ABSTRACT
BACKGROUND: Recent studies have reported the burden of attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and depressive disorder. Also, there is mounting evidence on the effects of environmental factors, such as ambient air pollution, on these disorders among children and adolescents. However, few studies have evaluated the burden of mental disorders attributable to air pollution exposure in children and adolescents. METHODS: We estimated the risk ratios of major mental disorders (ADHD, ASD, and depressive disorder) associated with air pollutants among children and adolescents using time-series data (2011-2019) obtained from a nationwide air pollution monitoring network and healthcare utilization claims data in the Republic of Korea. Based on the estimated risk ratios, we determined the population attributable fraction (PAF) and calculated the medical costs of major mental disorders attributable to air pollution. RESULTS: A total of 33,598 patients were diagnosed with major mental disorders during 9 years. The PAFs for all the major mental disorders were estimated at 6.9% (particulate matter < 10 µm [PM10]), 3.7% (PM2.5), and 2.2% (sulfur dioxide [SO2]). The PAF of PM10 was highest for depressive disorder (9.2%), followed by ASD (8.4%) and ADHD (5.2%). The direct medical costs of all major mental disorders attributable to PM10 and SO2 decreased during the study period. CONCLUSION: This study assessed the burden of major mental disorders attributable to air pollution exposure in children and adolescents. We found that PM10, PM2.5, and SO2 attributed 7%, 4%, and 2% respectively, to the risk of major mental disorders among children and adolescents.
Subject(s)
Air Pollution , Attention Deficit Disorder with Hyperactivity , Particulate Matter , Humans , Child , Adolescent , Republic of Korea/epidemiology , Air Pollution/adverse effects , Particulate Matter/adverse effects , Particulate Matter/analysis , Male , Female , Attention Deficit Disorder with Hyperactivity/epidemiology , Attention Deficit Disorder with Hyperactivity/etiology , Environmental Exposure/adverse effects , Mental Disorders/epidemiology , Mental Disorders/etiology , Autism Spectrum Disorder/epidemiology , Autism Spectrum Disorder/etiology , Air Pollutants/adverse effects , Air Pollutants/analysis , Sulfur Dioxide/adverse effects , Sulfur Dioxide/analysis , Child, Preschool , Risk Factors , Health Care CostsABSTRACT
Objective: To investigate the association between exposure to atmospheric pollutants and preterm birth in a river valley-type city and its critical exposure windows. Methods: A retrospective cohort study was used to collect data from the medical records of preterm and full-term deliveries in two hospitals in urban areas of a typical river valley-type city from January 2018 to December 2019. A total of 7,288 cases were included in the study with general information such as pregnancy times, the number of cesarean sections, occupation, season of conception and regularity of the menstrual cycle. And confounding factors affecting preterm birth were inferred using the chi-square test. The effects of exposure to each pollutant, including particulate matter 2.5 (PM2.5), particulate matter 10 (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO) and ozone (O3), during pregnancy on preterm birth and the main exposure windows were explored by establishing a logistic regression model with pollutants introduced as continuous variables. Results: Maternal age, pregnancy times, number of births, number of cesarean sections, season of conception, complications diseases, comorbidities diseases, hypertension disorder of pregnancy and neonatal low birth weight of the newborn were significantly different between preterm and term pregnant women. Logistic regression analysis after adjusting for the above confounders showed that the risk of preterm birth increases by 0.9, 0.6, 2.4% in T2 and by 1.0, 0.9, 2.5% in T3 for each 10 µg/m3 increase in PM2.5, PM10, NO2 concentrations, respectively. The risk of preterm birth increases by 4.3% in T2 for each 10 µg/m3 increase in SO2 concentrations. The risk of preterm birth increases by 123.5% in T2 and increases by 188.5% in T3 for each 10 mg/m3 increase in CO concentrations. Conclusion: Maternal exposure to PM2.5, PM10, NO2, CO was associated with increased risk on preterm birth in mid-pregnancy (T2) and late pregnancy (T3), SO2 exposure was associated with increased risk on preterm birth in mid-pregnancy (T2).
