Abdominal aortic branches of red-rumped agouti (Dasyprocta leporina Linnaeus, 1758).

Understanding the cardiovascular system is fundamental in diagnosing pathologies and interpreting exams, such as contrast radiographs. In this context, the present study describes the collateral abdominal aorta artery branches of red-rumped agouti. Ten red-rumped agoutis, six males and four females, were assessed. The vascular system was perfused with Neoprene 450 latex coloured with a yellow pigment, dissected and analysed. Three euthanized animals were perfused with a barium sulfate solution (1 g mL-1 ) associated with latex Neoprene 450 at a 1:3 ratio to obtain contrast-enhanced radiographs. The abdominal aorta emitted the celiac artery, which in turn originated the left gastric, hepatic and splenic arteries. The second collateral branch comprised the cranial mesenteric artery, followed by the renal arteries, which emitted the adrenal arteries, with the caudal emergence of the gonadal arteries. The caudal mesenteric artery appeared in a caudal direction. The abdominal aorta divided after reaching the pelvic cavity entrance, originating the right and left common iliac arteries. Before its bifurcation, the abdominal aorta dorsocaudally emitted its last collateral branch, the median sacral artery. The collateral branches of the aorta, therefore, resemble previously described rodent patterns, with few variations.

Collateral aortic branches in the collared peccary (Pecari tajacu Linnaeus, 1758).

The determination of arterial vascular distribution patterns can contribute to more detailed knowledge on arterial systems. In this context, the aim of the present study was to describe the collateral aortic branches in the collared peccary, aiming to define a standard model for this species, providing information through comparative anatomy for analysis of some evolutionary aspects of the order Artiodactyla. Ten young male animals were employed. The vascular system was washed with a saline solution and then perfused with Neoprene 450 latex coloured with red or yellow pigment, followed by collateral aorta branch dissections and analyses. The contrasted digital radiography technique was applied to two animals, which were initially perfused with a barium sulphate solution (1 g/ml) and Neoprene 450 latex at a 1:3 ratio, and subsequently, the digital radiographic examination was performed. The aortic arch of the collared peccary emitted the brachiocephalic trunk and the left subclavian artery, while eight symmetric pairs of dorsal intercostal arteries originated from the thoracic aorta. The abdominal aorta, in turn, exhibited the celiac, cranial mesenteric, renal, caudal mesenteric, testicular, external iliac, internal iliac and sacral arteries as the collateral branches in all studied animals. Therefore, no relevant variations were observed regarding the arrangement of the arterial distribution of the aorta, thus suggesting a static standard model in the collared peccary.

A State-of-the-art Review and Prospective Therapeutic Applications of Prenyl Flavonoids as Chemosensitizers against Antifungal Multidrug Resistance in Candida albicans.

Multidrug resistance (MDR) in the opportunistic pathogen Candida albicans is defined as non-susceptibility to at least one agent in two or more drug classes. This phenomenon has been increasingly reported since the rise in the incidence of fungal infections in immunocompromised patients at the end of the last century. After the discovery of efflux pump overexpression as a principal mechanism causing MDR in Candida strains, drug discovery targeting fungal efflux transporters has had a growing impact. Chemosensitization aims to enhance azole intracellular concentrations through combination therapy with transporter inhibitors. Consequently, the use of drug efflux inhibitors combined with the antifungal agent will sensitize the pathogen. As a result, the use of lower drug concentrations will reduce possible adverse effects on the host. Through an extensive revision of the literature, this review aims to provide an exhaustive and critical analysis of the studies carried out in the past two decades regarding the chemosensitization strategy to cope with multidrug resistance in C. albicans. This work provides a deep analysis of the research on the inhibition of drug-efflux membrane transporters by prenylated flavonoids and the interactions of these phytocompounds with azole antifungals as an approach to chemosensitize multidrug-resistant C. albicans strains. We highlight the importance of prenylflavonoids and their particular chemical and pharmacological characteristics that make them excellent candidates with therapeutic potential as chemosensitizers. Finally, we propose the need for further research on prenyl flavonoids as inhibitors of drug-efflux mediated fungal resistance.

