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1.
Brain Nerve ; 76(8): 923-931, 2024 Aug.
Article in Japanese | MEDLINE | ID: mdl-39117593

ABSTRACT

Headache is the most common condition encountered in neurological practice. However, despite the burden to patients, migraine, a typical primary headache, is not life-threatening, and evaluation shows no abnormalities; therefore, it is often treated using analgesics. Moreover, patients often do not visit hospitals and clinics because over-the-counter analgesics, such as nonsteroidal anti-inflammatory drugs are easily available. However, many patients continue to experience headaches. Migraine therapy has progressed remarkably following the advent of calcitonin gene-related peptide antibody drugs in recent years. Many patients with migraine do not visit hospitals and clinics and do not receive appropriate treatment. Therefore, in the future, neurologists will need to play a key role in patient education and in training physicians to enable accurate diagnosis of headaches.


Subject(s)
Headache , Humans , Headache/therapy , Headache/diagnosis , Headache/drug therapy , Migraine Disorders/diagnosis , Migraine Disorders/drug therapy , Migraine Disorders/therapy , Calcitonin Gene-Related Peptide/antagonists & inhibitors
2.
J Otolaryngol Head Neck Surg ; 53: 19160216241265685, 2024.
Article in English | MEDLINE | ID: mdl-39113464

ABSTRACT

BACKGROUND: Correctly diagnosing dizziness in children is essential for appropriate management; nevertheless, healthcare professionals face challenges due to children's limited ability to describe their symptoms and their cooperation during physical examination. The objective of this study is to describe the first 100 patients seen at a newly established pediatric vertigo center. METHODS: This is a retrospective review of a consecutive series of 100 patients seen at our pediatric vertigo clinic in a tertiary referral center from August 2019 until June 2022. Comprehensive clinical data were collected. The diagnoses were established by 2 pediatric otolaryngologists based on validated diagnostic criteria. Trends in diagnosis, investigation, and treatment of these patients were analyzed. RESULTS: A total of 100 children were included in the study. Vestibular migraine was the most common diagnosis (20%) followed by benign paroxysmal vertigo of childhood (14%). Eleven patients had combined pathologies. Fifteen out of 70 children (21%) had abnormal audiograms, 30 out of 48 children (62.5%) had abnormal vestibular testing, and 6 out of 31 (19%) patients had abnormal imaging. Fifty-one children received medical treatment, 23 received vestibular physiotherapy, and 9 patients had particle repositioning maneuvers; moreover, 17 of these patients received multimodal treatment. CONCLUSIONS: Our analysis suggests that imaging and audiology testing have relatively low yield in the assessment of pediatric vertigo. On the other hand, vestibular testing detected a high proportion of abnormalities, such as saccadic pursuit, vertical nystagmus, central positional nystagmus, and abnormal directional preponderance, particularly associated with vestibular migraine. Given the complexity of diagnosing vertigo in children, it is critical to establish multidisciplinary specialized centers capable of providing accurate diagnosis and treatment for these children.


Subject(s)
Vertigo , Humans , Retrospective Studies , Male , Child , Female , Child, Preschool , Adolescent , Vertigo/diagnosis , Vertigo/therapy , Migraine Disorders/diagnosis , Migraine Disorders/therapy , Vestibular Function Tests , Benign Paroxysmal Positional Vertigo/therapy , Benign Paroxysmal Positional Vertigo/diagnosis , Tertiary Care Centers
3.
Nutrients ; 16(14)2024 Jul 11.
Article in English | MEDLINE | ID: mdl-39064664