Subject(s)
Air Pollutants , Particulate Matter , Premature Birth , Humans , Female , Premature Birth/epidemiology , Retrospective Studies , Pregnancy , Air Pollutants/adverse effects , Air Pollutants/analysis , Adult , Particulate Matter/adverse effects , Particulate Matter/analysis , Infant, Newborn , Maternal Exposure/adverse effects , Maternal Exposure/statistics & numerical data , China/epidemiology , Sulfur Dioxide/analysis , Sulfur Dioxide/adverse effects , Nitrogen Dioxide/analysis , Nitrogen Dioxide/adverse effects , Carbon Monoxide/analysis , Carbon Monoxide/adverse effects , Air Pollution/adverse effects , Air Pollution/statistics & numerical data , Risk Factors , CitiesABSTRACT
Long-term mortality effects of particulate air pollution have been investigated in a causal analytic frame, while causal evidence for associations with gaseous air pollutants remains extensively lacking, especially for carbon monoxide (CO) and sulfur dioxide (SO2). In this study, we estimated the causal relationship of long-term exposure to nitrogen dioxide (NO2), CO, SO2, and ozone (O3) with mortality. Utilizing the data from National Morbidity, Mortality, and Air Pollution Study, we applied a variant of difference-in-differences (DID) method with conditional Poisson regression and generalized weighted quantile sum regression (gWQS) to investigate the independent and joint effects. Independent exposures to NO2, CO, and SO2 were causally associated with increased risks of total, nonaccidental, and cardiovascular mortality, while no evident associations with O3 were identified in the entire population. In gWQS analyses, an interquartile range-equivalent increase in mixture exposure was associated with a relative risk of 1.067 (95% confidence interval: 1.010-1.126) for total mortality, 1.067 (1.009-1.128) for nonaccidental mortality, and 1.125 (1.060-1.193) for cardiovascular mortality, where NO2 was identified as the most significant contributor to the overall effect. This nationwide DID analysis provided causal evidence for independent and combined effects of NO2, CO, SO2, and O3 on increased mortality risks among the US general population.
Subject(s)
Air Pollutants , Air Pollution , Environmental Exposure , Nitrogen Dioxide , Ozone , Sulfur Dioxide , Humans , United States/epidemiology , Air Pollution/adverse effects , Air Pollution/analysis , Air Pollutants/adverse effects , Air Pollutants/analysis , Environmental Exposure/adverse effects , Sulfur Dioxide/analysis , Sulfur Dioxide/adverse effects , Ozone/analysis , Ozone/adverse effects , Ozone/toxicity , Nitrogen Dioxide/analysis , Nitrogen Dioxide/adverse effects , Nitrogen Dioxide/toxicity , Male , Female , Middle Aged , Aged , Adult , Mortality , Carbon Monoxide/analysis , Carbon Monoxide/adverse effects , Cardiovascular Diseases/mortality , Particulate Matter/adverse effects , Particulate Matter/analysis , Adolescent , Young AdultABSTRACT
Air pollution and heavy metal exposure are emerging public health concerns. Prenatal exposure to air pollutants and heavy metals has been implicated in the development of congenital heart disease (CHD). However, the relationship between exposure to airborne heavy metals and CHD has not yet been investigated. Therefore, in this large population-based study, we investigated the association between air pollutants, including airborne heavy metals, and the risk of CHD using national health insurance claims data from South Korea. Data regarding 1,129,442 newborns and their mothers were matched with air pollutant levels during the first 8 weeks of gestation. In the five-air pollutant model, we found significant positive correlations between prenatal exposure to sulfur dioxide (SO2; odds ratio [OR] 6.843, 95% confidence interval [CI] 5.746-8.149) and cadmium (Cd; OR 1.513, 95% CI 1.187-1.930) and the risk of ventricular septal defects in newborns. This study highlights the association between prenatal exposure to air pollutants, including airborne heavy metals, and an elevated CHD risk. Further research is essential to validate and expand these findings, with the ultimate goal of enhancing public health outcomes.
Subject(s)
Air Pollutants , Databases, Factual , Heart Defects, Congenital , Prenatal Exposure Delayed Effects , Humans , Female , Pregnancy , Republic of Korea/epidemiology , Heart Defects, Congenital/epidemiology , Heart Defects, Congenital/etiology , Heart Defects, Congenital/chemically induced , Infant, Newborn , Air Pollutants/adverse effects , Air Pollutants/analysis , Prenatal Exposure Delayed Effects/epidemiology , Adult , Maternal Exposure/adverse effects , Male , Sulfur Dioxide/analysis , Sulfur Dioxide/adverse effects , Risk Factors , Air Pollution/adverse effects , Air Pollution/analysis , National Health Programs , Metals, Heavy/adverse effects , Metals, Heavy/analysis , Metals, Heavy/toxicityABSTRACT
The emission of sulphur dioxide (SO 2) from mining activities presents significant health hazards, particularly to communities near industrial zones. This mixed-methods study investigates the nexus between (SO 2) exposure and respiratory health in Kankoyo Township, Zambia. Employing community engagement, expert interviews, spatial analysis, and a retrospective examination of 15 years of health and (SO 2) data, the research identified a troubling correlation between (SO 2) exposure and adverse respiratory health effects among the local population. Expert interviews highlighted that respiratory issues constituted approximately 75% of health complications, with a notable reduction in asthma cases following the installation of a monitoring station and upgrades to smelter operations. Spatial analysis demonstrated that (SO 2) levels in Kankoyo exceeded the Zambian Environmental Management Agency (ZEMA) limits by 1713% identifying it as a significant pollution hotspot. Additionally, wind profile analysis indicated frequent low-speed winds from the east-northeast (ENE), contributing to pollutant accumulation. Based on these insights, the study recommends implementing real-time pollution data sharing, affordable air quality sensors, addressing medication shortages, establishing specialized respiratory clinics, launching IT-driven awareness campaigns, and further research into additional pollutants and confounding factors.
