ABSTRACT
BACKGROUND: Scarce evidence about the organic and functional abnormalities of systemic exertion intolerance disease (SEID) is found in literature and the pathophysiology is still unclear. METHODS: Following the CARE Guidelines, this case report describes a patient with a 5-year history of nonspecific symptoms, lately recognized as SEID. RESULTS: Low serum thyroid- and adrenocorticotropic stimulating hormone levels, and 24-h urinary cortisol excretion almost twice the upper limit were detected. Computed tomography scan found significant cortical atrophy. Low-dose modafinil improved the clinical outcome, added to nonpharmacologic approach. CONCLUSION: To ascertain an accurate SEID diagnosis and treatment are a challenge in daily clinical practice, that must be engaged based in clear methods and good practice recommendations. Thus, family practitioners should be aware of this diagnosis.
Subject(s)
Fatigue Syndrome, Chronic , Humans , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/therapy , Atrophy/complicationsABSTRACT
El síndrome de fatiga crónica es una enfermedad caracterizada, principalmente, por la manifestación de la fatiga, el dolor muscular difuso, y alteraciones en el sueño, en un periodo de no menos de 6 meses y que no son explicables por alguna causa. Es llamativo que, luego de un periodo de tiempo de padecer la COVID-19, los pacientes presenten síntomas similares a los hallados en el síndrome de fatiga crónica. A esta afección se la denomino síndrome pos-COVID. Los virus son los principales sospechosos en la aparición de ambos síndromes, estos podrían ocasionar la generación de daño mitocondrial, una neuroinflamación, alteración en el sistema glinfático o la disfunción en el eje hipotálamo-pituitario-adrenal entre otros. Dichos mecanismos serían los implicados en la aparición de los síntomas que padecen los pacientes con estos síndromes. El objetivo de esta revisión literaria es analizar y describir los posibles mecanismos que explicarían la manifestación de los síntomas del síndrome de fatiga crónica en los pacientes que hayan sufrido la COVID-19. Hasta el momento no existen tratamientos totalmente efectivos para erradicar los síntomas en ambos síndromes. Dado el abanico de síntomas que padecen estos pacientes, el enfoque terapéutico debe ser interdisciplinario para tratar de mejorar su calidad de vida.
Subject(s)
Humans , Quality of Life , Fatigue Syndrome, Chronic/etiology , Fatigue Syndrome, Chronic/prevention & control , Fatigue Syndrome, Chronic/therapy , Chronic Disease/therapy , Cognition Disorders/therapy , Mitochondrial Diseases/pathology , Diagnosis, Differential , Glymphatic System , Anosmia/therapy , COVID-19/complicationsABSTRACT
OBJECTIVE: To assess the feasibility of a mindfulness-based stress reduction (MBSR) program for adolescents with widespread chronic pain and other functional somatic symptoms and to make preliminary assessments of its clinical utility. STUDY DESIGN: Three cohorts of subjects completed an 8-week MBSR program. Child- and parent-completed measures were collected at baseline and 8 and 12 weeks later. Measures included the Functional Disability Inventory (FDI), the Fibromyalgia/Symptom Impact Questionnaire-Revised (FIQR/SIQR), the Pediatric Quality of Life Inventory, the Multidimensional Anxiety Scale (MASC2), and the Perceived Stress Scale. Subjects and parents were interviewed following the program to assess feasibility. RESULTS: Fifteen of 18 subjects (83%) completed the 8-week program. No adverse events occurred. Compared with baseline scores, significant changes were found in mean scores on the FDI (33% improvement, P = .026), FIQR/SIQR (26% improvement, P = .03), and MASC2 (child: 12% improvement, P = .02; parent report: 17% improvement, P = .03) at 8 weeks. MASC2 scores (child and parent) and Perceived Stress Scale scores were significantly improved at 12 weeks. More time spent doing home practice was associated with better outcomes in the FDI and FIQR/SIQR (44% and 26% improvement, respectively). Qualitative interviews indicated that subjects and parents reported social support as a benefit of the MBSR class, as well as a positive impact of MBSR on activities of daily living, and on pain and anxiety. CONCLUSIONS: MBSR is a feasible and acceptable intervention in adolescents with functional somatic syndromes and has preliminary evidence for improving functional disability, symptom impact, and anxiety, with consistency between parent and child measures. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02190474.