Tributaries of the hepatic vein in the ostrich (Struthio camelus) / Afluentes da veia porta-hepática no avestruz (Struthio camelus)

The ostrich (Struthio camelus, Linnaeus 1758) is the largest bird in the world. It is of great economic importance in Africa and is found across several countries. With developments in breeding systems, morphological studies that facilitate the application of the knowledge are necessary, considering the species has unique anatomical features. The objective of the present study was to describe the major tributaries of the hepatic vein in the species. Ten viscera of adult individuals of both sexes, which were injected with Neoprene latex through the hepatic vein, were used to visualize their tributaries. After the vascular repletion, the tissues were fixed and conserved in 10% formaldehyde aqueous solution. The hepatic carrier system was dissected and photo-documented. The left hepatic vein receives blood from the proventricle and gastric ventricle, while the right hepatic vein is responsible for the drainage of blood into the following organs: spleen, through the proventriculosplenic vein; pancreas, through the pancreaticoduodenal vein; jejunum, through the jejunum trunk; and the colon, which forms the cranial mesenteric vein.(AU)

O avestruz (Struthio camelus, Linnaeus 1758) é a maior ave do mundo, com uma importância comercial acentuada na África e expandindo-se para diversos países. Assim, com o desenvolvimento dos sistemas de criação, tornam-se necessários estudos morfológicos que subsidiem as áreas aplicadas, pois a espécie apresenta características anatômicas próprias. O objetivo deste estudo foi a descrição dos principais afluentes da veia porta-hepática nesta espécie. Para a realização do presente trabalho, foram utilizadas dez vísceras de animais adultos, de ambos os sexos, que foram injetados com Neoprene látex por meio da veia porta-hepática para evidenciar os seus afluentes. Após a repleção vascular, os animais foram fixados e conservados em solução aquosa de formaldeído a 10%. O sistema porta-hepático foi dissecado e fotodocumentado. Observou-se que a veia porta-hepática esquerda recebe sangue da região do proventrículo e ventrículo gástrico. A veia porta-hepática direita é a responsável pela drenagem do sangue nos seguintes órgãos: baço, por meio da veia proventriculoesplênica, pâncreas, pela veia pancreaticoduonais, jejuno, por meio do tronco jejunal, e o cólon, que forma a veia mesentérica cranial.(AU)

Tributaries of the hepatic vein in the ostrich (Struthio camelus) / Afluentes da veia porta-hepática no avestruz (Struthio camelus)

The ostrich (Struthio camelus, Linnaeus 1758) is the largest bird in the world. It is of great economic importance in Africa and is found across several countries. With developments in breeding systems, morphological studies that facilitate the application of the knowledge are necessary, considering the species has unique anatomical features. The objective of the present study was to describe the major tributaries of the hepatic vein in the species. Ten viscera of adult individuals of both sexes, which were injected with Neoprene latex through the hepatic vein, were used to visualize their tributaries. After the vascular repletion, the tissues were fixed and conserved in 10% formaldehyde aqueous solution. The hepatic carrier system was dissected and photo-documented. The left hepatic vein receives blood from the proventricle and gastric ventricle, while the right hepatic vein is responsible for the drainage of blood into the following organs: spleen, through the proventriculosplenic vein; pancreas, through the pancreaticoduodenal vein; jejunum, through the jejunum trunk; and the colon, which forms the cranial mesenteric vein.

O avestruz (Struthio camelus, Linnaeus 1758) é a maior ave do mundo, com uma importância comercial acentuada na África e expandindo-se para diversos países. Assim, com o desenvolvimento dos sistemas de criação, tornam-se necessários estudos morfológicos que subsidiem as áreas aplicadas, pois a espécie apresenta características anatômicas próprias. O objetivo deste estudo foi a descrição dos principais afluentes da veia porta-hepática nesta espécie. Para a realização do presente trabalho, foram utilizadas dez vísceras de animais adultos, de ambos os sexos, que foram injetados com Neoprene látex por meio da veia porta-hepática para evidenciar os seus afluentes. Após a repleção vascular, os animais foram fixados e conservados em solução aquosa de formaldeído a 10%. O sistema porta-hepático foi dissecado e fotodocumentado. Observou-se que a veia porta-hepática esquerda recebe sangue da região do proventrículo e ventrículo gástrico. A veia porta-hepática direita é a responsável pela drenagem do sangue nos seguintes órgãos: baço, por meio da veia proventriculoesplênica, pâncreas, pela veia pancreaticoduonais, jejuno, por meio do tronco jejunal, e o cólon, que forma a veia mesentérica cranial.

The antioxidant activity of a prenyl flavonoid alters its antifungal toxicity on Candida albicans biofilms.

The antioxidant effect of 8PP, a prenylflavonoid from Dalea elegans on Candida albicans biofilms, was investigated. We previously reported that sensitive (SCa) and resistant C. albicans (RCa) biofilms were strongly inhibited by this compound, in a dose-depending manner (50 µM-100 µM), with a prooxidant effect leading to accumulation of endogenous oxidative metabolites and increased antioxidant defenses. In this work, the antifungal activity of high concentrations of 8PP (200-1000 µM), the cellular stress imbalance and the architecture of biofilms were evaluated. Biofilms were studied by crystal violet and confocal scanning laser microscopy (CSLM) with COMSTAT analysis. Superoxide anion radical, the activity of the superoxide dismutase and the total antioxidant capacity were measured. Intracellular ROS were detected by a DCFH-DA and visualized by CSLM; reactive nitrogen intermediates by Griess. An antioxidant effect was detected at 1000 µM and levels of oxidant metabolites remained low, with major changes in the SCa. COMSTAT analysis showed that biofilms treated with higher concentrations exhibited different diffusion distances with altered topographic surface architectures, voids, channels and pores that could change the flow inside the matrix of biofilms. We demonstrate for first time, a concentration-dependent antioxidant action of 8PP, which can alter its antifungal activity on biofilms.

