A business process clustering algorithm using incremental covering arrays to explore search space and balanced Bayesian information criterion to evaluate quality of solutions.

The reuse of business processes (BPs) requires similarities between them to be suitably identified. Various approaches have been introduced to address this problem, but many of them feature a high computational cost and a low level of automation. This paper presents a clustering algorithm that groups business processes retrieved from a multimodal search system (based on textual and structural information). The algorithm is based on Incremental Covering Arrays (ICAs) with different alphabets to determine the possible number of groups to be created for each row of the ICA. The proposed algorithm also incorporates Balanced Bayesian Information Criterion to determine the optimal number of groups and the best solution for each query. Experimental evaluation shows that the use of ICAs with strength four (4) and different alphabets reduces the number of solutions needed to be evaluated and optimizes the number of clusters. The proposed algorithm outperforms other algorithms in various measures (precision, recall, and F-measure) by between 12% and 88%. Friedman and Wilcoxon non-parametric tests gave a 90-95% significance level to the obtained results. Better options of repository search for BPs help companies to reuse them. By thus reusing BPs, managers and analysts can more easily get to know the evolution and trajectory of the company processes, a situation that could be expected to lead to improved managerial and commercial decision making.

Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus.

Oropouche virus (OROV) is an emerging pathogen which causes Oropouche fever and meningitis in humans. Several outbreaks of OROV in South America, especially in Brazil, have changed its status as an emerging disease, but no vaccine or specific drug target is available yet. Our approach was to identify the epitope-based vaccine candidates as well as the ligand-binding pockets through the use of immunoinformatics. In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8+ T-cell epitopes were identified, including three 100% conserved epitopes (TSSWGCEEY, CSMCGLIHY, and LAIDTGCLY) as the potential vaccine candidates. The selected epitopes showed 95.77% coverage for the mixed Brazilian population. The docking simulation ensured the binding interaction with high affinity. A total of five highly conserved and nontoxic linear B-cell epitopes "NQKIDLSQL," "HPLSTSQIGDRC," "SHCNLEFTAITADKIMSL," "PEKIPAKEGWLTFSKEHTSSW," and "HHYKPTKNLPHVVPRYH" were selected as potential vaccine candidates. The predicted eight conformational B-cell epitopes represent the accessibility for the entered virus. In the posttherapeutic strategy, ten ligand-binding pockets were identified for effective inhibitor design against emerging OROV infection. Collectively, this research provides novel candidates for epitope-based peptide vaccine design against OROV.

Chemoinformatics: a perspective from an academic setting in Latin America.

This perspective discusses the current progress of a chemoinformatics group in a major university in Latin America. Three major aspects are discussed in a critical manner: research, education, and collaboration with industry and other public research networks. It is also presented an overview of the progress in applied research and development of research concepts. Efforts to teach chemoinformatics at the undergraduate and graduate levels are discussed. It is addressed how the partnership with industry and other not-for-profit research institutions not only brings additional sources of funding but, more importantly, increases the impact of the multidisciplinary work and offers the students to be exposed to other research environments. We also discuss the main perspectives and challenges that remain to be addressed in these settings.

Platform for Unified Molecular Analysis: PUMA.

We introduce a free platform for chemoinformatic-based diversity analysis and visualization of chemical space of user supplied data sets. Platform for Unified Molecular Analysis (PUMA) integrates metrics used to characterize compound databases including visualization of chemical space, scaffold content, and analysis of chemical diversity. The user's input is a file with SMILES, database names, and compound IDs. PUMA computes molecular properties of pharmaceutical relevance, Murcko scaffolds, and diversity analysis. The user can interactively navigate through the graphs and export image files and the raw data of the diversity calculations. The platform links two public online resources: Consensus Diversity Plots for the assessment of global diversity and Activity Landscape Plotter to analyze structure-activity relationships. Herein, we describe the functionalities of PUMA and exemplify its use through the analysis of compound databases of general interest. PUMA is freely accessible at the authors web-site https://www.difacquim.com/d-tools/ .

Analysis of Volatile Compounds by Advanced Analytical Techniques and Multivariate Chemometrics.