ABSTRACT

This review summarizes the relationship between diet, the gut microbiome, and migraine. Key findings reveal that certain dietary factors, such as caffeine and alcohol, can trigger migraine, while nutrients like magnesium and riboflavin may help alleviate migraine symptoms. The gut microbiome, through its influence on neuroinflammation (e.g., vagus nerve and cytokines), gut-brain signaling (e.g., gamma-aminobutyric acid), and metabolic function (e.g., short-chain fatty acids), plays a crucial role in migraine susceptibility. Migraine can also alter eating behaviors, leading to poor nutritional choices and further exacerbating the condition. Individual variability in diet and microbiome composition highlights the need for personalized dietary and prebiotic interventions. Epidemiological and clinical data support the effectiveness of tailored nutritional approaches, such as elimination diets and the inclusion of beneficial nutrients, in managing migraine. More work is needed to confirm the role of prebiotics, probiotics, and potentially fecal microbiome translation in the management of migraine. Future research should focus on large-scale studies to elucidate the underlying mechanisms of bidirectional interaction between diet and migraine and develop evidence-based clinical guidelines. Integrating dietary management, gut health optimization, and lifestyle modifications can potentially offer a holistic approach to reducing migraine frequency and severity, ultimately improving patient outcomes and quality of life.


Subject(s)
Brain-Gut Axis , Diet , Gastrointestinal Microbiome , Migraine Disorders , Humans , Gastrointestinal Microbiome/physiology , Migraine Disorders/microbiology , Migraine Disorders/therapy , Brain-Gut Axis/physiology , Brain , Feeding Behavior/physiology , Prebiotics/administration & dosage , Probiotics/therapeutic use
4.
Cells ; 13(13)2024 Jun 25.
Article in English | MEDLINE | ID: mdl-38994951

ABSTRACT

Migraine is a debilitating neurological disorder characterized by recurring episodes of throbbing headaches that are frequently accompanied by sensory disturbances, nausea, and sensitivity to light and sound [...].


Subject(s)
Migraine Disorders , Migraine Disorders/physiopathology , Migraine Disorders/therapy , Humans , Animals , Neurobiology
5.
Curr Opin Support Palliat Care ; 18(3): 107-112, 2024 Sep 01.
Article in English | MEDLINE | ID: mdl-38990711

ABSTRACT

PURPOSE OF REVIEW: Several innovative digital technologies have begun to be applied to diagnosing and treating migraine. We reviewed the potential benefits and opportunities from delivering migraine care through comprehensive digital clinics. RECENT FINDINGS: There are increasing applications of digitization to migraine diagnosis and management, including e-diaries, and patient self-management, especially after the COVID-19 pandemic. Digital care delivery appears to better engage chronic migraine sufferers who may struggle to present to physical clinics. SUMMARY: Digital clinics appear to be a promising treatment modality for patients with chronic migraine. They potentially minimize travel time, shorten waiting periods, improve usability, and increase access to neurologists. Additionally, they have the potential to provide care at a much lower cost than traditional physical clinics. However, the current state of evidence mostly draws on case-reports, suggesting a need for future randomized trials comparing digital interventions with standard care pathways.


Subject(s)
COVID-19 , Migraine Disorders , Telemedicine , Humans , Migraine Disorders/diagnosis , Migraine Disorders/therapy , Telemedicine/organization & administration , COVID-19/epidemiology , Self-Management/methods , SARS-CoV-2
7.
Rinsho Shinkeigaku ; 64(7): 465-473, 2024 Jul 27.
Article in Japanese | MEDLINE | ID: mdl-38910117

ABSTRACT

Migraine is a disease that is difficult to be recognized by those around the patients, even though it causes significant hindrances. In this study, we conducted an exploratory comparison of the perceptions on migraine among patients, family members living with them, and physicians treating migraine patients. Patients and family members shared a common understanding on the pain of migraine, and hoped to spend more/better time together as a family. However, although family members felt compassion for the patients, lack of understanding by and patients' concern for the surroundings led to feelings of resignation and endurance on the side of patients. Regarding physicians' medical care, our results suggested the importance to understand the wishes and obstacles of each patient and to propose treatment accordingly. In order to reduce the burden of migraine, it is necessary to create an environment and raise awareness that allows people around the patients to understand and support the pain and hopes that each patient feels.


