Hematoma duodenal en el adulto: aspectos clínicos imagenológicos. Presentación de tres casos / Duodenal hematoma in the adult: clinical imaging aspects. Presentation of three cases

Fundamento: el hematoma duodenal es una entidad poco frecuente y para su diagnóstico es preciso considerar la existencia de factores de riesgo, las manifestaciones clínicas y el modo de diagnóstico, entre estos, el imagenológico. Objetivo: mostrar distintas formas clínicas e imagenológicas de presentación del hematoma duodenal según tipo de estudio y tiempo de evolución. Presentación de casos: se presentaron tres casos de hematoma duodenal diagnosticados en diferentes periodos evolutivos. El antecedente traumático no fue recogido al inicio en dos de ellos pero las investigaciones imagenológicas orientaron su diagnóstico. El vómito y el dolor abdominal estuvieron presentes en los tres, la anemia, el tinte sub-ictérico y la toma del estado general en el caso de diagnóstico tardío de tres meses de evolución. El cuadro oclusivo intestinal alto surge secundario a una endoscopia con escleroterapia por úlcera sangrante en el tercer caso de forma aguda. En la ecografía, la radiografía contrastada del tubo digestivo y la tomografía axial computarizada se apreciaron variaciones del patrón en dependencia al tiempo de evolución. La ecografía como primer estudio detectó la colección en todos ellos y fue útil en el seguimiento, el estudio radiológico contrastado orientó el diagnóstico con predominio de patrón anfractuoso en el caso tardío, y la tomografía ofreció la mayor información. Conclusiones: para el diagnóstico del hematoma duodenal es necesario tenerlo presente e indagar sobre factores de riesgo, acudir a los medios diagnósticos disponibles y considerar que sus manifestaciones pueden variar según el tiempo de evolución. Se considera la tomografía como examen de elección (AU)

Background: the duodenal hematoma is an infrequent entity, usually of late diagnosis, which should be made according to risk factors, the clinical manifestations and imaging studies. Objective: to show different clinical and imaging forms of presentation of duodenal hematoma according to type of imaging study and time of progress.Cases reports: three cases of duodenal hematoma diagnosed in different follow up periods are presented. The history of the trauma was not recorded at the beginning in two cases neither considered as a predisposing factor, but the diagnostic research suspected the diagnosis. Vomiting and abdominal pain was seen in all three cases. Anemia, sub-jaundice dye and malaise were present at three months of follow up. Upper acute intestinal occlusive condition was secondary to endoscopic sclera-therapy due to digestive bleeding in the third case. Ultrasound, contrast radiography of the digestive tube and computerized axial tomography showed variations of the pattern depending on the modifications of the hematoma over time. Ultrasound as the first study detected the collection in all cases and was useful in the follow-up. Contrast radiological study was oriented towards the diagnosis and show predominance of regular patterns in case of late diagnosis. The Tomography achieved a greater diagnostic definition. Conclusions: for the diagnosis of duodenal hematoma, it is necessary to take into account and think about risk factors, and the proper management of imaging studies in relation to time of progress. Tomography is the examination of choice (AU)

Perforación duodenal por barotrauma durante colangiopancreatografía retrógrada endoscópica: caso clínico / Duodenal perforation due to barotrauma during endoscopic retrograde cholangiopancreatography: clinical case

Resumen Introducción: La perforación duodenal secundaria a la colangiopancreatografía retrógrada endoscópica (CPRE) es una complicación infrecuente y más aún cuando su mecanismo lesional es por barotrauma. La inyección de aire a alta presión produce un neumoretroperitoneo, cuya extensión y evolución lesional es incierta. Caso Clínico: Se comunica el caso de un hombre joven que sufrió una perforación duodenal durante una CPRE, su manejo quirúrgico y evolución. Discusión: El diagnóstico clínico-imagenológico suele ser precoz y claro si se detecta la lesión durante el procedimiento. El manejo terapéutico conservador o quirúrgico de esta entidad depende de varios factores que se analizan en el presente estudio.

