Subject(s)

Antimalarials/pharmacology , Antimalarials/therapeutic use , Malaria, Falciparum/drug therapy , Plasmodium falciparum/drug effects , Quinine/pharmacology , Quinine/therapeutic use , Adult , Doxycycline/pharmacology , Doxycycline/therapeutic use , Drug Resistance/drug effects , Drug Resistance/genetics , France , French Guiana , Humans , Malaria, Falciparum/diagnosis , Male , Membrane Transport Proteins/genetics , Mutation/genetics , Plasmodium falciparum/genetics , Plasmodium falciparum/isolation & purification , Point Mutation , Polymorphism, Genetic/genetics , Protozoan Proteins/genetics , Treatment Failure