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Ecological restoration is one of the most feasible ways to mitigate climate change and conserve ecosystems. However, the scope, intensity, effectiveness, and future potential of ecological restoration are restricted by unfavorable environmental conditions, especially limited water resources and complex topography. This paper proposes an assessment framework of ecological restoration potential under the coupled limits of water resources and slope gradient to quantitatively assess ecological restoration potential (ERP) under these two limiting factors. Results indicate that the current vegetation plantation in 20%, 0.19% and 32% areas of China's 31 provinces are larger, equal, and lower than the vegetation threshold permitted by local water resources respectively, which represents about 0.299 billion ha potential for additional restoration area. The ecological restoration potential under the integrated water resources and slope gradient constraints is 0.4 Pg C, less than half (47%) of the potential under the single limit of water resources (0.856 Pg C). However, this potential and China's existing carbon sink capacity related to terrestrial ecosystems is estimated to offset up to 8% of its current carbon dioxide emissions. Ecological restoration programs in areas with slope >5° will require additional economic investment to support Soil and Water Conservation programs, estimated to average about 212 trillion yuan. Succinctly, it is critical to integrate field investigations, process-based assessments and landscape design for sustainable ecological restoration. This work can provide techniques support for quantitative measurement of ecological restoration potential considering multiple limiting factors and guidance for sustainable implementation of ecological restoration programs.
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OBJECTIVE: Here, we explored the phenotype and function of MAIT cells in the peripheral blood of patients with HSP. METHODS: Blood samples from HSP patients and HDs were assessed by flow cytometry and single-cell RNA sequencing to analyze the proportion, phenotype, and function of MAIT cells. Th-cytokines in the serum of HSP patients were analyzed by CBA. IgA in cocultured supernatant was detected by CBA to analyze antibody production by B cells. RESULTS: The percentage of MAIT cells in HSP patients was significantly reduced compared with that in HDs. Genes related to T cell activation and effector were up-regulated in HSP MAIT cells, indicating a more activated phenotype. In addition, HSP MAIT cells displayed a Th2-like profile with the capacity to produce more IL-4 and IL-5, and IL-4 was correlated with IgA levels in the serum of HSP patients. Furthermore, CD40L was up-regulated in HSP MAIT cells, and CD40L+ MAIT cells showed an increased ability to produce IL-4 and to enhance IgA production by B cells. CONCLUSION: Our data demonstrate that MAIT cells in HSP patients exhibit an activated phenotype. The enhanced IL-4 production and CD40L expression of MAIT cells in HSP patients could take part in the pathogenesis of HSP.
Subject(s)
IgA Vasculitis , Mucosal-Associated Invariant T Cells , Humans , Antibody Formation , CD40 Ligand , Immunoglobulin A , Interleukin-4ABSTRACT
This paper proposes a process for updating monthly input-output tables with monthly macroeconomic statistics and published input-output tables. Reasonable assumptions are set up and 48 monthly input-output tables are prepared from 2018 to 2021 with the combination of the row range series method and nonlinear mathematical planning. The Weaver-Thomas composite index is used to analyze the role of the sector in the economic network, and the sectoral correlation indicators are used to analyze the correlation change of the sector's monthly electricity emissions to show an environmental application effect of the monthly input-output table. The results show that the monthly input-output tables can be prepared with acceptable accuracy, and they can reveal the sectoral network structure changes and sectoral carbon emissions changes in continuous monthly time series. The proposed approach contributes for the compilation of high-time-frequency input-output tables, so as to support high-frequency industrial environmental impact analysis.
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Current energy, water, and land (EWL) nexus research treats all resources equally, causing bias in complicated nexus studies. To make the analysis robust, we consider resource endowment and significance. Here, we provide a methodological framework where the urban industrial resource nexus strength is constructed and assign weights to resources according to policies, describing resource efficiency and representing it in ternary diagrams to assess the urban industrial nexus innovatively. Results showed that energy drives urban development under all weights, with energy resource efficiency exceeding 60%. From consumption-based accounting, energy continues to dominate most industries under physical weightings but emphasizes the significance of water and land. While, under economic weightings, land supplants energy's dominance in specific sectors. Setting weights helps understand resource interaction, establish synergy based on urban development objectives, and minimize robustness. Our findings provide quantitative evidence for assessing urban resource efficiency to highlight priority sectors for intervention in urban decision-making.