Introduction: Duodenal perforation during endoscopic retrograde cholangiopancreatography (ERCP) is a rare complication and even more if the mechanism of injury is secondary to barotrauma. The injection of high-pressure-air produces a pneumo-retroperitoneum, the extent and lesional evolution of which is uncertain. Clinical Case: We report the case of a young man who suffered a duodenal perforation during an ERCP, his surgical management and evolution. Discussion: The clinical-imaging diagnosis is usually early and clear if the lesion is detected during the procedure. Its conservative or surgical management will depends on several factors that are analyzed in the present study.

Damage control in penetrating duodenal trauma: less is better - the sequel.

The overall incidence of duodenal injuries in severely injured trauma patients is between 0.2 to 0.6% and the overall prevalence in those suffering from abdominal trauma is 3 to 5%. Approximately 80% of these cases are secondary to penetrating trauma, commonly associated with vascular and adjacent organ injuries. Therefore, defining the best surgical treatment algorithm remains controversial. Mild to moderate duodenal trauma is currently managed via primary repair and simple surgical techniques. However, severe injuries have required complex surgical techniques without significant favorable outcomes and a consequential increase in mortality rates. This article aims to delineate the experience in the surgical management of penetrating duodenal injuries via the creation of a practical and effective algorithm that includes basic principles of damage control surgery that sticks to the philosophy of "Less is Better". Surgical management of all penetrating duodenal trauma should always default when possible to primary repair. When confronted with a complex duodenal injury, hemodynamic instability, and/or significant associated injuries, the default should be damage control surgery. Definitive reconstructive surgery should be postponed until the patient has been adequately resuscitated and the diamond of death has been corrected.

El trauma de duodeno comúnmente se produce por un trauma penetrante que puede asociarse a lesiones vasculares y de órganos adyacentes. En el manejo quirúrgico se recomienda realizar un reparo primario o el empleo de técnicas quirúrgicas simples. Sin embargo, el abordaje de lesiones severas del duodeno es un tema controversial. Anteriormente, se han descrito técnicas como la exclusión pilórica o la pancreatoduodenectomía con resultados no concluyentes. El presente artículo presenta una propuesta del manejo de control de daños del trauma penetrante de duodeno, a través, de un algoritmo de cinco pasos. Este algoritmo plantea una solución para el cirujano cuando no es posible realizar el reparo primario. El control de daños del duodeno y su reconstrucción depende de una toma de decisiones respecto a la porción del duodeno lesionada y el compromiso sobre el complejo pancreatoduodenal. Se recomiendan medidas rápidas para contener el daño y se proponen vías de reconstrucción duodenal diferente a las clásicamente descritas. Igualmente, la probabilidad de complicaciones como fistula duodenales es considerable, por lo que proponemos, que el manejo de este tipo de fistulas de alto gasto se aborde por medio de una laparostomía retroperitoneal (lumbotomía). El abordaje del trauma penetrante de duodeno se puede realizar a través del principio "menos es mejor".

Duodenal Laceration Due to Blunt Trauma Caused by Horse Kick: A Case Report and Literature Review.

BACKGROUND Duodenal trauma usually consists of retroperitoneal lesions. Its management can be complicated by the location of the injury and difficulty in making an early diagnosis. Duodenal injuries are divided into blunt and penetrating trauma, and the possible results are hematoma, laceration, and devascularization. Duodenal lesions due to blunt trauma are usually accompanied by lesions of nearby organs. We present a rare case of a single duodenal laceration due to blunt abdominal trauma caused by a horse kick, along with a literature review. CASE REPORT A 13-year-old boy presented to our emergency department after being kicked by a horse in his abdomen. He was stable and complained of abdominal pain without any other specifications. Computed tomography imaging revealed a retropneumoperitoneum and free fluid in the abdominal cavity. The patient was taken for an emergency laparotomy, which showed a single duodenal laceration of the second and third portions of the duodenum. The laceration was repaired with a double-layer closure using monofilament 3-0 polypropylene suture. The patient recovered from his injuries and was well at his last follow-up. CONCLUSIONS This case highlights the possible outcomes of an innocent blunt trauma and the importance of early diagnosis for the best outcome of a duodenal laceration. It also identifies the dissociation between the patient's clinical presentation and his significant intra-abdominal injury.

Prognosis of mortality and evolution in pancreatoduodenal trauma in patients with wound by projectile of firearm.