Subject(s)
Air Pollutants , Environmental Exposure , Mining , Sulfur Dioxide , Humans , Sulfur Dioxide/analysis , Zambia/epidemiology , Air Pollutants/analysis , Adult , Female , Male , Middle Aged , Environmental Exposure/adverse effects , Adolescent , Young Adult , Child , Retrospective Studies , Respiratory Tract Diseases/epidemiology , Respiratory Tract Diseases/chemically induced , Child, Preschool , Aged , Environmental MonitoringABSTRACT
Shipping emissions were measured in Dunkirk, France. Elevated aerosol extinction coefficients (AEC), nitrogen dioxide (NO2) and sulphur dioxide (SO2) were observed up to 500 m from surface. Formaldehyde (HCHO) did not show an increase every time, which suggests that oxidation of emitted volatile organic compounds (VOCs) took longer than the transport to the observation path and dilution of direct emissions had occurred. Background NO2, HCHO, and SO2 levels were higher when the wind came over land or the surrounding industrial area, indicating that land-based sources contribute significantly; however, clear spikes in NO2 and SO2 were observed whenever ship plumes were sampled. Observations show that the ship emission contribution to pollution is significant, but land-based sources still dominate. The SO2/NO2 ratio was low throughout the campaign, although varying according to the ship type, confirming that the new fuel content regulations are being followed by most ships in this region.
Subject(s)
Air Pollutants , Environmental Monitoring , Ships , Sulfur Dioxide , Sulfur Dioxide/analysis , Air Pollutants/analysis , North Sea , Nitrogen Dioxide/analysis , Volatile Organic Compounds/analysis , France , Formaldehyde/analysis , Aerosols/analysis , Vehicle Emissions/analysisABSTRACT
In the confined space of the underground coal mine, which is dominated by transportation lanes, explosion-proof diesel-powered trackless rubber-wheeled vehicles are becoming the main transportation equipment, and the exhaust gas produced by them is hazardous to the health of workers and pollutes the underground environment. In this experiment, a similar test platform is built to study the effects of wind speed, vehicle speed, and different wind directions on the diffusion characteristics of exhaust gas. In this paper, CO and SO2 are mainly studied. The results show that the diffusion of CO and SO2 gas is similar and the maximum SO2 concentration only accounts for 11.4% of the CO concentration. Exhaust gas is better diluted by increasing the wind speed and vehicle speed, respectively. Downwind is affected by the reverse wind flow and diffuses to the driver's position, which is easy to cause occupational diseases. When the wind is a headwind, the exhaust gases spread upwards and make a circumvention movement, gathering at the top. When the wind speed and vehicle speed are both 0.6 m/s, the CO concentration corresponds to the change trend of the Lorentz function when the wind is downwind and the CO concentration corresponds to the change trend of the BiDoseResp function when the wind is headwind. The study of exhaust gas diffusion characteristics is of great significance for the subsequent purification of the air in the restricted mine space and the protection of the workers' occupational health.