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Industry , Narration , Policy , Urban Renewal , WaterABSTRACT
So far, urban scaling theory has proven that urban area, infrastructure, and economic output have a scaling relation with population. But if we consider ecological space as a part of urban infrastructure, would the same scaling characteristics exist? What is the scaling relationship between ecological spaces and economic social development in different stages of urbanization? This paper is based on this question and explores the trade-off between social economic system and ecosystem in 370 cities of China. The results show that the relationship between population and urban ecological space generally follows the scaling theory in terms of different types of ecological spaces and ecosystem services. For every 10-fold increase in population size, the total area of ecological space and ecosystem services increase by approximately 4 times. The manifestation of ecological space following the scaling laws is the aggregation behavior of better network connectivity. There is a trade-off between urban ecological space and socioeconomic development, with flow equilibrium reached at a population of 2 million and efficiency equilibrium reached at a population of 1 million. Starting from type I and type II megapolis, urban development gradually tends to stabilize, and there may even be a trend of slow decline in urban development potential. In the absence of ecological space, virtual network space can serve as a substitute for ecological space. The driving factors affect scaling behavior of ecological space, including connectivity of ecological space, spatial heterogeneity of natural conditions, and disturbance of economic and social activities. This research can help city to expand ecological space, promoting the added value of urban ecological assets and keeping the urban development potential within the optimal threshold range continuously.
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The debate about the negative impacts that production and consumption cause on the environment is in vogue. Strategies that point to a sustainable, healthy, and resilient path are being sought. One of these paths is the Circular Economy, which emerges as an alternative to reduce the socio-environmental impacts caused by the linear model of production-use-disposal, presenting opportunities to generate revenue, income, and wealth with circular processes. However, despite the circular economy being considered an essential strategy to improve overall performance toward sustainability in its three dimensions, recent research has shown that the predominant focus of circular approaches is on the economic and environmental dimensions. At the same time, the social aspects still need to be explored. This article addresses this problem, aiming to explore circular economy environmental, economic, and social elements in three economic blocs from 2000 to 2020 using the Five Sector Sustainability Model, establishing a baseline to co-create an equitable and regenerative future. The results showed that ASEAN in 2000 occupied the first position in the general ranking. The European Union had the best classification in the economic sector, and Mercosur was the best regarding social benefits. In 2020, while the European bloc was better positioned in the general ranking, the South American bloc occupied the last post in almost all sectors. Comparatively, the highest-ranked bloc in 2020 in overall sustainability is more in line with the UN SDG due to circular actions oriented towards the three fundamental pillars of sustainability.
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Environment , Income , European UnionABSTRACT
BACKGROUND/AIMS: Determining whether clinical trial findings are applicable to diverse, real-world patient populations can be challenging when the full demographic characteristics of enrolled patients are not consistently reported. Here, we present the results of a descriptive analysis of racial and ethnic demographic information for patients in Bristol Myers Squibb (BMS)-sponsored oncology trials in the United States (US) and describe factors associated with increased patient diversity. METHODS: BMS-sponsored oncology trials conducted at US sites with study enrollment dates between 1 January 2013 and 31 May 2021 were analyzed. Patient race/ethnicity information was self-reported in case report forms. As principal investigators (PIs) did not report their own race/ethnicity, a deep-learning algorithm (ethnicolr) was used to predict PI race/ethnicity. Trial sites were linked to counties to understand the role of county-level demographics. The impact of working with patient advocacy and community-based organizations to increase diversity in prostate cancer trials was analyzed. The magnitude of associations between patient diversity and PI diversity, US county demographics, and recruitment interventions in prostate cancer trials were assessed by bootstrapping. RESULTS: A total of 108 trials for solid tumors were analyzed, including 15,763 patients with race/ethnicity information and 834 unique PIs. Of the 15,763 patients, 13,968 (89%) self-reported as White, 956 (6%) Black, 466 (3%) Asian, and 373 (2%) Hispanic. Among 834 PIs, 607 (73%) were predicted to be White, 17 (2%) Black, 161 (19%) Asian, and 49 (6%) Hispanic. A positive concordance was observed between Hispanic patients and PIs (mean = 5.9%; 95% confidence interval (CI) = 2.4, 8.9), a less positive concordance between Black patients and PIs (mean = 1.0%; 95% CI = -2.7, 5.5), and no concordance between Asian patients and PIs. Geographic analyses showed that more non-White patients enrolled in study sites in counties with higher proportions of non-White residents (e.g. a county population that was 5%-30% Black had 7%-14% more Black patients enrolled in study sites). Following purposeful recruitment efforts in prostate cancer trials, 11% (95% CI = 7.7, 15.3) more Black men enrolled in prostate cancer trials. CONCLUSION: Most patients in these clinical trials were White. PI diversity, geographic diversity, and recruitment efforts were related to greater patient diversity. This report constitutes an essential step in benchmarking patient diversity in BMS US oncology trials and enables BMS to understand which initiatives may increase patient diversity. While complete reporting of patient characteristics such as race/ethnicity is critical, identifying diversity improvement tactics with the highest impact is essential. Strategies with the greatest concordance to clinical trial patient diversity should be implemented to make meaningful improvements to the diversity of clinical trial populations.
