurrent infection (54%), hemoptysis (35%), empyema (6%), and lung abscess (5%). There was no operative mortality. Complications occurred in 29 patients and the morbidity rate was 22.4%. Complete resection was achieved in 110 (85.2%) patients. Follow-up data were obtained for 123 (95%) of the patients. One patient died during follow-up. The mean follow-up of this patient was 9 months. Mean postoperative hospitalization time was 9.15 ± 6.25 days. Significantly better results were obtained in patients who had undergone a complete resection. CONCLUSIONS: Surgical treatment of bronchiectasis can be performed with acceptable morbidity and mortality at any age. The involved bronchiectatic sites should be resected completely for the optimum control of symptoms.


Subject(s)
Bronchiectasis/epidemiology , Risk Assessment/methods , Thoracotomy/methods , Adolescent , Adult , Bronchiectasis/diagnosis , Bronchiectasis/surgery , Bronchoscopy , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Middle Aged , Morbidity/trends , Retrospective Studies , Risk Factors , Survival Rate/trends , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , Turkey/epidemiology , Young Adult
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