BACKGROUND: The wounds caused by the firearm projectile are published to date in a public health problem in the world. As an example, we mentioned the injuries caused by firearms are the first cause of death in the age group between 1 to 19 years in the United States, as in Mexico. OBJECTIVE: Analysis of the prognostic factors of mortality and evaluation of the evolution in patients with TPD due to abdominal HPPAF. METHOD: Retrospective, observational, descriptive study. Helped by 49 clinical files of patients who were admitted to the department of surgery of the University Hospital José Eleuterio González, between 2011 to 2015 and whose diagnosis was due to pancreatic trauma (TP), duodenal trauma (TD) or pancreatoduodenal trauma (TPD) by wounds caused by the firearm projectile. RESULTS: During a collection period of 5 years, a total of 49 clinical records applicable to the study were obtained according to the inclusion criteria, of which 36 (73%) suffered only from TD, 37 (75%) from TP and 24 (49%) about TPD. Significant differences were obtained for mortality associated with TD and TPD, but not for TP. The most affected organ as a lesion associated with a TPD was the liver, followed by thoracic structures and the stomach. The most significant risk factor for mortality was a prolonged stay in the intensive care unit. CONCLUSIONS: Data obtained are consistent with those consulted, providing new reproducible statistics for future studies regarding the increasing violence in our country and around the world.

ANTECEDENTES: Las heridas por proyectil de arma de fuego constituyen un problema de salud pública en el mundo. Como ejemplo mencionamos que este tipo de lesiones son la primera causa de muerte en el grupo de edad de 1 a 19 años en los EE.UU., al igual que en México. OBJETIVO: Análisis de los factores pronósticos de mortalidad y evaluación de la evolución en pacientes con TPD por HPPAF abdominal. MÉTODO: Estudio retrospectivo, observacional y descriptivo, realizado con 49 expedientes clínicos de pacientes que fueron admitidos en el departamento de cirugía del Hospital Universitario José Eleuterio González entre los años 2011 y 2015, cuyo diagnostico fue herida por proyectil de arma de fuego con trauma pancreático (TP), duodenal (TD) o pancreatoduodenal (TPD). RESULTADOS: Durante un periodo de recolección de 5 años se obtuvieron 49 expedientes clínicos aplicables al estudio según los criterios de inclusión, de los cuales 36 pacientes (73%) sufrieron únicamente TD, 37 (75%) TP y 24 (49%) TPD. Se obtuvieron diferencias significativas para la mortalidad asociada a TD y TPD, pero no para TP. El órgano más afectado como lesión asociada a un TPD fue el hígado, seguido de las estructuras torácicas y el estómago. El factor de riesgo para mortalidad más significativo fue una estancia prolongada en la unidad de cuidados intensivos. CONCLUSIONES: Los datos conseguidos concuerdan con los consultados, otorgando nueva estadística reproducible para futuros estudios respecto a la violencia creciente en nuestro país y alrededor del mundo.

Duodenal injury in blunt abdominal trauma. Case report and literature review.

There are few reported cases of small bowel injury due to blunt abdominal trauma. We describe the clinical presentation and surgical management of these lesions. This is the clinical case of a polytraumatized male with a duodenal injury IIID3 according to AAST, who underwent resection of the intestinal segment with duodeno-duodenum anastomosis with favorable results. The infrequent presentation of injuries to the small intestine due to blunt trauma may lead the clinician to overlook the need for intentional interrogation about the kinematics of the trauma, while at the same time neglecting the taking of complementary diagnostic imaging studies, this because of a lack of clinical suspicion. It is important to analyze the patient's context, which will allow us to assess the need to delve into diagnostic studies in order to optimize their treatment.

Existen pocos casos notificados de lesión de intestino delgado por traumatismo contuso abdominal. Se describen la presentación clínica y el tratamiento quirúrgico de dichas lesiones, un caso clínico de un paciente masculino politraumatizado con lesión duodenal IIID3 según la AAST, objeto de resección de segmento intestinal con anastomosis duodenoduodenal terminoterminal con resultados favorables. La presentación infrecuente de lesiones de intestino delgado por traumatismo contuso puede llevar al clínico a soslayar la necesidad de un interrogatorio intencionado acerca de la cinemática del traumatismo y también de los estudios de imagen complementarios diagnósticos debido a la falta de sospecha clínica. Es importante analizar el contexto del paciente para valorar la necesidad de profundizar en estudios diagnósticos y optimizar el tratamiento.

