1.
Acta Neurol Belg
; 122(6): 1615-1617, 2022 12.
Article
En
| MEDLINE
| ID: mdl-34014491
2.
Acta Neurol Belg
; 122(6): 1603-1605, 2022 12.
Article
En
| MEDLINE
| ID: mdl-33595831
3.
Epilepsy Behav Rep
; 16: 100457, 2021.
Article
En
| MEDLINE
| ID: mdl-34142078
â¢Seizures have been observed in epilepsy patients receiving high dose intravenous or intrathecal Methotrexate (Mtx) therapy for the treatment of leukemias, due to reduction in valproic acid (VPA) levels.â¢Prolonged low dose weekly Mtx exposure can also produce reduction in VPA levels causing seizure relapse as reported in this case.â¢Mtx competes with VPA for binding to albumin as a result of which a larger proportion of VPA become unbound and is rapidly metabolized by the liver causing decline in VPA levels.â¢Awareness about pharmacological interactions of anti-epileptic drugs (AEDs) is essential in epilepsy management.