Evaluation of brachial plexus fascicles involvement on infraclavicular block: unfixed cadaver study.

BACKGROUND AND OBJECTIVES: This study shows how the diffusion of the anesthetic into the sheath occurs through the axillary infraclavicular space and hence proves the efficacy of the anesthetic block of the brachial plexus, and may thereby allow a consolidation of this pathway, with fewer complications, previously attached to the anesthesia. MATERIALS AND METHODS: 33 armpits of adult cadavers were analyzed and unfixed. We injected a solution of neoprene with latex dye in the infraclavicular space, based on the technique advocated by Gusmão et al., and put the corpses in refrigerators for three weeks. Subsequently, the specimens were thawed and dissected, exposing the axillary sheath along its entire length. RESULTS AND DISCUSSION: Was demonstrated involvement of all fasciculus of the plexus in 51.46%. In partial involvement was 30.30%, 18.24% of cases the acrylic was located outside the auxiliary sheath involving no issue. CONCLUSIONS: The results allow us to establish the infraclavicular as an effective and easy way to access plexus brachial, because the solution involved the fascicles in 81.76% partially or totally, when it was injected inside the axillary sheath. We believe that only the use of this pathway access in practice it may demonstrate the efficiency.

Origens, ramificações e distribuições das artérias faciais em suínos (Sus scrofa domesticus Linnaeus, 1758) da linhagem sadia / Origins, ramifications and distributions of facial arteries in pigs (Sus scrofa domesticus LINNAEUS, 1758 ) of the Sadia lineage

The origins, ramifications and distributions of the left and right facial arteries were studied in 30 stillborn pigs (Sus scrofa domesticus) of the Sadia lineage, 17 males and 13 females, with the aim of increasing morphological knowledge of these structures in terms of their localization and distribution. The species was chosen for its well known commercial importance. The specimen had its artery system filled with stained solution of neoprene latex 601 A and afterwards fixed in an aqueous solution of formaldehyde at 10%. It was observed that in 100% of the studied animals the facial arteries originated from the ventrolateral surface of  the external carotid artery, rostrally to the lingual artery. The gland branches divided, supplying the mandibular, parotid, monostomática portion of the sublingual and part of the cervical thymus in muscular branches, irrigating the medial pterygoid, masseter, ventral aspect of the digastrics and cutaneous of the face muscles. Furthermore, the pharyngal branch irrigated the soft palate, tympanic bula and basihyoid, and the submentalis artery was directed towards the submental and the dorsal face of the digastrics muscles.(AU)

Estudou-se as origens, ramificações e distribuições das artérias faciais direita e esquerda em 30 (trinta) suínos natimortos (Sus scrofa domesticus) da linhagem Sadia, 17 (dezessete) machos e 13(treze) fêmeas. Os espécimes tiveram os seus sistemas arteriais preenchidos com solução corada de neoprene látex 601 A e a seguir foram fixados em solução aquosa de formaldeído a 10%. Notou-se que em 100% dos animais pesquisados as artérias faciais originaram-se das superfícies ventrolaterais das artérias carótidas externas, rostralmente às artérias linguais. Ramificaram-se em ramos glandulares suprindo as glândulas mandibulares, parótidas, porção monostomática das glândulas sublinguais e parte cervical do timo; em ramos musculares irrigando os músculos pterigóideos mediais, masseteres, faces ventrais dos músculos digástricos e cutâneos da face. Ainda, o ramo faríngico nutrindo o palato mole, a bula timpânica e o basihióide, e por último as artérias submentonianas que direcionaram-se para os músculos milohióideos e faces dorsais dos músculos digástricos.(AU)

Origens, ramificações e distribuições das artérias faciais em suínos (Sus scrofa domesticus Linnaeus, 1758) da linhagem sadia / Origins, ramifications and distributions of facial arteries in pigs (Sus scrofa domesticus LINNAEUS, 1758 ) of the Sadia lineage

The origins, ramifications and distributions of the left and right facial arteries were studied in 30 stillborn pigs (Sus scrofa domesticus) of the Sadia lineage, 17 males and 13 females, with the aim of increasing morphological knowledge of these structures in terms of their localization and distribution. The species was chosen for its well known commercial importance. The specimen had its artery system filled with stained solution of neoprene latex 601 A and afterwards fixed in an aqueous solution of formaldehyde at 10%. It was observed that in 100% of the studied animals the facial arteries originated from the ventrolateral surface of  the external carotid artery, rostrally to the lingual artery. The gland branches divided, supplying the mandibular, parotid, monostomática portion of the sublingual and part of the cervical thymus in muscular branches, irrigating the medial pterygoid, masseter, ventral aspect of the digastrics and cutaneous of the face muscles. Furthermore, the pharyngal branch irrigated the soft palate, tympanic bula and basihyoid, and the submentalis artery was directed towards the submental and the dorsal face of the digastrics muscles.