Smelling is one of the five senses, which plays an important role in our everyday lives. Volatile compounds are, for example, characteristics of food where some of them can be perceivable by humans because of their aroma. They have a great influence on the decision making of consumers when they choose to use a product or not. In the case where a product has an offensive and strong aroma, many consumers might not appreciate it. On the contrary, soft and fresh natural aromas definitely increase the acceptance of a given product. These properties can drastically influence the economy; thus, it has been of great importance to manufacturers that the aroma of their food product is characterized by analytical means to provide a basis for further optimization processes. A lot of research has been devoted to this domain in order to link the quality of, e.g., a food to its aroma. By knowing the aromatic profile of a food, one can understand the nature of a given product leading to developing new products, which are more acceptable by consumers. There are two ways to analyze volatiles: one is to use human senses and/or sensory instruments, and the other is based on advanced analytical techniques. This work focuses on the latter. Although requirements are simple, low-cost technology is an attractive research target in this domain; most of the data are generated with very high-resolution analytical instruments. Such data gathered based on different analytical instruments normally have broad, overlapping sensitivity profiles and require substantial data analysis. In this review, we have addressed not only the question of the application of chemometrics for aroma analysis but also of the use of different analytical instruments in this field, highlighting the research needed for future focus.

Activity Landscape Plotter: A Web-Based Application for the Analysis of Structure-Activity Relationships.

Activity landscape modeling is a powerful method for the quantitative analysis of structure-activity relationships. This cheminformatics area is in continuous growth, and several quantitative and visual approaches are constantly being developed. However, these approaches often fall into disuse due to their limited access. Herein, we present Activity Landscape Plotter as the first freely available web-based tool to automatically analyze structure-activity relationships of compound data sets. Based on the concept of activity landscape modeling, the online service performs pairwise structure and activity relationships from an input data set supplied by the user. For visual analysis, Activity Landscape Plotter generates Structure-Activity Similarity and Dual-Activity Difference maps. The user can interactively navigate through the maps and export all the pairwise structure-activity information as comma delimited files. Activity Landscape Plotter is freely accessible at https://unam-shiny-difacquim.shinyapps.io/ActLSmaps /.

Chemometric evaluation of Cd, Co, Cr, Cu, Ni (inductively coupled plasma optical emission spectrometry) and Pb (graphite furnace atomic absorption spectrometry) concentrations in lipstick samples intended to be used by adults and children.

A method was developed for determining the concentrations of Cd, Co, Cr, Cu, Ni and Pb in lipstick samples intended to be used by adults and children using inductively coupled plasma optical emission spectrometry (ICP OES) and graphite furnace atomic absorption spectrometry (GF AAS) after treatment with dilute HNO3 and hot block. The combination of fractional factorial design and Desirability function was used to evaluate the ICP OES operational parameters and the regression models using Central Composite and Doehlert designs were calculated to stablish the best working condition for all analytes. Seventeen lipstick samples manufactured in different countries with different colors and brands were analyzed. Some samples contained high concentrations of toxic elements, such as Cr and Pb, which are carcinogenic and cause allergic and eczematous dermatitis. The maximum concentration detected was higher than the permissible safe limits for human use, and the samples containing these high metal concentrations were intended for use by children. Principal component analysis (PCA) was used as a chemometrics tool for exploratory analysis to observe the similarities between samples relative to the metal concentrations (a correlation between Cd and Pb was observed).

Simulating the dynamics of scale-free networks via optimization.

We deal here with the issue of complex network evolution. The analysis of topological evolution of complex networks plays a crucial role in predicting their future. While an impressive amount of work has been done on the issue, very little attention has been so far devoted to the investigation of how information theory quantifiers can be applied to characterize networks evolution. With the objective of dynamically capture the topological changes of a network's evolution, we propose a model able to quantify and reproduce several characteristics of a given network, by using the square root of the Jensen-Shannon divergence in combination with the mean degree and the clustering coefficient. To support our hypothesis, we test the model by copying the evolution of well-known models and real systems. The results show that the methodology was able to mimic the test-networks. By using this copycat model, the user is able to analyze the networks behavior over time, and also to conjecture about the main drivers of its evolution, also providing a framework to predict its evolution.

