ABSTRACT
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.
Subject(s)
Dry Eye Syndromes/genetics , HLA-A2 Antigen/genetics , HLA-B44 Antigen/genetics , Stevens-Johnson Syndrome/genetics , Trichiasis/genetics , Adolescent , Adult , Alleles , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Brazil , Child , Dry Eye Syndromes/ethnology , Dry Eye Syndromes/etiology , Dry Eye Syndromes/immunology , Epithelium, Corneal/immunology , Epithelium, Corneal/pathology , Ethnicity , Female , Gene Frequency , HLA-A2 Antigen/immunology , HLA-B44 Antigen/immunology , Humans , India , Male , Middle Aged , Multi-Ingredient Cold, Flu, and Allergy Medications/adverse effects , Republic of Korea , Retinal Pigment Epithelium/immunology , Retinal Pigment Epithelium/pathology , Risk Factors , Stevens-Johnson Syndrome/ethnology , Stevens-Johnson Syndrome/etiology , Stevens-Johnson Syndrome/immunology , Trichiasis/ethnology , Trichiasis/etiology , Trichiasis/immunologyABSTRACT
A síndrome do olho seco é uma entidade muito comum na pratica medica e, por apresentar uma sintomalogia muito inespecífica, compartilhada por diversas outras doenças oculares, costuma ser subdiagnosticada. Atualmente, o termo olho seco é definido como uma doença multifatorial do sistema lacrimal caracterizada por sintomas de desconforto, distúrbios visuais, com potencial dano à superfície ocular. É acompanhado de alteração de alterações na osmolaridade do filme lacrimal e inflamação da superfície ocular.