Estudou-se as origens, ramificações e distribuições das artérias faciais direita e esquerda em 30 (trinta) suínos natimortos (Sus scrofa domesticus) da linhagem Sadia, 17 (dezessete) machos e 13(treze) fêmeas. Os espécimes tiveram os seus sistemas arteriais preenchidos com solução corada de neoprene látex 601 A e a seguir foram fixados em solução aquosa de formaldeído a 10%. Notou-se que em 100% dos animais pesquisados as artérias faciais originaram-se das superfícies ventrolaterais das artérias carótidas externas, rostralmente às artérias linguais. Ramificaram-se em ramos glandulares suprindo as glândulas mandibulares, parótidas, porção monostomática das glândulas sublinguais e parte cervical do timo; em ramos musculares irrigando os músculos pterigóideos mediais, masseteres, faces ventrais dos músculos digástricos e cutâneos da face. Ainda, o ramo faríngico nutrindo o palato mole, a bula timpânica e o basihióide, e por último as artérias submentonianas que direcionaram-se para os músculos milohióideos e faces dorsais dos músculos digástricos.

Análise comparativa entre a vascularização arterial ventricular e do nó sinoatrial em corações de cães / Comparative analysis between both ventricular and sinoatrial node arterial vascularization in heart of dogs

Utilizamos nesta pesquisa 40 corações de cães adultos, machos e fêmeas, de idades variadas, que não portavam nenhuma afecção cardíaca. Os corações tiveram as artérias coronárias injetadas, separadamente, com Neoprene Látex 450, corado com pigmento vermelho, e posteriormente dissecados. Em todas estas preparações verificamos que na vascularização dos ventrículos predominava a artéria coronária esquerda que fornecia os ramos interventriculares paraconal e subsinuoso. Já, a região ocupada pelo nó sinoatrial ficava mais frequentemente (17 vezes, 42,5%) na dependência do ramo proximal atrial esquerdo ou de colateral deste vaso, oriundo do ramo circunflexo esquerdo, ou deste vaso associado ao ramo distal atrial direito (8 vezes, 20%), procedente do ramo circunflexo direito. Com menor frequência (14 vezes, 30%), a área tomada pelo nó sinoatrial, encontramos apenas colaterais do ramo circunflexo direito, mais exatamente somente o ramo distal atrial direito (10 vezes, 25%), apenas o ramo proximal atrial direito (3 vezes, 7,5%) ou ainda exclusivamente o ramo intermédio atrial direito (1 vez, 2,5%). Em um único caso (1 vez, 2,5%) no território do nó sinoatrial observamos apenas colateral do ramo circunflexo esquerdo, isto é o ramo distal atrial esquerdo. A análise destes resultados permite concluir, que nesta espécie não existe qualquer tipo de relação entre o tipo de vascularização dos ventrículos e a irrigação do nó sinoatrial. Sendo assim, considerar os ramos ventriculares isoladamente não é suficiente para um entendimento clínico-cirúrgico aplicado, uma vez que os ramos atriais apresentam uma importante contribuição para a vascularização do nó sinoatrial.(AU)

We analyzed 40 hearts of adult dogs, males and females of different ages, without cardiac disease. The hearts had the coronary arteries inject using Neoprene Latex 450, colored with red pigment, and which was then dissected. In the ventricular vascularization the left coronary artery was predominant and gave rise to the paraconal interventricular and subsinuous branches. The region occupied by the sinoatrial node was most frequently (17 times, 42.5%) in dependence of the left atrial proximal branch or in the collateral branch of that vessel, coming from the left circumflex branch, or this vessel was associated with the right atrial distal branch (8 times, 20%). With less frequency (14 times, 30%), in the area occupied by the sinoatrial node we found only the collaterals of the right circumflex branch, only the right atrial distal branch (10 times, 25%), only the right atrial proximal branch (3 times, 7.5%) or exclusively the right atrial intermediary branch (once, 2.5%). In just one case (once, 2.5%) in the area of the sinoatrial node we observed only the collateral of the left circumflex branch, i.e. the left atrial distal branch. According to our results we concluded that in this specie there is no relationship between the type of ventricular vascularization and irrigation of the sinoatrial node. In doing so, to consider just the ventricular branches is not sufficient for a clinical and surgical applied understanding, since the atrial branches make an important contribution to the sinoatrial node vascularization.(AU)