Subject(s)
Coal Mining , Confined Spaces , Vehicle Emissions , Wind , Vehicle Emissions/analysis , Sulfur Dioxide/analysis , Carbon Monoxide/analysis , Diffusion , Environmental Monitoring/methods , Air Pollutants/analysis , Air Pollutants, Occupational/analysis , Occupational Exposure/analysisABSTRACT
This study uses artificial neural networks (ANNs) to examine the intricate relationship between air pollutants, meteorological factors, and respiratory disorders. The study investigates the correlation between hospital admissions for respiratory diseases and the levels of PM10 and SO2 pollutants, as well as local meteorological conditions, using data from 2017 to 2019. The objective of this study is to clarify the impact of air pollution on the well-being of the general population, specifically focusing on respiratory ailments. An ANN called a multilayer perceptron (MLP) was used. The network was trained using the Levenberg-Marquardt (LM) backpropagation algorithm. The data revealed a substantial increase in hospital admissions for upper respiratory tract diseases, amounting to a total of 11,746 cases. There were clear seasonal fluctuations, with fall having the highest number of cases of bronchitis (N = 181), sinusitis (N = 83), and upper respiratory infections (N = 194). The study also found demographic differences, with females and people aged 18 to 65 years having greater admission rates. The performance of the ANN model, measured using R2 values, demonstrated a high level of predictive accuracy. Specifically, the R2 value was 0.91675 during training, 0.99182 during testing, and 0.95287 for validating the prediction of asthma. The comparative analysis revealed that the ANN-MLP model provided the most optimal result. The results emphasize the effectiveness of ANNs in representing the complex relationships between air quality, climatic conditions, and respiratory health. The results offer crucial insights for formulating focused healthcare policies and treatments to alleviate the detrimental impact of air pollution and meteorological factors.
Subject(s)
Air Pollutants , Air Pollution , Hospitalization , Neural Networks, Computer , Humans , Air Pollution/statistics & numerical data , Adult , Middle Aged , Adolescent , Air Pollutants/analysis , Young Adult , Female , Aged , Male , Hospitalization/statistics & numerical data , Respiratory Tract Diseases/epidemiology , Meteorological Concepts , Particulate Matter/analysis , Sulfur Dioxide/analysis , Child , Environmental Monitoring/methods , Child, Preschool , Respiratory Tract Infections/epidemiologyABSTRACT
The release of toxic gases into the atmosphere may reach concentrations that can cause undesirable health, economic, or aesthetic effects. It is therefore important to monitor the amounts of pollutants injected into the atmosphere from various sources. Most countries have a ground network with multiple measuring sites and instruments, that can measure the air quality index (AQI). However, the main challenge with the networks is the low spatial coverage. In this work, satellite data is used to calculate for the first time the spatial distribution of AQI and pollutant concentration over South Africa. The TROPOspheric Monitoring Instrument (TROPOMI) onboard Sentinel-5P data is used to calculate AQI from carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), and sulfur dioxide (SO2) gases. The results that the month of June has the worst air quality distribution throughout the country, while March has the best air quality distribution. Overall, the results clearly show that TROPOMI has the capability to measure air quality at a country and city level.Implications: In this work, satellite data is used to calculate for the first time the spatial distribution of the air quality index (AQI) and pollutant concentration over South Africa. The TROPOspheric Monitoring Instrument (TROPOMI) onboard Sentinel-5P data is used to calculate AQI from carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), and sulfur dioxide (SO2) gases. Currently, South Africa has a ground network of instruments that measure AQ, however, the network does not cover the whole country. In this work, we show that the use of TROPOMI can compliment the current network and provide data for the areas not covered.
Subject(s)
Air Pollutants , Air Pollution , Environmental Monitoring , South Africa , Environmental Monitoring/methods , Air Pollutants/analysis , Air Pollution/analysis , Ozone/analysis , Nitrogen Dioxide/analysis , Carbon Monoxide/analysis , Sulfur Dioxide/analysisABSTRACT
Introduction: Many decarbonization technologies have the added co-benefit of reducing short-lived climate pollutants, such as particulate matter (PM), nitrogen oxides (NOx), and sulfur dioxide (SO2), creating a unique opportunity for identifying strategies that promote both climate change solutions and opportunities for air quality improvement. However, stakeholders and decision-makers may struggle to quantify how these co-benefits will impact public health for the communities most affected by industrial air pollution. Methods: To address this problem, the LOCal Air Emissions Tracking Atlas (LOCAETA) fills a data availability and analysis gap by providing estimated air quality benefits from industrial decarbonization options, such as carbon capture and storage (CCS). These co-benefits are calculated using an algorithm that connects disparate datasets that separately report greenhouse gas emissions and other pollutants at U.S. industrial facilities. Results: Version 1.0 of LOCAETA displays the estimated primary PM2.5 emission reduction co-benefits from additional pretreatment equipment for CCS on industrial and power facilities across the state of Louisiana, as well as the potential for VOC and NH3 generation. The emission reductions are presented in the tool alongside facility pollutant emissions information and relevant air quality, environmental, demographic, and public health datasets, such as air toxics cancer risk, satellite and in situ pollutant measurements, and population vulnerability metrics. Discussion: LOCAETA enables regulators, policymakers, environmental justice communities, and industrial and commercial users to compare and contrast quantifiable public health benefits due to air quality impacts from various climate change mitigation strategies using a free and publicly-available tool. Additional pollutant reductions can be calculated using the same methodology and will be available in future versions of the tool.
