Plasma markers of neurodegeneration, latent cognitive abilities and physical activity in healthy aging.

Blood-based biomarkers of neurodegeneration demonstrate great promise for the diagnosis and prognosis of Alzheimer's disease. Ultra-sensitive plasma assays now allow for quantification of the lower concentrations in cognitively unimpaired older adults, making it possible to investigate whether these markers can provide insight also into the early neurodegenerative processes that affect cognitive function and whether the markers are influenced by modifiable risk factors. Adopting an exploratory approach in 93 healthy older adults (65-75 years), we used structural equation modelling to investigate cross-sectional associations between multiple latent cognitive abilities (working memory, episodic memory, spatial and verbal reasoning) and plasma amyloid beta (Aß42/Aß40 ratio), phosphorylated-tau 181 (ptau-181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL), as well as the influence of device-measured habitual physical activity on these associations. The results showed that NfL was negatively associated with working memory, and that NfL interacted with moderate-to-vigorous physical activity in its association with episodic memory. The study has thereby demonstrated the potential of neurodegenerative plasma markers for improving understanding of normative cognitive aging and encourages future research to test the hypothesis that high levels of NfL, indicative of white matter pathology, limit the beneficial effect of physical activity on episodic memory in healthy aging.

Regional differences in the Association of Healthy Aging with the incidence of falls: an analysis based on the China Health and Retirement Longitudinal Study from 2011 to 2020.

Background: Falls frequently occur among the older adult population. In this study, we examined the variations in fall incidence across different regions over time, focusing on the disparities between urban and rural areas among older adult Chinese individuals, Healthy aging is comprised of five dimensions: (1) absence of chronic diseases, (2) good physical functioning, (3) normal cognitive function, (4) active social participation, and (5) absence of depression. Additionally, we explored the relationship between healthy aging and the occurrence of falls in middle-aged and older adults. Falls are defined as events that occurred within the past two years. Results: Among 9,918 participants, 33.8% lived in urban areas and 23.0% achieved healthy aging. In contrast, 66.2% resided in rural areas with 16.5% achieving healthy aging. In 2011, rural residents had a higher fall incidence rate (17% in rural vs. 13.5% in urban); by 2020, the fall rate remained higher in rural areas (19.5% in rural vs. 17.3% in urban). Unhealthy aging (HR = 1.08, 95%CI: 1.00-1.16) were risk factors for falls. Subgroup analysis revealed that in rural areas, unhealthy aging increased the risk of falls. In urban areas, the increased risk of falls associated with unhealthy aging was not significant (Rural HR = 1.11, 95%CI:1.01-1.22; Urban HR = 1.05, 95%CI: 0.93-1.18). Conclusion: Healthy aging may be more strongly associated with a lower risk of falls in rural areas, while this association might be less pronounced in urban areas due to different environmental and social factors. This highlights the need for environment-specific fall prevention strategies and targeted measures for the older adult.

Design, develop, and implement the strategic information system on health, dependence, and healthy aging: an analysis of the Mexican experience.

BACKGROUND: The Decade of Healthy Aging (2021-2030) emerges as a 10 years strategy to improve the lives of older adults, their families, and the communities in which they live. One of the actions defined in this framework is related to improving the measurement, monitoring, and understanding of characteristics, factors, and needs related to aging and health. The aim was to analyze and assess the process of construction and development of the Strategic Information System on Health, Funcional Dependence and Aging (SIESDE, for its acronym in Spanish). SIESDE will provide strategic information in Mexico at the municipal, state, and national levels that support the public policies on healthy aging. METHODS: The system processes and analyzes the data sources of the Health Information Systems and the National System of Statistical and Geographical Information. SIESDE comprises three components: (1) Design, construction, and evaluation of the indicators; (2) storage, management, and visualization, and (3) diffusion and translation of information. RESULTS: A total of 135 indicators were built on seven themes: (1) demographic, socioeconomic, and aging conditions, (2) health, (3) functional dependence, (4) healthy aging, (5) health services, (6) social and physical environments, and (7) complex indicators. CONCLUSIONS: SIESDE is an effective system for providing an overall view of health, aging, and functional dependence.