Subject(s)
Family , Migraine Disorders , Physicians , Humans , Migraine Disorders/psychology , Migraine Disorders/therapy , Male , Female , Surveys and Questionnaires , Adult , Physicians/psychology , Middle Aged , Empathy , Perception , Physician-Patient Relations , Aged , Young Adult
8.
Clin Nutr ; 43(8): 1781-1787, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38941791

ABSTRACT

BACKGROUND: An increasing amount of evidence suggests that migraine is a response to cerebral energy deficiencies or oxidative stress levels that exceed antioxidant capacity. Current pharmacological options are inadequate in treating patients with chronic migraine, and a growing interest focuses on nutritional approaches as non-pharmacological treatments. The ketogenic diet, mimicking fasting that leads to an elevation of ketone bodies, is a therapeutic intervention targeting cerebral metabolism that has recently shown great promise in the prevention of migraines. Moreover, Mediterranean elements like vegetables, nuts, herbs, spices, and olive oil that are sources of anti-inflammatory elements (omega-3 fatty acids, polyphenols, vitamins, essential minerals, and probiotics) may create a positive brain environment by reducing imbalance in the gut microbiome. METHODS: On the basis of these indications, a combined Mediterranean-ketogenic diet was administered to chronic migraine patients for 4 (T1) and 8 weeks (T2), and anthropometric estimations were collected at T1 and T2 while biochemical parameters at only T2. RESULTS: A significant reduction (p < 0.01) in migraine frequency and intensity was detected as early as 4 weeks of dietary intervention, which was associated with a reduced fat mass (p < 0.001) as well as Homa index (p < 0.05) and insulin levels (p < 0.01) after 8 weeks. CONCLUSION: Overall, Mediterranean-ketogenic diet may be considered an effective non-pharmacological intervention for migraine, with positive outcomes on body composition.


Subject(s)
Diet, Ketogenic , Diet, Mediterranean , Migraine Disorders , Humans , Diet, Ketogenic/methods , Migraine Disorders/diet therapy , Migraine Disorders/therapy , Migraine Disorders/prevention & control , Pilot Projects , Female , Adult , Male , Middle Aged , Chronic Disease , Treatment Outcome
9.
J Med Internet Res ; 26: e55927, 2024 Jul 23.
Article in English | MEDLINE | ID: mdl-38828692

ABSTRACT

This study assessed the potential of large language models (OpenAI's ChatGPT 3.5 and 4.0, Google Bard, Meta Llama2, and Anthropic Claude2) in addressing 30 common migraine-related queries, providing a foundation to advance artificial intelligence-assisted patient education and insights for a holistic approach to migraine management.


Subject(s)
Benchmarking , Migraine Disorders , Patient Education as Topic , Humans , Migraine Disorders/therapy , Patient Education as Topic/methods , Artificial Intelligence
10.
Fortschr Neurol Psychiatr ; 92(7-08): 283-288, 2024 Jul.
Article in German | MEDLINE | ID: mdl-38866035

ABSTRACT

The landscape of acute migraine medication has changed fundamentally in recent years. It has been a gradual, often unnoticed process characterized less by spectacular introduction of new substances than by changes in patients' access to medications and individualized selection of treatment adapted to the patients' needs. Four triptans are now available over-the-counter in Germany which has a major influence on self-medication. The main new introduction was the 5HT1F-agonist lasmiditan as an alternative to triptans.