Inclusão digital e social: o uso do microcomputador enquanto promotor da reabilitação psicossocial / Inclusión digital y social: el uso de la microcomputadora como un promotor de la rehabilitación psicosocial / Digital and social inclusion: the use of the microcomputer as a promoter of psychosocial rehabilitation

Objetivo: Investigar o uso da tecnologia informática, sobretudo do microcomputador como aliado no processo de reabilitação psicossocial de pessoas em sofrimento psíquico, buscando identificar as repercussões do uso da informática no contexto social dessas pessoas. Métodos: Trata-se de uma pesquisa descritiva - interpretativa de abordagem qualitativa, realizada no município de Campina Grande/PB/Brasil, com 19 profissionais que atuam na rede de cuidado da saúde mental em 2010. Foi utilizada a técnica de análise de conteúdo tipo categorial-temática proposta por Bardin. Resultados: Os resultados apontam para inclusão das tecnologias digitais nos serviços de saúde mental como estratégias fundamentais no processo de reabilitação do usuário. Conclusão: O uso da tecnologia informática é uma ferramenta que promove inclusão social, autonomia e a autoestima dos usuários, fundamentais para o processo de transformação pessoal do portador de sofrimento psíquico

Objective: To investigate the use of computer technology, especially the microcomputer as an ally in the process of psychosocial rehabilitation of people in psychological distress, seeking to identify the effects of the use of information in the social context of these people. Methods: This was a descriptive - qualitative interpretative approach, performed in Campina Grande / PB / Brazil, with 19 professionals working in the network of mental health care in 2010. We used the technique of content analysis-categorical theme proposed by Bardin. Results: The results suggest that inclusion of digital technologies in mental health services as key strategies in the rehabilitation process of the user. Conclusion: The use of computer technology is a tool that promotes social inclusion, empowerment and self-esteem of users, fundamental to the process of personal transformation bearer of psychological distress

Objetivo: Investigar el uso de la tecnología informática, especialmente la microcomputadora como un aliado en el proceso de rehabilitación psicosocial de las personas en los trastornos psicológicos, tratando de identificar los efectos de la utilización de la información en el contexto social de estas personas. Métodos: Se realizó un estudio descriptivo - cualitativo interpretativo, realizado en Campina Grande / PB / Brasil, con 19 profesionales que trabajan en la red de atención de salud mental en 2010. Se utilizó la técnica de análisis de contenido categorial-tema propuesto por Bardin. Resultados: Los resultados sugieren que la inclusión de las tecnologías digitales en los servicios de salud mental como las estrategias clave en el proceso de rehabilitación del usuario. Conclusión: El uso de la tecnología informática es una herramienta que promueve la inclusión social, el empoderamiento y la autoestima de los usuarios, fundamental para el proceso de transformación personal portador de trastornos psicológicos

Marine biodiversity in the Atlantic and Pacific coasts of South America: knowledge and gaps.

The marine areas of South America (SA) include almost 30,000 km of coastline and encompass three different oceanic domains--the Caribbean, the Pacific, and the Atlantic--ranging in latitude from 12∘N to 55∘S. The 10 countries that border these coasts have different research capabilities and taxonomic traditions that affect taxonomic knowledge. This paper analyzes the status of knowledge of marine biodiversity in five subregions along the Atlantic and Pacific coasts of South America (SA): the Tropical East Pacific, the Humboldt Current,the Patagonian Shelf, the Brazilian Shelves, and the Tropical West Atlantic, and it provides a review of ecosystem threats and regional marine conservation strategies. South American marine biodiversity is least well known in the tropical subregions (with the exception of Costa Rica and Panama). Differences in total biodiversity were observed between the Atlantic and Pacific oceans at the same latitude. In the north of the continent, the Tropical East Pacific is richer in species than the Tropical West Atlantic, however, when standardized by coastal length, there is very little difference among them. In the south, the Humboldt Current system is much richer than the Patagonian Shelf. An analysis of endemism shows that 75% of the species are reported within only one of the SA regions, while about 22% of the species of SA are not reported elsewhere in the world. National and regional initiatives focusing on new exploration, especially to unknown areas and ecosystems, as well as collaboration among countries are fundamental to achieving the goal of completing inventories of species diversity and distribution.These inventories will allow accurate interpretation of the biogeography of its two oceanic coasts and latitudinal trends,and will also provide relevant information for science based policies.

Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlapped.

