Central auditory test performance predicts future neurocognitive function in children living with and without HIV.

Tests of the brain's ability to process complex sounds (central auditory tests) correlate with overall measures of neurocognitive performance. In the low- middle-income countries where resources to conduct detailed cognitive testing is limited, tests that assess the central auditory system may provide a novel and useful way to track neurocognitive performance. This could be particularly useful for children living with HIV (CLWH). To evaluate this, we administered central auditory tests to CLWH and children living without HIV and examined whether central auditory tests given early in a child's life could predict later neurocognitive performance. We used a machine learning technique to incorporate factors known to affect performance on neurocognitive tests, such as education. The results show that central auditory tests are useful predictors of neurocognitive performance and perform as well or in some cases better than factors such as education. Central auditory tests may offer an objective way to track neurocognitive performance in CLWH.

Ownership of change: Participatory development of a novel latent construct for neighborhoods and health equity research.

Processes of neighborhood change are important determinants of health. One salient dimension of the experience of neighborhood changes is a person's evolving sense of empowerment over the changes around them, such as development of new housing or shifts in economic opportunity. Community residents collaborating on a Participatory Action Research study developed the novel construct "ownership of change" to capture this psychosocial process, and hypothesized that it may help explain the relationship between neighborhood change and health. In this paper, we describe our participatory process for developing a way to measure ownership of change, explore the construct's validity, test the hypothesis that it is associated with health, and analyze qualitative data to understand the process through which one's sense of ownership of change is produced. We argue that the construct is useful for studying the role of neighborhood changes in shaping health, and that building ownership over neighborhood change must be a key dimension of urban planning and policy for health equity.

Prognosis of ischemia recurrence in patients with moderate intracranial atherosclerotic disease using quantitative MRA measurements.

Purpose: To investigate the relation between delayed ischemic stroke and the intracranial atherosclerotic disease (ICAD) hemodynamics as determined by Non-invasive Optimal Vessel Analysis (NOVA) MRI measurements. Materials and Methods: Thirty-three patients with ICAD were enrolled in this study. All patients underwent clinically indicated angioplasty followed by 2-dimensional phase contrast MR (2D PCMR) performed on a 3.0 Tesla MRI scanner using either a 16-channel neurovascular coil or 32-channel head coil. The volumetric flow rate measurements were calculated from 2D PCMR with Non-invasive Optimal Vessel Analysis (NOVA) software (VasSol, Chicago, IL, USA). Flow rate measurements were obtained in 20 major arteries distal, proximal and within the Circle of Willis. Patients were followed up for six month, and ischemia reoccurrence and location were recorded. Receiver operating characteristic (ROC) analysis was performed using flow rates measurements in the ipsilateral side of the ischemic event occurrence. Results: Complete set of measurements was achieved in n=34. Left and right hemisphere ischemia recurrence was observed in seven and three cases respectively. Best predictor of ischemic event reoccurrence was flow rate in the middle cerebral artery with area under the ROC of 0.821±0.109. Conclusions: This is an effectiveness study to determine whether blood flow measurements in the intracranial vasculature may be predictive of future ischemic events. Our results demonstrated significant correlation between the blood flow measurements using 2D PCMR processed with the NOVA software and the reoccurrence of ischemia. These results support further investigation for using this method for risk stratification of ICAD patients.

Amyloid-beta-related angiitis: a rare cause of recurrent transient neurological symptoms.

BACKGROUND: A 79-year-old woman presented with transient right-sided weakness. She subsequently developed further transient neurological signs and symptoms across a range of vascular territories. Diagnostic workup revealed no clear etiology. The patient developed a sudden, fatal intracerebral hemorrhage, and the diagnosis was only revealed at autopsy. INVESTIGATIONS: Neurological examination, head CT, brain MRI, fluid-attenuated inversion recovery imaging, magnetic resonance angiography, lumbar puncture, CT angiography, electroencephalography, and brain autopsy. DIAGNOSIS: Amyloid-beta-related angiitis. MANAGEMENT: The patient expired before treatment could be initiated. Immunosuppressants are recommended for future cases.