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Clinical Trials as Topic , Ethnicity , Patient Selection , Prostatic Neoplasms , Humans , Male , Prostatic Neoplasms/therapy , Self Report , United States , Racial GroupsABSTRACT
Not only insufficient water quantity but also inadequate water quality can pose constraints on agricultural production and result in potential economic losses. Such economic losses in agriculture may adversely impact downstream producers through reduced input supplies. In this study, we developed an index assessing potential economic losses in agriculture under both quantity- and quality-induced water scarcity, termed integrated Agricultural Water Scarcity Risk (AWSR). Combining integrated AWSR with a multi-regional input-output model, we estimated the spillovers of integrated AWSR along supply chains. Our results showed that the intersectoral transmission of virtual integrated AWSR (sectoral spillovers in terms of integrated AWSR) were 5 times the virtual quantity-based AWSR. Pollution significantly intensifies the indirect supply-chain repercussions of agricultural water scarcity. Moreover, we identified some primary virtual integrated AWSR exporters (e.g., Jiangsu-vegetables and Shandong-swine, of which the integrated AWSR had considerable spillover effects on downstream sectors) and importers (e.g., Henan-chemical industry and Henan-textiles, which were vulnerable to upstream integrated AWSR), that could not be detected in quantity-based AWSR results. This study underscores the importance of water quality in the assessments of AWSR. Strategies to mitigate the spillovers of AWSR might be inefficient without the consideration of water quality.
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Water Quality , Water Supply , Animals , Swine , Water Insecurity , Agriculture , ChinaABSTRACT
For emerging economies lacking public budgets, continuous improvement of urban wastewater treatment efficiency (UWTE) requires effective government supervision of wastewater treatment infrastructures (WTIs) and participation of private capital seeking to profit-maximising. However, to what extent this public-private partnership (PPP) model, aimed at a reasonable sharing of benefit and risk, in delivering WTIs can improve the UWTE is unknown. We evaluated the impact of the PPP model on the UWTE by collecting data from 1303 urban wastewater treatment PPP projects in 283 prefecture-level cities in China from 2014 to 2019 and used data envelopment analysis and Tobit regression model. The UWTE was significantly higher in prefecture-level cities that introduced the PPP model in the construction and operation of WTIs, particularly those with a feasibility gap subsidy, competitive procurement, privatised operation, and non-demonstration. Moreover, the effects of PPPs on UWTE were limited by the economic development level, marketisation, and climatic conditions.
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Substantial evidence indicates that China's afforestation statistically contributed to the ecosystem services (ES) improvement. However, we found the potential challenges behind this improvement, especially in water-limited areas. We propose an attribution analysis method, which can assess the specific contribution of natural, human and cognition degree drivers to ES dynamics. The results found that the ratio of natural and human drivers in the area north of China's 400 mm precipitation isopleth is 2:7. This means local vegetation capacity has already exceeded water limitation, implying a conflict between nature and humans. However, the natural contribution in the area between 400 and 800 mm precipitation isopleth is negative, whereas the human contribution is 91%. This means this area has fragile natural conditions and needs more flexible policies. The ratio of natural and human drivers in the region south of 800 mm precipitation isopleth is 6:3, suggesting the ecological policies here can be maintained.