Informe de progreso sobre la Década de las Naciones Unidas del Envejecimiento Saludable, 2021-2023

La Década de las Naciones Unidas del Envejecimiento Saludable (2021-2030) es una oportunidad para trabajar unidos con vistas a mejorar las vidas de las personas mayores, sus familias y sus comunidades. Para reconocer y aprovechar este trabajo, las Naciones Unidas publican este informe integral de progreso dirigido al público general sobre la implementación de la Década de las Naciones Unidas, que se ha desarrollado en colaboración con distintos organismos de las Naciones Unidas, y se ha elaborado con las aportaciones de una amplia gama de partes interesadas involucradas en lograr que la Década sea un éxito. Mediante la comparación de 10 indicadores de progreso nacionales para la Década en el 2020 y el 2022, El informe se basa en las cuatro esferas de acción de la Década, y sus objetivos específicos son evaluar el alcance de los avances logrados en la primera fase de ejecución de la Década (desde el 2021 hasta mediados del 2023); presentar las contribuciones a la Década realizadas por grupos de partes interesadas (los Estados Miembros, los organismos de las Naciones Unidas, la sociedad civil, el mundo académico, el sector privado, los grupos comunitarios y las propias personas mayores); e inspirar y motivar a las partes interesadas a colaborar en sus continuos esfuerzos para aplicar la Década a nivel nacional y ampliar las intervenciones para garantizar un envejecimiento saludable. Asimismo, los avances y los límites de la implementación de la Década se describen en este informe, e indican cómo se podrían acelerar las acciones de la siguiente fase. La principal conclusión del informe es que, a pesar de que se han logrado avances en la primera fase de la Década, los recursos para trabajar en pro de un envejecimiento saludable siguen siendo limitados, y es fundamental un mayor compromiso e inversión.

A qualitative study of healthy ageing and co-production.

Europe's ageing population increases the demand for housing solutions targeting older citizens' needs and preferences. Establishing age-friendly communities fostering social participation is essential for healthy ageing and various housing options with shared facilities prioritizing social contact have emerged. While involving older people in public service delivery is emphasized, studies on co-production with older people in building age-friendly communities remain limited. This study explores a co-production initiative between older citizens, a municipality and a real estate company in a newly established senior village focusing on organizational settings and physical facilities. A qualitative study inspired by the BIKVA methodology was conducted using focus group interviews with citizens, frontline staff, and management. Through reflexive thematic analysis, the physical environment, organizational setting and other factors influencing the co-production process were analysed. Citizens expressed satisfaction with the unique physical environment, the different activities and being involved in the co-production process on development and building up the senior village. However, the co-production initiative was influenced by the lack of frontline staff involvement, how the physical facilities were organized for building inclusive communities as well as the level of information provided to align expectations among stakeholders. Involving older citizens in the co-production of age-friendly community initiatives has the potential to take the identified challenges into account. To understand what constitutes an optimal environment for healthy ageing further research in collaboration with older citizens is needed.

WormCNN-Assisted Establishment and Analysis of Glycation Stress Models in C. elegans: Insights into Disease and Healthy Aging.

Glycation Stress (GS), induced by advanced glycation end-products (AGEs), significantly impacts aging processes. This study introduces a new model of GS of Caenorhabditis elegans by feeding them Escherichia coli OP50 cultured in a glucose-enriched medium, which better simulates human dietary glycation compared to previous single protein-glucose cross-linking methods. Utilizing WormCNN, a deep learning model, we assessed the health status and calculated the Healthy Aging Index (HAI) of worms with or without GS. Our results demonstrated accelerated aging in the GS group, evidenced by increased autofluorescence and altered gene expression of key aging regulators, daf-2 and daf-16. Additionally, we observed elevated pharyngeal pumping rates in AGEs-fed worms, suggesting an addictive response similar to human dietary patterns. This study highlights the profound effects of GS on worm aging and underscores the critical role of computer vision in accurately assessing health status and aiding in the establishment of disease models. The findings provide insights into glycation-induced aging and offer a comprehensive approach to studying the effects of dietary glycation on aging processes.

Relationship between participation in projects of incentives to promote walking and healthy aging among the older population: A four-year longitudinal study.

