Prognostic significance of the aspartate aminotransferase to lymphocyte ratio index in patients with acute myocardial infarction.

BACKGROUND: This study aimed to investigate the clinical value and prognostic significance of the alanine aspartate aminotransferase-to-lymphocyte ratio index (ALRI) in patients diagnosed with acute myocardial infarction (AMI). METHODS: Clinical indices of patients with AMI were collected from the Medical Information Mark for Intensive Care (MIMIC) III database and Wuhan Sixth Hospital. Cox regression analysis was used to explore whether ALRI was a risk factor for a worse prognosis in patients with AMI, and a nomogram including ALRI was created to estimate its predictive performance for 28-day mortality. RESULTS: Based on clinical data from the MIMIC-III database, we found that a high ALRI was closely associated with a variety of clinical parameters. It was an important risk factor for 28-day survival in patients with AMI (HR = 5.816). ALRI had a high predictive power for worse 28-day survival in patients with AMI (area under the curve [AUC] = 0.754). Additionally, we used clinical data from the Wuhan Sixth Hospital to verify the predictive power of ALRI in patients with AMI, and a high level of ALRI remained an independent risk factor for worse survival in patients with AMI (HR = 4.969). The AMI nomogram, including ALRI, displayed a good predictive performance for 28-day mortality in both the MIMIC-III (AUC = 0.826) and Wuhan Sixth Hospital cohorts (AUC = 0.795). CONCLUSION: The ALRI is closely related to the survival outcomes of patients with newly diagnosed AMI, indicating that it could serve as a novel biomarker for risk stratification such patients.

Kramers-Kronig relation between nonlinear absorption and refraction of C(60) and C(70).

Using the Z-scan technique with 532 nm 16 picosecond laser pulses, we observe reverse saturable absorption and positive nonlinear refraction of toluene solutions of both C(60) and C(70). By deducting the positive Kerr nonlinear refraction of the solvent, we notice that the solute molecules contribute to nonlinear refraction of opposite signs: positive for C(60) and negative for C(70). Attributing nonlinear absorption and refraction of both solutes to cascading one-photon excitations, we illustrate that they satisfy the Kramers-Kronig relation. Accordingly, we attest the signs and magnitudes of nonlinear refraction for both solutes at 532 nm by Kramers-Kronig transform of the corresponding nonlinear absorption spectra.

Magnetic-field-induced crossover to a nonuniversal regime in a Kondo dot.

We have measured the magnetic splitting Delta K of a Kondo peak in the differential conductance of a single-electron transistor while tuning the Kondo temperature T K along two different paths in parameter space: varying the dot-lead coupling at a constant dot energy and vice versa. At a high magnetic field B, the changes of DeltaK with TK along the two paths have opposite signs, indicating that Delta K is not a universal function of TK. At low B, we observe a decrease in DeltaK with TK along both paths, in agreement with theoretical predictions. Furthermore, we find Delta K/Delta<1 at low B and Delta K/Delta>1 at high B, where Delta is the Zeeman energy of the bare spin, in the same system.