ABSTRACT
This study evaluated retinal and choroidal microvascular changes in night shift medical workers and its correlation with melatonin level. Night shift medical workers (group A, 25 workers) and non-night shift workers (group B, 25 workers) were recruited. The images of macula and optic nerve head were obtained by swept-source OCT-angiography. Vessel density of retina, choriocapillaris (CC), choriocapillaris flow deficit (CC FD), choroidal thickness (CT) and choroidal vascularity index (CVI) were measured. 6-sulfatoxymelatonin concentration was analyzed from the morning urine. CC FD and CVI were significantly decreased and CT was significantly increased in group A (all P < 0.05). 6-sulfatoxymelatonin concentration was significantly lower in group A (P < 0.05), which was significantly positively correlated with CC FD size (r = 0.318, P = 0.024) and CVI of the most regions (maximum r-value was 0.482, P < 0.001), and was significantly negatively associated with CT of all regions (maximum r-value was - 0.477, P < 0.001). In night shift medical workers, the reduction of melatonin was significantly correlated with CT thickening, CVI reduction and CC FD reduction, which suggested that they might have a higher risk of eye diseases. CC FD could be a sensitive and accurate indicator to reflect CC perfusion.
Subject(s)
Choroid , Melatonin , Microvessels , Retinal Vessels , Tomography, Optical Coherence , Humans , Choroid/blood supply , Choroid/diagnostic imaging , Tomography, Optical Coherence/methods , Male , Adult , Female , Melatonin/urine , Melatonin/analogs & derivatives , Microvessels/diagnostic imaging , Retinal Vessels/diagnostic imaging , Middle Aged , Shift Work Schedule/adverse effects , Angiography/methods , Retina/diagnostic imagingABSTRACT
Artesunate (ART) is a derivative of artemisinin. Compared with artemisinin, ART has excellent water solubility, high stability and oral bioavailability. In this review, the application of ART in classic autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and ulcerative colitis is summarized. ART exhibited similar or even better efficacy than other highly effective immunosuppressive agents, such as methotrexate and cyclophosphamide. In addition, ART exerts its pharmacological effects mainly by inhibiting the production of inflammatory factors, reactive oxygen species, autoantibodies and the migration of cells to reduce damage to tissues or organs. Moreover, ART widely affected the NF-κB, PI3K/Akt, JAK/STAT and MAPK pathways to exert pharmacological effects.
A medicine called artesunate (ART), which comes from a plant, is sometimes used to treat malaria. It was first introduced by Chinese scientist Tu Youyou, who won the Nobel Prize in medicine. Autoimmune diseases (ADs) occur when the body's immune system attacks its own cells. ART has shown promise in treating ADs. ART works as well as, or even better than, other normal medicines used for ADs. ART can act in many ways and could be a promising medicine for the treatment of ADs.