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The role of ocean carbon sinks in global climate change mitigation and carbon neutrality is still affected by lack of research. Aiming at overcoming the present limitations, a comprehensive and holistic framework and accounting method of ocean carbon sink evaluation are proposed in this study, which consider both carbon sink types and their characteristic carbon storage cycle timescales. The results show that (1) China's total ocean carbon sink is 69.83-106.46 Tg C/year, among which the mariculture, coastal wetlands, and offshore carbon sinks are 2.27-4.06, 2.86-5.85, and 64.70-96.55 Tg C/year, respectively; (2) ocean-based solutions such as coastal protection and restoration, mariculture development, ocean alkalization, ocean fertilization, and marine bioenergy with carbon capture and storage have substantial mitigation potential, but further investigation is required before large-scale deployment; (3) although China's ocean carbon sinks only counterbalanced 3.27-4.99% of its fossil fuel emissions, their tremendous enhancing potential and specific advantages cannot be ignored, and enhancing measures must be taken according to regional characteristics; (4) some uncertainties and limitations still exist, and problems such as double counting, carbon sink offset, and so forth need to be further considered. In a word, this study provides a basis for the development of ocean-based solutions on closing climate mitigation gaps.
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Carbon Cycle , Carbon Sequestration , Carbon/analysis , China , Ecosystem , Oceans and SeasABSTRACT
Revegetation has significantly contributed to improvements in ecosystem services, such as carbon sequestration and soil retention. Yet, vegetation expansion in water-limited regions may generate conflict of water demand between nature and humans. Present studies are still lacking when it comes to identifying the permissible vegetation capacity, i.e. net primary productivity (NPP) threshold, based on the local water resources limits, and further proposing adjustment and optimization strategies to keep water use balanced in anthropogenic-biological systems. Under such a circumstance, this study assesses the difference between the actual NPP and NPP thresholds at regional and ecosystem scales in China. The results show that 8 out of 31 provinces have their provincial actual NPP above the regional NPP thresholds, mainly concentrated in northern China between 400 and 800 mm iso-precipitation line, i.e. North China Plain (Beijing-Tianjin-Hebei), the middle reaches of the Yellow River Basin (Shaanxi and Henan provinces), and the Northeast China (Heilongjiang, Jilin and Liaoning). Forest ecosystems dominate the difference between the actual total woodland and grassland ecosystems NPP and the permissible NPP thresholds in these regions, ranging from 67% (Beijing) to 99% (Tianjin). If the current vegetation intensity in these regions remains unchanged, the areas of woodland and grassland ecosystems should be optimized 0-48% and 0-100% of their present areas to balance the water demand between the ecosystems and humans, without considering the potential consequence of climate change and soil erosion. Although 23 provinces have their regional actual NPP below their permissible NPP thresholds, 6 out of 23 provinces still have their woodland and grassland ecosystems NPP above the corresponding NPP thresholds, mainly focusing on the Northwestern China north over the 400 mm iso-precipitation line, including Inner Mongolia, Qinghai, Hainan, Shanxi, Gansu and Xinjiang. Forest ecosystems also dominate the negative NPP differences in these regions, ranging from 91% (Inner Mongolia) to 46% (Gansu). These reveal the hidden and potential pressure in the 6 provinces to balance limited water resources in the local anthropogenic-biological system. This study provides a method to assess the water-resources permissible NPP threshold and further proposes the specific adjustment and optimization plans for the areas with actual NPP above the corresponding NPP thresholds, which can provide guidance for ecological restoration program implementations in a more sustainable way.
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Many nations are taking measures to address the negative impacts of development projects in order to achieve the goal of No Net Loss (NNL) of ecosystem services. It still faces the most fundamental and critical problem- the unified accounting of ecosystem service. To address this problem, we conducted an emergy-based ecosystem service assessment to tackle the challenges and obstacles of current accounting methods and established a new accounting framework to provide a unified measurement for ecosystem service marketing. We adopted the Credit-Debit method of wetland mitigation banking and the emergy-based method to evaluate the ecosystem services of 82 ecological projects. The results have shown that: (1) The emergy-based credit covers more types of ecosystem services, and shows advantages in terms of objectivity, accuracy, dynamic monitoring, and generalization; (2) The new accounting method can provide cross-scale and cross-type ecosystem service; (3) The Em-credit helps to promote the trans-regional eco-bank system in a large scale and at multiple levels, and it can improve the effective supervision and predict the eco-bank in a long period.