Análise comparativa entre a vascularização arterial ventricular e do nó sinoatrial em corações de cães / Comparative analysis between both ventricular and sinoatrial node arterial vascularization in heart of dogs

Utilizamos nesta pesquisa 40 corações de cães adultos, machos e fêmeas, de idades variadas, que não portavam nenhuma afecção cardíaca. Os corações tiveram as artérias coronárias injetadas, separadamente, com Neoprene Látex 450, corado com pigmento vermelho, e posteriormente dissecados. Em todas estas preparações verificamos que na vascularização dos ventrículos predominava a artéria coronária esquerda que fornecia os ramos interventriculares paraconal e subsinuoso. Já, a região ocupada pelo nó sinoatrial ficava mais frequentemente (17 vezes, 42,5%) na dependência do ramo proximal atrial esquerdo ou de colateral deste vaso, oriundo do ramo circunflexo esquerdo, ou deste vaso associado ao ramo distal atrial direito (8 vezes, 20%), procedente do ramo circunflexo direito. Com menor frequência (14 vezes, 30%), a área tomada pelo nó sinoatrial, encontramos apenas colaterais do ramo circunflexo direito, mais exatamente somente o ramo distal atrial direito (10 vezes, 25%), apenas o ramo proximal atrial direito (3 vezes, 7,5%) ou ainda exclusivamente o ramo intermédio atrial direito (1 vez, 2,5%). Em um único caso (1 vez, 2,5%) no território do nó sinoatrial observamos apenas colateral do ramo circunflexo esquerdo, isto é o ramo distal atrial esquerdo. A análise destes resultados permite concluir, que nesta espécie não existe qualquer tipo de relação entre o tipo de vascularização dos ventrículos e a irrigação do nó sinoatrial. Sendo assim, considerar os ramos ventriculares isoladamente não é suficiente para um entendimento clínico-cirúrgico aplicado, uma vez que os ramos atriais apresentam uma importante contribuição para a vascularização do nó sinoatrial.

We analyzed 40 hearts of adult dogs, males and females of different ages, without cardiac disease. The hearts had the coronary arteries inject using Neoprene Latex 450, colored with red pigment, and which was then dissected. In the ventricular vascularization the left coronary artery was predominant and gave rise to the paraconal interventricular and subsinuous branches. The region occupied by the sinoatrial node was most frequently (17 times, 42.5%) in dependence of the left atrial proximal branch or in the collateral branch of that vessel, coming from the left circumflex branch, or this vessel was associated with the right atrial distal branch (8 times, 20%). With less frequency (14 times, 30%), in the area occupied by the sinoatrial node we found only the collaterals of the right circumflex branch, only the right atrial distal branch (10 times, 25%), only the right atrial proximal branch (3 times, 7.5%) or exclusively the right atrial intermediary branch (once, 2.5%). In just one case (once, 2.5%) in the area of the sinoatrial node we observed only the collateral of the left circumflex branch, i.e. the left atrial distal branch. According to our results we concluded that in this specie there is no relationship between the type of ventricular vascularization and irrigation of the sinoatrial node. In doing so, to consider just the ventricular branches is not sufficient for a clinical and surgical applied understanding, since the atrial branches make an important contribution to the sinoatrial node vascularization.

Efeito do uso do traje de neoprene sobre variáveis técnicas, fisiológicas e perceptivas de nadadores / Effects of a neoprene suit over technical, physiological and perceptive variables of swimmers

Ao contrário do que ocorre em provas de piscina, competições em águas abertas estão sujeitas as condições ambientais, sendo uma delas as baixas temperaturas. Em determinadas circunstâncias é permitido o uso de roupas especiais para evitar hipotermia. O objetivo do estudo foi verificar os efeitos do uso da roupa de neoprene em um grupo composto por triatletas e nadadores, comparado ao uso de vestimentas convencionais (sunga) sobre variáveis cinemáticas e psicofisiológicas do nado. Participaram 20 homens (12 triatletas e oito nadadores) de idade 22,0 ± 6,6 anos com desempenhos que correspondem a 75 ± 7,7 por cento do melhor tempo brasileiro na prova de 400 m. Os atletas realizaram duas repetições máximas e duas submáximas de 400 m em nado "crawl", com e sem o uso da roupa de neoprene. Foram comparadas a velocidade média (VM), comprimento de braçada (CB), frequência de braçada (FB), índice de nado (IN), percepção subjetiva de esforço (PSE), frequência cardíaca (FC), e concentração de lactato sanguíneo (LAC). Um conjunto de ANOVAs com medidas repetidas do tipo "two-way" foi aplicado. Quando diferenças foram encontradas o teste de Tukey foi empregado. Com o traje de neoprene, em máxima intensidade, o tempo para nadar a distância foi 6,4 por cento menor, com manutenção da FB e aumento da CB, as variáveis psicofisiológicas não diferiram estatisticamente. Em esforço submáximo, o uso do traje de neoprene resultou em menor FB, maior CB, maior IN e em menores valores de FC, LAC e PSE (p < 0,05). O uso do traje proporcionou melhoria do desempenho nos aspectos biomecânicos, fisiológicos e perceptivos e que o aumento da VM em esforço máximo não depende exclusivamente de alterações na FB e CB. Possivelmente, incrementos nos parâmetros associados ao nado pode ter melhorado a eficiência mecânica do movimento, a qual pode ter provido uma economia de movimento que resultou em melhor desempenho.

