Subject(s)
Scrub Typhus , Humans , Infant, Newborn , Scrub Typhus/diagnosis , Scrub Typhus/epidemiologyABSTRACT
BACKGROUND: Mucormycosis of the gastrointestinal tract is a rare fungal infection of neonates. CASE CHARACTERISTICS: 48-hours-old term neonate presented with intestinal obstruction and perforation. No significant risk factors were present. Histopathological examination of the resected gangrenous bowel revealed mucormycosis. Cutaneous involvement due to systemic spread led to dermal necrosis in toes. OUTCOME: Though cutaneous lesions responded promptly to antifungal therapy, gastrointestinal manifestations required multiple antifungal therapy for prolonged period apart from surgical debridement. MESSAGE: Precise histopathological diagnosis and early appropriate therapy can prevent dismal outcomes in neonatal mucormycosis.
Subject(s)
Dermatomycoses/diagnosis , Enterocolitis, Necrotizing/microbiology , Mucormycosis/diagnosis , Enterocolitis, Necrotizing/diagnosis , Humans , Infant, Newborn , Male , Mucormycosis/complicationsABSTRACT
Microvillus inclusion disease is a rare autosomal recessive disorder of intestinal epithelium causing intractable secretary diarrhea in the first two months of life and about 140 cases have been reported worldwide till now. Here authors report 2 cases of Microvillus inclusion disease (MVID) diagnosed in neonates by electron microscopy study of small intestinal biopsy.
Subject(s)
Diarrhea/congenital , Malabsorption Syndromes/congenital , Microvilli/pathology , Biopsy , Consanguinity , Fatal Outcome , Female , Humans , Infant, Newborn , Intestine, Small , Male , Microscopy, Electron, Scanning , MucolipidosesABSTRACT
The molecular epidemiology of nosocomial rotavirus infection in children admitted to the paediatric ward of a large hospital in southern India was studied by transmission electron microscopy and RNA electrophoresis on stool samples. Six hundred and twenty-six samples were collected and rotaviruses were detected in 35 of them. A predominant electropherotype was found in all the samples, and there was no seasonal variation in the incidence of infection. The predominant electropherotype pattern in this study was different from the electropherotype patterns of strains isolated elsewhere in the country and also from the pattern of the strains isolated earlier from children with acute diarrhoea at the same hospital.