PARIETAL PERITONEUM GRAFT FOR DUODENUM INJURIES IN AN ANIMAL MODEL.

BACKGROUND: Duodenal injuries and their surgical procedure cause a high morbidity and mortality. AIM: To assess the overall effectiveness of the auto-graft of peritoneum in the treatment of the perforation of the duodenum, aiming to reduce surgery time, costs, complexity and mortality. METHODS: Twelve New Zealand rabbits, ages 4-6 months, both sexes, underwent designed surgical grade III duodenal injuries that were repaired 18 h after. Rabbits were surgically treated with the proposed auto-graft of peritoneum. RESULTS: No postoperative deaths were observed; the animals presented corporal weight increase and were euthanized six months later. There was no significant difference between both groups relating to the postoperative evolution or in the histological changes. CONCLUSION: Auto-graft of the peritoneum and posterior fascia is a useful option for duodenal repair and that is worth of evaluation for humans.

Parietal peritoneum graft for duodenum injuries in an animal model / Enxerto de peritônio parietal em lesão duodenal: modelo animal

ABSTRACT Background: Duodenal injuries and their surgical procedure cause a high morbidity and mortality. Aim: To assess the overall effectiveness of the auto-graft of peritoneum in the treatment of the perforation of the duodenum, aiming to reduce surgery time, costs, complexity and mortality. Methods: Twelve New Zealand rabbits, ages 4-6 months, both sexes, underwent designed surgical grade III duodenal injuries that were repaired 18 h after. Rabbits were surgically treated with the proposed auto-graft of peritoneum. Results: No postoperative deaths were observed; the animals presented corporal weight increase and were euthanized six months later. There was no significant difference between both groups relating to the postoperative evolution or in the histological changes. Conclusion: Auto-graft of the peritoneum and posterior fascia is a useful option for duodenal repair and that is worth of evaluation for humans.

RESUMO Racional: Lesões duodenais e seu procedimento cirúrgico causam alta morbimortalidade. Objetivo: Avaliar a eficácia geral de retalho peritoneal no tratamento da perfuração do duodeno, visando reduzir o tempo, os custos, a complexidade e a mortalidade cirúrgicas. Métodos: Doze coelhos da raça Nova Zelândia, com idades entre 4-6 meses, ambos os sexos, foram submetidos a lesões duodenais cirúrgicas de grau III, que foram reparadas 18 h depois. Coelhos foram tratados cirurgicamente com a proposta de auto-enxerto de peritônio. Resultados: Não foram observados óbitos pós-operatórios; os animais apresentaram aumento de peso corporal e foram eutanasiados seis meses depois. Não houve diferença significativa entre os dois grupos em relação à evolução pós-operatória ou nas alterações histológicas. Conclusão: A auto-enxertia do peritônio e da fáscia posterior é uma opção útil para o reparo duodenal e vale a pena ser avaliada em seres humanos.

Hallazgos endoscópicos en el tubo digestivo secundarios a la ingesta de cáusticos en niños atendidos en el Departamento de Urgencias / Endoscopic findings of the digestive tract secondary to caustic ingestion in children seen at the Emergency Department

Antecedentes. La ingesta de sustancias cáusticas en pediatría constituye una causa frecuente de atención médica en Urgencias. El uso indiscriminado de limpiadores químicos y la facilidad de adquisición son factores determinantes para estas lesiones. Población y métodos. Estudio descriptivo analítico. Se incluyeron niños < 16 años, entre enero de 1998 y diciembre de 2017. Se identificó el agente químico cáustico ingerido por el niño como ácido o alcalino. Se realizó una endoscopía digestiva para tipificar el grado de quemadura. Se comparó el grado de quemadura con el tipo de cáustico; por medio de la prueba de chi² o exacta de Fisher, se consideró significativo el valor de P < 0,05. Resultados. Ingresaron 133 niños en Urgencias por ingesta de cáusticos. El agente cáustico fue ácido en el 41 % y alcalino en el 59 %. El agente ácido más frecuente fue el ácido muriático (36,8 %), mientras que el alcalino fue la sosa (soda) cáustica (41,4 %). La quemadura del esófago fue más frecuente en la ingesta de sosa en comparación con otros cáusticos (p= 0,001), mientras que la quemadura del estómago (p= 0,001) y del duodeno (p= 0,002) fue estadísticamente significativa en la ingesta de ácido muriático. El grupo de edad que más frecuentemente ingirió algún cáustico (93,2 %) fueron los menores de 5 años. Conclusiones. El cáustico ingerido con mayor frecuencia fue un agente alcalino, que provocó quemadura esofágica, mientras que un agente ácido provocó quemaduras en el estómago y el duodeno evidenciadas por endoscopía.

