Papillary thyroid carcinoma (PTC) is generally recognized as a slow-growing tumor. However, a small subset of patients may still experience relapse or metastasis shortly after therapy, leading to a poor prognosis and raising concerns about excessive medical treatment. One major challenge lies in the inadequacy of effective biomarkers for accurate risk stratification. Long non-coding RNAs (lncRNAs), which are closely related to malignant characteristics and poor prognosis, play a significant role in the genesis and development of PTC through various pathways. The objective of this review is to provide a comprehensive summary of the biological functions of lncRNAs in PTC, identify prognosis-relevant lncRNAs, and explore their potential mechanisms in drug resistance to BRAF kinase inhibitors, tumor dedifferentiation, and lymph node metastasis. By doing so, this review aims to offer valuable references for both basic research and the prediction of PTC prognosis.
Carcinoma, Papillary , RNA, Long Noncoding , Thyroid Neoplasms , Humans , Thyroid Cancer, Papillary/genetics , Prognosis , Thyroid Neoplasms/pathology , RNA, Long Noncoding/genetics , Carcinoma, Papillary/pathology , Neoplasm Recurrence, Local , Proto-Oncogene Proteins B-raf/metabolism