In open water swimming competitions, athletes are prone to environmental conditions and are frequently exposed to low temperatures, in contrast to what occurs in indoor competitions. In some circumstances the use of special swimming suits is allowed to avoid hypothermia. The aim of this study was to verify the effects of the use of a neoprene swimming suit in comparison to a conventional swimming suit on a number of cinematic and psychophysiological variables. Twenty athletes experienced in swimming competitions (12 triathletes and 8 swimmers; 22.0± 6.6 yearsold), whose the performance was 75 ± 7.7 percent of the National record. Athletes performed two maximal and two submaximal 400m crawl simulated competition with a whole body neoprene swimming suit and with a conventional swimming suit. Mean speed (VM) stroke length (CB), stroke frequency (FB), swimming index (IN), rate of perceived effort (PSE), heart rate, and blood lactate concentration (LAC) were compared between conditions. The time to perform maximal trials with the use of the neoprene swimming suit was 6.4 percent shorter than when wearing the traditional swimming suit. FB and the psychophysiological variables remained unchanged, while CB increased in response to the use of the neoprene swimming suit. The use of the neoprene swimming suit in submaximal trials provided smaller FB, FC, LAC and PSE and larger CB and IN in comparison to the use of the traditional swimming suit. The results indicated that the neoprene swimming suit increases performance in biomechanical, physiological and perceptive aspects. The VM increase in maximal efforts does not depend exclusively on changes in FB and CB. Possibly, increments of the parameters related to the swimming may have improved the mechanical efficiency of the movement, which may have provided a movement economy that resulted in a better performance.

Vascular organization of the hystricomorph placenta: a comparative study in the agouti, capybara, guinea pig, paca and rock cavy.

The placental vasculature of five hystricomorph rodents was examined by latex injection of the blood vessels, immunohistochemistry and scanning electron microscopy of vessel casts. The pattern of branching of the vessels is described at the level of fine structure. The placenta is divided into lobes separated by interlobular trophoblast. Fetal arteries course through the interlobular areas and give rise to capillaries from which blood drains into veins at the centre of the lobes. Maternal blood reaches the placenta through spiral arteries that pass around the perimeter of the subplacenta. They supply large maternal blood sinuses, lined by trophoblast, which run through the interlobular areas and into the centre of the lobes. Here they supply fine channels that run parallel to the fetal capillaries, so that maternal blood flows from the centre of the lobe to the periphery. This arrangement provides the morphological basis for countercurrent exchange. The maternal channels of the labyrinth drain into spaces formed by the latticework of the interlobular trophoblast and thence through venous lacunae to a basal venous lacunar ring. The subplacenta is supplied by a single fetal artery. The vessels within the subplacenta pursue a tortuous course with dilatations and constrictions as in an endocrine gland.

Aspectos morfológicos do funículo espermático do préa (Galea spixii spixii) / Morphological aspects of the funiculus spermaticus of the préa (Galea spixii spixii)

Estudando os aspectos morfológicos de 14 pares de funículos espermáticos de preá (Galea spixii spixii), adultos, observa-se histologicamente, em quatro pares, que os seus componentes acham-se envolvidos por delgada cápsula de tecido conjuntivo frouxo recoberta pelo mesotélio. Sob esta cápsula, envolvendo completamente o funículo, encontra-se densa camada de tecido adiposo. Seus componentes estäo envolvidos por tecido conjuntivo frouxo. A artéria testicular mostra-se sempre contornada pelas veias testiculares, e possui: moderada túnica média, cujas fibras musculares lisas säo mantidas por uma orgenada rede de fibras reticulares; túnica interna constituída por endotélio, tecido conjuntivo subendotelial e nítida lâmina elástica interna; e a túnica externa, representada essencialmente por fibras colágenas com raras fibras reticulares e elásticas, que se confundde com a adventícia das veias e com o tecido conjuntivo intervascular. As veias testiculares formam o plexo pampiniforme, apresentam lumens amplos e irregulares, calibres variáveis, com paredes constituídas praticamente de endotélio vascular, desprovidas de válvulas e apresentam íntima relaçäo com a artéria. O segmento da artéria testicular obtido com Neoprene látex "450", em 10 moldes, exibe trajeto sinuoso, e como comprimentos médio, máximo e mínimo, respectivamente, 14,57cm, 16,60cm e 12,20cm à direita e 13,22cm, 12,20cm, e 11,70cm à esquerda; valores que näo apresentam diferenças significantes, ao nível de 5 por cento.