Subject(s)
Air Pollutants , Air Pollution , Environmental Monitoring , Particulate Matter , Air Pollution/analysis , Air Pollutants/analysis , Particulate Matter/analysis , Humans , Louisiana , Industry , Sulfur Dioxide/analysis , Climate Change , Nitrogen Oxides/analysisABSTRACT
The level of sulfur dioxide (SO2) and viscosity in mitochondria play vital roles in various physiological and pathological processes. Abnormalities in mitochondrial SO2 and viscosity are closely associated with numerous biological diseases. It is of great significance to develop novel fluorescence probes for simultaneous detection of SO2 and viscosity within mitochondria. Herein, we have developed a water-soluble, mitochondrial-targeted and near-infrared fluorescent probe, CMBT, for the simultaneous detection of SO2 and viscosity. The probe CMBT incorporates benzothiazolium salt as a mitochondrial targeting moiety and 7-diethylaminocoumarin as a rotor for viscosity detection, respectively. Based on the prompt reaction between nucleophilic HSO3-/SO32- and the backbone of the benzothiazolium salt derivative, probe CMBT displayed high sensitivity and selectivity toward SO2 with a limit of detection as low as 0.17 µM. As viscosity increased, the twisted intramolecular charge transfer (TICT) process was restricted, resulting in fluorescence emission enhancement at 690 nm. Moreover, probe CMBT demonstrated exceptional mitochondrial targeting ability and was successfully employed to image variations of SO2 and viscosity in living cells and mice. The work highlights the great potential of the probe as a convenient tool for revealing the relationship between SO2 and viscosity in biological systems.
Subject(s)
Fluorescent Dyes , Mitochondria , Sulfur Dioxide , Sulfur Dioxide/analysis , Sulfur Dioxide/chemistry , Fluorescent Dyes/chemistry , Animals , Mitochondria/chemistry , Mitochondria/metabolism , Viscosity , Mice , Humans , Optical Imaging/methods , HeLa Cells , Limit of DetectionABSTRACT
BACKGROUND: Long-term exposure to air pollution has been linked to cancer incidence. However, the evidence is limited regarding the effect of short-term exposure to air pollution on cancer mortality. OBJECTIVES: This study aimed to investigate associations between short-term exposure to air pollutants (sulfur dioxide (SO2), nitrogen dioxide (NO2), particulate matter with an aerodynamic diameter <10 mm (PM10) and PM2.5) and cancer daily mortality. METHODS: This study used air quality, meteorological and daily cancer death data from 2014 to 2019 in Hangzhou, China. Generalised additive models (GAM) with quasi-Poisson regression were used to analyse the associations between air pollutants and cancer mortality with adjustment for confounding factors including time trends, day of week, temperature and humidity. Then, we conducted stratified analyses by sex, age, season and education. In addition, stratified analyses of age, season and education were performed within each sex to determine whether sex difference was modified by such factors. RESULTS: After adjusting for potential confounders, the GAM results indicated a statistically significant relationship between increased cancer mortality and elevated air pollution concentrations, but only in the female population. For every 10 µg/m3 rise in pollutant concentration, the increased risk of cancer death in females was 6.82% (95% CI 3.63% to 10.10%) for SO2 on lag 03, and 2.02% (95% CI 1.12% to 2.93%) for NO2 on lag 01 and 0.89% (95% CI 0.46% to 1.33%) for PM10 on lag 03 and 1.29% (95% CI 0.64% to 1.95%) for PM2.5 on lag 03. However, no statistically significant association was found among males. Moreover, the differences in effect sizes between males and females were more pronounced during the cold season, among the elderly and among subjects with low levels of education. CONCLUSIONS: Increased cancer mortality was only observed in females with rising concentrations of air pollutants. Further research is required to confirm this sex difference. Advocate for the reduction of air pollutant emissions to protect vulnerable groups.