This overview covers the different chemometric strategies linked to chromatographic methodologies that have been used and presented in the recent literature to cope with problems related to incomplete separation, the presence of unexpected components in the sample, matrix effect and changes in the analytical signal due to pre-treatment of sample. Among the different chemometric strategies it focuses on pre-treatment of data to correct background and time shift of chromatographic peaks and the use of second-order algorithms to cope with overlapping peaks from analytes or from analytes and interferences in liquid chromatography coupled to diode array, fast-scanning fluorescence spectroscopy and mass spectrometry detectors. Finally the review presents the strategies used to deal with changes in the analytical response as result of matrix effect in liquid and gas chromatography, as well as the use of standardization strategies to correct modifications in the analytical signal as a consequence of sample pre-treatment in liquid chromatography.

Bioética, construção de conhecimento e e-learning: novos desafios ao ensino da bioética / Bioethics, knowledge construction and e-learning: new challenges to the bioethics teaching

A disciplina de Bioética é oferecida aos alunos de graduação da FOUSP no primeiro semestre do primeiro ano. De certo, a reflexão sobre dilemas éticos não termina com o fim da disciplina de Bioética, então, na tentativa de auxiliar o aluno na reflexão de dilemas a que venha enfrentar após ter cursado a disciplina de Bioética, planejou-se o desenvolvimento de um material didático, sem custos para os alunos, de fácil acesso, para que o aluno pudesse re-encontrar o conteúdo estudado na disciplina de Bioética durante todo o período de sua graduação. Atualmente, o uso da informática, de suas novas ferramentas eletrônicas e a diminuição do custo para a aquisição de computadores têm favorecido o desenvolvimento de ambientes virtuais de aprendizagem na área da educação. Assim, o objetivo principal deste trabalho foi desenvolver um conteúdo para o material didático eletrônico de Bioética, de modo que possa ser utilizado como material de apoio no processo de ensino-aprendizagem pelos alunos de graduação da FOUSP. Os textos elaborados sobre cada tema apresentado aos alunos foram formatados em páginas eletrônicas utilizando os programas FlashPageFlip e Photoshop CS4. O material produzido foi disponibilizado aos alunos em uma plataforma de ensino chamada Moodle. Como as informações sobre cada tema não se esgotam no texto elaborado para este material de estudos de apoio, ao final do texto de cada tema, há indicações de outras referências livros, sites, artigos, jornais, filmes. Essas indicações permitem que o aluno amplie o mapa de conhecimento, inicialmente delineado pelo professor, de acordo com sua necessidade pessoal. Buscou-se, em cada tema, apresentar uma contextualização do assunto - com informações sobre dados estatísticos, situação no Brasil e no mundo, contexto social e histórico, etc - identificar as principais questões éticas envolvidas e os diferentes argumentos, os valores envolvidos e os possíveis conflitos entre eles. Para uma primeira avaliação, foi utilizado um questionário semi-estruturado com perguntas fechadas e perguntas abertas. Foram convidados 140 alunos convidados para participar da pesquisa e 62,85% responderam ao questionário. Os resultados foram avaliados por cálculo de estatística simples e as perguntas abertas serviram para receber sugestões dos usuários para possíveis melhorias futuras. Concluímos que mesmo com todas as vantagens que os recursos virtuais podem oferecer ao ensino da Bioética, tais recursos ainda não são capazes de substituir o principal elemento do ensino: as vivências com o outro. Estas só poderão ser transformadas em experiências humanas quando lhes atribuímos um significado baseado em juízos de valores. O material de estudos de apoio eletrônico produzido foi tido como satisfatório pelos alunos/usuários enquanto auxílio nos estudos de temáticas bioéticas. Dentre as sugestões de melhorias estão a possibilidade de maior interações entre professor e aluno propiciadas por essas redes.