OBJECTIVE: This study aimed to evaluate the association between the Yokohama Walking Point Program, which promotes walking through feedback on step counts and incentives, and the extension of healthy life expectancy. METHODS: A total of 4298 individuals aged over 65 years who responded to the 2013 and 2016 surveys and who were not certified as needing long-term care in 2016 were included in this study. The participants were categorized into "non-participation," "participation without uploading," and "participation with uploading" groups based on their involvement and uploading of pedometer data. The objective variable was the occurrence of long-term care certification and deaths over the subsequent four years. A modified Poisson regression model was applied, adjusting for 15 variables before project initiation. RESULTS: A total of 440 participants (10.2 %) were included in the "participation with uploading" group and 206 (4.8 %) in the "participation without uploading" group. Compared with "non-participation," the risk ratio was 0.77 (95 % confidence interval (CI): 0.59-0.99) for "participation with uploading" and 1.02 (95 % CI: 0.75-1.38) for "participation without uploading". In the sensitivity analysis censoring death as an inapplicable outcome and considering functional decline, participation with uploading showed a risk ratio of 0.79 (95 % CI: 0.60-1.04) for the likelihood of functional decline. CONCLUSIONS: The use of pedometers and health point programs based on walking activity is associated with enhancing the health of older individuals participating in the program, representing a population-centric strategy targeting all citizens.

Information search under uncertainty across transdiagnostic psychopathology and healthy ageing.

When making decisions in everyday life, we often rely on an internally generated sense of confidence to help us revise and direct future behaviours. For instance, confidence directly informs whether further information should be sought prior to commitment to a final decision. Many studies have shown that aging and both clinical and sub-clinical symptoms of psychopathology are associated with systematic alterations in confidence. However, it remains unknown whether these confidence distortions influence information-seeking behaviour. We investigated this question in a large general population sample (N = 908). Participants completed a battery of psychiatric symptom questionnaires and performed a perceptual decision-making task with confidence ratings in which they were offered the option to seek helpful information (at a cost) before committing to a final decision. Replicating previous findings, an 'anxious-depression' (AD) symptom dimension was associated with systematically low confidence, despite no detriment in objective task accuracy. Conversely, a 'compulsive behaviour and intrusive thoughts' (CIT) dimension was associated with impaired task accuracy but paradoxical over-confidence. However, neither symptom dimension was significantly associated with an increased or decreased tendency to seek information. Hence, participants scoring highly for AD or CIT did not use the option to information seek any more than average to either increase their confidence (AD) or improve the accuracy of their decisions (CIT). In contrast, older age was associated with impaired accuracy and decreased confidence initially, but increased information seeking behaviour mediated increases in both accuracy and confidence for final decisions. Hence, older adults used the information seeking option to overcome initial deficits in objective performance and to increase their confidence accordingly. The results show an appropriate use of information seeking to overcome perceptual deficits and low confidence in healthy aging which was not present in transdiagnostic psychopathology.

Utilizing the determinants of healthy aging to guide the choice of social prescriptions for older adults. / Utilisation des déterminants du vieillissement en bonne santé pour guider le choix des prescriptions sociales pour les aînés.

Executive summary: The age of Canada's population is increasing, necessitating innovative methods and tools for assessing the needs of older adults and identifying effective health and social prescriptions. In Alberta, a community-based, senior-serving organization undertook the development and piloting of the Healthy Aging Asset Index, an assessment tool and social prescribing guide for use by a variety of professionals within the community. Tool development was rooted in medical complexity assessment and social work practice, and adhered to the determinants of healthy aging established by Alberta's Healthy Aging Framework, which is based on the determinants of healthy aging published by the World Health Organization. Results from the pilot showed improvement in the functionality of older adults within the determinants over time, as they were supported in addressing areas of personal vulnerability. Adopting tools such as the Healthy Aging Asset Index can bring cohesiveness to the support that older adults receive across the care continuum and has the potential to shift the balance of care away from the health system and towards the community, thus improving the capacity of health systems and government to meet the needs of Canada's older adults.

