ABSTRACT
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist, increasing the prevalence of both entities and impacting on symptoms and prognosis. CVD should be suspected in patients with COPD who have high/very high risk scores on validated scales, frequent exacerbations, precordial pain, disproportionate dyspnea, or palpitations. They should be referred to cardiology if they have palpitations of unknown cause or angina pain. COPD should be suspected in patients with CVD if they have recurrent bronchitis, cough and expectoration, or disproportionate dyspnea. They should be referred to a pulmonologist if they have rhonchi or wheezing, air trapping, emphysema, or signs of chronic bronchitis. Treatment of COPD in cardiovascular patients should include long-acting muscarinic receptor antagonists (LAMA) or long-acting beta-agonists (LABA) in low-risk or high-risk non-exacerbators, and LAMA/LABA/inhaled corticosteroids in exacerbators who are not controlled with bronchodilators. Cardioselective beta-blockers should be favored in patients with CVD, the long-term need for amiodarone should be assessed, and antiplatelet drugs should be maintained if indicated. (AU)
Subject(s)
Humans , Lung Diseases , Pulmonary Disease, Chronic Obstructive , Cardiovascular Diseases , Prognosis , Chest PainABSTRACT
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently coexist, increasing the prevalence of both entities and impacting on symptoms and prognosis. CVD should be suspected in patients with COPD who have high/very high risk scores on validated scales, frequent exacerbations, precordial pain, disproportionate dyspnea, or palpitations. They should be referred to cardiology if they have palpitations of unknown cause or angina pain. COPD should be suspected in patients with CVD if they have recurrent bronchitis, cough and expectoration, or disproportionate dyspnea. They should be referred to a pulmonologist if they have rhonchi or wheezing, air trapping, emphysema, or signs of chronic bronchitis. Treatment of COPD in cardiovascular patients should include long-acting muscarinic receptor antagonists (LAMA) or long-acting beta-agonists (LABA) in low-risk or high-risk non-exacerbators, and LAMA/LABA/inhaled corticosteroids in exacerbators who are not controlled with bronchodilators. Cardioselective beta-blockers should be favored in patients with CVD, the long-term need for amiodarone should be assessed, and antiplatelet drugs should be maintained if indicated.
Subject(s)
Cardiovascular Diseases , Pulmonary Disease, Chronic Obstructive , Humans , Cardiovascular Diseases/complications , Administration, Inhalation , Muscarinic Antagonists/therapeutic use , Pulmonary Disease, Chronic Obstructive/drug therapy , Drug Therapy, Combination , Adrenal Cortex Hormones/therapeutic use , Dyspnea , Pain/drug therapy , Adrenergic beta-2 Receptor Agonists/therapeutic use , Bronchodilator Agents/therapeutic useABSTRACT
Heart transplant (HT) remains the best therapeutic option for patients with advanced heart failure (HF). The allocation criteria aim to guarantee equitable access to HT and prioritize patients with a worse clinical status. To review the HT allocation criteria, the Heart Failure Association of the Spanish Society of Cardiology (HFA-SEC), the Spanish Society of Cardiovascular and Endovascular Surgery (SECCE) and the National Transplant Organization (ONT), organized a consensus conference involving adult and pediatric cardiologists, adult and pediatric cardiac surgeons, transplant coordinators from all over Spain, and physicians and nurses from the ONT. The aims of the consensus conference were as follows: a) to analyze the organization and management of patients with advanced HF and cardiogenic shock in Spain; b) to critically review heart allocation and priority criteria in other transplant organizations; c) to analyze the outcomes of patients listed and transplanted before and after the modification of the heart allocation criteria in 2017; and d) to propose new heart allocation criteria in Spain after an analysis of the available evidence and multidisciplinary discussion. In this article, by the HFA-SEC, SECCE and the ONT we present the results of the analysis performed in the consensus conference and the rationale for the new heart allocation criteria in Spain.