Background. Caustic ingestion in pediatrics is a common cause of visits to the Emergency Department. An indiscriminate use of cleaning chemicals and an easy access to them are determining factors for these injuries. Population and methods. Descriptive, analytical study. Children aged < 16 years hospitalized between January 1998 and December 2017 were included. The ingested caustic substance was identified as acid or alkaline. A gastrointestinal endoscopy was done to establish the burn grade. The grade of the burn was compared to the type of caustic substance using the χ² test or the Fisher's exact test; a P value < 0.05 was considered significant. Results. A total of 133 children were admitted to the Emergency Department due to caustic ingestion. The caustic agent was acid in 41 % of cases and alkaline, in 59 %. The most common acid caustic substance was muriatic acid (36.8 %) and the most common alkaline caustic agent was caustic soda (41.4 %). An esophageal burn was the most common consequence of caustic soda ingestion compared to other caustic agents (p = 0.001), whereas muriatic acid ingestion was the most statistically significant cause of stomach burn (p = 0.001) and duodenal burn (p = 0.002). The age group that most commonly ingested some caustic agent (93.2 %) corresponded to children younger than 5 years. Conclusions. The most common type of ingested caustic agent was alkaline, which caused esophageal burn; whereas, the ingestion of an acid caustic substance caused stomach and duodenal burns, as evidenced by endoscopy.

Endoscopic findings of the digestive tract secondary to caustic ingestion in children seen at the Emergency Department. / Hallazgos endoscópicos en el tubo digestivo secundarios a la ingesta de cáusticos en niños atendidos en el Departamento de Urgencias.

BACKGROUND: Caustic ingestion in pediatrics is a common cause of visits to the Emergency Department. An indiscriminate use of cleaning chemicals and an easy access to them are determining factors for these injuries. POPULATION AND METHODS: Descriptive, analytical study. Children aged < 16 years hospitalized between January 1998 and December 2017 were included. The ingested caustic substance was identified as acid or alkaline. A gastrointestinal endoscopy was done to establish the burn grade. The grade of the burn was compared to the type of caustic substance using the χ2 test or the Fisher's exact test; a P value < 0.05 was considered significant. RESULTS: A total of 133 children were admitted to the Emergency Department due to caustic ingestion. The caustic agent was acid in 41 % of cases and alkaline, in 59 %. The most common acid caustic substance was muriatic acid (36.8 %) and the most common alkaline caustic agent was caustic soda (41.4 %). An esophageal burn was the most common consequence of caustic soda ingestion compared to other caustic agents (p = 0.001), whereas muriatic acid ingestion was the most statistically significant cause of stomach burn (p = 0.001) and duodenal burn (p = 0.002). The age group that most commonly ingested some caustic agent (93.2 %) corresponded to children younger than 5 years. CONCLUSIONS: The most common type of ingested caustic agent was alkaline, which caused esophageal burn; whereas, the ingestion of an acid caustic substance caused stomach and duodenal burns, as evidenced by endoscopy.

Antecedentes. La ingesta de sustancias cáusticas en pediatría constituye una causa frecuente de atención médica en Urgencias. El uso indiscriminado de limpiadores químicos y la facilidad de adquisición son factores determinantes para estas lesiones. Población y métodos. Estudio descriptivo analítico. Se incluyeron niños < 16 años, entre enero de 1998 y diciembre de 2017. Se identificó el agente químico cáustico ingerido por el niño como ácido o alcalino. Se realizó una endoscopía digestiva para tipificar el grado de quemadura. Se comparó el grado de quemadura con el tipo de cáustico; por medio de la prueba de chi2 o exacta de Fisher, se consideró significativo el valor de P < 0,05. Resultados. Ingresaron 133 niños en Urgencias por ingesta de cáusticos. El agente cáustico fue ácido en el 41 % y alcalino en el 59 %. El agente ácido más frecuente fue el ácido muriático (36,8 %), mientras que el alcalino fue la sosa (soda) cáustica (41,4 %). La quemadura del esófago fue más frecuente en la ingesta de sosa en comparación con otros cáusticos (p= 0,001), mientras que la quemadura del estómago (p= 0,001) y del duodeno (p= 0,002) fue estadísticamente significativa en la ingesta de ácido muriático. El grupo de edad que más frecuentemente ingirió algún cáustico (93,2 %) fueron los menores de 5 años. Conclusiones. El cáustico ingerido con mayor frecuencia fue un agente alcalino, que provocó quemadura esofágica, mientras que un agente ácido provocó quemaduras en el estómago y el duodeno evidenciadas por endoscopía.