Subject(s)
Air Pollutants , Air Pollution , Environmental Exposure , Neoplasms , Nitrogen Dioxide , Particulate Matter , Sulfur Dioxide , Humans , Neoplasms/mortality , China/epidemiology , Female , Male , Air Pollution/adverse effects , Particulate Matter/adverse effects , Particulate Matter/analysis , Air Pollutants/adverse effects , Air Pollutants/analysis , Middle Aged , Environmental Exposure/adverse effects , Sulfur Dioxide/analysis , Sulfur Dioxide/adverse effects , Aged , Nitrogen Dioxide/analysis , Nitrogen Dioxide/adverse effects , Adult , Seasons , Young Adult , Adolescent , Child , Sex FactorsABSTRACT
First-ever measurements of particulate matter (PM2.5, PM10, and TSP) along with gaseous pollutants (CO, NO2, and SO2) were performed from June 2019 to April 2020 in Faisalabad, Metropolitan, Pakistan, to assess their seasonal variations; Summer 2019, Autumn 2019, Winter 2019-2020, and Spring 2020. Pollutant measurements were carried out at 30 locations with a 3-km grid distance from the Sitara Chemical Industry in District Faisalabad to Bhianwala, Sargodha Road, Tehsil Lalian, District Chiniot. ArcGIS 10.8 was used to interpolate pollutant concentrations using the inverse distance weightage method. PM2.5, PM10, and TSP concentrations were highest in summer, and lowest in autumn or winter. CO, NO2, and SO2 concentrations were highest in summer or spring and lowest in winter. Seasonal average NO2 and SO2 concentrations exceeded WHO annual air quality guide values. For all 4 seasons, some sites had better air quality than others. Even in these cleaner sites air quality index (AQI) was unhealthy for sensitive groups and the less good sites showed Very critical AQI (> 500). Dust-bound carbon and sulfur contents were higher in spring (64 mg g-1) and summer (1.17 mg g-1) and lower in autumn (55 mg g-1) and winter (1.08 mg g-1). Venous blood analysis of 20 individuals showed cadmium and lead concentrations higher than WHO permissible limits. Those individuals exposed to direct roadside pollution for longer periods because of their occupation tended to show higher Pb and Cd blood concentrations. It is concluded that air quality along the roadside is extremely poor and potentially damaging to the health of exposed workers.
Subject(s)
Air Pollutants , Air Pollution , Environmental Monitoring , Particulate Matter , Pakistan , Humans , Air Pollutants/analysis , Particulate Matter/analysis , Air Pollution/statistics & numerical data , Seasons , World Health Organization , Sulfur Dioxide/analysis , Cities , Nitrogen Dioxide/analysis , Environmental Exposure/statistics & numerical data , Carbon Monoxide/analysisABSTRACT
The presence of harmful substances in the atmosphere poses significant risks to the environment and public health. These pollutants can come from natural sources like dust and wildfires, or from human activities such as industrial, transportation, and agricultural practices. The objective of this study was to assess air quality on the East Coast of Peninsular Malaysia by analyzing historical data from the Department of Environment, Malaysia. Daily measurements of PM10, O3, SO2, NO2, and CO were collected from eight monitoring stations over 11 years (2011-2021) and analyzed using environmetric techniques. Hierarchical agglomerative cluster analysis (HACA) classified two stations as belonging to the high pollution cluster (HPC), three stations as part of the moderate pollution cluster (MPC), and three stations as the low pollution cluster (LPC). Discriminant analysis revealed a correct assignment rate of 90.50%, indicating that all five parameters were able to differentiate pollution levels with high significance (p < 0.0001). Principal component analysis (PCA) was conducted to validate the pattern of air quality variables in relation to the identified clusters (HPC, MPC, and LPC). The results showed that two verifactors (VFs) were extracted in HPC and LPC, while three VFs were identified in MPC. The cumulative variance explained by the PCA for HPC, MPC, and LPC was 69.43%, 82.32%, and 62.16%, respectively. Finally, an artificial neural network (ANN) was used to forecast the air pollutant index (API) levels, using the R2 and RMSE performance metrics. The PCA-MLP Model A yielded an R2 value of 0.8470 and an RMSE of 6.6470, while PCA-MLP Model B achieved an R2 value of 0.8591 and an RMSE of 6.3000, both indicating a significant and strong correlation.
Subject(s)
Air Pollutants , Air Pollution , Environmental Monitoring , Malaysia , Environmental Monitoring/methods , Air Pollutants/analysis , Air Pollution/statistics & numerical data , Principal Component Analysis , Particulate Matter/analysis , Sulfur Dioxide/analysis , Nitrogen Dioxide/analysisABSTRACT
Air pollution is associated with elevated cardiovascular mortality and an increase in cardiovascular risk factors. However, the literature data on associations between air pollution and cardiovascular risk factors are contradictory. To explore the relationship between residential exposure to atmospheric pollutants and cardiovascular risk factors (lipid biomarker and blood pressure levels). We studied a sample of 2339 adult participants in the ELISABET study from the Dunkirk and Lille urban areas of France. The mean annual exposure to atmospheric pollutants (PM10, NO2 and SO2) at the home address was estimated via an air dispersion model. The associations were probed in multivariate linear regression models. The mean NO2 level was 26.05 µg/m3 in Lille and 19.96 µg/m3 in Dunkirk. The mean PM10 level was 27.02 µg/m3 in Lille and 26.53 µg/m3 in Dunkirk. We detected a significant association between exposure to air pollutants and the high-density lipoprotein (HDL) (which is a protective factor against cardiovascular diseases) level: for a 2 µg/m3 increment in PM10, the HDL level decreased by 1.72% (p = 0.0037). None of the associations with other lipid variables or with blood pressure were significant. We didn't find evidence significant associations for most of the risk factors but, long-term exposure of adults to moderate levels of ambient air pollution was associated with a decrement in HDL.