Subject(s)
Migraine Disorders , Tryptamines , Migraine Disorders/therapy , Migraine Disorders/drug therapy , Humans , Tryptamines/therapeutic use , Piperidines/therapeutic use , Serotonin Receptor Agonists/therapeutic use , Benzamides/therapeutic use , Pyridines/therapeutic use
11.
Fortschr Neurol Psychiatr ; 92(7-08): 304-309, 2024 Jul.
Article in German | MEDLINE | ID: mdl-38885653

ABSTRACT

As a common neurological disorder (10-15% of the population), migraine is associated with numerous comorbidities, particularly other pain syndromes, mental illnesses and functional disorders. These 'psychosomatic' comorbidities increase with migraine severity. Severely affected, comorbid patients also often have a poorer response to specific migraine therapy. Interestingly, migraine and the comorbidities mentioned have a number of common aetiological or facilitating factors, e.g. genetic factors, and show a higher incidence in women and in people with previous traumatic experiences, as well as (in the case of pain syndromes) signs of central sensitization. Another common feature is the association with current or chronic stress. We propose an extended diathesis-stress model that takes into account interrelated but individually different vulnerabilities and, depending on the stress experience, can depict both the occurrence of individual disorders (e.g. an isolated migraine) and the joint occurrence of migraine with other pain syndromes and other psychosomatic comorbidities. In summary, psychosomatic comorbidities should always be kept in mind in migraine therapy and, if necessary, treated early and multimodally.


Subject(s)
Comorbidity , Migraine Disorders , Psychophysiologic Disorders , Migraine Disorders/epidemiology , Migraine Disorders/therapy , Migraine Disorders/psychology , Humans , Psychophysiologic Disorders/epidemiology , Psychophysiologic Disorders/therapy , Psychophysiologic Disorders/psychology , Mental Disorders/epidemiology , Mental Disorders/psychology , Mental Disorders/complications , Female , Stress, Psychological/epidemiology , Stress, Psychological/psychology
12.
Fortschr Neurol Psychiatr ; 92(7-08): 294-297, 2024 Jul.
Article in German | MEDLINE | ID: mdl-38885654

ABSTRACT

Primary headaches can be prevented by medication, exercise, behavioral therapy, or lifestyle changes. It is important to note that if medication is used for prophylaxis, non-drug approaches should also be recommended as a complement. Patients often wish to address their headaches without medication. Except for cognitive behavioral therapy and biofeedback, the evidence for nonmedication approaches to headache management has not been definitively established. This article reviews the current literature on the evidence for endurance exercise, relaxation exercises, physical therapy, lifestyle factors, and complementary procedures. For tension-type headache, there is an increasing number of studies reporting positive results from physical therapy; long-term follow-up, however, are still pending. Aerobic endurance exercise has the best evidence as a measure for prevention of migraine. However, other methods can also be used.


Subject(s)
Headache , Humans , Headache/prevention & control , Headache/therapy , Life Style , Physical Therapy Modalities , Complementary Therapies/methods , Exercise , Evidence-Based Medicine , Relaxation Therapy , Migraine Disorders/prevention & control , Migraine Disorders/therapy , Tension-Type Headache/prevention & control , Tension-Type Headache/therapy , Cognitive Behavioral Therapy , Exercise Therapy
13.
Int J Mol Sci ; 25(12)2024 Jun 17.
Article in English | MEDLINE | ID: mdl-38928361

ABSTRACT

Migraine is a common and debilitating neurological disorder characterized by the recurrent attack of pulsating headaches typically localized on one side of the head associated with other disabling symptoms, such as nausea, increased sensitivity to light, sound and smell and mood changes. Various clinical factors, including the excessive use of migraine medication, inadequate acute treatment and stressful events, can contribute to the worsening of the condition, which may evolve to chronic migraine, that is, a headache present on >15 days/month for at least 3 months. Chronic migraine is frequently associated with various comorbidities, including anxiety and mood disorders, particularly depression, which complicate the prognosis, response to treatment and overall clinical outcomes. Emerging research indicates a connection between alterations in the composition of the gut microbiota and mental health conditions, particularly anxiety and depression, which are considered disorders of the gut-brain axis. This underscores the potential of modulating the gut microbiota as a new avenue for managing these conditions. In this context, it is interesting to investigate whether migraine, particularly in its chronic form, exhibits a dysbiosis profile similar to that observed in individuals with anxiety and depression. This could pave the way for interventions aimed at modulating the gut microbiota for treating difficult-to-manage migraines.