Blood supply to the human sternocleidomastoid muscle by the sternocleidomastoid branch of the occipital artery.

The contribution of the sternocleidomastoid branch of the occipital artery, superior arterial pedicle (SAP), to the irrigation of the sternocleidomastoid muscle (SCM) was evaluated in fresh human cadavers by injecting Neoprene-latex for minute dissection. From its insertion in the mastoid process of the temporal bone, the SCM was divided into six levels. The Neoprene-latex injected into the SAP reached the upper three levels in all SCMs studied, which corresponds to the middle part of the studied SCM. In 43.3% of the SCM, this branch reached level four and in 36.6%, it reached level five.

Dados anatômicos da placenta em caprinos estudados por injeção intravascular de neoprene / Anatomic research on the goat placenta by neoprene injection

Estudamos a placenta quanto aos seus aspectos morfológicos em 30 caprinos sem raça definida, adultos oriundos do Estado do Piauí, mediante a análise de esquemas de modelos obtidos pela injeção de látex Neoprene "650". Obtivemos 17 casos, ou seja, 56,66 por cento de gestações únicas e 13 casos, ou seja, 43,33 por cento de gestações gemelares. A área do hilo placentário varia de 1 a 6 cm de diâmetro e está situada no centro da placenta, região caracterizada pela apresentação do pedículo umbilical. O formato dos cotilédones varia de ovóide, circular, elíptica, piriforme ou reniforme, sendo que a maioria mostra-se ovóide. O número total de cotilédones em 30 gestações é igual a 3.117, sendo a média 104 cotilédones por gestação. Nas gestações únicas em 16 casos (94,11 por cento), o corno uterino gestante apresenta maior número de cotilédones do que o corno uterino não-gestante. Nas gestações gemelares, em 7 observações (53,84 por cento), o corno uterino esquerdo mostra maior número de cotilédones do que o corno uterino direito.(AU)

he morphologic aspects of the goat placenta were the subjects of our research. Thirty adult, mixed-breed goats, from the State of Piauí (Brazil), were studied, and the models obtained by Neoprene "650" latex injection were analyzed. We found that in 17 cases (56.66%) single gestation occurred, while in 13 animals (43.33%) gemellary gestations were present. The diameter of the hilus placental area ranged from 1 to 6 centimeters. It was located in the center of the placenta, an area characterized by the presence of the umbilical pedicle. Concerning the cotyledon shape, the great majority was ovoid, although circled, elliptical, pyriform and reniform shapes were also found. The total number of cotyledons in all thirty pregnancies was 3.117, which shows an average of 104 cotyledons per gestation. In 16 cases of single gestation (94.11%), the pregnant uterine horn had a greater number of cotyledons than the contralateral one. In 7 animals with gemellary gestation (53.84%), the left uterine horn had a greater number of cotyledons than the right uterine one.(AU)

Observaciones anatómicas de la parte ambiens de la arteria cerebelar superior / Anatomical observations of the ambiens segment of the superior cerebellar artery

Se analiza la parte ambiens de la arteria cerebelar superior (ACS) considerando lado, sexo y parámetros no considerados generalmente en la literatura, como son el grupo étnico (GE) y el índice ecfálico-horizontal (IC-H). Actualmente la literatura clínica especializada (Mani et al.; Saeki & Rhoton; Tulleken & Luiten; Newton & Potts y Shrontz et al, entre otros) insiste en la necesidad de un conocimiento anatómico preciso, necesario para el éxito en intervenciones neuroquirúrgicas, como el abordaje de la fosa posterior del cráneo. En base a lo planteado y en trabajos previos, hemos iniciado una revisión anatómica de la ACS, aportando datos que contribuyen a su estudio y que pueden ser de utilidad práctica. El trabajo fue realizado en 70 encéfalos de individuos adultos, brasileños, de ambos sexos, provenientes del Servicio de Verificaciónde Obitos de la Escola Paulista de Medicina, Sao Paulo, Brasil, y a los cuales se les registraron datos antropológicos. Los encéfalos fueron extraídos según técnica de Kaplan. El calibre más frecuente de la parte ambiens de la arteria cerebelar superior, en el sexo masculino y en ambos lados, fluctúa entre 1,5 y 1,9 mm, siendo el porcentaje similar en el lado derecho de los individuos de sexo femenino. Este rango se presentó en ambos lados de los individuos blancos, pero en los individuos no-blancos la frecuencia mayor se presentó entre 0,9 y 1,4 mm en ambos lados. En los individuos braqui-hiperbraquicéfalos la mayor frecuencia se presentó entre 1,5 y 1,9 mm, en cambio, en los individuos dólico-mesocéfalos la mayor frecuencia se presentó en el rango de 0,9 a 1,4 mm en ambos lados. El número de las ramas perforantes de la parte ambiens de la ACS, en ambos lados, sexos, grupos étnicos e índices cefálicos, fluctuó entre 4 y 8 y el diámetro más frecuente de éstas, fue de 0,2 mm, en todos los individuos estudiados