The Bioethics discipline is offered to the undergraduates of FOUSP in the first semester of the first term. Certainly, the reflexion about ethical dilemmas does not finish with the end of the Bioethics discipline, so, in the attempt of helping the student in the reflexion about dilemmas that may come to be faced after having attended to the Bioethics discipline, it was planned the development of a didactic material, with no cost to the students, of easy access. So that the student could review the content studied in the Bioethics discipline during the whole period of the undergraduation course. At the present time, the use of computing, of its new electronic tools and the decrease in the cost for the acquisition computers have being favoring the development of virtual learning environments in the education area. Therefore, the main objective of this paper was to develop some content for the electronic didactic material of Bioethics, in order to be used as a support material in the teaching-learning process by the undergraduate students of FOUSP. The texts elaborated about each theme presented to the students were formatted in electronic pages using the programs FlashPageFlip and Photoshop CS4. The material produced was made available to the students in the platform Moodle. As the information about each theme does not become exhausted in the text elaborated for this support study material, at end of the text of each theme there are indications of other references. These indications allow the student to increase the knowledge map initially outlined by the teacher according to his/her necessity. It was sought to contextualize each subject, identify the main ethical issues involved and the different arguments, the values involved and the possible conflicts among them. A semi-structured questionnaire was used in the first evaluation. 140 students were invited to participate of the research and 62.85% answered to the questionnaire. The results were evaluated through a simple statistical calculation and the open questions were used to receive suggestions from the users for possible future improvements. We concluded that even with all the advantages that the virtual resources can offer to the teaching of Bioethics, such resources are still not capable of substituting the main element of the teaching, the experience with the other. The experiences will only be able to be transformed in human experiences when we attribute them a meaning based on value judgments. The material produced was considered satisfactory by the students in the support in the studies of bioethics themes. Among the suggestions of improvement is the possibility of a higher interaction between the teacher and the student enabled by the networks.

Screening Brazilian commercial gasoline quality by hydrogen nuclear magnetic resonance spectroscopic fingerprintings and pattern-recognition multivariate chemometric analysis.

The identification of gasoline adulteration by organic solvents is not an easy task, because compounds that constitute the solvents are already in gasoline composition. In this work, the combination of Hydrogen Nuclear Magnetic Resonance ((1)H NMR) spectroscopic fingerprintings with pattern-recognition multivariate Soft Independent Modeling of Class Analogy (SIMCA) chemometric analysis provides an original and alternative approach to screening Brazilian commercial gasoline quality in a Monitoring Program for Quality Control of Automotive Fuels. SIMCA was performed on spectroscopic fingerprints to classify the quality of representative commercial gasoline samples selected by Hierarchical Cluster Analysis (HCA) and collected over a 6-month period from different gas stations in the São Paulo state, Brazil. Following optimized the (1)H NMR-SIMCA algorithm, it was possible to correctly classify 92.0% of commercial gasoline samples, which is considered acceptable. The chemometric method is recommended for routine applications in Quality-Control Monitoring Programs, since its measurements are fast and can be easily automated. Also, police laboratories could employ this method for rapid screening analysis to discourage adulteration practices.

La informática aplicada a la salud reproductiva posibilita una mejor práctica clínica: [revisión] / Better clinical practice made possible by IT in reproductive health: [review]

En abril de 2006, los US Centers for Disease Control and Prevention (CDC) publicaron normativas clínicas acerca de la salud reproductiva con el objetivo de promover mejoras en la evolución de los embarazos en Estados Unidos. La integración de la salud reproductiva en la práctica cotidiana todavía representa un desafío para los médicos clínicos. Esto se debe en parte a la percepción de que la salud reproductiva es una prestación agregada en lugar de un aspecto integral de la atención primaria de las mujeres en edad fértil. La provisión de estas prestaciones por los sistemas de atención primaria se ha limitado debido a la falta de promoción de métodos clínicos que contribuyan a la evaluación del riesgo y los procesos de intervención. Las novedades en el contexto de la informática aplicada a la salud expanden las posibilidades de perfeccionar los importantes servicios de la salud reproductiva en la actividad médica cotidiana. Una revisión de estos avances informáticos relacionados con la salud reproductiva podría contribuir a la optimización de estos servicios por parte de los médicos clínicos.(AU)

La informática aplicada a la salud reproductiva posibilita una mejor práctica clínica: [revisión] / Better clinical practice made possible by IT in reproductive health: [review]

