Protein kinase inhibitors infused intraventricularly or into the ventromedial hypothalamus block short latency facilitation of lordosis by oestradiol.

An injection of unesterified oestradiol (E2 ) facilitates receptive behaviour in E2 benzoate (EB)-primed, ovariectomised female rats when it is administered i.c.v. or systemically. The present study tested the hypothesis that inhibitors of protein kinase A (PKA), protein kinase G (PKG) or the Src/mitogen-activated protein kinase (MAPK) complex interfere with E2 facilitation of receptive behaviour. In Experiment 1, lordosis induced by i.c.v. infusion of E2 was significantly reduced by i.c.v. administration of Rp-cAMPS, a PKA inhibitor, KT5823, a PKG inhibitor, and PP2 and PD98059, Src and MAPK inhibitors, respectively, between 30 and 240 minutes after infusion. In Experiment 2, we determined whether the ventromedial hypothalamus (VMH) is one of the neural sites at which those intracellular pathways participate in lordosis behaviour induced by E2 . Administration of each of the four protein kinase inhibitors into the VMH blocked facilitation of lordosis induced by infusion of E2 also into the VMH. These data support the hypothesis that activation of several protein kinase pathways is involved in the facilitation of lordosis by E2 in EB-primed rats.

Preservation or Restoration of Segmental and Regional Spinal Lordosis Using Minimally Invasive Interbody Fusion Techniques in Degenerative Lumbar Conditions: A Literature Review.

STUDY DESIGN: A literature review. OBJECTIVE: The purpose of this study was to review lumbar segmental and regional alignment changes following treatment with a variety of minimally invasive surgery (MIS) interbody fusion procedures for short-segment, degenerative conditions. SUMMARY OF BACKGROUND DATA: An increasing number of lumbar fusions are being performed with minimally invasive exposures, despite a perception that minimally invasive lumbar interbody fusion procedures are unable to affect segmental and regional lordosis. METHODS: Through a MEDLINE and Google Scholar search, a total of 23 articles were identified that reported alignment following minimally invasive lumbar fusion for degenerative (nondeformity) lumbar spinal conditions to examine aggregate changes in postoperative alignment. RESULTS: Of the 23 studies identified, 28 study cohorts were included in the analysis. Procedural cohorts included MIS ALIF (two), extreme lateral interbody fusion (XLIF) (16), and MIS posterior/transforaminal lumbar interbody fusion (P/TLIF) (11). Across 19 study cohorts and 720 patients, weighted average of lumbar lordosis preoperatively for all procedures was 43.5° (range 28.4°-52.5°) and increased 3.4° (9%) (range -2° to 7.4°) postoperatively (P < 0.001). Segmental lordosis increased, on average, by 4° from a weighted average of 8.3° preoperatively (range -0.8° to 15.8°) to 11.2° at postoperative time points (range -0.2° to 22.8°) (P < 0.001) in 1182 patient from 24 study cohorts. Simple linear regression revealed a significant relationship between preoperative lumbar lordosis and change in lumbar lordosis (r = 0.413; P = 0.003), wherein lower preoperative lumbar lordosis predicted a greater increase in postoperative lumbar lordosis. CONCLUSION: Significant gains in both weighted average lumbar lordosis and segmental lordosis were seen following MIS interbody fusion. None of the segmental lordosis cohorts and only two of the 19 lumbar lordosis cohorts showed decreases in lordosis postoperatively. These results suggest that MIS approaches are able to impact regional and local segmental alignment and that preoperative patient factors can impact the extent of correction gained (preserving vs. restoring alignment). LEVEL OF EVIDENCE: 4.

Avaliação da lordose lombar e sua relação com a dor lombopélvica em gestantes / Evaluation of lumbar lordosis and its relation to the lumbopelvic pain in pregnants

O objetivo deste trabalho foi avaliar a magnitude da lordose lombar, sua influência na dor lombopélvica e a qualidade de vida em gestantes. Para tal, foi realizado um estudo com 20 mulheres não gestantes (C) e 13 gestantes ao longo dos trimestres gestacionais (G1, G2 e G3). Todas as mulheres foram submetidas à avaliação inicial para registro dos dados pessoais, hábitos de vida, antecedentes pessoais, uso de medicamentos, história ginecológica e obstétrica. Posteriormente, as voluntárias do grupo controle foram avaliadas uma vez e as gestantes foram avaliadas em três momentos distintos, no 10, 20 e 30 trimestres gestacionais. A avaliação do grau de lordose lombar foi realizada por meio de técnica fotogramétrica; a avaliação de locais de dor, o tipo de dor e sua intensidade foram feitas por meio do Questionário McGill de dor; e a avaliação da qualidade de vida foi feita pelo Questionário WHOQOL-bref. Neste trabalho, não foi possível observar padrão de alteração da curvatura lombar no decorrer da gestação. Também não foi observada relação entre a curvatura lombar e a dor lombopélvica relacionada à gestação.

The purpose of this study was to evaluate the magnitude of lumbar lordosis, its influence on lumbopelvic pain and quality of life in pregnant women. To this end, a study was done with 20 non-pregnant women (C) and 13 pregnant women during the trimesters of pregnancy (G1, G2 and G3). All women underwent initial assessment for registration of personal data, lifestyle, personal history, medications, gynecological and obstetric history. Later, the volunteers in the control group were evaluated once and pregnant women were evaluated at three different times, the first, second and third trimesters of pregnancy. The evaluation of the degree of lumbar lordosis was performed by a photogrammetric technique. The assessment of points/places of pain, the kind of pain and its intensity were made by McGill Pain Questionnaire, and the quality of life assessment was made by WHOQOL-bref. In this study, it was not possible to observe a pattern of change in lumbar curvature during pregnancy. There was also no relationship between lumbar curvature and lumbopelvic pain related to pregnancy.