Subject(s)
Heart Failure , Heart Transplantation , Adult , Humans , Child , Spain/epidemiology , Heart Failure/surgery , Consensus , Shock, CardiogenicSubject(s)
Humans , Male , Female , Young Adult , Adult , Middle Aged , Heart Arrest , Heart Transplantation , Heart Failure/drug therapy , Spain , Retrospective Studies , Tissue and Organ ProcurementABSTRACT
INTRODUCTION AND OBJECTIVES: The present report describes the clinical characteristics and outcomes of heart transplants in Spain and updates the data to 2019. METHODS: We describe the clinical characteristics and outcomes of heart transplants performed in Spain in 2019, as well as trends in this procedure from 2010 to 2018. RESULTS: In 2019, 300 transplants were performed (8794 since 1984; 2745 between 2010 and 2019). Compared with previous years, the most notable findings were the decreasing rate of urgent transplants (38%), and the consolidation of the type of circulatory support prior to transplant, with an almost complete disappearance of counterpulsation balloon (0.7%), stabilization in the use of extracorporeal membrane oxygenation (9.6%), and an increase in the use of ventricular assist devices (29.0%). Survival from 2016 to 2018 was similar to that from 2013 to 2015 (P=.34). Survival in both these periods was better than that from 2010 to 2012 (P=.002 and P=.01, respectively). CONCLUSIONS: Heart transplant activity has remained stable during the last few years, as have outcomes (in terms of survival). There has been a trend to a lower rate of urgent transplants and to a higher use of ventricular assist devices prior to transplant.
Subject(s)
Cardiology , Heart Failure , Heart Transplantation , Heart Failure/surgery , Humans , Registries , Societies, Medical , Spain/epidemiologyABSTRACT
BACKGROUND: Cold ischemia time (CIT) has been associated to heart transplantation (HT) prognosis. However, there is still uncertainty regarding the CIT cutoff value that might have relevant clinical implications. METHODS: We analyzed all adults that received a first HT during the period 2008-2018. CIT was defined as the time between the cross-clamp of the donor aorta and the reperfusion of the heart. Primary outcome was 1-month mortality. RESULTS: We included 2629 patients, mean age was 53.3 ± 12.1 years and 655 (24.9%) were female. Mean CIT was 202 ± 67 min (minimum 20 min, maximum 600 min). One-month mortality per CIT quartile was 9, 12, 13, and 19%. One-year mortality per CIT quartile was 16, 19, 21, and 28%. CIT was an independent predictor of 1-month mortality, but only in the last quartile of CIT >246 min (odds ratio 2.1, 95% confidence interval 1.49-3.08, p < .001). We found no relevant differences in CIT during the study period. However, the impact of CIT in 1-month and 1-year mortality decreased with time (p value for the distribution of ischemic time by year 0.01), particularly during the last 5 years. CONCLUSIONS: Although the impact of CIT in HT prognosis seems to be decreasing in the last years, CIT in the last quartile (>246 min) is associated with 1-month and 1-year mortality. Our findings suggest the need to limit HT with CIT > 246 min or to use different myocardial preservation systems if the expected CIT is >4 h.
Subject(s)
Cold Ischemia , Heart Transplantation , Adult , Aged , Female , Graft Survival , Humans , Male , Middle Aged , Registries , Time Factors , Tissue DonorsABSTRACT
INTRODUCCIÓN Y OBJETIVOS: La insuficiencia cardiaca (IC) avanzada conlleva altas tasas de hospitalización y mortalidad. El estudio LION-HEART fue un ensayo clínico aleatorizado y controlado con placebo que evaluó la eficacia y la seguridad de la administración intravenosa de dosis intermitentes de levosimendán en pacientes ambulatorios con IC avanzada. El objetivo del presente estudio es realizar un análisis de costes para determinar si la menor tasa de hospitalizaciones por IC observada en pacientes tratados con levosimendán en el estudio LION-HEART puede generar ahorros para el Sistema Nacional de Salud, en comparación con la opción de no tratar a los pacientes con IC avanzada. MÉTODOS: Se realizó un modelo económico que incluyó las tasas de hospitalización por IC del estudio LION-HEART y los costes de hospitalización por IC y de adquisición y administración intravenosa