The Healthy Aging Asset Index (HAAI) is an assessment tool that can be used to guide social prescribing by a variety of professionals in the community. The determinants of healthy aging can be used to inform social prescriptions in different domains. The HAAI can support shifting care away from the health system and into the community, and improve the capacity of health systems. Further investment is needed to support the implementation of the HAAI and social prescribing pathways within community-based organizations.

L'indice des ressources pour un vieillissement en bonne santé (HAAI) est un outil d'évaluation de la prescription sociale utilisable par divers professionnels de la collectivité. Utiliser les déterminants du vieillissement en bonne santé peut éclairer la pratique de la prescription sociale dans différents domaines. L'outil HAAI peut aider à offrir certains soins en milieu communautaire plutôt qu'au sein du système de santé, améliorant ainsi la capacité des systèmes de santé à fournir des soins. Des investissements supplémentaires sont nécessaires pour soutenir la mise en oeuvre de l'outil HAAI et les parcours de prescription sociale au sein des organisations communautaires.

Integrating social prescribing in a Canadian regional health system to support healthy aging. / Intégration de la prescription sociale dans un système de santé régional canadien pour favoriser le vieillissement en santé.

INTRODUCTION: Social prescribing (SP) is a rapidly growing health and social model of care. The concept of social prescribing is based on well-known clinical practices such as community referrals, integrated health and social care, and navigator models. Although SP began in the United Kingdom's mental health and social care field, there are many examples of different models of SP foci and pathways. Here in Canada, SP is emerging at several provincial locations, with differences in its delivery reflecting the local context of people and places.

British Columbia (BC) has developed a province-wide social prescribing model supporting older adults through close partnerships between health care and community organizations. A regional health authority, Fraser Health, has a specific regional team focussing on integrating social prescribing into the health system through meaningful engagement and continuous co-creation with multisectoral partners, using strategies such as change management and Plan-Do-Study-Act cycles. Environmental and organizational support are big facilitators that have supported the continuation of the designated integration effort. Long-term funding and more partnerships between health care and community organizations will be critical to sustaining the social prescribing model in BC.

La Colombie-Britannique a élaboré un modèle de prescription sociale à l'échelle de la province pour soutenir les aînés grâce à des partenariats étroits entre les établissements de soins de santé et les organismes communautaires. Une régie régionale de santé, Fraser Health, a une équipe régionale spécialisée qui travaille à intégrer la prescription sociale au système de santé par des interactions significatives avec des partenaires multisectoriels et l'élaboration conjointe continue de programmes, au moyen de stratégies comme la gestion du changement et les cycles de planification, d'exécution, d'étude et d'action (de Plan-Do-Study-Act, soit Planification-Exécution-Étude-Action). Les ressources du milieu et le soutien des organismes sont des facteurs importants qui ont facilité la poursuite de ces travaux d'intégration. Un financement à long terme et une hausse des partenariats entre les établissements de soins de santé et les organismes communautaires seront essentiels à la pérennisation du modèle de prescription sociale en Colombie-Britannique.

Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet-A Scoping Review.

As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary interventions can significantly impact this process by modulating fundamental molecular pathways. This review focuses on the potential of targeted dietary strategies in promoting healthy aging and the mechanisms by which specific nutrients and dietary patterns influence key pathways involved in cellular repair, inflammation, and metabolic regulation. Caloric restriction, intermittent fasting, the Mediterranean diet, as well as the ketogenic diet showed promising effects on promoting healthy aging, possibly by modulating mTORC1 AMPK, an insulin signaling pathway. By understanding the intricate interplay between diet and molecular pathways, we can develop personalized dietary strategies that not only prevent age-related diseases, but also promote overall health and well-being throughout the aging process.

What Does It Mean to Successfully Age?: Multinational Study of Older Adults' Perceptions.