Estudo experimental do sequenciamento das manobras da ligamentotaxia na descompressão do canal vertebral / Experimental study of ligamentotaxis maneuvers sequencing in vertebral canal decompression

A descompressão do canal vertebral, para aliviar as estruturas nervosas, pode ser realizada por meio da ligamentotaxia. O objetivo foi analisar a influência da seqüência de realização da ligamentotaxia sobre a descompressão do canal vertebral. Foram utilizados segmentos de vértebras de suínos (Landrace). Um equipamento especialmente desenvolvido foi utilizado para produção de fratura do tipo explosão. Após a tomografia computadorizada, 10 espécimes que melhores apresentavam fraturas do tipo explosão foram fixados com fixador interno (Synthes). Foram formados dois grupos. No primeiro (n=5) foi realizada a lordose e depois a distração. Posteriormente, foram submetidos à nova compressão por meio de morsa até o retorno da fratura à posição inicial, a seguir foram novamente submetidos à distração e lordose. No segundo grupo (n=5) foi realizada a distração e depois a lordose. Após cada manobra era realizado o exame tomográfico para medir o diâmetro do canal vertebral. Os deslocamentos dos fragmentos dos corpos vertebrais fraturados foram mensurados e comparados utilizando t de Student (p<0,05). Comparando os deslocamentos entre os grupos, não foram observadas diferenças estatísticas (p<0,06). Esse resultado é próximo ao nível de significância adotado, sugerindo uma forte tendência que demonstra a eficácia superior da manobra iniciada pela realização da lordose.

Vertebral canal decompression, intended to provide relief to nervous structures, may be performed by means of legamentotaxis. The objective of this study was to assess the influence of the ligamentotaxis sequence on vertebral canal decompression. Vertebral segments of Landrace swine specimens were used. A device especially developed for producing a burst-type fracture was employed. Subsequently to the computerized tomography scan, 10 specimens that best showed a burst-type fracture were fixated with internal fixator (Synthes). Two groups were formed. On the first group (n=5), lordosis followed by distraction were performed. Then, they were submitted to distraction and lordosis. On the second group (n=5), distraction was provided first, and then lordosis was performed. After each maneuver, vertebral canal was measured by tomography scan. Fractured vertebral body fragments were measured and compared using the Student's t test (p<0,05). By comparing dislocations between groups, no statistical differences were found (p<0,06). This result is close to the significance level adopted, suggesting a strong trend towards a better effectiveness of the maneuver started with lordosis.

Radiographic evaluation of cervical spine of subjects with temporomandibular joint internal disorder

Apesar de a etiofisiopatologia dos distúrbios internos (DI) da articulação temporomandibular (ATM) ser ainda desconhecida, sugere-se que as posturas de cabeça e corpo estariam associadas a seu desencadeamento, desenvolvimento e sua perpetuação. O objetivo deste estudo foi verificar a relação entre alterações radiográficas de coluna cervical e distúrbios internos da ATM. Este estudo avaliou 30 indivíduos com distúrbios da ATM (grupo teste) e 20 saudáveis (grupo controle). Os indivíduos submeteram-se à avaliação clínica e radiográfica. A avaliação clínica consistiu de anamnese e exame físico do sistema estomatognático. A avaliação radiográfica consistiu de análise de radiografias laterais de coluna cervical por fisioterapeutas e traçados. O grupo teste apresentou o dobro da prevalência de hiperlordose de coluna cervical (20,7% versus 10,5%) e quase a metade (41,4% versus 79,0%) de retificação (p = 0,03). Em um segundo momento, o grupo teste foi subdividido em três subgrupos em função da gravidade clínica da disfunção temporomandibular, avaliada pelo índice de Helkimo. Não houve diferença estatisticamente significante entre os subgrupos, mas se constatou uma tendência do subgrupo com disfunção grave a apresentar prevalência de hiperlordose cervical. Esses resultados sugerem uma tendência dos indivíduos com disfunção temporomandibular (DTM) grave a apresentarem hiperlordose. No entanto, futuros estudos devem ser feitos, analisando-se um maior número de indivíduos portadores de DTM grave para corroborar nossos achados.

Radiographic evaluation of cervical spine of subjects with temporomandibular joint internal disorder.

Although the etiopathophysiology of internal temporomandibular joint internal disorders (TMJ ID) is still unknown, it has been suggested that head and body posture could be related to its initial onset, development and perpetuation. The purpose of the present study was to observe the relationship between cervical spine X-ray abnormalities and TMJ ID. This investigation evaluated 30 subjects with internal TMJ disorder symptoms (test group) and 20 healthy subjects (control group). Subjects were submitted to clinical and radiographic evaluation. Clinical evaluation comprised anamnesis and stomatognathic system physical examination. Radiographic evaluation comprised analysis of lateral cervical spine X-rays by three physical therapists and tracing on the same images. The test group presented twice as much cervical spine hyperlordosis as the control group (20.7% versus 10.5%), but almost half of rectification prevalence (41.4 versus 79.0%, p = 0.03). After that, the test group was divided into three subgroups according to TMJ dysfunction severity, evaluated by Helkimo's index. These subgroups were not significantly different, but the subgroup with more severe TMD showed a tendency to cervical spine hyperlordosis prevalence. Results showed a tendency for subjects with more severe TMD to exhibit cervical spine hyperlordosis. Nevertheless, studies with a larger number of subjects suffering from severe TMD are encouraged in order to corroborate the present findings.