de levosimendán. El horizonte temporal del análisis fue de 12 meses. Se realizaron 2 análisis, uno determinístico y otro probabilístico (simulación de Monte Carlo de segundo orden). RESULTADOS: Según el análisis determinístico, el ahorro total por cada paciente tratado con levosimendán ascendería a -698,48 euros. En el análisis probabilístico, el ahorro por paciente tratado con levosimendán sería de -849,94 (IC95%, 133,12 a -2.255,31) euros. La probabilidad de que se produzcan ahorros con levosimendán en comparación con la opción de no tratar sería del 94,8%. CONCLUSIONES: El tratamiento ambulatorio intermitente con levosimendán puede generar ahorros para el Sistema Nacional de Salud, en comparación con la opción de no tratar a los pacientes con IC avanzada
INTRODUCTION AND OBJECTIVES: Advanced heart failure (HF) leads to high hospitalization and mortality rates. The LION-HEART study was a randomized, placebo-controlled clinical trial that evaluated the safety and efficacy of intravenous administration of intermittent doses of levosimendan in outpatients with advanced HF. The aim of the present study was to perform a cost analysis to determine whether the lower rate of hospitalizations for HF, observed in patients treated with levosimendan in the LION-HEART study, can generate savings for the Spanish national health system compared with the option of not treating patients with advanced HF. METHODS: An economic model was used that included IC hospitalization rates from the LION-HEART study, the costs of hospitalization due to HF and those of the acquisition and intravenous administration of levosimendan. The time horizon of the analysis was 12 months. Two analyses were carried out, one deterministic and the other probabilistic (second-order Monte Carlo simulation). RESULTS: In the deterministic analysis, the total saving for each patient treated with levosimendan would amount to−698.48. In the probabilistic analysis, the saving per patient treated with levosimendan would be−849.94 (95%CI, 133.12 to−2,255.31). The probability of savings with levosimendan compared with the no treatment option would be 94.8%. CONCLUSIONS: Intermittent ambulatory treatment with levosimendan can generate savings for the Spanish national health system compared with the option of not treating patients with advanced HF
Subject(s)
Humans , Male , Female , Aged , Heart Failure/economics , Simendan/economics , Vasodilator Agents/economics , Ambulatory Care/economics , Heart Failure/drug therapy , Simendan/therapeutic use , Vasodilator Agents/therapeutic use , Hospitalization/economics , Hospitalization/statistics & numerical data , Cost-Benefit Analysis , Infusions, Intravenous/economicsABSTRACT
INTRODUCTION AND OBJECTIVES: Advanced heart failure (HF) leads to high hospitalization and mortality rates. The LION-HEART study was a randomized, placebo-controlled clinical trial that evaluated the safety and efficacy of intravenous administration of intermittent doses of levosimendan in outpatients with advanced HF. The aim of the present study was to perform a cost analysis to determine whether the lower rate of hospitalizations for HF, observed in patients treated with levosimendan in the LION-HEART study, can generate savings for the Spanish national health system compared with the option of not treating patients with advanced HF. METHODS: An economic model was used that included IC hospitalization rates from the LION-HEART study, the costs of hospitalization due to HF and those of the acquisition and intravenous administration of levosimendan. The time horizon of the analysis was 12 months. Two analyses were carried out, one deterministic and the other probabilistic (second-order Monte Carlo simulation). RESULTS: In the deterministic analysis, the total saving for each patient treated with levosimendan would amount to-698.48. In the probabilistic analysis, the saving per patient treated with levosimendan would be-849.94 (95%CI, 133.12 to-2,255.31). The probability of savings with levosimendan compared with the no treatment option would be 94.8%. CONCLUSIONS: Intermittent ambulatory treatment with levosimendan can generate savings for the Spanish national health system compared with the option of not treating patients with advanced HF.