Subject(s)
Air Pollutants , Air Pollution , Cardiovascular Diseases , Environmental Exposure , Particulate Matter , Humans , France/epidemiology , Male , Female , Middle Aged , Adult , Air Pollutants/analysis , Air Pollution/adverse effects , Cardiovascular Diseases/epidemiology , Particulate Matter/analysis , Aged , Blood Pressure , Heart Disease Risk Factors , Risk Factors , Nitrogen Dioxide/analysis , Sulfur Dioxide/analysisABSTRACT
Inflammation is a complex physiological response involving various cellular and molecular events. Sulfur dioxide (SO2), recognized as both an endogenous signaling molecule and anti-inflammatory agent, plays a crucial role in modulating inflammation and maintaining cellular homeostasis. To gain deeper insights into the dynamics of inflammation-related processes, real-time monitoring of SO2 concentrations within cellular organelles is imperative. Here, we developed a near-infrared fluorescent probe, R2, equipped with lysosomal targeting features. R2 effectively monitors dynamic SO2 concentration changes during inflammation. The fluorescence intensity at 703 nm of R2 shows a strong linear correlation with the concentration of SO2, displaying a rapid response time to SO2 within 10 s and maintaining excellent photostability. The successful application of R2 in elucidating dynamic SO2 concentration changes in lysosomal during cellular and rat inflammatory processes underscores its significant potential as a tool for understanding the pathogenesis of inflammation-related diseases.
Subject(s)
Fluorescent Dyes , Inflammation , Lysosomes , Sulfur Dioxide , Lysosomes/metabolism , Lysosomes/chemistry , Sulfur Dioxide/analysis , Animals , Inflammation/metabolism , Fluorescent Dyes/chemistry , Humans , Rats , Mice , Spectrometry, Fluorescence , MaleABSTRACT
The biomimetic electronic nose (e-nose) technology is a novel technology used for the identification and monitoring of complex gas molecules, and it is gaining significance in this field. However, due to the complexity and multiplicity of gas mixtures, the accuracy of electronic noses in predicting gas concentrations using traditional regression algorithms is not ideal. This paper presents a solution to the difficulty by introducing a fusion network model that utilizes a transformer-based multikernel feature fusion (TMKFF) module combined with a 1DCNN_LSTM network to enhance the accuracy of regression prediction for gas mixture concentrations using a portable electronic nose. The experimental findings demonstrate that the regression prediction performance of the fusion network is significantly superior to that of single models such as convolutional neural network (CNN) and long short-term memory (LSTM). The present study demonstrates the efficacy of our fusion network model in accurately predicting the concentrations of multiple target gases, such as SO2, NO2, and CO, in a gas mixture. Specifically, our algorithm exhibits substantial benefits in enhancing the prediction performance of low-concentration SO2 gas, which is a noteworthy achievement. The determination coefficient (R2) values of 93, 98, and 99% correspondingly demonstrate that the model is very capable of explaining the variation in the concentration of the target gases. The root-mean-square errors (RMSE) are 0.0760, 0.0711, and 3.3825, respectively, while the mean absolute errors (MAE) are 0.0507, 0.0549, and 2.5874, respectively. These results indicate that the model has relatively small prediction errors. The method we have developed holds significant potential for practical applications in detecting atmospheric pollution detection and other molecular detection areas in complex environments.
Subject(s)
Electronic Nose , Gases , Gases/chemistry , Gases/analysis , Neural Networks, Computer , Algorithms , Sulfur Dioxide/analysis , Artificial IntelligenceABSTRACT
Air pollution poses a major threat to both the environment and public health. The air quality index (AQI), aggregate AQI, new health risk-based air quality index (NHAQI), and NHAQI-WHO were employed to quantitatively evaluate the characterization of air pollution and the associated health risk in Gansu Province before (P-I) and after (P-II) COVID-19 pandemic. The results indicated that AQI system undervalued the comprehensive health risk impact of the six criteria pollutants compared with the other three indices. The stringent lockdown measures contributed to a considerable reduction in SO2, CO, PM2.5, NO2 and PM10; these concentrations were 43.4%, 34.6%, 21.4%, 17.4%, and 14.2% lower in P-II than P-I, respectively. But the concentration of O3 had no obvious improvement. The higher sandstorm frequency in P-II led to no significant decrease in the ERtotal and even resulted in an increase in the average ERtotal in cities located in northwestern Gansu from 0.78% in P-I to 1.0% in P-II. The cumulative distribution of NHAQI-based population-weighted exposure revealed that 24% of the total population was still exposed to light pollution in spring during P-II, while the air quality in other three seasons had significant improvements and all people were under healthy air quality level.