Subject(s)
Gastrointestinal Microbiome , Migraine Disorders , Humans , Migraine Disorders/microbiology , Migraine Disorders/therapy , Migraine Disorders/psychology , Brain-Gut Axis , Anxiety/microbiology , Depression/microbiology , Dysbiosis/microbiology , Animals
14.
Curr Pain Headache Rep ; 28(7): 621-626, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38865075

ABSTRACT

PURPOSE OF REVIEW: This review assesses the effectiveness and safety of light therapy, particularly green light therapy, as an emerging non-pharmacological treatment for chronic migraine (CM). It aims to highlight alternative or complementary approaches to traditional pharmacological remedies, focusing the need for diverse treatment options. RECENT FINDINGS: Despite sensitivity to light being a defining feature of migraine, light therapy has shown promising signs in providing substantial symptom relief. Studies have provided insights into green light therapy's role in managing CM. These studies consistently demonstrate its efficacy in reducing the frequency, severity, and symptoms of migraines. Additional benefits observed include improvements in sleep quality and reductions in anxiety. Importantly, green light therapy has been associated with minimal side effects, indicating its potential as a suitable option for migraine sufferers. In addition to green light, other forms of light therapy, such as infrared polarized light, low-level laser therapy (LLLT), and intravascular irradiation of blood (ILIB), are also being explored with potential therapeutic effects. Light therapies, especially green light therapy, are recognized as promising, safe, and non-pharmacological interventions for treating CM. They have been shown to be effective in decreasing headache frequency and enhancing the overall quality of life. However, current studies, often limited by small sample sizes, prompt more extensive clinical trials to better understand the full impact of light therapies. The exploration of other light-based treatments, such as LLLT and ILIB, warrants further research to broaden the scope of effective migraine management strategies.


Subject(s)
Migraine Disorders , Phototherapy , Humans , Migraine Disorders/therapy , Phototherapy/methods , Chronic Disease , Treatment Outcome
15.
Cephalalgia ; 44(6): 3331024241261080, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38860524

ABSTRACT

BACKGROUND: Acupuncture has been used for the treatment of chronic migraine, but high-quality evidence is scarce. We aimed to evaluate acupuncture's efficacy and safety compared to topiramate for chronic migraine. METHODS: This double-dummy randomized controlled trial included participants aged 18-65 years diagnosed with chronic migraine. They were randomly assigned (1:1) to receive acupuncture (three sessions/week) plus topiramate placebo (acupuncture group) or topiramate (50-100 mg/day) plus sham acupuncture (topiramate group) over 12 weeks, with the primary outcome being the mean change in monthly migraine days during weeks 1-12. RESULTS: Of 123 screened patients, 60 (mean age 45.8, 81.7% female) were randomly assigned to acupuncture or topiramate groups. Acupuncture demonstrated significantly greater reductions in monthly migraine days than topiramate (weeks 1-12: -2.79 [95% CI: -4.65 to -0.94, p = 0.004]; weeks 13-24: -3.25 [95% CI: -5.57 to -0.92, p = 0.007]). No severe adverse events were reported. CONCLUSIONS: Acupuncture may be safe and effective for treating chronic migraine. The efficacy of 12 weeks of acupuncture was sustained for 24 weeks and superior to that of topiramate. Acupuncture can be used as an optional preventive therapy for chronic migraine. TRIAL REGISTRATION: ISRCTN.org Identifier 13563102.