Subject(s)
Ambulatory Care/economics , Cardiotonic Agents/economics , Cardiotonic Agents/therapeutic use , Heart Failure/drug therapy , Hydrazones/economics , Hydrazones/therapeutic use , Simendan/therapeutic use , Administration, Intravenous , Aged , Aged, 80 and over , Costs and Cost Analysis , Female , Heart Failure/economics , Humans , Male , Middle Aged , Outpatients , Risk Factors , Simendan/economics , Spain/epidemiology , Treatment OutcomeSubject(s)
Algorithms , Cardiac Resynchronization Therapy , Cardiovascular Agents/therapeutic use , Death, Sudden, Cardiac/prevention & control , Defibrillators, Implantable , Extracorporeal Membrane Oxygenation , Heart Failure/therapy , Practice Guidelines as Topic , Acute Disease , Adrenergic beta-Antagonists/therapeutic use , Aminobutyrates/therapeutic use , Angiotensin Receptor Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Benzazepines/therapeutic use , Biphenyl Compounds , Chronic Disease , Drug Combinations , Early Medical Intervention , Echocardiography , Europe , Heart Failure/blood , Heart Failure/diagnosis , Humans , Ivabradine , Mineralocorticoid Receptor Antagonists/therapeutic use , Natriuretic Peptides/blood , Spain , Stroke Volume , Tetrazoles/therapeutic use , ValsartanABSTRACT
La insuficiencia cardiaca tiene una elevada prevalencia y es el proceso asistencial con mayor carga de enfermedad en España. Las unidades de insuficiencia cardiaca se han desarrollado para sistematizar el diagnóstico, el tratamiento y el seguimiento clínico de los pacientes con dicha enfermedad proporcionando una estructura que coordine las actuaciones de distintas entidades y personas implicadas en el cuidado de los pacientes, con el fin último de mejorar su pronóstico y la calidad de vida. Se dispone de amplia evidencia sobre las bondades de las unidades o los programas de insuficiencia cardiaca, y estas unidades han tenido un importante despliegue en nuestro país. Uno de los retos a los que se enfrenta el análisis de las unidades de insuficiencia cardiaca es normalizar su clasificación determinando qué «programas» se puede identificar como «unidades» de insuficiencia cardiaca, así como su nivel de complejidad, y cuáles no. La finalidad de este documento es exponer los estándares elaborados por la Sociedad Española de Cardiología para clasificar y establecer los requisitos para las unidades de insuficiencia cardiaca dentro del marco del proyecto SEC-Excelente (AU)
The prevalence of heart failure remains high and represents the highest disease burden in Spain. Heart failure units have been developed to systematize the diagnosis, treatment, and clinical follow-up of heart failure patients, provide a structure to coordinate the actions of various entities and personnel involved in patient care, and improve prognosis and quality of life. There is ample evidence on the benefits of heart failure units or programs, which have become widespread in Spain. One of the challenges to the analysis of heart failure units is standardization of their classification, by determining which programs can be identified as heart failure units and by characterizing their complexity level. The aim of this article was to present the standards developed by the Spanish Society of Cardiology to classify and establish the requirements for heart failure units within the SEC-Excellence project (AU)
Subject(s)
Humans , Heart Failure , Coronary Care Units/organization & administration , Quality of Health Care/standards , Quality Improvement/organization & administration , Hospital AccreditationABSTRACT
The prevalence of heart failure remains high and represents the highest disease burden in Spain. Heart failure units have been developed to systematize the diagnosis, treatment, and clinical follow-up of heart failure patients, provide a structure to coordinate the actions of various entities and personnel involved in patient care, and improve prognosis and quality of life. There is ample evidence on the benefits of heart failure units or programs, which have become widespread in Spain. One of the challenges to the analysis of heart failure units is standardization of their classification, by determining which "programs" can be identified as heart failure "units" and by characterizing their complexity level. The aim of this article was to present the standards developed by the Spanish Society of Cardiology to classify and establish the requirements for heart failure units within the SEC-Excellence project.
Subject(s)
Coronary Care Units/standards , Heart Failure/therapy , Adolescent , Adult , Aged , Consensus , Coronary Care Units/classification , Critical Pathways/standards , Equipment and Supplies, Hospital/standards , Female , Health Information Systems/standards , Health Personnel/standards , Heart Failure/diagnosis , Humans , Male , Middle Aged , Outcome Assessment, Health Care , Quality of Health Care/standards , Spain , Terminology as Topic , Young AdultABSTRACT
El objetivo general de la Guía de Práctica Clínica es proporcionar a los agentes encargados de la asistencia y cuidados de este tipo de pacientes, una herramienta que les permita tomar las mejores decisiones sobre algunos de los problemas que ocasionan su atención y que no han sido resueltos. Esta Guía ha sido desarrollada para generar recomendaciones sobre el tratamiento de la insuficiencia cardiaca crónica (ICC). Abarca los siguientes aspectos: TRATAMIENTO FARMACOLÓGICO: - Inhibidores de la enzima convertidora de la angiotensina ( o antagonistas de los receptores de la angiotensina), Betabloqueantes y antagonistas de la aldosterona en pacientes mayores de 65 años con disfunción sistólica. En pacientes con con fracción de eyección preservada o ligeramente deprimida. - Efectividad de la eplerona frente a espironolactona. - Eficacia del sacubitrilo/valsartán sustituyendo a un inhibidor de la enzima convertidora de la angiotensina (o a un antagonista del receptor de la angiotensina II), junto a betabloqueante y antagonistas de la aldosterona. TRATAMIENTO NO FARMACOLÓGICO: -Control temprano tras el alta hospitalaria. -Eficacia de las medidas higiénico-dietéticas. -Monitorización mediante péptidos natriuréticos para control del tratamiento farmacológico. -Eficacia de los programas de telemedicina. -Eficacia de las rehabilitación cardiaca basada en el ejercicio. -Eficacia de los desfibriladores automáticos implantables en mayores de 65 años.