Subject(s)
Air Pollutants , Air Pollution , COVID-19 , Particulate Matter , China/epidemiology , Humans , Air Pollution/adverse effects , Air Pollution/analysis , COVID-19/epidemiology , Air Pollutants/analysis , Air Pollutants/adverse effects , Particulate Matter/analysis , Particulate Matter/adverse effects , SARS-CoV-2/isolation & purification , Environmental Monitoring/methods , Environmental Exposure/adverse effects , Public Health , Sulfur Dioxide/analysis , Sulfur Dioxide/adverse effects , Risk Assessment , Ozone/analysisABSTRACT
Morbidity and mortality from several diseases are increased on days of higher ambient air pollution. We carried out a daily time-series analysis with distributive lags to study the influence of short-term air pollution exposure on COVID-19 related hospitalization in Santiago, Chile between March 16 and August 31, 2020. Analyses were adjusted for temporal trends, ambient temperature, and relative humidity, and stratified by age and sex. 26,579 COVID-19 hospitalizations were recorded of which 24,501 were laboratory confirmed. The cumulative percent change in hospitalizations (95% confidence intervals) for an interquartile range increase in air pollutants were: 1.1 (0.2, 2.0) for carbon monoxide (CO), 0.30 (0.0, 0.50) for nitrogen dioxide (NO2), and 2.7 (1.9, 3.0) for particulate matter of diameter ≤ 2.5 microns (PM2.5). Associations with ozone (O3), particulate matter of diameter ≤ 10 microns (PM10) and sulfur dioxide (SO2) were not significant. The observed effect of PM2.5 was significantly greater for females and for those individuals ≥ 65 years old. This study provides evidence that daily increases in air pollution, especially PM2.5, result in a higher observed risk of hospitalization from COVID-19. Females and the elderly may be disproportionately affected.
Subject(s)
Air Pollutants , Air Pollution , COVID-19 , Hospitalization , Particulate Matter , Humans , COVID-19/epidemiology , Chile/epidemiology , Hospitalization/statistics & numerical data , Female , Male , Air Pollution/adverse effects , Air Pollution/analysis , Aged , Middle Aged , Particulate Matter/adverse effects , Particulate Matter/analysis , Air Pollutants/analysis , Air Pollutants/adverse effects , Environmental Exposure/adverse effects , Adult , Carbon Monoxide/analysis , SARS-CoV-2/isolation & purification , Nitrogen Dioxide/analysis , Ozone/analysis , Sulfur Dioxide/analysis , Young AdultABSTRACT
Adiyaman, a city recently affected by an earthquake, is facing significant air pollution challenges due to both anthropogenic activities and natural events. The sources of air pollution have been investigated using meteorological variables. Elevated southerly winds, especially prominent in spring and autumn, significantly contribute to dust transport, leading to a decline in local air quality as detected by the HYSPLIT model. Furthermore, using Suomi-NPP Thermal Anomaly satellite product, it is detected and analyzed for crop burning activities. Agricultural practices, including stubble burning, contribute to the exacerbation of PM10 pollution during the summer months, particularly when coupled with winds from all directions except the north. In fall and winter months, heating is identified as the primary cause of pollution. The city center located north of the station is the dominant source of pollution throughout all seasons. The study established the connection between air pollutants and meteorological variables. Furthermore, the Spearman correlation coefficients reveal associations between PM10 and SO2, indicating moderate positive correlations under pressure conditions (r = 0.35, 0.52). Conversely, a negative correlation is observed with windspeed (r = -0.35, -0.50), and temperature also exhibits a negative correlation (r = -0.39, -0.54). During atmospheric conditions with high pressure, PM10 and SO2 concentrations are respectively 41.2% and 117.2% higher. Furthermore, pollutant concentration levels are 29.2% and 53.3% higher on days with low winds. Last, practical strategies for mitigating air pollution have been thoroughly discussed and proposed. It is imperative that decision-makers engaged in city planning and renovation give careful consideration to the profound impact of air pollution on both public health and the environment, particularly in the aftermath of a recent major earthquake.