Subject(s)
Acupuncture Therapy , Migraine Disorders , Topiramate , Humans , Topiramate/therapeutic use , Topiramate/administration & dosage , Migraine Disorders/prevention & control , Migraine Disorders/therapy , Female , Male , Middle Aged , Adult , Acupuncture Therapy/methods , Chronic Disease , Treatment Outcome , Single-Blind Method , Young Adult , Combined Modality Therapy/methods , Adolescent , Aged
16.
Zh Nevrol Psikhiatr Im S S Korsakova ; 124(5. Vyp. 2): 110-117, 2024.
Article in Russian | MEDLINE | ID: mdl-38934675

ABSTRACT

OBJECTIVE: To evaluate the effectiveness of a multidisciplinary program, including Cognitive behavioral therapy (CBT), in the treatment of patients with chronic migraine (CM) and concomitant chronic insomnia (CI). MATERIAL AND METHODS: The study included 96 patients with CM and CI, average age 35.7±8.6. All patients underwent clinical interviews and testing using clinical and psychological techniques. Patients were randomized into two groups: group 1 received study treatment (an multudisciplinary program including CBT for pain and insomnia, combined with standard treatment for migraine), group 2 received standard treatment for migraine (preventive and acute pharmacotherapy for migraine, recommendations about lifestyle and sleep hygiene). All patients were assessed for clinical and psychological parameters before treatment and at 3, 6, 12 and 18 months follow-up. RESULTS: At 3 month follow-up a statistically significant improvement was observed in group 1: a decrease in the frequency of headaches and the use of painkillers, parameters on the Insomnia Severity Index (ITI), the State-Trait Anxiety Inventory (STAI), the Beck Depression Inventory, and the Migraine Disability Assessment (MIDAS) (p<0.05). At 6, 12 and 18 months follow-up the achieved improvements were maintained. At 3 month follow-up, group 2 showed a statistically significant improvement in only 4 parameters: a decrease in the frequency of headaches and painkiller use, and parameters for ITI and MIDAS. These parameters increased to values that were not statistically significantly different from the parameters before treatment in group 2 at 6 month follow-up. At 3 month follow-up in group 165% of patients achieved clinical effect (CE) according to CM (headache frequency decreased by 50% or more), in group 2 - 40%, which was not statistically significantly different (p>0.001); in group 1, 76% of patients achieved CE according to CI (ITI decreased by 8 points or more), which is statistically significantly more than in group 2 with 45% of patients with CE (p<0.001). At 18 month follow-up, in group 1, 81.5% of patients achieved CE according to CM, which is statistically significantly more than in group 2 with 33% of patients with CE (p<0.001); in group 1, 85% of patients achieved CE according to CI, which is statistically significantly more than in group 2, where 38% of patients had CE (p<0.001). CONCLUSION: High effectiveness of CBT in patients with CM and combined CI was noted.


Subject(s)
Cognitive Behavioral Therapy , Migraine Disorders , Sleep Initiation and Maintenance Disorders , Humans , Sleep Initiation and Maintenance Disorders/therapy , Migraine Disorders/therapy , Migraine Disorders/psychology , Migraine Disorders/complications , Cognitive Behavioral Therapy/methods , Female , Adult , Male , Prospective Studies , Treatment Outcome , Middle Aged , Chronic Disease
17.
J Bodyw Mov Ther ; 39: 116-121, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38876614

ABSTRACT

Adverse side effects from pharmacological treatments cause people with migraine to delay or avoid taking medication. Exercise is effective, but the effect of environment is unknown. The purpose was to determine if a natural environment affects monthly migraine load. Sedentary individuals (8 female, 1 non-binary) who experienced migraines participated. Participants completed one month of exercise (3 x week, 30-min, 60-70% estimated HRmax) indoors as well as in a natural outdoor environment in a randomized counterbalanced order. Migraine load was determined using the Headache Impact Test (HIT-6) and Migraine Disability Assessment (MIDAS) at the beginning and end of each month. Data were analyzed using repeated measures ANOVA. No interactions were evident for HIT-6 (p = 0.80), MIDAS (p = 0.72), migraine days (p = 0.508), or pain intensity (p = 0.66). No main effects were noted. Compliance was greater in the outdoor environment, with more exercise sessions completed in nature (Indoor = 72%, Outdoor = 90%, p < 0.001). Exercise environment did not impact MIDAS or HIT-6 questionnaire results, number of migraine days, or pain intensity. While there was no reduction in migraine load, it is possible that other health benefits were experienced due to greater compliance in a natural environment.


