Subject(s)
Cerebral Infarction , Intracranial Thrombosis , Magnetic Resonance Imaging , Venous Thrombosis , Humans , Male , Female , Middle Aged , Adult , Retrospective Studies , Venous Thrombosis/pathology , Intracranial Thrombosis/pathology , Intracranial Thrombosis/diagnostic imaging , Intracranial Thrombosis/metabolism , Young Adult , Cerebral Infarction/pathology , Cerebral Infarction/diagnostic imaging , Cerebral Infarction/metabolism , Fibrin Fibrinogen Degradation Products/metabolism , Headache/etiology , Cerebral Cortex/pathology , Cerebral Cortex/blood supply , Cerebral Cortex/diagnostic imaging , Diagnosis, Differential , Temporal Lobe/pathology , Temporal Lobe/diagnostic imaging , Cerebral Hemorrhage/diagnostic imaging , Cerebral Hemorrhage/pathology , Seizures/etiology , Brain Edema/pathology , Frontal Lobe/pathology , Frontal Lobe/diagnostic imaging , Frontal Lobe/blood supplyABSTRACT
To investigate the clinical and pathological characteristics of duodenal-type follicular lymphoma (D-FL), and to deepen the understanding of Duodenal-type follicular lymphoma. The clinical symptoms, endoscopic features, pathologic features, immunophenotype, molecular pathological features and treatment follow-up of 18 D-FL patients diagnosed in Department of Pathology, Beijing Tiantan Hospital affiliated to Capital Medical University between January 2020 and July 2023 were summarized. A total of 18 patients with D-FL were included, including 10 males and 8 females. The median age was 49 (32-69) years respectively. Most of the patients were found during gastroenteroscopy or presented with the common gastrointestinal symptoms of stomach pain, acid reflux, vomiting and diarrhea. Most endoscopic findings were multiple small gray and white polyposis. In the pathological morphology, the mucous layer and submucous layer showed lymphoid follicular structures with full and strained follicles. The immunophenotype showed that the tumor cells strongly expressed CD20 and BCL2 and had low proliferation activity. Immunoglobulin clonal analysis of 1 case showed IgK monoclonal rearrangement (1/1). FISH showed 1 case of BCL2 gene rearrangement (1/3). All patients did not receive targeted chemotherapy and adopted a wait-and-see strategy. Median follow-up was 12 (2-34) months. This study shows that D-FL is an indolent lymphoma, which tends to occur in the duodenum and has a good prognosis.