Duodenal hematoma following EGD: comparison with blunt abdominal trauma-induced duodenal hematoma.

BACKGROUND: Duodenal hematoma (DH) is a rare complication of esophagogastroduodenoscopy (EGD) with duodenal biopsy and uncommon, but better described following blunt abdominal trauma (BAT). We aimed to describe DH incidence and investigate risk factors for DH development post-EGD and compare its features to those post-BAT. METHODS: Multiple electronic databases were searched for the diagnosis of DH from 2000 to 2012. Inclusion criteria were patients 0 to 21 years of age who developed a DH following EGD with biopsy or BAT. Exclusion criteria were DH secondary to any other mechanism, EGD performed at another medical center, and insufficient information in the electronic medical record to determine treatments or outcomes. RESULTS: A total of 14 post-EGD and 15 post-BAT patients with DH were included in the study. There were 26,905 EGDs with duodenal biopsies performed during the study period, for an incidence of 1:1922 procedures. Thirteen of 14 (93%) post-EGD DH events occurred between 2007 and 2012 (P < 0.001). The proportion of procedures performed under general anesthesia versus moderate sedation, and performed in the supine position versus left lateral decubitus were close to but did not reach statistical significance. DH-related complications and time to hematoma resolution was similar between groups. CONCLUSIONS: In a 13-year study period, 14 patients developed DH after EGD, for an incidence of 1:1922. Method of sedation and supine positioning of the patient during endoscopy warrant further investigation as potential risks. The clinical course and time to recovery with conservative management are similar between patients with EGD and BAT-induced DH.

Cuerpo extraño intra-abdominal: caso clínico y revisión de literatura / Intra-abdominal foreign body: clinical case and review of the literature

Cases of intra-abdominal foreign bodies are rare and caused mainly by retained elements after surgery and by, in general, accidental swallowing and subsequent perforation of the gastrointestinal tract. We report the case of a 74 year-old female patient, presenting with fever, abdominal pain and weight loss. An abdominal TC showed the presence of a foreign body that had caused a perforation of duodenum and gallbladder neck; surgery showed that it was a 4 cm ‘twist-tie’. The description of the case presents differential diagnoses, based on a review of the literature. This is a rare event and corresponds to the third publication of a case of a twist-tie intra-abdominal foreign body, according to a review of other medical publications.

Los cuerpos extraños intraabdominales son infrecuentes y se deben en gran medida a accidentes quirúrgicos y a ingesta, en general, accidental y posterior perforación del tracto digestivo. Se reporta un caso de una mujer de 74 años con fiebre, dolor abdominal y baja de peso, cuyo estudio mediante tomografía computada de abdomen muestra un cuerpo extraño que perfora duodeno y el bacinete. La cirugía demostró que se trataba de un “twist tie” de 4 cm que perforaba esas estructuras. En la descripción del caso se plantean los diagnósticos diferenciales basados en revisión de la literatura. Se presenta este caso por ser muy infrecuente, correspondiendo a la tercera publicación de un cuerpo extraño intra-abdominal por twist tie, de acuerdo con la revisión de las publicaciones médicas.

Is there a role for pyloric exclusion after severe duodenal trauma?