Subject(s)
Cross-Over Studies , Exercise Therapy , Migraine Disorders , Patient Compliance , Humans , Migraine Disorders/therapy , Female , Male , Adult , Exercise Therapy/methods , Pilot Projects , Middle Aged , Environment , Chronic Disease , Pain Measurement
19.
Curr Neurol Neurosci Rep ; 24(8): 245-254, 2024 Aug.
Article in English | MEDLINE | ID: mdl-38864968

ABSTRACT

PURPOSE OF REVIEW: To review replicated and highlight novel studies of sleep in children and adults with episodic and chronic migraine. RECENT FINDINGS: Attack-related sleep symptoms are most common in the prodrome and may represent early activation of the hypothalamus rather than migraine triggers. Interictally, patients with migraine report poor sleep quality and high rates of insomnia symptoms. Cognitive behavioral therapy for insomnia in adults and adolescents with chronic migraine and comorbid insomnia results in significant improvement on their headache burden. Thus far, objective studies report that migraine per se is a not associated with sleep apnea. At the present time, there is minimal evidence that migraine is under circadian influence. The current body of evidence suggests that the insomnia symptoms and poor sleep quality commonly reported by patients with migraine are not attack-related but occur interictally and are a marker of worsening disease. The development of clinical guidelines to approach sleep symptoms and expansion of CBT-I trials in those with episodic migraine would be clinically valuable.


Subject(s)
Migraine Disorders , Humans , Migraine Disorders/therapy , Migraine Disorders/physiopathology , Migraine Disorders/complications , Sleep Wake Disorders/therapy , Sleep Wake Disorders/physiopathology , Sleep Wake Disorders/etiology , Sleep Initiation and Maintenance Disorders/therapy , Sleep Initiation and Maintenance Disorders/etiology , Sleep Initiation and Maintenance Disorders/physiopathology , Sleep/physiology , Cognitive Behavioral Therapy/methods
20.
Altern Ther Health Med ; 30(5): 18-23, 2024 May.
Article in English | MEDLINE | ID: mdl-38819188

ABSTRACT

Migraines constitute a neurological disorder characterized by severe and recurrent headaches, significantly impacting the quality of life especially when unresponsive to treatment. This is particularly pronounced in individuals with difficult-to-treat migraines, leading to heightened physical and psychosocial disability. The study aims to design and implement a psychological intervention protocol (MIDITRA) focused on improving the physical and psychological well-being of those suffering from difficult-to-treat migraines. The efficacy of this intervention will be assessed in a pilot study involving 30 adults with chronic, difficult-to-treat migraines. This is an open study, adopting a longitudinal experimental design, and involving inter-subject comparisons between an experimental group (receiving psychological treatment) and a control group (without treatment), being assessed at two post-treatment time points. Additionally, an intra-subject analysis will be conducted, comparing repeated measures to assess changes within each subject before (with two pre-treatment measurements) and after psychological treatment (with two post-treatment measurements). Treated patients will receive a 10-session group psychological intervention. The analysis will focus on the therapeutic benefits of applying the MIDITRA protocol, specifically aiming to reduce migraine-related disability, diminish the negative impact of headaches, enhance the quality of life, mitigate pain catastrophizing, increase life satisfaction, elevate positive affect, decrease negative affect, lower psychological stress, boost resilience, and reduce anxiety and depression.


Subject(s)
Migraine Disorders , Quality of Life , Humans , Migraine Disorders/therapy , Migraine Disorders/psychology , Adult , Quality of Life/psychology , Male , Female , Pilot Projects , Psychosocial Intervention/methods , Middle Aged
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