Subject(s)
Humans , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , Angiotensin Receptor Antagonists/therapeutic use , Heart Failure/therapy , Defibrillators, Implantable , Adrenergic beta-Antagonists/therapeutic use , Exercise Therapy/methods , Valsartan/therapeutic use , Diet, Healthy/methods , GRADE ApproachABSTRACT
La insuficiencia cardiaca aguda (ICA) supone un elevado uso de recursos, carga económica y morbimortalidad, tanto en los servicios de urgencias como durante la hospitalización o durante su control ambulatorio. La variabilidad actual existente en el diagnóstico, tratamiento y la continuidad asistencial ha inducido que diferentes sociedades científicas (cardiología, medicina interna y urgencias) redacten este documento de consenso sobre recomendaciones prácticas que den soporte a todos los profesionales intervinientes en el manejo de la ICA y permita homogeneizar la toma de decisiones. El enfoque de estas recomendaciones, basadas en la revisión de la literatura y la experiencia clínica, se ha realizado abarcando diferentes puntos críticos del proceso asistencial de los pacientes con ICA: en el servicio de urgencias, en cuanto a la evaluación inicial del paciente con clínica sugestiva de ICA, orientación diagnóstica, primeras decisiones terapéuticas, monitorización, evaluación del pronóstico y criterios de derivación; durante la hospitalización, con el desarrollo de un protocolo básico terapéutico; tras el alta, con la definición de objetivos de manejo y tratamiento de la ICA al alta del paciente; y de forma global, mediante la mejora o creación de una organización en la atención multidisciplinar y la continuidad asistencial en la ICA (AU)
Acute heart failure (AHF) requires considerable use of resources, is an economic burden, and is associated with high complication and mortality rates in emergency departments, on hospital wards, or outpatient care settings. Diagnosis, treatment, and continuity of care are variable at present, leading 3 medical associations (for cardiology, internal medicine, and emergency medicine) to undertake discussions and arrive at a consensus on clinical practice guidelines to support those who manage AHF and encourage standardized decision making. These guidelines, based on a review of the literature and clinical experience with AHF, focus on critical points in the care pathway. Regarding emergency care, the expert participants considered the initial evaluation of patients with signs and symptoms that suggest AHF, the initial diagnosis, first decisions about therapy, monitoring, assessment of prognosis, and referral criteria. For care of the hospitalized patient, the group developed a protocol for essential treatment. Objectives for the management and treatment of AHF on discharge were also covered through the creation or improvement of multidisciplinary care systems to provide continuity of care (AU)
Subject(s)
Female , Humans , Male , /methods , /standards , Heart Failure/epidemiology , Heart Failure/economics , Emergencies/epidemiology , Emergency Medical Services/organization & administration , Emergency Medical Services/standards , Heart Failure/diagnosis , Heart Failure/therapy , Indicators of Morbidity and Mortality , International Cooperation/policiesABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Heart Transplantation/trends , Heart-Assist Devices/standards , Heart-Assist Devices/trends , Heart-Assist Devices , Cardiomyopathy, Dilated/diagnosis , Cardiomyopathy, Dilated/rehabilitation , Cardiomyopathy, Dilated/surgery , Bacteremia/complications , Bacteremia/drug therapySubject(s)
Cardiotonic Agents/administration & dosage , Heart Failure , Heart Transplantation , Myocardial Contraction/drug effects , Vasoconstrictor Agents/administration & dosage , Ventricular Function, Left/drug effects , Adult , Female , Heart Failure/diagnosis , Heart Failure/physiopathology , Heart Failure/surgery , Humans , Male , Middle Aged , Myocardial Contraction/physiology , Postoperative Period , Preoperative Period , Prognosis , Severity of Illness Index , Ventricular Function, Left/physiologyABSTRACT
No disponible
Subject(s)
Humans , Heart Transplantation/trends , Heart Failure/surgery , Heart Failure/epidemiology , Spain/epidemiology , Patient Selection , Immunosuppressive Agents/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Graft Rejection/epidemiology , Postoperative ComplicationsABSTRACT