BACKGROUND AND OBJECTIVES: Successful aging is a mainstay of the gerontological literature, but it is not without criticism, including the often-limited way that it is studied and measured as well as the exclusion of older adults' voices in its formulation and understanding. This study sought to address these issues through a qualitative investigation across multiple countries. RESEARCH DESIGN AND METHODS: This was a mixed-methods, cross-sectional, exploratory study using an online survey. Nations that received the survey included Australia, New Zealand, the United Kingdom, Ireland, Canada, and the Unites States. Participants aged 65 and older were asked to describe what successful aging means to them in an open-ended survey item. Summative content analysis was utilized to examine the responses. RESULTS: Successful aging was defined by 1,994 participants, and 6 themes along with 20 subthemes were found. In contrast to conception that successful aging is solely or predominantly related to the absence of disease and decline, the most prominent theme in this study was "active, independent, and engaged" as the hallmark of success. DISCUSSION AND IMPLICATIONS: Although health and health maintenance were present in other themes, these findings support a multidimensional definition of successful aging that promotes the perspectives of older people. Future research should seek to further investigate the ways in which person-in-environment factors influence definitions of successful aging, including culture, gender and gender identity, race and ethnicity, and socioeconomic background.

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, and mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties, has emerged as a promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms of curcumin's effects and the optimal dosages for different conditions necessitate further investigation. This systematic review synthesizes current evidence on curcumin's potential in addressing age-related disorders, emphasizing its impact on cognitive function, neurodegeneration, and muscle health in older adults. By evaluating the safety, efficacy, and mechanisms of action of curcumin supplementation, this review aims to provide insights into its therapeutic potential for promoting healthy aging. A systematic search across three databases using specific keywords yielded 2256 documents, leading to the selection of 15 clinical trials for synthesis. Here, we highlight the promising potential of curcumin as a multifaceted therapeutic agent in combating age-related disorders. The findings of this review suggest that curcumin could offer a natural and effective approach to enhancing the quality of life of aging individuals. Further research and well-designed clinical trials are essential to validate these findings and optimize the use of curcumin in personalized medicine approaches for age-related conditions.

Understanding healthy ageing in India: insights from multivariate regression trees.

BACKGROUND: Population ageing represents a significant global challenge, particularly pronounced in countries like India. AIMS: This study aims to explore how factors such as socio-economic status, behaviour, and health influence healthy ageing across the Indian older population. METHODS: In this study, we utilized the Longitudinal Ageing Study in India - wave 1 dataset for analysis purposes. Scores were generated for five dimensions of healthy aging, including physical, functional, mental, cognitive, and social aspects and these scores were treated as the target variables. Multivariate Regression Trees analysis was employed to identify the behavioural and socio-demographic factors associated with each dimension of healthy ageing. RESULTS: Years of education emerge as crucial across all dimensions, positively impacting cognitive health and mitigating age-related decline in healthy ageing. Marital status, engagement in household activities, spiritual practices, and living arrangements impacts the scores of different aspects of healthy ageing. Gender disparities in healthy aging are noticeable in the 60-74 age group, with women generally having lower scores. Safety of the living environment is a crucial determinant of the mental health of the elderly across all age groups.These findings highlight the complex interplay of factors in healthy ageing outcomes. CONCLUSION: Our study emphasizes the pivotal role of education in fostering healthy ageing in India. Factors such as environmental safety and social participation also influence well-being. Targeted interventions addressing education, gender equality, safety, and healthcare access are vital for enhancing the ageing experience and overall well-being of older adults.

[The potential of public organizations in creating conditions of healthy aging for sustainable demographic development of the Russian regions].

The article considers issues of potential of public organizations to develop conditions for healthy aging in order to ensure sustainable development of Russian regions differing in their socio-economic, socio-cultural and demographic characteristics. It is established that individual approach is to be applied in developing and implementing measures, since elderly Russians constitute very heterogeneous social demographic group, characterizing by differences in age, health condition, social, economic and professional status, life motivation, family/single/nursing type of residence, etc. It is indicated that work will require time, financial expenses and labor costs. The achievement of sustainable development of Russian regions depends on ability and readiness of regional and municipal authorities, public and commercial organizations and entire population. It is determined that age-related stigmatization and ageism can not be overcame through decisions made by persons of power. No less significant is public opinion, determining position of employers, physicians, teachers and other specialists on whom healthy longevity of population depends. The conclusion is made that present demographic changes are a predictor of development of position of state authorities and public opinion that needed attention is to be paid to promoting of healthy aging, to expending necessary financial, infrastructural, informational and human resources. Only in this case Russian regions can count on social dividends that will follow preliminary comprehensive investments into developing conditions for healthy aging of local residents.