Duodenal trauma is an infrequent injury, but linked to high morbidity and mortality. Surgical management of duodenal injuries is dictated by: patient's hemodynamic status, injury severity, time of diagnosis, and presence of concomitant injuries. Even though most cases can be treated with primary repair, some experts advocate adjuvant procedures. Pyloric exclusion (PE) has emerged as an ancillary method to protect suture repair in more complex injuries. However, the effectiveness of this procedure is debatable. The "Evidence Based Telemedicine - Trauma & Acute Care Surgery" (EBT-TACS) Journal Club performed a critical appraisal of the literature and selected three relevant publications on the indications for PE in duodenal trauma. The first study retrospectively compared 14 cases of duodenal injuries greater than grade II treated by PE, with 15 cases repaired primarily, all of which penetrating. Results showed that PE did not improve outcome. The second study, also retrospective, compared primary repair (34 cases) with PE (16 cases) in blunt and penetrating grade > II duodenal injuries. The authors concluded that PE was not necessary in all cases. The third was a literature review on the management of challenging duodenal traumas. The author of that study concluded that PE is indicated for anastomotic leak management after gastrojejunostomies. In conclusion, the choice of the surgical procedure to treat duodenal injuries should be individualized. Moreover, there is insufficient high quality scientific evidence to support the abandonment of PE in severe duodenal injuries with extensive tissue loss.

Is there a role for pyloric exclusion after severe duodenal trauma? / Existe lugar para a exclusão pilórica no trauma duodenal grave?

Duodenal trauma is an infrequent injury, but linked to high morbidity and mortality. Surgical management of duodenal injuries is dictated by: patient's hemodynamic status, injury severity, time of diagnosis, and presence of concomitant injuries. Even though most cases can be treated with primary repair, some experts advocate adjuvant procedures. Pyloric exclusion (PE) has emerged as an ancillary method to protect suture repair in more complex injuries. However, the effectiveness of this procedure is debatable. The "Evidence Based Telemedicine - Trauma & Acute Care Surgery" (EBT-TACS) Journal Club performed a critical appraisal of the literature and selected three relevant publications on the indications for PE in duodenal trauma. The first study retrospectively compared 14 cases of duodenal injuries greater than grade II treated by PE, with 15 cases repaired primarily, all of which penetrating. Results showed that PE did not improve outcome. The second study, also retrospective, compared primary repair (34 cases) with PE (16 cases) in blunt and penetrating grade > II duodenal injuries. The authors concluded that PE was not necessary in all cases. The third was a literature review on the management of challenging duodenal traumas. The author of that study concluded that PE is indicated for anastomotic leak management after gastrojejunostomies. In conclusion, the choice of the surgical procedure to treat duodenal injuries should be individualized. Moreover, there is insufficient high quality scientific evidence to support the abandonment of PE in severe duodenal injuries with extensive tissue loss.

O trauma duodenal é incomum, mas possui alta morbimortalidade. As condições clínicas dos pacientes, gravidade das lesões, tempo de diagnóstico e lesões associadas influenciam na escolha do procedimento operatório. A maioria das lesões duodenais é tratada com reparo primário. Procedimentos adjuvantes para proteger a linha de sutura e evitar deiscência podem ser úteis em lesões complexas. Embora a exclusão pilórica (EP) seja utilizada em lesões duodenais graves, há controvérsia quanto a sua necessidade. A reunião "Telemedicina Baseada em Evidências - Cirurgia do Trauma e Emergência" (TBE-CiTE) revisou a literatura e selecionou três publicações relevantes sobre as indicações de EP no trauma duodenal. O primeiro estudo, retrospectivo, comparou 14 pacientes com ferimentos penetrantes duodenais grau > II, tratados com EP, com 15 pacientes semelhantes tratados com reparo primário; não houve diferença nos resultados. O segundo, também retrospectivo, comparou o reparo primário (34 casos) com EP (16 casos), em lesões duodenais contusas ou penetrantes grau > II. Os autores concluíram que a EP não é necessária para todos os pacientes, apesar de lesões duodenais graves. O terceiro estudo constituiu-se de revisão da literatura sobre os desafios do tratamento dos traumatismos duodenais. Na experiência do autor, a EP é útil nos casos de fístula de anastomoses gastrojejunais. Conclui-se que a escolha do procedimento operatório no tratamento das lesões duodenais deve ser individualizada. Não há evidência cientifica de boa qualidade para justificar o abandono da EP no tratamento das lesões duodenais graves com grande perda tecidual.

