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Nat Prod Res ; 37(8): 1321-1327, 2023 Apr.
Article in English | MEDLINE | ID: mdl-34933632

ABSTRACT

Two new cytisine-like alkaloids, hositisines C (1) and D (2), were isolated from the seeds of Ormosia hosiei along with four known compounds, (-)-tinctorine (3), ß-adenosine (4), 2'-deoxyadenosine (5), and 7, 2', 4'-trihydroxy-5-methoxyisoflavanone (6). Their structures were established using extensive spectroscopic techniques (UV, IR, CD, HRESIMS, 1 D and 2 D NMR). In the cytotoxic activity, compounds 1-3 and 5-fluorouracil (positive control) displayed inhibitory effects against HepG2 cells, exhibiting IC50 values of 44.52 ± 7.83 µM, 111.49 ± 12.76 µM, 127.72 ± 18.67 µM, and 16.37 ± 3.82 µM.


Subject(s)
Alkaloids , Fabaceae , Molecular Structure , Fabaceae/chemistry , Alkaloids/chemistry , Quinolizines/pharmacology , Azocines/pharmacology , Seeds/chemistry
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