Subject(s)
Chronic Disease/therapy , Disability Evaluation , Mindfulness/methods , Stress, Psychological/prevention & control , Stress, Psychological/therapy , Adolescent , Child , Chronic Disease/psychology , Cohort Studies , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/therapy , Female , Fibromyalgia/diagnosis , Fibromyalgia/therapy , Headache/diagnosis , Headache/therapy , Humans , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/therapy , Male , Musculoskeletal Pain/diagnosis , Musculoskeletal Pain/therapy , Pilot Projects , Prognosis , Risk Adjustment , Risk Assessment , Statistics, Nonparametric , Treatment OutcomeABSTRACT
In recent years, different authors have described various musculoskeletal oxygenation alterations in patients with fibromyalgia with or without myalgic encephalomyelitis. These patients suffer from meteor-sensitivity worsening their symptoms in lower atmospheric pressure climates (decreased oxygen pressure). They also respond successfully to hyperbaric chamber treatment (increased oxygen pressure), and to coenzime Q10 intake (improved use of oxygen). Having reviewed these findings, oxygen therapy is postulated in higher concentration and pressures to relief the symptoms of fibromyalgia with or without myalgic encephalomyelitis. This article also centralizes on three fibromyalgia and myalgic encephalomyelitis patients who had a severe exacerbation of their symptoms, but responded successfully to treatment with pure oxygen for a limited time. The small number of patients treated and the lack of statistical methodology prevents us from arriving at definitive conclusions. However, medical oxygen could be considered a good alternative therapy to treat patients suffering acute episodes of their symptoms, when they do not respond to other therapeutic strategies. It also suggests the design of a future protocol of chronic oxygen therapy for patients with fibromyalgia with or without myalgic encephalomyelitis.
Subject(s)
Fatigue Syndrome, Chronic/therapy , Fibromyalgia/therapy , Oxygen Inhalation Therapy , Fatigue Syndrome, Chronic/metabolism , Fibromyalgia/metabolism , Humans , Oxygen/metabolismABSTRACT
A síndrome de fadiga crônica (SFC) é uma condição clínica que, apesar de muito prevalente, tem tratamento controverso. A suplementação com substratos como glutamina e vitaminas pode atuar como adjuvante terapêutico. Os autores descrevem um medicamento que pode atender essa finalidade, composto por glutamina 200mg, glutamato de cálcio 250mg, cloridrato de piridoxina 20mg e fosfato de ditetraetilamônio 6mg. São descritas também as ações de cada um dos componentes, e como podem auxiliar na terapêutica da SFC e em períodos de convalescença em diversas condições.
The chronic fatigue syndrome (CFS) is a clinical condition which, although highly prevalent, treatment is controversial and supplementation of substrates such as glutamine and vitamins can act as therapeutic adjuvant. A drug composition that can serve this purpose, the composition is glutamine 200mg, 250mg calcium glutamate, 20mg pyridoxine hydrochloride and phosphate ditetraetilammonium 6mg is described. Also described the actions of each component and how they can assist in the treatment of CFS and in periods of convalescence from various other conditions described.
Subject(s)
Humans , Male , Female , Fatigue Syndrome, Chronic/diet therapy , Fatigue Syndrome, Chronic/therapy , Convalescence , Dietary Vitamins , Glutamates/therapeutic use , Glutamine/therapeutic use , Minerals/therapeutic use , Pyridoxine/therapeutic use , Dietary Supplements , Tetraethylammonium/therapeutic useABSTRACT
El síndrome de fatiga crónica es un trastorno frecuente caracterizado por fatiga persistente y debilitante, que no mejora con el descanso, de al menos seis meses de duración y que, generalmente se acompaña de otros síntomas. Su etiología es desconocida y su diagnóstico requiere la exclusión de otras patologías. El tratamiento no esta firmemente establecido; según la evidencia actual las psicoterapias conductuales y las terapias físicas con ejercicios graduados son los tratamientos que aportarían mas beneficiosos, resultando importante considerar el manejo individualizado y sintomático.
Chronic Fatigue Syndrome is a common disorder characterized by persistent and debilitating fatigue that does not improve withrest, at least six months' duration, usually accompanied by other symptoms. Its etiology is unknown and its diagnosis requiresthe exclusion of other pathologies. The treatment is not firmly established, according to the current evidence behavioralpsychotherapies and graduate exercise's physical therapies are contributing more beneficial treatments. It is importantto consider a symptomatic and individualized management.