En abril de 2006, los US Centers for Disease Control and Prevention (CDC) publicaron normativas clínicas acerca de la salud reproductiva con el objetivo de promover mejoras en la evolución de los embarazos en Estados Unidos. La integración de la salud reproductiva en la práctica cotidiana todavía representa un desafío para los médicos clínicos. Esto se debe en parte a la percepción de que la salud reproductiva es una prestación agregada en lugar de un aspecto integral de la atención primaria de las mujeres en edad fértil. La provisión de estas prestaciones por los sistemas de atención primaria se ha limitado debido a la falta de promoción de métodos clínicos que contribuyan a la evaluación del riesgo y los procesos de intervención. Las novedades en el contexto de la informática aplicada a la salud expanden las posibilidades de perfeccionar los importantes servicios de la salud reproductiva en la actividad médica cotidiana. Una revisión de estos avances informáticos relacionados con la salud reproductiva podría contribuir a la optimización de estos servicios por parte de los médicos clínicos.

The use of GIS for the integration of traditional and scientific knowledge in supporting artisanal fisheries management in southern Brazil.

The integration of local harvesters' knowledge of attitudes and practices toward the resources they harvest with scientific information is essential to natural resources management. However, the development and implementation of management policies have, in most cases, not been effective because of a failure to use all available sources of information and knowledge. In fisheries management, local knowledge is usually not collected in a systematic format and little published literature has discussed the use of local knowledge data collection and analysis methods. This paper describes the implementation of geographic information systems to systematize, analyze, and display traditional and scientific information to support fisheries management in the Patos Lagoon Estuary, southern Brazil. Artisanal fishing data were documented through a series of interviews conducted during and after fishing trips at harvest spots, and scientific data on environmental variables were obtained from different research institutions. A multi-layer GIS database integrating local fishers' and scientific knowledge information was developed with ArcGIS 8.3 ArcView tools to integrate and translate information into an accessible and interpretable format. The geo-spatial database interface allowed the selection of specific data characteristics by target species, harvest areas, fishers' communities, fishing gear, catch-per-unit of effort (CPUE), and monthly landings. The observed fishing spatial dynamics presented among the fishers' communities shows that, in most cases, artisanal fishermen tend to concentrate in shallow estuarine waters surrounding their villages.

Uso de softwares para gerenciamento de rebanhos bovinos leiteiros / Use of softwares for the management of dairy cattle

The softwares for the management of dairy herd available in the market were studied considering the expectations of the rural producer. Twenty-three farmers whose properties were computerized were interviewed. It was used a qualitative semi-structured questionnaire containing 49 questions: 46 of them were multiple choice and 3 open ones. The proportionate results and the quality of the information were the most important criteria for specific software in helping the administrative decisions. In spite of the training, so much for data collection as for the use of the softwares, it was little valued by the producers. The results showed that the use of these systems is fitting the expectations of the user especially in the zootechnic and administrative areas.(AU)

Uso de softwares para gerenciamento de rebanhos bovinos leiteiros / Use of softwares for the management of dairy cattle

The softwares for the management of dairy herd available in the market were studied considering the expectations of the rural producer. Twenty-three farmers whose properties were computerized were interviewed. It was used a qualitative semi-structured questionnaire containing 49 questions: 46 of them were multiple choice and 3 open ones. The proportionate results and the quality of the information were the most important criteria for specific software in helping the administrative decisions. In spite of the training, so much for data collection as for the use of the softwares, it was little valued by the producers. The results showed that the use of these systems is fitting the expectations of the user especially in the zootechnic and administrative areas.

La Informatización en el estudio de las ciencias Médicas en el municipio Contramaestre: valoración de impacto / Computarization in the study of the medical sciences in Contramaestre Municipality: impact evaluation

Ante el impacto de las Nuevas Tecnologías de la Información y las Comunicaciones (NTIC) y el desarrollo de las Ciencias Médicas en el Municipio Contramaestre se hizo necesario trazar y llevar a cabo una estrategia que permitiera adecuar el desarrollo del Proceso de Enseñanza y Aprendizaje a las condiciones especificas de los locales y equipamiento en el municipio, demostrándose en estudios realizados el impacto, científico–social, económico, y hasta medioambiental que ha causado la informatización de la Enseñanza de las ciencias Médicas en el Municipio Contramaestre y se presenta de forma digital los resultados alcanzados por dicho proyecto teniendo como objeto de estudio fundamental los Policlínicos que integran el Proyecto Policlínico Universitario(AU)