Manejo quirúrgico del trauma de estómago y duodeno en el Hospital Nacional Hipólito Unanue, 2008-2012 / Surgical management of the trauma of the stomach and duodenum at the National Hospital Hipolito Unanue, 2008 - 2012

Objetivo: Conocer las características del manejo quirúrgico de pacientes con trauma abdominal: Duodeno y Estómago que ingresaron al Hospital Nacional Hipólito Unanue en el período Enero 2008 - Diciembre 2012. Metodología: Se presenta un estudio transversal, descriptivo cuyo universo representa los pacientes atendidos durante el período descrito y la muestra la constituyen los 41 pacientes con trauma de estómago y los 13 pacientes con trauma duodenal. Resultados: El mecanismo principal de lesión fue el trauma abdominal abierto por proyectil de arma de fuego en ambos casos, los segmentos del duodeno más afectados fueron la 1era y 2da porción y en el trauma de estómago lo fue el cuerpo en su pared anterior. El tratamiento quirúrgico para la lesión duodenal fue la triple ostomía y para la lesión de estómago la rafia en dos planos. La mortalidad fue de 53,9 por ciento para el trauma duodenal y 7,4 por ciento para el trauma de estómago. Conclusiones: El trauma de estómago y duodeno constituyen una patología poco frecuente en nuestro medio representado por el 11,4 por ciento y 3,6 por ciento del total de pacientes que ingresan con diagnóstico de trauma abdominal, la mortalidad depende del tiempo que transcurre entre el evento y el tratamiento quirúrgico, las lesiones que no se evidencian en una primera cirugía o aquellos traumas asociados que terminan por descompensar al paciente.

Objective: Determine the characteristics of the surgical management of patients with abdominal trauma: Stomach and Duodenum admitted to National Hospital Hipolito Unanue in the period January 2008 December 2012. Methodology: A cross-sectional descriptive study whose universe represents patients seen during the period described and the sample are the 41 trauma patients with stomach and duodenal trauma 13 patients is presented. Results: The primary mechanism of injury was abdominal trauma by gun opened fire in both cases, the most affected segments of the duodenum were the 1st and 2nd portion and stomach trauma was the body in its anterior wall. The surgical treatment for duodenal injury was the triple ostomy and stomach injury raffia in two planes. Mortality was 53.9 per cent for duodenal trauma and 7.4 per cent for trauma stomach. Conclusions: The trauma of the stomach and duodenum are a rare pathology in our environment represented by 3.6 per cent and 11.4 per cent of all patients admitted with a diagnosis of abdominal trauma, mortality depends on the time between the event and surgical treatment, lesions that are not apparent at first surgery or those associated traumas that eventually decompensate the patient.

Inflammatory intestinal damage induced by 5-fluorouracil requires IL-4.

BACKGROUND: 5-Fluorouracil (5-FU) induces intestinal mucositis, which is characterized by epithelial ulcerations in the mucosa and clinical manifestations, such as pain and dyspeptic symptoms. Cytokines participate in the inflammatory and functional events of intestinal mucositis. IL-4 is an important mediator of intestinal inflammation, with either anti-inflammatory or pro-inflammatory functions, depending on the model of intestinal inflammation. This study aimed to evaluate the role of IL-4 in 5-FU-induced intestinal mucositis. METHODS: IL-4+/+ or IL-4-/- mice (25-30 g) were intraperitoneally injected with 5-FU (450 mg/Kg) or saline (C). After 3 days, the mice were sacrificed and the duodenum was evaluated for epithelial damage, MPO activity and cytokine concentration. RESULTS: 5-FU induced significant damage in the intestinal epithelium of IL-4+/+ mice (reduction in the villus/crypt ratio: control=3.31±0.21 µm, 5-FU=0.99±0.10 µm). However, the same treatment did not induce significant damage in IL-4-/- mice (5-FU=2.87±0.19 µm) compared to wild-type mice. 5-FU-induced epithelial damage increased the MPO activity (neutrophil number) and the level of pro-inflammatory cytokines (IL-4, TNF-α, IL-1ß and CXCL-8) in the duodenum. These results were not observed in IL-4-/- mice treated with 5-FU. CONCLUSION: Our data suggest that IL-4 participates as a pro-inflammatory cytokine in a 5-FU-induced intestinal damage model and suggests that IL-4 antagonists may be novel therapeutics for this condition.