Subject(s)
Humans , Male , Female , Diagnosis, Differential , Fatigue Syndrome, Chronic , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/etiology , Fatigue Syndrome, Chronic/therapy , Stress, Psychological , Depressive Disorder , Mental DisordersSubject(s)
Autonomic Nervous System Diseases/physiopathology , Fatigue Syndrome, Chronic/physiopathology , Hypotension, Orthostatic/physiopathology , Syncope, Vasovagal/physiopathology , Autonomic Nervous System Diseases/diagnosis , Autonomic Nervous System Diseases/therapy , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/therapy , Humans , Hypotension, Orthostatic/diagnosis , Hypotension, Orthostatic/therapy , Syncope, Vasovagal/diagnosis , Syncope, Vasovagal/therapy , Syndrome , Tilt-Table TestSubject(s)
Humans , Autonomic Nervous System Diseases/physiopathology , Fatigue Syndrome, Chronic/physiopathology , Hypotension, Orthostatic/physiopathology , Syncope, Vasovagal/physiopathology , Autonomic Nervous System Diseases/diagnosis , Autonomic Nervous System Diseases/therapy , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/therapy , Hypotension, Orthostatic/diagnosis , Hypotension, Orthostatic/therapy , Syndrome , Syncope, Vasovagal/diagnosis , Syncope, Vasovagal/therapy , Tilt-Table TestABSTRACT
This paper explores the treatment of Chronic Fatigue Syndrome following a viral infection in young people. (AU)
Subject(s)
Case Reports , Humans , Male , Female , Adult , Fatigue Syndrome, Chronic/therapy , Phosphates/therapeutic use , Calcarea PhosphoricaABSTRACT
The objetive of this review was to ascertain the incidence of childhood sexual abuse: to ascertain the long-term effects of childhood sexual abuse and to collate the experiences of homeopoaths in caring for survivors. Childhood sexual abuse (CSA) is common with a high percentage of homeopathic patients giving a positive history. It is associated with... (AU)
Subject(s)
Case Reports , Humans , Female , Adult , Middle Aged , Child Abuse, Sexual , Homeopathy , Fatigue/therapy , Vaginitis/therapy , Fatigue Syndrome, Chronic/therapyABSTRACT
EI reumatismo de partes blandas constituye la primera causa de consulta reumatológica y en la mayoría de los casos ocurre sin compromiso sistémico y como consecuencia de trauma crónico o sobre uso. Ellos pueden ser locales en los casos de bursitis, tendinitis o tenosinovitis regionales como la lumbalgia y el síndrome miofascial y generalizados como la fibromialgia y el síndrome de fatiga crónica. Su enfoque diagnóstico es eminentemente clínico, su tratamiento exige un enfoque interdisciplinario.
Subject(s)
Bursitis/diagnosis , Bursitis/therapy , Low Back Pain/diagnosis , Low Back Pain/therapy , Fibromyalgia/diagnosis , Fibromyalgia/therapy , Rheumatic Diseases , Fatigue Syndrome, Chronic/diagnosis , Fatigue Syndrome, Chronic/therapy , Tendinopathy/diagnosis , Tendinopathy/therapy , Tenosynovitis/diagnosis , Tenosynovitis/therapyABSTRACT
Tomando por referencial a definição de caso da Síndrome da Fadiga Crônica (SFC), realizada pelo Center of Disease Control em 1988, os autores fazem uma revisão desta entidade nosológica nos seus aspectos Etiológico, Epidemiológico, Diagnóstico, Terapêutico e Prognóstico. Fazendo um resgate histórico do termo Neurastenia e acentuando as suas semelhanças com a SFC, até então não sistematizada nas classificações de desordens mentais vigentes
Subject(s)
Humans , Male , Female , Amitriptyline , Clomipramine , Herpesvirus 4, Human , Imipramine , Neurasthenia , Nortriptyline , Fatigue Syndrome, Chronic/therapy , Fluoxetine , Pemoline , Magnesium Sulfate/administration & dosage , Magnesium Sulfate/therapeutic useABSTRACT
For the past few years an increasing number of patients have been presenting with "symptoms suggestive of myalgic encephalomyelitis" (?ME). A very active and vociferous support group has been formed. Controversy about the nature of the illness has raged in the medical profession since the Royal Free disease outbreak in the 1950s