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Ecosystem , Wetlands , Conservation of Natural ResourcesABSTRACT
Water and land are crucial natural resources for agricultural development. It is necessary to allocate water and land resources effectively in order to achieve the maximum economic profits and the minimum environmental costs. In this research, an inexact two-stage fractional programming model was developed for the allocation of water and land resources, which is integrated interval-parameters (IPP), two-stage stochastic programming (TSP), fractional programming (FP). This model could optimally allocate water and land resources at the same time under the scenario of the maximum economic profit and the minimum environmental cost; it was proved to be beneficial in (1) dealing with the conflicts between economic development and environmental protection and give insights in trade-off among the agricultural system; (2) allocating water and land resources for five crops under multiple flow level simultaneously; and (3) describing the uncertain inputs as interval-parameters to reduce model uncertainties. The developed model was applied to the northeast region of China. The optimal allocation schemes of water and land resources, the maximum economic profits, and the minimum environmental costs were obtained. The results showed that economic profits in the agricultural system in the northeast region of China would not definitely be connected with the allocation of water and land resources, and solid waste pollution would bear the largest environmental cost. The developed model could help decision-makers to get a deeper understanding of the agricultural system and manage water and land resources in an efficient and environment-friendly way.
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Models, Theoretical , Water , Agriculture , China , Conservation of Natural Resources , Resource Allocation , Water ResourcesABSTRACT
Ecological restoration programs have significantly contributed to the improvement of ecosystem services in the past two decades. However, due to climate change and rapid land use change, planning and management of ecosystem services restoration programs are still challenging, particularly how to identify and quantify the specific contribution of natural and human drivers of ecosystem services dynamics, how to assess and simulate the integrated impacts of climate-land use change interactions on changes in ecosystem services, insufficient simulation of mid- and long-term impacts of different ecological restoration programs, and lack of identification of ecological restoration thresholds. To overcome the challenges, we propose a new framework for restoring ecosystem services programs as potential solutions to the challenges. The framework includes attribution analysis of changes in ecosystem services, assessment and projections of ecosystem services dynamics under the integrated impacts of climate-land use change interactions, simulation of mid- and long-term effects of ecological programs and identification of ecological restoration threshold, which forms the logic chain of the framework, i.e. theory foundation-techniques support-application cases-policy implications. We finally recommend four related research directions and steps forward to overcome the challenges, including (1) Step 1: establish attribution analysis method of ecosystem services dynamics based on ecological thermodynamics and partial differential equation; (2) Step 2: Assess and simulate the impacts of coupled climate-land use change interactions on ecosystem services dynamics; (3) Step 3: Simulate the mid- and long-term impacts of different ecological restoration programs; and (4) Step 4: Identify ecological restoration thresholds. This study could provide insights for improving management of ecosystem services restoration programs in the context of rapid land use change and continuous climate change.
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Ecosystem , Environmental Restoration and Remediation , Policy , Climate ChangeABSTRACT
Thirty years ago, the systems ecologist Howard T. Odum introduced the concept of transformity, which is a thermodynamic measure of quality within the trial and error evolutionary dynamics of ecosystems, namely an indicator of rank in the hierarchical system structure of the biosphere. Based on a global database of individual processes and whole economies, this paper extends, refines, and updates Odum's idea, demonstrating the strength of the postulated relation. In particular, an inverse linear logarithmic relationship is shown to hold between resource quantity (exergy) and quality (emergy), which is the result of an overall energetic efficiency characteristic of energy transformation processes of the biosphere. This relation extends from natural renewable energy sources to human information (including global internet data flows) and know-how embedded in national economies, thus identifying a consistent theory of hierarchical organization of the biosphere grounded in energetics and ultimately setting constraints to illusions of unlimited growth.