Organización de las arterias digitales palmares en individuos brasileños / Organization of the palmar digital arteries in brazilian individuals

La irrigación de la palma está dad fundamentalmente por las arterias ulnar y radial, las que pudene anastomosarse a través de ramas de las mismas, para formar los conocidos arcos palmares superficial y profundo. Del primero de ellos se originan las arterias digitales palmares comunes (DPC) y algunas arterias digitales palmares propias (DPP). Agrupamos y clasificamos a estas arterias, tanto en presencia del arco palmar superficial (APS) como en ausencia del mismo. Para ello, utilizamos 90 regiones palmares de 45 cadáveres formolizados de individuos brasileños, adultos, de ambos sexos, pertenecientes a la disciplina de anatomía descriptiva e topográfica de la Universidade Federal de Sao Paulo, Brasil. Del total de muestras, 30 de ellas fueron inyectadas con látex neopreno (Artifix L-14). El APS fue observado en 70 por ciento de los casos. En éstos consideramos 7 tipos de origen y disposición de las aa. digitales palmares. El tipo A con 4aa. DPC (1º,2º,3º y 4ºespacio) más la arteria DPP ulnar del dedo mínimo y la arteria DPP radial del indicador derivada de la arteria DPC del 1º espacio, fue observado en 42,2 por ciento. El tipo B (8,9 por ciento) difiere del tipo A, solamente en que la arteria DPP radial del indicador provino de la formación arterial profunda. La ausencia del APS se observó en 30 por ciento. En estos casos las arterias digitales palmares se clasificaron en 6 tipos. El padrón A fue el más frecuente (12,2 por ciento), donde las arterias DPC del 2º,3º y 4º espacio y la arteria del dedo mínimo procedieron de la arteria ulnar y la del 1º espacio que participa en la irrigación del pulgar y d la parte radial del indicador, fue otorgada por la rama palmar superficial de la arteria radial, arteria principal del pulgar o arteria mediana. El padrón que siguió en frecuencia fue el C, con un 6,7 por ciento y en éste la arteria ulnar emitió la arteria DPP ulnar del dedo mínimo más las arterias DPC para los espacios 3º y 4º, las del 1º y 2º espacio provinieron de la arteria mediana, anastomosada o no, con una rama de la arteria radial

Investigación de los efectos neurofisiológicos de la inhalación aguda de neoprén en el gato / Investigation of the neurophysiological effects of acute neopren inhalation in the cat

En 15 gatos encéfalo aislados o curarizados, se estudiaron los fectos neurofisiológicos de la inhalación aguda de disolventes orgánicos de neoprén (Tolueno, n-hexano, benceno). La actividad eléctrica se registró medinate electrodos implantados estereotáxicamente en hipocampo, amígdalas, formación reticular mesencefálica y núcleo caudado. Se hizo monitoreo de EEG y ECG. El disolvente orgánico fue impulsado por medio de la ventilación mecánica. La actividad electrográfica de base durante los 30 a 40 min que duró cada sesión experimental, varió desde los signos de máxima alerta hasta intensificación de sincronización modulada que alternó con desincronización. Frecuentemente esta actividad estuvo desfasada entre las diversas estructuras estudiadas. Se observaron descargas paroxísticas parciales principalmente en hipocampo y amígdala. También se observaron descargas paroxísticas generalizadas con orígenes aparentes distintos. En cinco gatos se hizo fotoestimulación, en dos provocó paroxismos generalizados y en uno, crisis focal amigadliana. La frecuencia óptima fue de 3 Hz

Transplante de pancreas experimental / Experimental pancreas transplantation

Experimental pancreatic transplantation was performed in dogs using different surgical techniques. Ten dogs underwent whole organ graft with diversion of exocrine secretion by anastomosis of duodenal segment to bladder (six animals) and of duodenum to a jejunal loop (four animals). Segmental pancreatic grafts were performed in 10 dogs with ductal filling with polymer in six animal and duct ligation in four dogs. It is concluded that segmental pancreatic graft with ductal filling with polymer is preferable to the other surgical techniques (AU)