Las neoplasias son una complicación frecuente y grave tras el trasplante cardiaco y una de las causas más importantes de muerte a largo plazo. El Registro Español de Tumores Postrasplante Cardiaco se inició en 2004, es online e incluye a todos los pacientes con trasplante cardiaco en España y con actualización continua de todos los tumores postrasplante. Los más frecuentes son cutáneos (54%), seguidos de los tumores no cutáneos no linfoides (39%) y linfomas (7%). La incidencia aumenta con la edad y el tiempo postrasplante y es mayor en varones. A los 15 años solo un 62% de los pacientes están libres de tumores. El pronóstico varía según el tipo de tumor. La incidencia de linfomas ha disminuido a la mitad en la última década. El Registro ayuda a conocer la incidencia, los factores de riesgo y el pronóstico de los tumores postrasplante y establecer estrategias de mejora (AU)
Neoplasia is a common and serious complication that occurs after heart transplantation and is one of the most important causes of death over the long term. The Spanish Post-Heart-Transplant Tumor Registry, which began in 2004, is an on-line record of all patients who have undergone heart transplantation in Spain. It includes continually updated information on post-transplantation tumors. The most common neoplasias are skin tumors (54%), followed by noncutaneous, nonlymphoid tumors (39%) and lymphomas (7%). Their incidence increases with age and time from transplantation and is higher in males. After 15 years, only 62% of patients are tumor-free. Prognosis varies according to the type of tumor. The incidence of lymphomas has decreased by half in the last decade. The Registry provides useful information on the incidence, risk factors and prognosis of tumors that occur after transplantation and can help in devising better management strategies (AU)
Subject(s)
Humans , Heart Transplantation/statistics & numerical data , Heart Failure/surgery , Neoplasms/epidemiology , Postoperative Complications , Risk FactorsABSTRACT
EN: Acute heart failure (AHF) requires considerable use of resources, is an economic burden, and is associated with high complication and mortality rates in emergency departments, on hospital wards, or outpatient care settings. Diagnosis, treatment, and continuity of care are variable at present, leading 3 medical associations (for cardiology, internal medicine, and emergency medicine) to undertake discussions and arrive at a consensus on clinical practice guidelines to support those who manage AHF and encourage standardized decision making. These guidelines, based on a review of the literature and clinical experience with AHF, focus on critical points in the care pathway. Regarding emergency care, the expert participants considered the initial evaluation of patients with signs and symptoms that suggest AHF, the initial diagnosis, first decisions about therapy, monitoring, assessment of prognosis, and referral criteria. For care of the hospitalized patient, the group developed a protocol for essential treatment. Objectives for the management and treatment of AHF on discharge were also covered through the creation or improvement of multidisciplinary care systems to provide continuity of care.
ES: La insuficiencia cardiaca aguda (ICA) supone un elevado uso de recursos, carga económica y morbimortalidad, tanto en los servicios de urgencias como durante la hospitalización o durante su control ambulatorio. La variabilidad actual existente en el diagnóstico, tratamiento y la continuidad asistencial ha inducido que diferentes sociedades científicas (cardiología, medicina interna y urgencias) redacten este documento de consenso sobre recomendaciones prácticas que den soporte a todos los profesionales intervinientes en el manejo de la ICA y permita homogeneizar la toma de decisiones. El enfoque de estas recomendaciones, basadas en la revisión de la literatura y la experiencia clínica, se ha realizado abarcando diferentes puntos críticos del proceso asistencial de los pacientes con ICA: en el servicio de urgencias, en cuanto a la evaluación inicial del paciente con clínica sugestiva de ICA, orientación diagnóstica, primeras decisiones terapéuticas, monitorización, evaluación del pronóstico y criterios de derivación; durante la hospitalización, con el desarrollo de un protocolo básico terapéutico; tras el alta, con la definición de objetivos de manejo y tratamiento de la ICA al alta del paciente; y de forma global, mediante la mejora o creación de una organización en la atención multidisciplinar y la continuidad asistencial en la ICA.