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The current lack of research on the evaluation of marine ecosystem services makes the value of marine protection, development and restoration underestimated during the decision-making process. Based on the non-monetary ecosystem service evaluation framework, a marine ecosystem service classification and accounting method has been established in this study, and the world's coastal ecosystem services have been measured as an example. The results show that (1) the world's coastal ecosystem service value is about 4.13E+23 sej/yr, of which Asia and North America contribute about 55% of the total service value; (2) the top ten countries in terms of the world's coastal ecosystem service values are Canada, Indonesia, Australia, the United States, Brazil, the Russian Federation, Norway, the Philippines, Mexico, and China, which contribute about 60% of the total service value; (3) estuaries have the highest ecosystem service values, followed by mangroves, seagrass beds, tidal flats, salt marshes, and warm water coral reefs; (4) developed countries can make better use of their coastal resources and pay more attention to the marine protection while the opposite is true in developing countries, which means that developed countries still occupy an advantageous position in the process of marine protection, development and utilization. This study assesses the coastal ecosystem service values in various coastal countries from the perspective of ecosystem contributors, emphasizes the importance of protecting them in marine management, and provides a certain reference basis and theoretical support for decision-makers in formulating marine-related protection and development strategies.
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Coral Reefs , Ecosystem , Australia , Estuaries , WetlandsABSTRACT
Although the concept of damage cost accounting is already well-studied and applied, its application to pollution still lacks of an integrated accounting framework, while the spatial-temporal variability of accounting results has not been fully discussed. To fill this gap, this review frames the existing models and their limitations into static and dynamic categories, outlining the characteristics of different methods, which consider both human and non-human damages caused by pollution. Existing data sources, that could be used for accounting purposes, are detailed. Finally, this work discusses the relevance of spatial scales for the computation process, in order to obtain a more detailed information support for environmental policies for future compensatory actions. Conclusions highlights the need to develop a more comprehensive database of exposure-response relationships and to incorporate system alternatives into models to achieve a more accurate damage assessment.
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The expansion of cities and their impacts currently constitutes a challenge for the achievement of sustainable development goals (SDGs). In this respect, assessments of resource consumption and the delivery of appropriate policies to support resource conservation are of paramount importance. Previous works in the literature have focused on one specific resource (e.g., water, energy, food) at the household level, while others have analysed the inter-relations among different resources (i.e., the nexus approach) at larger spatial scales (e.g., urban level). Moreover, household behavioural attitudes are generally excluded while assessing resource consumption scenarios. This work overcomes previous limitations by proposing a causal-loop structure derived from the literature, from which simulations of different scenarios can be generated that consider the nexus between food, energy and water at the household level. These simulations can provide alternative scenarios to assess the impacts of monetary policies as well as education and communication actions on the enhancement of resource savings and consider both their current use and household preferences. The metropolitan area of Napoli was chosen as the testbed area for the simulations. The results, in relation to the testbed, proved that communication actions would be most appropriate to increase the level of resource savings. The business-as-usual scenario was especially sensitive to variations in individual preferences towards pro-environmental behaviours and showed their higher impacts on the results. Improvements of this method and its derived scenarios in the context of the urban planning process could support the implementation of informed policies towards the conservation of key resources and promotion of sustainable citizen behaviour.
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City Planning/methods , Conservation of Natural Resources/methods , Cities , Commerce/methods , Food , Public Policy , Sustainable Development , Water , Water Supply/methodsABSTRACT
The value realization of agro-ecological products is of great significance to China's food security, ecological protection, and strategic blueprint. We reviewed the concepts and boundaries of agricultural ecosystem and agro-ecological products (including agricultural products, other ecosystem services and dis-services). Based on the emergy method, the agricultural ecosystem service quantification method was proposed and the ecosystem services and dis-services of typical agricultu-ral products per unit area in China were calculated. Further, the type-specific values realization pathways of the agro-ecological products were discussed. It was found that 1) the values of the agro-ecological products, which has been realized through market mechanism, can further be added by the means of increasing green degrees or special degree, and establishing agricultural industrial chains; 2) the values of the agro-ecological products, which have not yet been realized through market mechanism, should be compensated or realized through ecological product empowerment and regional shared brand quality commitment; 3) the values of the agro-ecological products can be preserved or increased through reducing the harmfulness of N, P, pesticides and insecticides to ecosystem and human health by multi-approaches-based GHG emission reduction, land nutrient management strategies, and rational landscape architecture; 4) some financial solutions can be promoted, e.g., cancellation of secondary agricultural subsidies, the establishment of ecological trading platform and the certification of ecological products. This study contributes to propose the value realization pathways of agro-ecological products, advance the development of green finance, and promote the modernization of natural resource management capabilities.